Preparation Process,Pharmacological Activity and Molecular Mechanism of Valepotriate

In recent years,with the continuous development of the medicinal value of valepotriate and the great attention of scholars.The traditional extraction and purification process can no longer meet the current market standards and needs.The modern technology of valepotriate is of great significance to its application and development.This paper reviews the extraction and purification process,molding process and pharmacological activity of valepotriate,providing a theoretical basis for the research and application of valepotriate.

Purification Process,Content Determination,Pharmacological Activity and Molecular Mechanism of Neogambogic Acid

Neogambogic acid is characterized by broad antitumor spectrum,good antitumor effect and low toxicity and side effects.This paper reviews the purification process,content determination and pharmacologic activity of neogambogic acid,in order to provide a theoretical reference for the research and application of neogambogic acid.

A review of pharmacological activity and application potential in food of tea polyphenols

Tea polyphenols(TP)is a class of polyhydroxy compounds isolated from tea.Modern biological and medical studies have shown that TP has many pharmacological activities,such as anti-inflammatory,anti-virus,anti-oxidation,anti-tumor and anti-radiation.Furthermore,these substances can be used as a potential drug component to positively guide the occurrence and development of certain diseases.Furthermore,because of the activities of TP,such as anti-oxidation and anti-bacteria,it can be applied in food preservation,color preservation,deodorization,and treatment of food processing by-products.Based on the research progress of TP in recent years,this paper summarizes the pharmacological activities of TP and expounds on its application potential in the field of food.In order to provide a theoretical reference for the research,development and utilization of TP.

In vitro Pharmacological Activity of Chromenes in Disk of Helianthus annuus

[Objectives]The anti-tumor,anti-bacterial,anti-acetylcholinesterase and anti-α-glucosidase activity in vitro of five chromenes isolated from Helianthus annuus disk was studied,in order to provide reference for the development and utilization of H.annuus disk resources.[Methods]The effect of different concentrations of chromenes on the survival rate of leukemia HL-60 cells,lung cancer A549 cells,liver cancer SMMC-7721 cells,breast cancer MCF-7 cells and colon cancer SW480 cells was detected by MTS method,and the IC50 was calculated.The inhibitory activity of chromenes against Escherichia coli,Staphylococcus aureus subsp.aureus,Salmonella enterica subsp.enterica,Pseudomonas aeruginosa and Candida albicans was detected by microdilution method.The DTNB substrate method was used to detect the inhibitory activity of chromenes on acetylcholine.The PNPG substrate method was used to detect the inhibitory activity of chromenes onα-glucosidase.[Results]The five chromenes had no obvious in vitro inhibitory activity on the five kinds of tumor cells,with IC50 greater than 40μM.The five chromenes had no obvious in vitro inhibitory activity against the four kinds of bacteria and C.albicans.The five chromenes had certain inhibitory activity on acetylcholinesterase,and among them,6-acetyl-2,2-dimethylchromene and 6-acetyl-7-hydroxy-2,3-dimethylchromene showed strong inhibitory activity on acetylcholinesterase,with IC50 of 28.253 and 16.945μM,respectively,both smaller than that(0.275μM)of the positive control tacrine(P<0.01).The five chromenes showed good inhibitory effect onα-glucosidase,and among them,7-hydroxy-6-hydroxyacetyl-2,2-dimethylchromene and 6-acetyl-7-hydroxy-2,3-dimethylchromene had stronger inhibitory activity,with IC50 of 20.240 and 21.052μM,respectively,significantly better than that(169.780μM)of the positive control acarbose(P<0.01).[Conclusions]The five chromenes in H.annuus disk have certain in vitro inhibitory activity against acetylcholinesterase andα-glucosidase and certain potential in fighting neurodegenerative diseases and diabetes.

Advances in Research of Components,Pharmacological Activity and Clinical Application of Vicatia thibetica de Boiss

Vicatia thibetica de Boiss is a Tibetan medicinal herb and mainly contains chemical components such as flavonoids,β-sitosterol and ferulic acid.It has good pharmacological effects such as anti-inflammatory,analgesic,anti-fatigue,anti-oxidation,anti-aging and enhancing immunity.Based on relevant domestic and foreign literature,this paper comprehensively reviews the main components,pharmacological activity and clinical prescription application of V.thibetica de Boiss,to provide a reference for the in-depth research and comprehensive development and utilization of V.thibetica de Boiss.

Chemical composition and pharmacological activity of seco-prezizaane-type sesquiterpenes

The seco-prezizaane-type sesquiterpenes(SPS),as a special class of sesquiterpenes with a highly oxidative five-ring cage structure and seven consecutive chiral centers,are isolated from the genus Illicium,which have a variety of biological activities,including neurotoxicity and neurotrophic effects,etc.This review summarizes the chemical constituents and pharmacological effects of SPS,and discusses the potential trend and scope of future research.

