The ligand ttd(ttd=1,4,8,9-Tetraaza-triphenylene-2,3-dicarbonitrile) and a novel spin crossover complex [Fe(ttd)2(NCS)2]·H2O were synthesized, and charac terized by elemental analysis, IR, MS, and UV-vis spectros...The ligand ttd(ttd=1,4,8,9-Tetraaza-triphenylene-2,3-dicarbonitrile) and a novel spin crossover complex [Fe(ttd)2(NCS)2]·H2O were synthesized, and charac terized by elemental analysis, IR, MS, and UV-vis spectroscopy. The temperature dependence of magnetic susceptibility shows that there are a little break betwe en 150～190K and an unusual step transition with a 50K width between 190～240K. Compared with the other complexes with the resemble structure, it can be found t hat the influence of ligand is very notable.展开更多
给出一个存在随机时延和数据包丢失的网络控制系统(Networked Control System,NCS)模型,并分析了其渐近稳定的LMI条件.为了降低数据包丢失对系统稳定性的影响,在系统中增加了补偿器,并建立了具有丢包补偿器和随机网络诱导时延的NCS模型...给出一个存在随机时延和数据包丢失的网络控制系统(Networked Control System,NCS)模型,并分析了其渐近稳定的LMI条件.为了降低数据包丢失对系统稳定性的影响,在系统中增加了补偿器,并建立了具有丢包补偿器和随机网络诱导时延的NCS模型.在此模型的基础上,给出了系统渐近稳定和γ次优、最优的充分条件,并且获得了系统最优H∞控制的输出反馈控制律.对同一算例进行Matlab仿真,结果表明具有丢包补偿器的NCS趋于稳定的速度更快.展开更多
Non-uniform linear array(NULA)configurations are well renowned due to their structural ability for providing increased degrees of freedom(DOF)and wider array aperture than uniform linear arrays(ULAs).These characteris...Non-uniform linear array(NULA)configurations are well renowned due to their structural ability for providing increased degrees of freedom(DOF)and wider array aperture than uniform linear arrays(ULAs).These characteristics play a significant role in improving the direction-of-arrival(DOA)estimation accuracy.However,most of the existing NULA geometries are primarily applicable to circular sources(CSs),while they limitedly improve the DOF and continuous virtual aperture for noncircular sources(NCSs).Toward this purpose,we present a triaddisplaced ULAs(Tdis-ULAs)configuration for NCS.The TdisULAs structure generally consists of three ULAs,which are appropriately placed.The proposed antenna array approach fully exploits the non-circular characteristics of the sources.Given the same number of elements,the Tdis-ULAs design achieves more DOF and larger hole-free co-array aperture than its sparse array competitors.Advantageously,the number of uniform DOF,optimal distribution of elements among the ULAs,and precise element positions are uniquely determined by the closed-form expressions.Moreover,the proposed array also produces a filled resulting co-array.Numerical simulations are conducted to show the performance advantages of the proposed Tdis-ULAs configuration over its counterpart designs.展开更多
In South Korea,the vocational education and training institutions,such as the vocational colleges,the vocational high schools,and the vocational training institutions is applying the National Competency Standards(NCS)...In South Korea,the vocational education and training institutions,such as the vocational colleges,the vocational high schools,and the vocational training institutions is applying the National Competency Standards(NCS).NCS is function as a key link in development of the human resource development(HRD),linking work,education and training,and qualifications by analyzing and presenting systematically the job demands of the industrial field.The 4-year universities that focus generally on the theoretical studies do not yet have applied NCS in South Korea.However,in the case of 4-year universities,the importance of professional education is emphasized by being derived and independed from more precise the individual science through the advancement of science and technology,and the division of social functions.Therefore,it is desirable to apply NCS to improve the practical expertise of 4-year university students.For this purpose,this study aims to compare the curriculum of national K-University and the NCS contents,and to find out how to apply it to the curriculum of 4-year universities in order to bring about the functions and the characteristics of education and training.展开更多
DNA topoisomerases are essential nuclear enzymes in correcting topological DNA errors and maintaining DNA integrity.Topoisomerase inhibitors are a significant class of cancer chemotherapeutics with a definite curative...DNA topoisomerases are essential nuclear enzymes in correcting topological DNA errors and maintaining DNA integrity.Topoisomerase inhibitors are a significant class of cancer chemotherapeutics with a definite curative effect.Natural products are a rich source of lead compounds for drug discovery,including anti-tumor drugs.In this study,we found that narciclasine(NCS),an amaryllidaceae alkaloid,is a novel inhibitor of topoisomerase I(topo I).Our data demonstrated that NCS inhibited topo I activity and reversed its unwinding effect on p-HOT DNA substrate.However,it had no obvious effect on topo II activity.The molecular mechanism of NCS inhibited topo I showed that NCS did not stabilize topo-DNA covalent complexes in cells,indicating that NCS is not a topo I poison.A blind docking result showed that NCS could bind to topo I,suggesting that NCS might be a topo I suppressor.Additionally,NCS exhibited a potent anti-proliferation effect in various cancer cells.NCS arrested the cell cycle at G_(2)/M phase and induced cell apoptosis.Our study reveals the antitumor mechanisms of NCS and provides a good foundation for the development of anti-cancer drugs based on topo I inhibition.展开更多
介绍了网络控制系统(networked control system,NCS)中存在的基本问题.从网络体系架构、线性及非线性NCS建模与设计、控制与调度协同设计、故障检测与容错控制等5个方面综述了网络控制系统的研究成果和最新进展.最后阐述了该领域亟待解...介绍了网络控制系统(networked control system,NCS)中存在的基本问题.从网络体系架构、线性及非线性NCS建模与设计、控制与调度协同设计、故障检测与容错控制等5个方面综述了网络控制系统的研究成果和最新进展.最后阐述了该领域亟待解决的关键问题和进一步的研究方向.展开更多
文摘The ligand ttd(ttd=1,4,8,9-Tetraaza-triphenylene-2,3-dicarbonitrile) and a novel spin crossover complex [Fe(ttd)2(NCS)2]·H2O were synthesized, and charac terized by elemental analysis, IR, MS, and UV-vis spectroscopy. The temperature dependence of magnetic susceptibility shows that there are a little break betwe en 150～190K and an unusual step transition with a 50K width between 190～240K. Compared with the other complexes with the resemble structure, it can be found t hat the influence of ligand is very notable.
