Saldigones A-C(1,3,4),three new isoprenylated flavonoids with diverse flavanone,pterocarpan,and isoflavanone architec-tures,were characterized from the roots of Salvia digitaloides,together with a known isoprenylated ...Saldigones A-C(1,3,4),three new isoprenylated flavonoids with diverse flavanone,pterocarpan,and isoflavanone architec-tures,were characterized from the roots of Salvia digitaloides,together with a known isoprenylated flavanone(2).Notably,it’s the first report of isoprenylated flavonoids from Salvia species.The structures of these isolates were elucidated by extensive spectroscopic analysis.All of the compounds were evaluated for their activities on Cav3.1 low voltage-gated Ca^(2+)channel(LVGCC),of which 2 strongly and dose-dependently inhibited Cav3.1 peak current.展开更多
Nineteen diterpenoids, including saldigitin A(1) bearing an unprecedented 10-methylated 6/7/6 carbon ring system, two new icetexanes(2, 3), and two new nor-abietanes(5, 6) were characterized from the roots of Salvia d...Nineteen diterpenoids, including saldigitin A(1) bearing an unprecedented 10-methylated 6/7/6 carbon ring system, two new icetexanes(2, 3), and two new nor-abietanes(5, 6) were characterized from the roots of Salvia digitaloides. Their structures were elucidated by the analysis of the spectroscopic data,X-ray crystallography, and TDDFT calculations of ECD spectra. The novel architecture of 1 should be biogenetically derived through the cleavage and re-cyclization of the B/C rings from the normal abietane skeleton. Biologically, 1–5 exhibited noticeable inhibitions on Ca_(v)3.1 low voltage-gated Ca2+channel(LVGCC), with IC50values in the range of 3.43–11.70 μmol/L. They are the first example of diterpenoids with 6/7/6 carbon rings system as Ca_(v)3.1 antagonists.展开更多
基金the Foundation of Supported by National Natural Science Foundation of China(32070392 and 32070393)the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(2019QZKK0502-0303).
文摘Saldigones A-C(1,3,4),three new isoprenylated flavonoids with diverse flavanone,pterocarpan,and isoflavanone architec-tures,were characterized from the roots of Salvia digitaloides,together with a known isoprenylated flavanone(2).Notably,it’s the first report of isoprenylated flavonoids from Salvia species.The structures of these isolates were elucidated by extensive spectroscopic analysis.All of the compounds were evaluated for their activities on Cav3.1 low voltage-gated Ca^(2+)channel(LVGCC),of which 2 strongly and dose-dependently inhibited Cav3.1 peak current.
基金financially supported by the National Natural Science Foundation of China (Nos. 32070392 and 32070393)the Second Tibetan Plateau Scientific Expedition and Research(STEP) Program (Nos. 2019QZKK0502-0303 and 2019QZKK0502-0304)+2 种基金Natural Science Foundation of Yunnan Province (Nos.202001AS070040 and 202101AV070010)Yunnan Young&Elite Talents Project (No. YNWR-QNBJ-2020-277)CAS “Light of West China” Program (2021)。
文摘Nineteen diterpenoids, including saldigitin A(1) bearing an unprecedented 10-methylated 6/7/6 carbon ring system, two new icetexanes(2, 3), and two new nor-abietanes(5, 6) were characterized from the roots of Salvia digitaloides. Their structures were elucidated by the analysis of the spectroscopic data,X-ray crystallography, and TDDFT calculations of ECD spectra. The novel architecture of 1 should be biogenetically derived through the cleavage and re-cyclization of the B/C rings from the normal abietane skeleton. Biologically, 1–5 exhibited noticeable inhibitions on Ca_(v)3.1 low voltage-gated Ca2+channel(LVGCC), with IC50values in the range of 3.43–11.70 μmol/L. They are the first example of diterpenoids with 6/7/6 carbon rings system as Ca_(v)3.1 antagonists.