Chemical constituents and pharmacological effects of Lonicerae japonicae

Lonicera japonica,also known as honeysuckle,is an evergreen shrub in the family of Syzygium.By consulting Sciencedirect databases and Web of Science databases,79 related articles were found,of which 22 were related to chemical composition and pharmacological activity.These articles show that L.japonica has a wide range of pharmacological activities,including antiviral,anti-tumor,and antioxidant effects.These activities have important applications in the pharmaceutical,food,and fragrance industries.This review focuses on the chemical composition and pharmacological effects of L.japonicae,which is of great significance to the development of new drugs and therapeutic methods.

Chemical constituents and pharmacological effects of Croton crassifolius

Croton crassifolius(CC)is a kind of traditional Chinese medicine rich in terpenoids,with among which diterpene species are the most.CC had biological activities in the treatment of cancer,inflammation,ulcerative colitis,osteoporosis and Alzheimer’s disease.This study reviews the chemical compositions and pharmacological activities of CC to provide reference for further research.

Phytochemical profile and pharmacological activity of Aegle marmelos Linn

Aegle marmelos Linn.（Rutaceae）, commonly known as ＂bael＂ in Nepal and India, is a valuable medicinal plant and is considered sacred by the Hindus. It is used to cure several diseases in the Indian traditional medicine system of Ayurveda and has had similar uses among many ethnic communities residing in Indian subcontinent for over 5000 years. Its leaves, bark, stem, fruits and seeds have been used for various medicinal purposes. Bael fruits are especially effective in the treatment of chronic diarrhea, dysentery and peptic ulcers, while they are also useful as a laxative and cure for respiratory infections. Scientific studies have validated many of the ethnomedicinal uses of A. marmelos, which include antibacterial,antiviral, antidiarrheal, gastroprotective, anti-ulcerative colitis, hepatoprotective, antidiabetic, cardioprotective and radioprotective effects. Recently, this plant has also received attention as an anticancer agent for the treatment of various types of cancers. Thus, this review focuses on scientific evidence verifying the important pharmacological activity such as antioxidant, antidiabetic, antimicrobial, hepatoprotective,cardioprotective and anticancer activity of A. marmelos.

Purification Process and Biological Activity of Daphnoretin

Daphnoretin,belonging to coumarin compounds,is the main active ingredient of Wikstroemia indica,and has anti-inflammatory,anti-depression,anti-tumor and other pharmacological activities.This article reviews the extraction and purification process,content determination methods and pharmacological activity of daphnoretin,in order to provide a theoretical reference for optimization of purification process,improvement of content determination technique and further clinical application of daphnoretin.

Study on the pharmacological activities and chemical structures of Viburnum dilatatum

Viburnum dilatatum(jiami in Chinese),belonging to the Caprifollaceae family,is widely distributed in Japan and China.Phytochemical investigations of Viburnum dilatatum(V.dilatatum)have resulted in the isolation of triterpenoids,phenolic glycosides essential oil,norisoprenoids,etc.Research results have shown that the chemical constituents of V.dilatatum possess various pharmacological activities,including antihyperglycemic,antioxidant activity and antiulcer effects.This study reviewed the chemical constituents and pharmacological activities of V.dilatatum to provide practical and useful information for further research and development of this plant.

Research progress on chemical constituents and pharmacological activities of Amomum longiligulare T.L.Wu

In order to develop and utilize the tropical medicinal resource Amomum(A.)longiligulare T.L.Wu more reasonably and effectively,this paper summarizes the research progress in chemical constituents and pharmacological activities of A.longiligulare by consulting the literatures,so as to provide a certain theoretical basis for exploring its material basis.The chemical constituents of A.longiligulare mainly include volatile oil,diphenylheptane and flavonoids,which have good efficacy in anti-peptic ulcer,as well as antioxidant,analgesic and other pharmacological activities.This paper briefly discusses the reasons for the differences in the composition of volatile oil studied by different scholars.By summarizing its pharmacological activities,it is found that its various pharmacological activities may be the basis of its anti-peptic ulcer.

A review of research on the chemical constituents and pharmacological effects of Elephantopus tomentosus L.

Elephantopus tomentosus,belonging to the genus Elephantopus,is widely distributed in the coastal areas of southern China and tropical regions,used locally as traditional folk medicine.Previous phytochemistry studies on Elephantopus tomentosus led to the isolation of sesquiterpenoids,triterpenoids,flavonoids and other compounds.Research has shown that these compounds possess multiple biological activities,which have attracted great attention of researchers worldwide.This study reviews the chemical constituents and biological activities of the Elephantopus tomentosus in order to better explore and utilize Elephantopus tomentosus.

