It is well know that a human linguistic communicative behavior,listening and speaking occupies a very important position in both our daily life and foreign language teaching.Now the classroom becomes more student-cent...It is well know that a human linguistic communicative behavior,listening and speaking occupies a very important position in both our daily life and foreign language teaching.Now the classroom becomes more student-centered with the teacher allowing for students to output the language more often on their own.In order to improve the students' listening and speaking,the Communicative Approach has been exploited,which is based on communicative efficiency.It sees communicative competence of language.展开更多
The ultimate goal of language teaching is to develop students’ communicative competence. However,university English teachers often find it difficult to reach the aim in the English classroom, especially in the skills...The ultimate goal of language teaching is to develop students’ communicative competence. However,university English teachers often find it difficult to reach the aim in the English classroom, especially in the skills of listening and speaking.Their efforts in promoting students’ communicative competence are not fully felt by the students.Students also find it discouraging in the course of language learning.Communicative approach,which is an effective method to develop students’ communicative competence in the real life,stimulates the students learning interests and promotes students’ listening and speaking abilities.This paper aims to illustrate the aspects of communicative approach and its application to the foreign language teaching and learning.展开更多
With the world globalization, China's communication with other countries has become more frequent. It is in great demand that a large number of college graduates who not only master their major but also do well in...With the world globalization, China's communication with other countries has become more frequent. It is in great demand that a large number of college graduates who not only master their major but also do well in communication in English with English speakers. However, such graduates are scare because the backward teaching method-the Grammar-Traditional Method, cannot meet what the contemporary Chinese society demands. The reforms of the college English teaching are urgent and necessary. This paper first explores the major problems existing in the college English teaching. Furthermore, it introduces the basic theory of the Communicative Approach and analyzes its advantages in college English teaching.展开更多
The traditional ways of teaching in China put emphasis on the development of reading and grammar.So students are famous for their high marks in reading and low marks in listening,and lack of communicative competence.T...The traditional ways of teaching in China put emphasis on the development of reading and grammar.So students are famous for their high marks in reading and low marks in listening,and lack of communicative competence.To solve this problem,this study introduces Communicative Approach(CA) to the English listening class.In order to investigate the effects of the CA on students' listening abilities further,a 18-week comparative study on two classes is conducted.The data show that students' listening abilities and attitudes in the CA class is significantly higher and more positive than those in the traditional class,which indicates that CA is an effective approach in improving students' listening abilities compared to the traditional approach.展开更多
Benefiting from the development of Federated Learning(FL)and distributed communication systems,large-scale intelligent applications become possible.Distributed devices not only provide adequate training data,but also ...Benefiting from the development of Federated Learning(FL)and distributed communication systems,large-scale intelligent applications become possible.Distributed devices not only provide adequate training data,but also cause privacy leakage and energy consumption.How to optimize the energy consumption in distributed communication systems,while ensuring the privacy of users and model accuracy,has become an urgent challenge.In this paper,we define the FL as a 3-layer architecture including users,agents and server.In order to find a balance among model training accuracy,privacy-preserving effect,and energy consumption,we design the training process of FL as game models.We use an extensive game tree to analyze the key elements that influence the players’decisions in the single game,and then find the incentive mechanism that meet the social norms through the repeated game.The experimental results show that the Nash equilibrium we obtained satisfies the laws of reality,and the proposed incentive mechanism can also promote users to submit high-quality data in FL.Following the multiple rounds of play,the incentive mechanism can help all players find the optimal strategies for energy,privacy,and accuracy of FL in distributed communication systems.展开更多
