Potential effects of ultraviolet-C radiation on the mole rats (<i>Spalax leucodon</i>) hematological values

In this study, the effect of ultraviolet-C (UVC) radiation on hematologic parameters of mole rats (Spalax leucodon) was studied. Ten mole rats of both sexes, weighing 150-200 g, were used. The rats were exposed to 8 hours daily UVC radiation for 45 days. Before the radiation exposure (as a control) and on day 7, 14, 30 and 45, blood specimens were obtained from the experimental groups. Then blood samples were analyzed and compared to the control groups. A significant decrease or increase of hematological parameters was observed in some experimental groups in terms of the control groups of values (p p > 0.05). These results showed that the UVC radiation has sig-nificant effects on some hematological parameters of mole rats according to the radiation exposure time and a dose.

长寿型啮齿类动物的抗肿瘤机制

啮齿类动物是广泛应用于生物医学的重要模式动物,包括先天性胸腺缺陷型的裸鼠、不患癌的裸鼹鼠(Heterocephalus glaber)和盲鼹鼠(Spalax galili)等。哺乳动物的衰老过程与癌症发生率有关,衰老的程度与患癌机率呈正相关。由于啮齿类动物约占哺乳动物的40%,因此研究长寿型啮齿类动物抗肿瘤机制对于抗癌机制的研究具有十分重要的作用。复制性衰老是啮齿类动物中普遍存在的抗肿瘤机制,但在裸鼹鼠和盲鼹鼠体内发现了独特的抗肿瘤机制:盲鼹鼠主要的抗肿瘤机制是由细胞释放IFN-β,激活p53和Rb信号通路,进而导致细胞集中性死亡;裸鼹鼠的抗肿瘤机制是由高分子量透明质酸引起的早期接触性抑制介导。此外,裸鼹鼠和盲鼹鼠的基因组中还含有高表达与调节细胞死亡和抗炎机制相关的基因。本文对裸鼹鼠和盲鼹鼠的独特抗肿瘤机制进行了综述,以期为该领域的相关研究提供参考。