加味阳和汤治疗浆细胞性乳腺炎的临床疗效观察

【目的】观察加味阳和汤对浆细胞性乳腺炎的临床治疗效果。【方法】将43例浆细胞性乳腺炎患者分为2组,其中治疗组25例采用自拟加味阳和汤内服结合外科换药治疗,对照组18例采用抗生素抗炎结合外科换药治疗,观察2组临床疗效,比较2组患者的复发率和平均疗程情况。【结果】(1)治疗组治愈15例,好转8例,未愈2例,总有效率为92.0%;对照组治愈5例,好转7例,未愈6例,总有效率为66.7%;2组比较差异有统计学意义(P<0.05),提示治疗组疗效优于对照组。(2)治疗组平均疗程为(30.3±6.3)d,对照组为(51.9±8.2)d,2组比较差异有统计学意义(P<0.01)。(3)治疗组复发率为4.0%,对照组为22.2%,2组比较差异无统计学意义(P>0.05)。【结论】自拟加味阳和汤治疗浆细胞性乳腺炎疗效确切,值得临床推广应用。

温阳化瘀法治疗系统性硬皮病的临床观察

【目的】探讨温阳化瘀法对系统性硬皮病 (SSc)患者的临床疗效及对外周血循环内皮细胞、皮质醇水平的影响。【方法】采用温阳化瘀法 ,以阳和汤加味治疗系统性硬皮病 16例 ,观察系统性硬皮病的临床症状、体征 ,并检测血浆循环内皮细胞、皮质醇水平的变化。【结果】经两个疗程 (6个月 )的治疗后 ,16例SSc患者中临床痊愈 1例 ,显效 4例 ,有效 8例 ,无效 3例 ,总有效率为 81 2 5 %。实验指标检测结果显示 ,患者的血管内皮细胞水平降低 ,皮质醇水平升高 ,与治疗前比较差异均有显著性 (P <0 0 1)。【结论】温阳化瘀法是治疗系统性硬皮病的有效方法 ,有改善患者临床症状和体征的作用 ,其作用机理可能与保护血管内皮细胞和调节内分泌—免疫网络系统作用有关。

Efficacy and safety of Shaoyang Xibi decoction in patients with knee osteoarthritis:a multi-center,single-blind,randomized controlled trial

PURPOSE: To observe the efficacy and safety of Shaoyang Xibi decoction(SYXBD) in patients with knee osteoarthritis(KOA), and to verify that the theory of "Shaoyang dominating bone" in Traditional Chinese Medicine(TCM) can be applied to KOA treatment.METHODS: Participants were randomly allocated to two groups: SYXBD(treatment group, n = 66)and Meloxicam(control group, n = 66). Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC) and 36-Item Short Form Health Survey(SF-36) were used to assess efficacy before the treatment and 8 weeks after the treatment.RESULTS: Baseline data before the treatment between the two groups were similar. The WOMAC scores significantly decreased and the SF-36 scores significantly increased after 8-week treatment in both groups compared with before the treatment(P < 0.05). SYXBD significantly decreased pain scores(P < 0.001), physical function scores(P <0.001) and the total scores(P < 0.001) in WOMAC compared to Meloxicam. SYXBD significantly improved physical function(P = 0.021), bodily pain(P = 0.002) and general health(P = 0.014), with no significant difference in role emotional(P = 0.053),role physical(P = 0.517), vitality(P = 0.241), social function(P = 0.712) and mental health(P = 0.800)in SF-36 compared to Meloxicam. No adverse events were reported in the treatment group while13 adverse events happened in the control group during the study.CONCLUSION: SYXBD, prepared based on the theory of "Shaoyang dominating bone", has a better curative efficay and safety in patients with KOA compared with Meloxicam. The TCM theory of "Shaoyang dominating bone" may be useful in KOA treatment.

Masquelet技术联合阳和汤加减方法治疗胫骨骨髓炎的效果

目的探析Masquelet技术联合阳和汤加减方法治疗胫骨骨髓炎的临床效果。方法选取2015年7月~2016年5月阳春市中医院创伤一科收治的78例胫骨骨髓炎患者作为研究对象,采用随机数字表法将其分为A组(n=39)和B组(n=39),A组患者采用Masquelet技术与阳和汤加减方共同治疗,B组患者采用Masquelet技术单纯治疗。比较两组患者的骨痂生长评分、骨折愈合时间、并发症发生情况。结果A组患者治疗后3、6个月骨痂生长评分均高于B组,差异有统计学意义(P<0.05);A组患者的骨折愈合时间短于B组,差异有统计学意义(P<0.05);A组患者的下肢深静脉血栓形成(DTV)、肝肾功能受损和病症复发不良事件发生率均低于B组,差异有统计学意义(P<0.05)。结论对胫骨骨髓炎患者予以阳和汤加减方法与Masquelet技术共同治疗,能取得较好治疗效果,加快骨痂生长,缩短骨折愈合时间,减少并发症发生率,减轻患者不适感。