In this article, a novel scalarization technique, called the improved objective-constraint approach, is introduced to find efficient solutions of a given multiobjective programming problem. The presented scalarized pr...In this article, a novel scalarization technique, called the improved objective-constraint approach, is introduced to find efficient solutions of a given multiobjective programming problem. The presented scalarized problem extends the objective-constraint problem. It is demonstrated that how adding variables to the scalarized problem, can lead to find conditions for (weakly, properly) Pareto optimal solutions. Applying the obtained necessary and sufficient conditions, two algorithms for generating the Pareto front approximation of bi-objective and three-objective programming problems are designed. These algorithms are easy to implement and can achieve an even approximation of (weakly, properly) Pareto optimal solutions. These algorithms can be generalized for optimization problems with more than three criterion functions, too. The effectiveness and capability of the algorithms are demonstrated in test problems.展开更多
This paper approaches the Communicative Approach (CA) from ontological perspective by making structural and functional analyses with consideration of influential variables in the communicative language teaching. In ...This paper approaches the Communicative Approach (CA) from ontological perspective by making structural and functional analyses with consideration of influential variables in the communicative language teaching. In terms of entitative dimension, the basic components of the CA are communicative subjects, context and situation, content, and mode. From the functional perspective, the CA helps to improve the learners' ability to communicate in the target language, the dual construction of the learners and the target culture, and the mutual development of the teacher and the learners.展开更多
BACKGROUND Total hip arthroplasty is as an effective intervention to relieve pain and improve hip function.Approaches of the hip have been exhaustively explored about pros and cons.The efficacy and the complications o...BACKGROUND Total hip arthroplasty is as an effective intervention to relieve pain and improve hip function.Approaches of the hip have been exhaustively explored about pros and cons.The efficacy and the complications of hip approaches remains inconclusive.This study conducted an umbrella review to systematically appraise previous meta-analysis(MAs)including conventional posterior approach(PA),and minimally invasive surgeries as the lateral approach(LA),direct anterior approach(DAA),2-incisions method,mini-lateral approach and the newest technique direct superior approach(DSA)or supercapsular percutaneouslyassisted total hip(SuperPath).AIM To compare the efficacy and complications of hip approaches that have been published in all MAs and randomized controlled trials(RCTs).METHODS MAs were identified from MEDLINE and Scopus from inception until 2023.RCTs were then updated from the latest MA to September 2023.This study included studies which compared hip approaches and reported at least one outcome such as Harris Hip Score(HHS),dislocation,intra-operative fracture,wound compliData were independently selected,extracted and assessed by two reviewers.Network MA and cluster rank and surface under the cumulative ranking curve(SUCRA)were estimated for treatment efficacy and safety.RESULTS Finally,twenty-eight MAs(40 RCTs),and 13 RCTs were retrieved.In total 47 RCTs were included for reanalysis.The results of corrected covered area showed high degree(13.80%).Among 47 RCTs,most of the studies were low risk of bias in part of random process and outcome reporting,while other domains were medium to high risk of bias.DAA significantly provided higher HHS at three months than PA[pooled unstandardized mean difference(USMD):3.49,95%confidence interval(CI):0.98,6.00 with SUCRA:85.9],followed by DSA/SuperPath(USMD:1.57,95%CI:-1.55,4.69 with SUCRA:57.6).All approaches had indifferent dislocation and intraoperative fracture rates.SUCRA comparing early functional outcome and composite complications(dislocation,intra-operative fracture,wound complication,and nerve injury)found DAA was the best approach followed by DSA/SuperPath.CONCLUSION DSA/SuperPath had better earlier functional outcome than PA,but still could not overcome the result of DAA.This technique might be the other preferred option with acceptable complications.展开更多
We read and discussed the study entitled“Complication rates after direct anterior vs posterior approach for Hip Hemiarthroplasty in elderly individuals with femoral neck fractures”with great interest.The authors hav...We read and discussed the study entitled“Complication rates after direct anterior vs posterior approach for Hip Hemiarthroplasty in elderly individuals with femoral neck fractures”with great interest.The authors have done justice to the topic of comparison of anterior and posterior surgical approaches for bipolar hemiarthroplasty which has been an everlasting debate in the existing literature.However,there are certain aspects of this study that need clarification from the authors.展开更多
Background: Cutaneous oncology encompasses a broad range of skin malignancies, including melanoma, cutaneous squamous cell carcinoma (SCC), and basal cell carcinoma (BCC), all of which pose significant global health c...Background: Cutaneous oncology encompasses a broad range of skin malignancies, including melanoma, cutaneous squamous cell carcinoma (SCC), and basal cell carcinoma (BCC), all of which pose significant global health challenges. The World Health Organization (WHO) estimates that melanoma incidence has increased by approximately 50% over the past three decades. While SCC and BCC are generally less aggressive than melanoma, they contribute significantly to the overall burden of skin cancer due to their high prevalence. Traditional treatment modalities for these malignancies, such as surgery, radiation, and chemotherapy, have shown limitations in