文摘给出一个存在随机时延和数据包丢失的网络控制系统(Networked Control System,NCS)模型,并分析了其渐近稳定的LMI条件.为了降低数据包丢失对系统稳定性的影响,在系统中增加了补偿器,并建立了具有丢包补偿器和随机网络诱导时延的NCS模型.在此模型的基础上,给出了系统渐近稳定和γ次优、最优的充分条件,并且获得了系统最优H∞控制的输出反馈控制律.对同一算例进行Matlab仿真,结果表明具有丢包补偿器的NCS趋于稳定的速度更快.
基金supported by the National Natural Science Foundation of China(62031017,61971221)the Fundamental Research Funds for the Central Universities of China(NP2020104)。
文摘Non-uniform linear array(NULA)configurations are well renowned due to their structural ability for providing increased degrees of freedom(DOF)and wider array aperture than uniform linear arrays(ULAs).These characteristics play a significant role in improving the direction-of-arrival(DOA)estimation accuracy.However,most of the existing NULA geometries are primarily applicable to circular sources(CSs),while they limitedly improve the DOF and continuous virtual aperture for noncircular sources(NCSs).Toward this purpose,we present a triaddisplaced ULAs(Tdis-ULAs)configuration for NCS.The TdisULAs structure generally consists of three ULAs,which are appropriately placed.The proposed antenna array approach fully exploits the non-circular characteristics of the sources.Given the same number of elements,the Tdis-ULAs design achieves more DOF and larger hole-free co-array aperture than its sparse array competitors.Advantageously,the number of uniform DOF,optimal distribution of elements among the ULAs,and precise element positions are uniquely determined by the closed-form expressions.Moreover,the proposed array also produces a filled resulting co-array.Numerical simulations are conducted to show the performance advantages of the proposed Tdis-ULAs configuration over its counterpart designs.
文摘In South Korea,the vocational education and training institutions,such as the vocational colleges,the vocational high schools,and the vocational training institutions is applying the National Competency Standards(NCS).NCS is function as a key link in development of the human resource development(HRD),linking work,education and training,and qualifications by analyzing and presenting systematically the job demands of the industrial field.The 4-year universities that focus generally on the theoretical studies do not yet have applied NCS in South Korea.However,in the case of 4-year universities,the importance of professional education is emphasized by being derived and independed from more precise the individual science through the advancement of science and technology,and the division of social functions.Therefore,it is desirable to apply NCS to improve the practical expertise of 4-year university students.For this purpose,this study aims to compare the curriculum of national K-University and the NCS contents,and to find out how to apply it to the curriculum of 4-year universities in order to bring about the functions and the characteristics of education and training.
基金the National Natural Science Foundation of China(Grant Nos.21907044,81460559 and 82160697)Yunnan Fundamental Research Projects(Grant Nos.202101AT070155 and 202201AS070086)+2 种基金Basic Research Plan of Yunnan Provincial Science and Technology Department-Kunming Medical University(Grant Nos.202101AY070001-011,202201AY070001-003 and 202101AY070001-041)the Ten Thousand Talent Plans for Young Top-notch Talents of Yunnan Province(Hongyu Zhou,Dandan Liu),Yunnan Academician Expert Workstation(Grant No.202305AF150054)Basic Research Project of Yunnan Provincial Department of Education(Grant No.2022J0213).
文摘DNA topoisomerases are essential nuclear enzymes in correcting topological DNA errors and maintaining DNA integrity.Topoisomerase inhibitors are a significant class of cancer chemotherapeutics with a definite curative effect.Natural products are a rich source of lead compounds for drug discovery,including anti-tumor drugs.In this study,we found that narciclasine(NCS),an amaryllidaceae alkaloid,is a novel inhibitor of topoisomerase I(topo I).Our data demonstrated that NCS inhibited topo I activity and reversed its unwinding effect on p-HOT DNA substrate.However,it had no obvious effect on topo II activity.The molecular mechanism of NCS inhibited topo I showed that NCS did not stabilize topo-DNA covalent complexes in cells,indicating that NCS is not a topo I poison.A blind docking result showed that NCS could bind to topo I,suggesting that NCS might be a topo I suppressor.Additionally,NCS exhibited a potent anti-proliferation effect in various cancer cells.NCS arrested the cell cycle at G_(2)/M phase and induced cell apoptosis.Our study reveals the antitumor mechanisms of NCS and provides a good foundation for the development of anti-cancer drugs based on topo I inhibition.
