A series of 1,5-disubstituted 1,2,3-triazoles are synthesized by a one-pot process from anti-3-aryl-2,3-dibromopropanoic acids and organic azides mediated by sodium hydride in dimethyl sulfoxide.The reaction is mild a...A series of 1,5-disubstituted 1,2,3-triazoles are synthesized by a one-pot process from anti-3-aryl-2,3-dibromopropanoic acids and organic azides mediated by sodium hydride in dimethyl sulfoxide.The reaction is mild and simple,does not require a transition-metal catalyst,and gives products in good to excellent yields.展开更多
The effects of the substituents on the cyclopentadienyl ring and the reducing agents on the catalytic activity and the stability of titanocene/NaH or n BuLi systems for the hydrogenation of olefins were investiga...The effects of the substituents on the cyclopentadienyl ring and the reducing agents on the catalytic activity and the stability of titanocene/NaH or n BuLi systems for the hydrogenation of olefins were investigated. For the catalyst systems composed of titanocene/NaH or n BuLi, the nature and the number of the substituents on the cyclopentadienyl ring control the catalytic behavior of those two systems. The effect of the reducing agent on the catalytic activity is relatively small. In addition, the characters of the hydrogenation of various olefins catalyzed respectively by Cp 2TiCl 2/NaH or n BuLi systems were compared.展开更多
A series of chiral N-Boc-α-aminoaldehydes were synthesized in good yields and high purity via esterification of Boc-L-amino acids followed by reduction with sodium bis (2-methoxy- ethoxy)aluminum hydride.
A facile and efficient approach was developed to access 5, 7-disubstitued thiazolo[5,4-d]pyrimidine-4, 6(5H, 7H)-diones through condensation of N-substituted 5-amino-4-carbethoxythiazole with structurally diverse is...A facile and efficient approach was developed to access 5, 7-disubstitued thiazolo[5,4-d]pyrimidine-4, 6(5H, 7H)-diones through condensation of N-substituted 5-amino-4-carbethoxythiazole with structurally diverse isocyanates in the presence of sodium hydride. The easy availability of substrates and tolerance of structural diversity in this reaction make it attractive to be used for construction of libraries in drug discovery process.展开更多
基金supported by the Natural Science Foundation of China(No.21272174)the Key Projects of Shanghai in Biomedicine(No.08431902700)the Scientific Research Foundation of the State Education Ministry for Returned Overseas Chinese Scholars
文摘A series of 1,5-disubstituted 1,2,3-triazoles are synthesized by a one-pot process from anti-3-aryl-2,3-dibromopropanoic acids and organic azides mediated by sodium hydride in dimethyl sulfoxide.The reaction is mild and simple,does not require a transition-metal catalyst,and gives products in good to excellent yields.
基金Supported by the Educational Com mittee of L iaoning Province
文摘The effects of the substituents on the cyclopentadienyl ring and the reducing agents on the catalytic activity and the stability of titanocene/NaH or n BuLi systems for the hydrogenation of olefins were investigated. For the catalyst systems composed of titanocene/NaH or n BuLi, the nature and the number of the substituents on the cyclopentadienyl ring control the catalytic behavior of those two systems. The effect of the reducing agent on the catalytic activity is relatively small. In addition, the characters of the hydrogenation of various olefins catalyzed respectively by Cp 2TiCl 2/NaH or n BuLi systems were compared.
基金supported by the National Natural Science Foundation of China(No.30230400)"863"Hi-Tech Program of China(No.2004 AA2 Z3781)the State Key Program of Basic Research of China(No.2004GB518907).
文摘A series of chiral N-Boc-α-aminoaldehydes were synthesized in good yields and high purity via esterification of Boc-L-amino acids followed by reduction with sodium bis (2-methoxy- ethoxy)aluminum hydride.
基金supported by the National Natural Science Foundation of China(No.30500634) and NSF of Beijing (No.7102112)
文摘A facile and efficient approach was developed to access 5, 7-disubstitued thiazolo[5,4-d]pyrimidine-4, 6(5H, 7H)-diones through condensation of N-substituted 5-amino-4-carbethoxythiazole with structurally diverse isocyanates in the presence of sodium hydride. The easy availability of substrates and tolerance of structural diversity in this reaction make it attractive to be used for construction of libraries in drug discovery process.