achieving durable responses and minimizing systemic toxicity. As a result, there is an increasing need for more effective and less toxic treatment options. Immunotherapeutic strategies have emerged as a promising avenue in oncology, with the potential to revolutionize treatment approaches for cutaneous malignancies. Objectives: This literature review aims to undertake an in-depth examination of immunotherapeutic strategies for melanoma, SCC, and BCC. Specifically, the review focuses on the role of immune checkpoint inhibitors, adoptive cell therapies, and emerging immunotherapies, assessing their impact on treatment outcomes, survival rates, and patient quality of life. Methods: A literature search was conducted using databases such as PubMed, Google Scholar, and Scopus. The search terms included “cutaneous oncology”, “immunotherapy”, “immune checkpoint inhibitors”, “adoptive cell therapy”, “melanoma”, “cutaneous squamous cell carcinoma”, and “basal cell carcinoma”. Peer-reviewed articles published in the last 10 years that reported clinical outcomes from immunotherapy-based treatments for cutaneous malignancies were included. The studies were reviewed and analyzed based on their reported clinical outcomes, including survival rates, adverse events, and quality of life metrics. Results: Our review identified significant advancements in immunotherapeutic strategies for cutaneous oncology. Immune checkpoint inhibitors, such as pembrolizumab and nivolumab, demonstrated improved overall survival rates, particularly in melanoma patients. In addition, adoptive cell therapies, including tumor-infiltrating lymphocyte (TIL) therapies, showed promise in managing both cutaneous SCC and BCC, with reported reductions in tumor burden and durable responses. Emerging immunotherapies, such as cancer vaccines and oncolytic viruses, are in early clinical trials but exhibit potential in enhancing antitumor immunity and expanding treatment options. Conclusions: Immunotherapeutic strategies represent a critical advancement in the management of cutaneous malignancies, offering improved outcomes compared to traditional therapies. Immune checkpoint inhibitors and adoptive cell therapies are already reshaping clinical practice, while emerging immunotherapies provide exciting avenues for future research. These therapies not only enhance survival rates but also reduce systemic toxicities, representing a transformative approach to treating skin cancer. Further research and clinical trials are needed to refine these strategies and expand their applicability to a broader patient population.展开更多
In community planning,due to the lack of evidence regarding the selection of media tools,this study examines how a common but differentiated ideal speech situation can be created as well as how more appropriate media ...In community planning,due to the lack of evidence regarding the selection of media tools,this study examines how a common but differentiated ideal speech situation can be created as well as how more appropriate media tools can be defined and selected in the community planning process.First,this study describes the concept and theoretical basis of media used in community planning from the perspectives of the multiple effects of media evolution on communicative planning.Second,the classification criteria and typical characteristics of media tools used to support community planning are clarified from three dimensions:acceptability,cost effectiveness,and applicability.Third,strategies for applying media tools in the four phases of communicative planning-namely,state analysis,problem identification,contradictory solution and optimization-are described.Finally,trends in the development of media tools for community planning are explored in terms of multistakeholder engagement,supporting scientific decision-making and multiple-type media integration.The results provide a reference for developing more inclusive,effective,and appropriate media tools for enhancing decision-making capacity and modernizing governance in community planning and policy-making processes.展开更多
Classroom Anxiety is very common and to some extent it influences students' achievements in foreign language learning. So, how to solve this problem in order to help students have a good performance in foreign langua...Classroom Anxiety is very common and to some extent it influences students' achievements in foreign language learning. So, how to solve this problem in order to help students have a good performance in foreign language learning is a very urgent issue. According to the writer's study, communicative approach is an effective method to deal with it.展开更多
1. Introduction In educational theory, as with most things, there exist fashions and trends. Within the field of foreign language teaching the communicative approach is with good reason very fasharable in the west. Th...1. Introduction In educational theory, as with most things, there exist fashions and trends. Within the field of foreign language teaching the communicative approach is with good reason very fasharable in the west. The name certainly makes it difficult to argue with, who would want to use the ’non-communicative’ approach to teaching a foreign language? The need to communicate in a language is what makes language teaching different from teaching many other subjects. If you study geography, you learn about places, but if you only learn about a language it is not enough.展开更多
