Proactive Semantic Interference (PSI) and failure to recover from PSI (frPSI), are novel constructs assessed by the LASSI-L. These measures are sensitive to cognitive changes in early Mild Cognitive Impairment (MCI) a...Proactive Semantic Interference (PSI) and failure to recover from PSI (frPSI), are novel constructs assessed by the LASSI-L. These measures are sensitive to cognitive changes in early Mild Cognitive Impairment (MCI) and preclinical AD determined by Aβ load using PET. The goal of this study was to compare a new computerized version of the LASSI-L (LASSI-Brief Computerized) to the standard paper-and-pencil version of the test. In this study, we examined 110 cognitively unimpaired (CU) older adults and 79 with amnestic MCI (aMCI) who were administered the paper-and-pencil form of the LASSI-L. Their performance was compared with 62 CU older adults and 52 aMCI participants examined using the LASSI-BC. After adjustment for covariates (degree of initial learning, sex, education, and language of evaluation) both the standard and computerized versions distinguished between aMCI and CU participants. The performance of CU and aMCI groups using either form was relatively commensurate. Importantly, an optimal combination of Cued B2 recall and Cued B1 intrusions on the LASSI-BC yielded an area under the ROC curve of .927, a sensitivity of 92.3% and specificity of 88.1%, relative to an area under the ROC curve of .815, a sensitivity of 72.5%, and a specificity of 79.1% obtained for the paper-and-pencil LASSI-L. Overall, the LASSI-BC was comparable, and in some ways, superior to the paper-and-pencil LASSI-L. Advantages of the LASSI-BC include a more standardized administration, suitability for remote assessment, and an automated scoring mechanism that can be verified by a built-in audio recording of responses.展开更多
G-DINA(the generalizeddeterministic input,noisy and gate)模型限制条件少,应用范围广,满足大量心理与教育评估测验数据的要求。研究提出一种适用于G-DINA等模型的同时标定新题Q矩阵与项目参数的认知诊断计算机化自适应测验(CD-CAT)...G-DINA(the generalizeddeterministic input,noisy and gate)模型限制条件少,应用范围广,满足大量心理与教育评估测验数据的要求。研究提出一种适用于G-DINA等模型的同时标定新题Q矩阵与项目参数的认知诊断计算机化自适应测验(CD-CAT)在线标定新方法SCADOCM,以期促进CD-CAT在实践中的推广与应用。本研究分别基于模拟题库以及真实题库进行研究,结果表明:相比传统的SIE方法,SCADOCM在各实验条件下均具有较为理想的标定精度与标定效率,应用前景较好;SIE方法不适用于饱和的G-DINA等模型,其各实验条件下的Q矩阵标定精度均较低。展开更多
目的比较常规CT征象和直方图参数对腺泡型、非腺泡型肺腺癌的鉴别效能的差异。方法回顾性收集在本院手术的185例患者共195个肺结节,其中腺泡型104个,非腺泡型91个。收集患者的人口学资料、肿瘤标记物。采用单因素分析及二元Logistic回...目的比较常规CT征象和直方图参数对腺泡型、非腺泡型肺腺癌的鉴别效能的差异。方法回顾性收集在本院手术的185例患者共195个肺结节,其中腺泡型104个,非腺泡型91个。收集患者的人口学资料、肿瘤标记物。采用单因素分析及二元Logistic回归分析建立常规CT征象模型、直方图(HA)模型及二者联合模型,通过曲线下面积(AUC)比较三种模型对鉴别腺泡型、非腺泡型肺腺癌的鉴别效能。结果单因素分析显示,腺泡型中,纯磨玻璃结节的占比低于非腺泡型(P=0.040);腺泡型中,病灶的CT平均值(P=0.023)、CT中位数数值(P=0.027)、紧凑度(P=0.003)、球形度(P=0.013)、熵(P<0.001)高于非腺泡型,病灶的峰度(P<0.001)、偏度(P<0.001)低于非腺泡型。二元Logistic回归分析以及ROC曲线显示联合模型及HA模型较常规CT征象模型具有更高的鉴别效能(AUC:直方图VS常规CT:0.763 VS 0.550,P<0.001;联合模型VS常规CT:0.768 VS 0.550,P<0.001);联合模型较HA模型无统计学差异(联合模型VS直方图:0.768 VS 0.763,P=0.768)。结论HA参数较常规CT征象能够更有效的鉴别腺泡型和非腺泡型肺腺癌。展开更多
文摘Proactive Semantic Interference (PSI) and failure to recover from PSI (frPSI), are novel constructs assessed by the LASSI-L. These measures are sensitive to cognitive changes in early Mild Cognitive Impairment (MCI) and preclinical AD determined by Aβ load using PET. The goal of this study was to compare a new computerized version of the LASSI-L (LASSI-Brief Computerized) to the standard paper-and-pencil version of the test. In this study, we examined 110 cognitively unimpaired (CU) older adults and 79 with amnestic MCI (aMCI) who were administered the paper-and-pencil form of the LASSI-L. Their performance was compared with 62 CU older adults and 52 aMCI participants examined using the LASSI-BC. After adjustment for covariates (degree of initial learning, sex, education, and language of evaluation) both the standard and computerized versions distinguished between aMCI and CU participants. The performance of CU and aMCI groups using either form was relatively commensurate. Importantly, an optimal combination of Cued B2 recall and Cued B1 intrusions on the LASSI-BC yielded an area under the ROC curve of .927, a sensitivity of 92.3% and specificity of 88.1%, relative to an area under the ROC curve of .815, a sensitivity of 72.5%, and a specificity of 79.1% obtained for the paper-and-pencil LASSI-L. Overall, the LASSI-BC was comparable, and in some ways, superior to the paper-and-pencil LASSI-L. Advantages of the LASSI-BC include a more standardized administration, suitability for remote assessment, and an automated scoring mechanism that can be verified by a built-in audio recording of responses.