Licorice:comprehensive review of its chemical composition,pharmacodynamics,and medicinal value

Licorice,a perennial herb of Leguminosa,is one of the oldest and most widely used herbal medicines worldwide.Its distinct sweet flavor and rich medicinal value make it an integral component of traditional Chinese medicine(TCM)formulations,which continue to be widely employed.The main chemical constituents of licorice include triterpenoid saponins,flavonoids,and polysaccharides.Experimental and clinical studies have demonstrated that various extracts and pure compounds derived from licorice exhibit a wide range of pharmacological properties including anti-inflammatory,antioxidant,antimicrobial,antiviral,antitumor,immune-regulatory,and neuroprotective activities.The bioactive constituents of licorice offer therapeutic benefits for cardiovascular and cerebrovascular diseases,diabetes mellitus,and liver disorders.This comprehensive review discusses the primary chemical constituents of licorice and their pharmacological activities,describes in vivo and in vitro models employed for studying licorice,and its potential targets and mechanisms of action.Furthermore,we discuss the toxicological profile,side effects,dosage recommendations,and clinical applications of licorice.This review aims to establish a foundation for further research on the safe and effective utilization of licorice while facilitating an in-depth exploration of its properties and fostering the development of novel therapeutic agents.

A review on pharmacological and analytical aspects of diosgenin:a concise report

Diosgenin is a steroidal sapogenin found in plants such as Dioscorea nipponoca,Solanum incanum,Solanum xanthocarpum and Trigonella foenum graecum.Diosgenin,biologically active phytochemicals have been used for the treatment of various types of disorder such as leukemia,inflammation,hypercholesterolemia and cancer.It is also able to prevent bone loss to the same extent as that of oestrogen.It is a typical initial intermediate for synthesis of steroidal compounds,oral contraceptives and sex hormones.Dioscorea,Costus and Trigonella are mainly used for the production of diosgenin.On the basis of literature survey it divulges that diosgenin has very impressive pharmacological profile and could be used as a medicine for the treatment of different types of disorders in the future.Thus,the present work aims to provide collective information in concern with its pharmacological activity and phytoanalytical techniques.This review will be beneficial to researches for the development of an alternative method for the treatment of innumerable diseases from diosgenin.

Development of Pharmacological Effects of Aquilariae Lignum Resinatum

Aquilariae Lignum Resinatum is a common medicine for regulating qi.As an ancient medicinal material,Aquilariae Lignum Resinatum has been widely used in traditional Chinese medicine.Therefore,this paper introduced the research and progress of pharmacological action of Aquilariae Lignum Resinatum in detail,which lays a foundation for further research and development of Aquilariae Lignum Resinatum.

Volatile oil from Litsea lancilimba Merr.: a review of its chemical structure and biological activity

Litsea lancilimba Merr.is a Cinnamomum plant of Lauraceae.Phytochemical investigations of the Litsea lancilimba Merr.have resulted in the isolation of Volatile oil,flavonoid glycosides,tannins,alkaloids,lignans,organic acids and so on.Studies have showed that volatile oil is the main chemical component.Recent trials have demonstrated the efficacy of Litsea lancilimba Merr.in strengthening the function of stomach.The fruits have also been demonstrated to possess anti-inflammatory and bacteriostatic activities.This review deals mainly with the chemical structure and biological activities of Litsea lancilimba Merr.oil.

Chemical composition and pharmacological activities of Polygonum cuspidatum

Polygonum cuspidatum is a traditional Chinese medicine,and its medicinal part is dry rhizome.It is mainly used to treat damp heat jaundice,burns,carbuncle,ulcer poisoning,amenorrhea,and snake bite.Recent studies have found that P.cuspidatum also contains active ingredients against coronaviruses.This paper reviews the chemical constituents and pharmacological activities of P.cuspidatum,so as to provide a scientific basis for the development and utilization of P.cuspidatum resources in the future.

A review:The chemical components and pharmacological activities of Piper auritum Kunth

Piper auritum Kunth,a member of the Piperacea family,is a small shrub native to the Central American tropics.This plant was traditionally used in Latin American countries for the treatment of various medical conditions.Increase in the recent studies of P.auritum’s chemical components leads to the isolation of monoterpenoids,sesquiterpenoids,phenylpropanoids and several other compounds.Previous research has revealed that these secondary metabolites have diverse pharmacological activities including antidiabetic,antioxidant,anti-inflammatory,anti-pathogeny microorganism and repellent activity.This review summarizes relevant findings on P.auritum,and hopes to contribute to the exploration of its potentials for further development as an alternative medicine.

Research progress of phenolic compounds and pharmacological effects in Cerasus

The phenolic compounds in Cerasus were complex,mainly including flavonoids,phenolic acids and lignin,and had antioxidant,anti-inflammatory,anti-tumor,hypoglycemic and other pharmacological activities.Its fruit contains calcium,sugar,iron,phosphorus,protein,carotene and vitamin C,which has high nutritional value.This paper reviews the research progress of chemical constituents and pharmacological effects of Cerasus in recent years,so as to provide reference for its further research.