In English language teaching, both the traditional and communicative approaches have their own advantages and shortcomings. So what we need to do is taking the advantages of communicative approaches without upsetting ...In English language teaching, both the traditional and communicative approaches have their own advantages and shortcomings. So what we need to do is taking the advantages of communicative approaches without upsetting the patterns of traditional practices—combining traditional and communicative approaches.展开更多
There is an increasing attention on oxidative derivatives of triglycerides,a group of potential thermal processing induced food toxicants,which are formed during the thermal processing of food lipids.This review aims ...There is an increasing attention on oxidative derivatives of triglycerides,a group of potential thermal processing induced food toxicants,which are formed during the thermal processing of food lipids.This review aims to summarize current knowledge about their formation mechanisms,detection approaches,and toxicology impacts.Oxidative derivatives of triglycerides are generated through the oxidation,cyclization,polymerization,and hydrolysis of triglycerides under high-temperature and abundant oxygen.The analytical techniques,including GC,HPSEC,MS,^(1)H-NMR were discussed in analyzing these components.In addition,their toxic effects on human health,including effects on the liver,intestines,cardiovascular system,immune system,and metabolism were elucidated.Information in this review could be used to improve the understanding of oxidative derivatives of triglycerides and ultimately improve academic and industrial strategies for eliminating these compounds in thermal processing food systems.展开更多
In open pit mining,uncontrolled block instabilities have serious social,economic and regulatory consequences,such as casualties,disruption of operation and increased regulation difficulties.For this reason,bench face ...In open pit mining,uncontrolled block instabilities have serious social,economic and regulatory consequences,such as casualties,disruption of operation and increased regulation difficulties.For this reason,bench face angle,as one of the controlling parameters associated with block instabilities,should be carefully designed for sustainable mining.This study introduces a discrete fracture network(DFN)-based probabilistic block theory approach for the fast design of the bench face angle.A major advantage is the explicit incorporation of discontinuity size and spatial distribution in the procedure of key blocks testing.The proposed approach was applied to a granite mine in China.First,DFN models were generated from a multi-step modeling procedure to simulate the complex structural characteristics of pit slopes.Then,a modified key blocks searching method was applied to the slope faces modeled,and a cumulative probability of failure was obtained for each sector.Finally,a bench face angle was determined commensurate with an acceptable risk level of stability.The simulation results have shown that the number of hazardous traces exposed on the slope face can be significantly reduced when the suggested bench face angle is adopted,indicating an extremely low risk of uncontrolled block instabilities.展开更多
Foreign language teaching is to make a learner communicate with the native language speaker smoothly.And Communicative Approach is a very effective way for language aquisition.Combining the methods and features of CA ...Foreign language teaching is to make a learner communicate with the native language speaker smoothly.And Communicative Approach is a very effective way for language aquisition.Combining the methods and features of CA and the present situation of English teaching,this paper aims to discuss the application of CA in English teaching in vocational school and show people the superiority of it.展开更多
Vocabulary is the essential material of language and one of the important elements of language.Communicative approach plays a decisive role in English vocabulary teaching.It is a good teaching method to improve studen...Vocabulary is the essential material of language and one of the important elements of language.Communicative approach plays a decisive role in English vocabulary teaching.It is a good teaching method to improve students'abilities of listening and speaking.In this paper,the writer introduced several successful vocabulary teaching examples which used communicative approaches.They could be helpful for secondary school English teachers during their vocabulary teaching process.展开更多
Although English writing teachers paid great energy and time on students' writings in terms of revision of sentence structure, grammar, word choice, spelling and punctuation, students' English writing abilitie...Although English writing teachers paid great energy and time on students' writings in terms of revision of sentence structure, grammar, word choice, spelling and punctuation, students' English writing abilities have been progressed much less than expected. In other words, students' writings are characteristic of plain content, disorder of organization, simple sentence structure, generalized vocabulary, poor grammar. By the method of deduction, combined benefits and weaknesses of product-oriented approach with process-oriented approach, the communicative approach, comes to be applied in EFL writing for sophomore college English majors. Communicative approach by combination of meaningful learning, the anticipation of reward, the intrinsic motivation, the autonomy, language culture connection the communicative principle, the task principle brings much more effective success in writing teaching.展开更多