文摘目的探讨短程团体认知行为治疗(Group Cognitive Behavioral Therapy,GCBT)对青少年抑郁症患者的疗效,观察短程GCBT和计算机化认知行为治疗(Computerized Cognitive Behavioral Therapy,CCBT)联合对青少年抑郁治疗疗效。方法随机选取2022年8月—2023年8月福建省福州神经精神病防治院精神科门诊及医学心理咨询中心门诊收治的90例青少年抑郁症患者为研究对象,通过随机数表法分为CCBT组(n=30,因未完成5次治疗脱落19例,最终11例)、GCBT组(n=30,因未完成5次团体治疗脱落3例,最终27例)及CCBT+GCBT组(n=30)。在服用抗抑郁药物基础上,CCBT组合并5周的CCBT,GCBT组合并5周的GCBT,CCBT+GCBT组合并5周的GCBT及CCBT。治疗频率均为1次/周。比较3组治疗前、后汉密尔顿抑郁量表(24 Items Hamilton Depression Scale,HAMD-24)评分及减分率,中学生心理健康量表(Mental Health Scale for Middle School Students,MSSMHS)总均分及各因子分。结果5周治疗后,3组HAMD-24评分[CCBT组16(9,18)分、GCBT组18(13,21)分、CCBT+GCBT组13.5(8,20.25)分]均有明显下降,差异有统计学意义(Z=-2.847、-4.545、-4.784,P均<0.05)。3组HAMD减分率比较,差异无统计学意义(P=0.069)。CCBT+GCBT组MSSMHS总均分及强迫、敌对、人际关系敏感、抑郁、焦虑、情绪不平衡及心理不平衡等因子分与治疗前比较,差异有统计学意义(P均<0.05);GCBT组MSSMHS总均分及强迫、敌对、抑郁及情绪不平衡等因子分与治疗前比较,差异有统计学意义(P均<0.05)。CCBT+GCBT组MSSMHS人际关系敏感及心理不平衡因子分较GCBT组明显改善,差异有统计学意义(P均<0.05)。结论短程CCBT及GCBT等治疗能有效改善青少年患者的抑郁症状,且CCBT与GCBT联合治疗疗效更优于单纯GCBT,且能有效降低CCBT高脱失率。
文摘G-DINA(the generalizeddeterministic input,noisy and gate)模型限制条件少,应用范围广,满足大量心理与教育评估测验数据的要求。研究提出一种适用于G-DINA等模型的同时标定新题Q矩阵与项目参数的认知诊断计算机化自适应测验(CD-CAT)在线标定新方法SCADOCM,以期促进CD-CAT在实践中的推广与应用。本研究分别基于模拟题库以及真实题库进行研究,结果表明:相比传统的SIE方法,SCADOCM在各实验条件下均具有较为理想的标定精度与标定效率,应用前景较好;SIE方法不适用于饱和的G-DINA等模型,其各实验条件下的Q矩阵标定精度均较低。
文摘目的比较常规CT征象和直方图参数对腺泡型、非腺泡型肺腺癌的鉴别效能的差异。方法回顾性收集在本院手术的185例患者共195个肺结节,其中腺泡型104个,非腺泡型91个。收集患者的人口学资料、肿瘤标记物。采用单因素分析及二元Logistic回归分析建立常规CT征象模型、直方图(HA)模型及二者联合模型,通过曲线下面积(AUC)比较三种模型对鉴别腺泡型、非腺泡型肺腺癌的鉴别效能。结果单因素分析显示,腺泡型中,纯磨玻璃结节的占比低于非腺泡型(P=0.040);腺泡型中,病灶的CT平均值(P=0.023)、CT中位数数值(P=0.027)、紧凑度(P=0.003)、球形度(P=0.013)、熵(P<0.001)高于非腺泡型,病灶的峰度(P<0.001)、偏度(P<0.001)低于非腺泡型。二元Logistic回归分析以及ROC曲线显示联合模型及HA模型较常规CT征象模型具有更高的鉴别效能(AUC:直方图VS常规CT:0.763 VS 0.550,P<0.001;联合模型VS常规CT:0.768 VS 0.550,P<0.001);联合模型较HA模型无统计学差异(联合模型VS直方图:0.768 VS 0.763,P=0.768)。结论HA参数较常规CT征象能够更有效的鉴别腺泡型和非腺泡型肺腺癌。
