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PLK1抑制剂(R)-BI-2536的合成
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作者 陶燕 《当代化工研究》 CAS 2024年第16期173-175,共3页
为进一步优化PLK1抑制剂(R)-BI-2536的合成,以3-羟基-4-硝基苯甲酸为起始原料,经过甲基化、水解、缩合和还原反应4步合成中间体酰胺化合物,以2-氨基丁酸为起始原料,经过酯化、还原胺化、取代、关环和N-甲基化反应5步合成了中间体二氢喋... 为进一步优化PLK1抑制剂(R)-BI-2536的合成,以3-羟基-4-硝基苯甲酸为起始原料,经过甲基化、水解、缩合和还原反应4步合成中间体酰胺化合物,以2-氨基丁酸为起始原料,经过酯化、还原胺化、取代、关环和N-甲基化反应5步合成了中间体二氢喋啶酮类化合物,最后通过亲核取代反应完成了PLK1的抑制剂(R)-BI-2536的合成,总收率为19.2%,其结构由1H NMR和MS表征。 展开更多
关键词 (r)-bi-2536 PLK1抑制剂 合成
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A New Halogenated Biindole and A New Apo-carotenone from Green Alga Chaetomorpha basiretorsa Setchell 被引量:6
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作者 DaYongSHI LiJunHAN +5 位作者 JieSUN ShuaiLI SuJuanWANG YongChunYANG XiaoFAN JianGongSHI 《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第6期777-780,共4页
关键词 Green alga Chaetomorpha basiretorsa Sethcell 4 4′-dichloro-5 5′-dibromo-7 7′-di- methoxy-2 2′-bi-1H-indole 1′S* 4′r*-8-(4′-hydroxy-2′ 6′ 6′-trimethylcyclohex-2-enyl)-6-methyl- oct-3E 5E 7E-trien-2-one.
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The characterization of Γ-modules in terms of fuzzy soft Γ-submodules 被引量:1
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作者 ZHOU Min XIANG Da-jing ZHAN Jian-ming 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2013年第2期217-239,共23页
In this paper,we focus on combining the theories of fuzzy soft sets with Γ-modules,and establishing a new framework for fuzzy soft Γ-submodules.The main contributions of the paper are 3-fold.First,we present the con... In this paper,we focus on combining the theories of fuzzy soft sets with Γ-modules,and establishing a new framework for fuzzy soft Γ-submodules.The main contributions of the paper are 3-fold.First,we present the concepts of(R,S)-bi-Γ-submodules,quasi-Γ-submodules and regular Γ-modules.Meanwhile,some illustrative examples are given to show the rationality of the definitions introduced in this paper.Second,several new kinds of generalized fuzzy soft Γ-submodules are proposed,and related properties and mutual relationships are also investigated.Third,we discover some intrinsic connections between the generalized fuzzy soft Γ-submodules presented in this paper and crisp Γ-submodules,and describe the relationships between regular Γ-modules and the generalized fuzzy soft Γ-submodules presented in this paper. 展开更多
关键词 Fuzzy soft set Γ-module (∈ γ γ q δ)(resp. (■ γ γ δ))-fuzzy soft left r-Γ-submodule(right r-Γ-submodules r S)-bi-Γ-submodule quasi-Γ-submodule) regular Γ-module
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A Facile Synthesis of Enantiomerically Pure (R)-6-Arylbinols
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作者 王文伶 龙玉华 +1 位作者 邹志富 杨定乔 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2012年第5期1092-1096,共5页
This work reported a convenient method for the preparation of enantiomerically pure 6-aryl-2,2'-dihydroxy-1, l'- binaphthyl derivatives starting from the commercially available (R)-2,2'-hydroxy-l, l'-binaphthyl ... This work reported a convenient method for the preparation of enantiomerically pure 6-aryl-2,2'-dihydroxy-1, l'- binaphthyl derivatives starting from the commercially available (R)-2,2'-hydroxy-l, l'-binaphthyl [(R)-I] via bromi- nation, hydrolysis and Suzuki cross coupling reaction. This novel synthetie method was characterized with high re- gioselectivity, simple operation, mild reaction conditions, and excellent yield (up to 73%). On the other hand, we synthesized the target unknown compounds, which were confirmed by IR, 1H NMR, 13C NMR, MS and elementary analysis. 展开更多
关键词 r)-1 1'-bi-2-naphthols derivatives Suzuki cross coupling reaction chiral auxiliary SYNTHESIS
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