It is important for surgeons performing sarcoma surgery to know that bone resection and tumor prosthesis applications in soft tissue sarcomas(STS)have unique features in terms of indication,surgical approach and follo...It is important for surgeons performing sarcoma surgery to know that bone resection and tumor prosthesis applications in soft tissue sarcomas(STS)have unique features in terms of indication,surgical approach and follow-up,in terms of the management of these cases.Some STS are associated with bone and major neurovascular structures.Bone-associated STS are generally relatively large and relatively deep-seated.Additionally,the tendency for metastasis is high.In some cases,the decision about which structures to resect is difficult.These cases are often accompanied by poor oncological and surgical outcomes.Management of cases should be done by a multidisciplinary team in advanced centers specialized in this field.The surgical team must have sufficient knowledge and experience in the field of limb-sparing surgery.Preoperative evaluation and especially good planning of bone and soft tissue reconstruction are vital.展开更多
文摘It is well know that a human linguistic communicative behavior,listening and speaking occupies a very important position in both our daily life and foreign language teaching.Now the classroom becomes more student-centered with the teacher allowing for students to output the language more often on their own.In order to improve the students' listening and speaking,the Communicative Approach has been exploited,which is based on communicative efficiency.It sees communicative competence of language.
文摘The ultimate goal of language teaching is to develop students’ communicative competence. However,university English teachers often find it difficult to reach the aim in the English classroom, especially in the skills of listening and speaking.Their efforts in promoting students’ communicative competence are not fully felt by the students.Students also find it discouraging in the course of language learning.Communicative approach,which is an effective method to develop students’ communicative competence in the real life,stimulates the students learning interests and promotes students’ listening and speaking abilities.This paper aims to illustrate the aspects of communicative approach and its application to the foreign language teaching and learning.
文摘With the world globalization, China's communication with other countries has become more frequent. It is in great demand that a large number of college graduates who not only master their major but also do well in communication in English with English speakers. However, such graduates are scare because the backward teaching method-the Grammar-Traditional Method, cannot meet what the contemporary Chinese society demands. The reforms of the college English teaching are urgent and necessary. This paper first explores the major problems existing in the college English teaching. Furthermore, it introduces the basic theory of the Communicative Approach and analyzes its advantages in college English teaching.
文摘The traditional ways of teaching in China put emphasis on the development of reading and grammar.So students are famous for their high marks in reading and low marks in listening,and lack of communicative competence.To solve this problem,this study introduces Communicative Approach(CA) to the English listening class.In order to investigate the effects of the CA on students' listening abilities further,a 18-week comparative study on two classes is conducted.The data show that students' listening abilities and attitudes in the CA class is significantly higher and more positive than those in the traditional class,which indicates that CA is an effective approach in improving students' listening abilities compared to the traditional approach.
基金sponsored by the National Key R&D Program of China(No.2018YFB2100400)the National Natural Science Foundation of China(No.62002077,61872100)+4 种基金the Major Research Plan of the National Natural Science Foundation of China(92167203)the Guangdong Basic and Applied Basic Research Foundation(No.2020A1515110385)the China Postdoctoral Science Foundation(No.2022M710860)the Zhejiang Lab(No.2020NF0AB01)Guangzhou Science and Technology Plan Project(202102010440).
文摘Benefiting from the development of Federated Learning(FL)and distributed communication systems,large-scale intelligent applications become possible.Distributed devices not only provide adequate training data,but also cause privacy leakage and energy consumption.How to optimize the energy consumption in distributed communication systems,while ensuring the privacy of users and model accuracy,has become an urgent challenge.In this paper,we define the FL as a 3-layer architecture including users,agents and server.In order to find a balance among model training accuracy,privacy-preserving effect,and energy consumption,we design the training process of FL as game models.We use an extensive game tree to analyze the key elements that influence the players’decisions in the single game,and then find the incentive mechanism that meet the social norms through the repeated game.The experimental results show that the Nash equilibrium we obtained satisfies the laws of reality,and the proposed incentive mechanism can also promote users to submit high-quality data in FL.Following the multiple rounds of play,the incentive mechanism can help all players find the optimal strategies for energy,privacy,and accuracy of FL in distributed communication systems.
