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Effects of Muscle Electrical Activity on the Transmission of Developing Neuromuscular Junction
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作者 汤云贵 谢佐平 +2 位作者 毛健 何展全 赵南明 《Science China Chemistry》 SCIE EI CAS 1994年第5期573-580,共8页
Miniature endplate potentials (MEPPS) caused by the spontaneous release of ACh from the growth cone of cholinergic neurons, are recorded by the whole-cell patch-clamp technique on a large number of 1-day cultured myob... Miniature endplate potentials (MEPPS) caused by the spontaneous release of ACh from the growth cone of cholinergic neurons, are recorded by the whole-cell patch-clamp technique on a large number of 1-day cultured myoballs which have contact neurites of co-cultured neurons. Both muscle cell and neuron are dissociated from the 1-day-old (about stage 20) Xenopus embryo. Frequency and/or amplitude of MEPPs can obviously increase after the repetitive high-level depolarization caused by the stimuli on muscle cells. No detectable changes of single ACh receptor channel property are observed by using the single-channel recording technique. These results suggest that the mechanism of the increase of MEPPs after electrical activity of postsynaptic muscle cells probably involve some alteration of presynaptic membrane. 展开更多
关键词 electrical activity of MUSCLE cell PATCH-CLAMP technique miniature ENDPLATE POTENTIALS (mepps) ACETYLCHOLINE (ACh) receptor channel.
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