A series of five new Schiff bases(1–5) were synthesized by reacting 2-(trifluoromethoxy) aniline with different aromatic aldehydes. The Schiff base compounds were characterized by spectroscopic and analytical methods...A series of five new Schiff bases(1–5) were synthesized by reacting 2-(trifluoromethoxy) aniline with different aromatic aldehydes. The Schiff base compounds were characterized by spectroscopic and analytical methods. Crystal structure of one new compound was also reported. The pharmacological properties, including antibacterial(14 bacterial species), antifungal(7 strains), antimalarial, anti-trypanosomal and anti-HIV activities of the compounds, were investigated. Cytotoxicity of the tested compounds was evaluated against human cervix adernocarcinoma cells(He La). Bacterial minimum inhibitory concentration(MIC) results by broth microdilution method showed that Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Proteus vulgaris, Klebsiella oxytoc and Klebsiella pneumonia were more sensitive in the presence of tested compounds with an MIC value of 15.6 μg/m L. All the tested compounds showed good to moderate activity against fungi. The sensitivity of Aspergillus fumigatus was higher than other strains with a minimum cell death concentration(MFC) of 15.6 μg/m L. Compound 1 showed greater antimalarial and anti-trypanosomal properties with very low to no cytotoxic effects against He La cells as compared with compound 5, while other compounds exhibited poor activity. Compounds 1–5 demonstrated good activity against HIV type-1. These Schiff base compounds could be used as good antimicrobial agents.展开更多
The fluorescence spectra of N--salicylidene-p-(N,N--dimethylamino)aniline have beeninvestigated in various solvents. Three kinds of fluorescence have been found in the solutionsof various concentrations. They are the ...The fluorescence spectra of N--salicylidene-p-(N,N--dimethylamino)aniline have beeninvestigated in various solvents. Three kinds of fluorescence have been found in the solutionsof various concentrations. They are the excited intermediate (EI) which is formed when theproton transfer has occurred but essentially retains the geometry of the enol tautomer, theexciplex (EX) which consists of a ground monomer and an excited state intermediate and theexcited dimer (ED) which is caused by ground state aggregate. The fluorescence lifetimesof the fluorophores have been measured in tetrahydrofuran (THF). Luminescent mechanismhas been discussed based on the fluorescence spectra and the kinetic data of the compound.展开更多
文摘A series of five new Schiff bases(1–5) were synthesized by reacting 2-(trifluoromethoxy) aniline with different aromatic aldehydes. The Schiff base compounds were characterized by spectroscopic and analytical methods. Crystal structure of one new compound was also reported. The pharmacological properties, including antibacterial(14 bacterial species), antifungal(7 strains), antimalarial, anti-trypanosomal and anti-HIV activities of the compounds, were investigated. Cytotoxicity of the tested compounds was evaluated against human cervix adernocarcinoma cells(He La). Bacterial minimum inhibitory concentration(MIC) results by broth microdilution method showed that Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Proteus vulgaris, Klebsiella oxytoc and Klebsiella pneumonia were more sensitive in the presence of tested compounds with an MIC value of 15.6 μg/m L. All the tested compounds showed good to moderate activity against fungi. The sensitivity of Aspergillus fumigatus was higher than other strains with a minimum cell death concentration(MFC) of 15.6 μg/m L. Compound 1 showed greater antimalarial and anti-trypanosomal properties with very low to no cytotoxic effects against He La cells as compared with compound 5, while other compounds exhibited poor activity. Compounds 1–5 demonstrated good activity against HIV type-1. These Schiff base compounds could be used as good antimicrobial agents.
基金Project supported by the National Natural Science Foundation of China.
文摘The fluorescence spectra of N--salicylidene-p-(N,N--dimethylamino)aniline have beeninvestigated in various solvents. Three kinds of fluorescence have been found in the solutionsof various concentrations. They are the excited intermediate (EI) which is formed when theproton transfer has occurred but essentially retains the geometry of the enol tautomer, theexciplex (EX) which consists of a ground monomer and an excited state intermediate and theexcited dimer (ED) which is caused by ground state aggregate. The fluorescence lifetimesof the fluorophores have been measured in tetrahydrofuran (THF). Luminescent mechanismhas been discussed based on the fluorescence spectra and the kinetic data of the compound.