文摘In this article, a novel scalarization technique, called the improved objective-constraint approach, is introduced to find efficient solutions of a given multiobjective programming problem. The presented scalarized problem extends the objective-constraint problem. It is demonstrated that how adding variables to the scalarized problem, can lead to find conditions for (weakly, properly) Pareto optimal solutions. Applying the obtained necessary and sufficient conditions, two algorithms for generating the Pareto front approximation of bi-objective and three-objective programming problems are designed. These algorithms are easy to implement and can achieve an even approximation of (weakly, properly) Pareto optimal solutions. These algorithms can be generalized for optimization problems with more than three criterion functions, too. The effectiveness and capability of the algorithms are demonstrated in test problems.
文摘This paper approaches the Communicative Approach (CA) from ontological perspective by making structural and functional analyses with consideration of influential variables in the communicative language teaching. In terms of entitative dimension, the basic components of the CA are communicative subjects, context and situation, content, and mode. From the functional perspective, the CA helps to improve the learners' ability to communicate in the target language, the dual construction of the learners and the target culture, and the mutual development of the teacher and the learners.
文摘BACKGROUND Total hip arthroplasty is as an effective intervention to relieve pain and improve hip function.Approaches of the hip have been exhaustively explored about pros and cons.The efficacy and the complications of hip approaches remains inconclusive.This study conducted an umbrella review to systematically appraise previous meta-analysis(MAs)including conventional posterior approach(PA),and minimally invasive surgeries as the lateral approach(LA),direct anterior approach(DAA),2-incisions method,mini-lateral approach and the newest technique direct superior approach(DSA)or supercapsular percutaneouslyassisted total hip(SuperPath).AIM To compare the efficacy and complications of hip approaches that have been published in all MAs and randomized controlled trials(RCTs).METHODS MAs were identified from MEDLINE and Scopus from inception until 2023.RCTs were then updated from the latest MA to September 2023.This study included studies which compared hip approaches and reported at least one outcome such as Harris Hip Score(HHS),dislocation,intra-operative fracture,wound compliData were independently selected,extracted and assessed by two reviewers.Network MA and cluster rank and surface under the cumulative ranking curve(SUCRA)were estimated for treatment efficacy and safety.RESULTS Finally,twenty-eight MAs(40 RCTs),and 13 RCTs were retrieved.In total 47 RCTs were included for reanalysis.The results of corrected covered area showed high degree(13.80%).Among 47 RCTs,most of the studies were low risk of bias in part of random process and outcome reporting,while other domains were medium to high risk of bias.DAA significantly provided higher HHS at three months than PA[pooled unstandardized mean difference(USMD):3.49,95%confidence interval(CI):0.98,6.00 with SUCRA:85.9],followed by DSA/SuperPath(USMD:1.57,95%CI:-1.55,4.69 with SUCRA:57.6).All approaches had indifferent dislocation and intraoperative fracture rates.SUCRA comparing early functional outcome and composite complications(dislocation,intra-operative fracture,wound complication,and nerve injury)found DAA was the best approach followed by DSA/SuperPath.CONCLUSION DSA/SuperPath had better earlier functional outcome than PA,but still could not overcome the result of DAA.This technique might be the other preferred option with acceptable complications.
文摘We read and discussed the study entitled“Complication rates after direct anterior vs posterior approach for Hip Hemiarthroplasty in elderly individuals with femoral neck fractures”with great interest.The authors have done justice to the topic of comparison of anterior and posterior surgical approaches for bipolar hemiarthroplasty which has been an everlasting debate in the existing literature.However,there are certain aspects of this study that need clarification from the authors.
