目的比较3种药敏检测方法检测替加环素对多重耐药鲍曼不动杆菌敏感性的差异。方法收集2018年临床分离耐碳青霉烯类鲍曼不动杆菌60株,采用MIC Test Strip(MTS)法、VITEK-2法、纸片扩散法分别检测替加环素对耐碳青霉烯类鲍曼不动杆菌的敏...目的比较3种药敏检测方法检测替加环素对多重耐药鲍曼不动杆菌敏感性的差异。方法收集2018年临床分离耐碳青霉烯类鲍曼不动杆菌60株,采用MIC Test Strip(MTS)法、VITEK-2法、纸片扩散法分别检测替加环素对耐碳青霉烯类鲍曼不动杆菌的敏感性。结果按照FDA标准,以MTS法为参考,VITEK-2法的一致率较高,纸片扩散法的一致率较低。Vitek-2法的MIC值比MTS法的MIC值低1~2个稀释度,利用MTS法检测替加环素对耐碳青霉烯鲍曼不动杆菌的耐药率达到23.3%,出现耐药株。结论对于耐碳青霉烯类鲍曼不动杆菌,Vitek-2法和纸片扩散法均不适合检测替加环素的敏感性,不能作为常规方法,需用MTS法确认。展开更多
Microtubules (MTs) are cytoskeletal elements formed by a non-covalent association of α- and β-tubulin heterodimers. They provide structure and shape to all eukaryotic cells and are implicated in a variety of fundame...Microtubules (MTs) are cytoskeletal elements formed by a non-covalent association of α- and β-tubulin heterodimers. They provide structure and shape to all eukaryotic cells and are implicated in a variety of fundamental cellular processes including cell motility, cell division, mechanotransduction as well as long-distance intracellular cargo transport. In neurons, they constitute the molecular frame that maintains the lengthy axonal projections. In view of the relative size of some axons in the human body, which can reach up to 1 m, the active transport of e.g., vesicles over the MT arrays to the synaptic cleft, is of particular importance.展开更多
This paper summarized and reviewed recent studies of micro transportation systems (MTS) in the MEMS (Micro Electro-Mechanical System) field. Micro transportation systems can be identified and classified into three cat...This paper summarized and reviewed recent studies of micro transportation systems (MTS) in the MEMS (Micro Electro-Mechanical System) field. Micro transportation systems can be identified and classified into three categories based on the contact types between the objects and the actuators (i.e. liquid-based, solid- based and air-bearing type). Their advantages and disadvantages were also analyzed and compared. The au- thors have proposed and developed three types of solid-based MTS utilizing electrostatic comb-drive actua- tors and ratchet mechanisms to drive the micro container in straight and curved paths. These MTSs have been fabricated with silicon-on-insulator (SOI)-MEMS technology and tested successfully. In the near future, MTSs can be applied in different fields such as medicine (to classify and test blood cells), in bioengineering (to capture, sort and combine bio-cells, DNA), or in micro robot systems.展开更多
文摘目的比较3种药敏检测方法检测替加环素对多重耐药鲍曼不动杆菌敏感性的差异。方法收集2018年临床分离耐碳青霉烯类鲍曼不动杆菌60株,采用MIC Test Strip(MTS)法、VITEK-2法、纸片扩散法分别检测替加环素对耐碳青霉烯类鲍曼不动杆菌的敏感性。结果按照FDA标准,以MTS法为参考,VITEK-2法的一致率较高,纸片扩散法的一致率较低。Vitek-2法的MIC值比MTS法的MIC值低1~2个稀释度,利用MTS法检测替加环素对耐碳青霉烯鲍曼不动杆菌的耐药率达到23.3%,出现耐药株。结论对于耐碳青霉烯类鲍曼不动杆菌,Vitek-2法和纸片扩散法均不适合检测替加环素的敏感性,不能作为常规方法,需用MTS法确认。
基金supported by ANR-13-JSV2-0002,Centre d’Excellence en maladies Neuro-dégénératives(CoEN)de Montpellier and France Alzheimer
文摘Microtubules (MTs) are cytoskeletal elements formed by a non-covalent association of α- and β-tubulin heterodimers. They provide structure and shape to all eukaryotic cells and are implicated in a variety of fundamental cellular processes including cell motility, cell division, mechanotransduction as well as long-distance intracellular cargo transport. In neurons, they constitute the molecular frame that maintains the lengthy axonal projections. In view of the relative size of some axons in the human body, which can reach up to 1 m, the active transport of e.g., vesicles over the MT arrays to the synaptic cleft, is of particular importance.
文摘This paper summarized and reviewed recent studies of micro transportation systems (MTS) in the MEMS (Micro Electro-Mechanical System) field. Micro transportation systems can be identified and classified into three categories based on the contact types between the objects and the actuators (i.e. liquid-based, solid- based and air-bearing type). Their advantages and disadvantages were also analyzed and compared. The au- thors have proposed and developed three types of solid-based MTS utilizing electrostatic comb-drive actua- tors and ratchet mechanisms to drive the micro container in straight and curved paths. These MTSs have been fabricated with silicon-on-insulator (SOI)-MEMS technology and tested successfully. In the near future, MTSs can be applied in different fields such as medicine (to classify and test blood cells), in bioengineering (to capture, sort and combine bio-cells, DNA), or in micro robot systems.