文摘Background: Cutaneous oncology encompasses a broad range of skin malignancies, including melanoma, cutaneous squamous cell carcinoma (SCC), and basal cell carcinoma (BCC), all of which pose significant global health challenges. The World Health Organization (WHO) estimates that melanoma incidence has increased by approximately 50% over the past three decades. While SCC and BCC are generally less aggressive than melanoma, they contribute significantly to the overall burden of skin cancer due to their high prevalence. Traditional treatment modalities for these malignancies, such as surgery, radiation, and chemotherapy, have shown limitations in achieving durable responses and minimizing systemic toxicity. As a result, there is an increasing need for more effective and less toxic treatment options. Immunotherapeutic strategies have emerged as a promising avenue in oncology, with the potential to revolutionize treatment approaches for cutaneous malignancies. Objectives: This literature review aims to undertake an in-depth examination of immunotherapeutic strategies for melanoma, SCC, and BCC. Specifically, the review focuses on the role of immune checkpoint inhibitors, adoptive cell therapies, and emerging immunotherapies, assessing their impact on treatment outcomes, survival rates, and patient quality of life. Methods: A literature search was conducted using databases such as PubMed, Google Scholar, and Scopus. The search terms included “cutaneous oncology”, “immunotherapy”, “immune checkpoint inhibitors”, “adoptive cell therapy”, “melanoma”, “cutaneous squamous cell carcinoma”, and “basal cell carcinoma”. Peer-reviewed articles published in the last 10 years that reported clinical outcomes from immunotherapy-based treatments for cutaneous malignancies were included. The studies were reviewed and analyzed based on their reported clinical outcomes, including survival rates, adverse events, and quality of life metrics. Results: Our review identified significant advancements in immunotherapeutic strategies for cutaneous oncology. Immune checkpoint inhibitors, such as pembrolizumab and nivolumab, demonstrated improved overall survival rates, particularly in melanoma patients. In addition, adoptive cell therapies, including tumor-infiltrating lymphocyte (TIL) therapies, showed promise in managing both cutaneous SCC and BCC, with reported reductions in tumor burden and durable responses. Emerging immunotherapies, such as cancer vaccines and oncolytic viruses, are in early clinical trials but exhibit potential in enhancing antitumor immunity and expanding treatment options. Conclusions: Immunotherapeutic strategies represent a critical advancement in the management of cutaneous malignancies, offering improved outcomes compared to traditional therapies. Immune checkpoint inhibitors and adoptive cell therapies are already reshaping clinical practice, while emerging immunotherapies provide exciting avenues for future research. These therapies not only enhance survival rates but also reduce systemic toxicities, representing a transformative approach to treating skin cancer. Further research and clinical trials are needed to refine these strategies and expand their applicability to a broader patient population.
基金supported by the National Key Research and Development Program of China under the theme“Key technologies for urban sustainable development evaluation and decision-making support”[Grant No.2022YFC3802900].
文摘In community planning,due to the lack of evidence regarding the selection of media tools,this study examines how a common but differentiated ideal speech situation can be created as well as how more appropriate media tools can be defined and selected in the community planning process.First,this study describes the concept and theoretical basis of media used in community planning from the perspectives of the multiple effects of media evolution on communicative planning.Second,the classification criteria and typical characteristics of media tools used to support community planning are clarified from three dimensions:acceptability,cost effectiveness,and applicability.Third,strategies for applying media tools in the four phases of communicative planning-namely,state analysis,problem identification,contradictory solution and optimization-are described.Finally,trends in the development of media tools for community planning are explored in terms of multistakeholder engagement,supporting scientific decision-making and multiple-type media integration.The results provide a reference for developing more inclusive,effective,and appropriate media tools for enhancing decision-making capacity and modernizing governance in community planning and policy-making processes.
文摘Classroom Anxiety is very common and to some extent it influences students' achievements in foreign language learning. So, how to solve this problem in order to help students have a good performance in foreign language learning is a very urgent issue. According to the writer's study, communicative approach is an effective method to deal with it.
文摘1. Introduction In educational theory, as with most things, there exist fashions and trends. Within the field of foreign language teaching the communicative approach is with good reason very fasharable in the west. The name certainly makes it difficult to argue with, who would want to use the ’non-communicative’ approach to teaching a foreign language? The need to communicate in a language is what makes language teaching different from teaching many other subjects. If you study geography, you learn about places, but if you only learn about a language it is not enough.
文摘In English language teaching, both the traditional and communicative approaches have their own advantages and shortcomings. So what we need to do is taking the advantages of communicative approaches without upsetting the patterns of traditional practices—combining traditional and communicative approaches.
基金funded by the National Natural Science Foundation of China (Grant No.32272426).
文摘There is an increasing attention on oxidative derivatives of triglycerides,a group of potential thermal processing induced food toxicants,which are formed during the thermal processing of food lipids.This review aims to summarize current knowledge about their formation mechanisms,detection approaches,and toxicology impacts.Oxidative derivatives of triglycerides are generated through the oxidation,cyclization,polymerization,and hydrolysis of triglycerides under high-temperature and abundant oxygen.The analytical techniques,including GC,HPSEC,MS,^(1)H-NMR were discussed in analyzing these components.In addition,their toxic effects on human health,including effects on the liver,intestines,cardiovascular system,immune system,and metabolism were elucidated.Information in this review could be used to improve the understanding of oxidative derivatives of triglycerides and ultimately improve academic and industrial strategies for eliminating these compounds in thermal processing food systems.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.42102313 and 52104125)the Fundamental Research Funds for the Central Universities(Grant No.B240201094).
文摘In open pit mining,uncontrolled block instabilities have serious social,economic and regulatory consequences,such as casualties,disruption of operation and increased regulation difficulties.For this reason,bench face angle,as one of the controlling parameters associated with block instabilities,should be carefully designed for sustainable mining.This study introduces a discrete fracture network(DFN)-based probabilistic block theory approach for the fast design of the bench face angle.A major advantage is the explicit incorporation of discontinuity size and spatial distribution in the procedure of key blocks testing.The proposed approach was applied to a granite mine in China.First,DFN models were generated from a multi-step modeling procedure to simulate the complex structural characteristics of pit slopes.Then,a modified key blocks searching method was applied to the slope faces modeled,and a cumulative probability of failure was obtained for each sector.Finally,a bench face angle was determined commensurate with an acceptable risk level of stability.The simulation results have shown that the number of hazardous traces exposed on the slope face can be significantly reduced when the suggested bench face angle is adopted,indicating an extremely low risk of uncontrolled block instabilities.
文摘Foreign language teaching is to make a learner communicate with the native language speaker smoothly.And Communicative Approach is a very effective way for language aquisition.Combining the methods and features of CA and the present situation of English teaching,this paper aims to discuss the application of CA in English teaching in vocational school and show people the superiority of it.
文摘Vocabulary is the essential material of language and one of the important elements of language.Communicative approach plays a decisive role in English vocabulary teaching.It is a good teaching method to improve students'abilities of listening and speaking.In this paper,the writer introduced several successful vocabulary teaching examples which used communicative approaches.They could be helpful for secondary school English teachers during their vocabulary teaching process.
文摘Although English writing teachers paid great energy and time on students' writings in terms of revision of sentence structure, grammar, word choice, spelling and punctuation, students' English writing abilities have been progressed much less than expected. In other words, students' writings are characteristic of plain content, disorder of organization, simple sentence structure, generalized vocabulary, poor grammar. By the method of deduction, combined benefits and weaknesses of product-oriented approach with process-oriented approach, the communicative approach, comes to be applied in EFL writing for sophomore college English majors. Communicative approach by combination of meaningful learning, the anticipation of reward, the intrinsic motivation, the autonomy, language culture connection the communicative principle, the task principle brings much more effective success in writing teaching.
文摘It is important for surgeons performing sarcoma surgery to know that bone resection and tumor prosthesis applications in soft tissue sarcomas(STS)have unique features in terms of indication,surgical approach and follow-up,in terms of the management of these cases.Some STS are associated with bone and major neurovascular structures.Bone-associated STS are generally relatively large and relatively deep-seated.Additionally,the tendency for metastasis is high.In some cases,the decision about which structures to resect is difficult.These cases are often accompanied by poor oncological and surgical outcomes.Management of cases should be done by a multidisciplinary team in advanced centers specialized in this field.The surgical team must have sufficient knowledge and experience in the field of limb-sparing surgery.Preoperative evaluation and especially good planning of bone and soft tissue reconstruction are vital.