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Disappearance of unaffected motor cortex activation by repetitive transcranial magnetic stimulation in a patient with cerebral infarct 被引量:1
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作者 Jeong Pyo Seo Sung Ho Jang 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第7期761-762,共2页
The ipsilateral motor pathway from the unaffected motor cortex to the affected extremity is one of the motor recovery mechanisms following stroke (Jang, 2011). Because stroke patients who had shown recovery by this ... The ipsilateral motor pathway from the unaffected motor cortex to the affected extremity is one of the motor recovery mechanisms following stroke (Jang, 2011). Because stroke patients who had shown recovery by this mechanism usually showed poorer motor function, compared with patients who showed recovery by other mechanisms, several researchers have considered this mechanism as a maladaptive plasticity (]ang, 2013). 展开更多
关键词 Disappearance of unaffected motor cortex activation by repetitive transcranial magnetic stimulation in a patient with cerebral infarct MCA
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Observation of activation status of motor-related cortex of patients with acute ischemic stroke through functional magnetic resonance imaging 被引量:1
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作者 Ziqian Chen Hui Xiao +6 位作者 Ping Ni Gennian Qian Shangwen Xu Xizhang Yang Youqiang Ye Jinhua Chen Biyun Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2006年第3期221-225,共5页
BACKGROUND: About more than three fourth of patients with stroke have motor dysfunction at different degrees, especially hand motor dysfunction. Functional magnetic resonance imaging (fMRI) provides very reliable v... BACKGROUND: About more than three fourth of patients with stroke have motor dysfunction at different degrees, especially hand motor dysfunction. Functional magnetic resonance imaging (fMRI) provides very reliable visible evidence for studying central mechanism of motor dysfunction after stroke, and has guiding and applicable value for clinical therapy. OBJECTIVE: To observe the activation of motor-related cortex of patients with acute ischemic stroke with functional magnetic resonance imaging, and analyze the relationship between brain function reconstruction and motor restoration after stroke. DESIGN : A contrast observation SETTING: Medical Imaging Center, Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA. PARTICIPANTS : Nine patients with acute ischemic stroke who suffered from motor dysfunction and received the treatment in the Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA between August and December 2005 were recruited, serving as experimental group. The involved patients including 5 male and 4 female, aged 16 to 87 years, all met the diagnostic criteria of cerebrovascular disease revised by The Fourth National Conference on Cerebrovascular Disease, mainly presenting paralysis in clinic, and underwent fMRI. Another 9 right handed persons matched in age and gender who simultaneously received healthy body examination were recruited, serving as control group. All the subjects were informed of the detected items. METHODS : ①Muscular strength of patients of the experimental group was evaluated according to Brunnstrom grading muscular strength (Grade Ⅰ -Ⅳ). ②Passive finger to finger motion was used as the mission (alternate style of quiescence, left hand motion and quiescence, nght hand motion was repeated 3 times, serving as 1 sequence, 20 s per block and 20 s time interval. The whole process of scanning was 260 s), and subjects of 2 groups were given Bold-fMRI examination with GEl .5T double gradient 16-channel magnetic resonance imaging system. All the data were given off-line management, and fMRI was treated with SPM2 softwere. The activation of passive finger-to-finger motion-related cortex of subjects in 2 groups was observed. ③ Results of fMRI of subjects in 2 groups were compared. The size of activation region of brain and signal intensity were measured and unilateral index was calculated. The data of activation region of cerebral hemisphere of different sides at finger motion were given statistical analysis of unilateral index. Differences among unilateral indexes at hand motion were compared between intact and affected hands of patients in experimental group. The relationship between unilateral index and muscular strength of affected hands at affected hand motion in patients of the experimental group was performed Spearman correlation analysis. MAIN OUTCOME MEASURES: ① The activation of motion-related cortex passive finger-to-finger motion between handedness and non-handedness was detected with functional magnetic resonance imaging of subjects in 2 groups. ②Relationship between unilateral index and muscular strength of subjects of experimental group at affected hand motion. RESULTS: Nine patients with ischemic stroke and 9 controls all participated in the final result analysis. ① Passive fMRI detection results between handedness and non-handedness of controls: Right-handed finger-to-finger motion of subjects of control group mainly activated contralateral sensonmotor cortex, and left-handed finger-to-finger motion not only activated above-mentioned brain region, but also activated supplementary motor area (SMA) of contralateral brain region; ②In the experimental group, sensorimotor cortex of contralateral hemisphere was activated at affected hand motion, and homolateral posterior parietal cortex (PPC)was also obviously activated. Bilateral sensonmotor cortex was activated at affected hand motion in 2 patients, and homolateral activation area was larger than contralateral one. At intact hand motion, contralateral sensorimotor cortex was activated, but no obvious homolateral activation area was found. ③ Correlation of unilateral index with muscular strength: Passive finger-to-finger fMRI ( between affected and intact hands of subjects of experimental group: Unilateral index at passive single finger motion of affected and intact hand of subjects of experimental group was -0.018±0.01 and 0.319±0.187, respectively, with significant difference (t=4.059, P 〈 0.01 ). Unilateral index was significantly positively correlated with the muscular strength of affected hand at affected hand motion(r=0.834, P 〈 0.05).CONCLUSION : ①fMRI can objectively shows different activation states of motor cortex between patients with ischemic stroke and healthy controls, and brain functional compensation and recombination exist. Both primary sensorimotor cortex and SMA of bilateral hemispheres participant in affected hand motion, at the same time, parietal lobe and cortex of intact side also obviously participant in the affected hand motion. ②Correlation analysis of unilateral index and muscular strength of affected hand performed through fMRI can be used as an effective means to investigate the relationship between motion rehabilitation and brain functional recombination after stroke. 展开更多
关键词 Observation of activation status of motor-related cortex of patients with acute ischemic stroke through functional magnetic resonance imaging FOV
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Altered intrinsic functional connectivity of the primary visual cortex in youth patients with comitant exotropia: a resting state fMRI study 被引量:13
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作者 Pei-Wen Zhu Xin Huang +5 位作者 Lei Ye Nan Jiang Yu-Lin Zhong Qing Yuan Fu-Qing Zhou Yi Shao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2018年第4期668-673,共6页
AIM: To evaluate the differences in the functional connectivity(FC) of the primary visual cortex(V1) between the youth comitant exotropia(CE) patients and health subjects using resting functional magnetic reson... AIM: To evaluate the differences in the functional connectivity(FC) of the primary visual cortex(V1) between the youth comitant exotropia(CE) patients and health subjects using resting functional magnetic resonance imaging(f MRI) data.METHODS: Totally, 32 CEs(25 males and 7 females) and 32 healthy control subjects(HCs)(25 males and 7 females) were enrolled in the study and underwent the MRI scanning. Two-sample t-test was used to examine differences in FC maps between the CE patients and HCs. RESULTS: The CE patients showed significantly less FC between the left brodmann area(BA17) and left lingual gyrus/cerebellum posterior lobe, right middle occipital gyrus, left precentral gyrus/postcentral gyrus and right inferior parietal lobule/postcentral gyrus. Meanwhile, CE patients showed significantly less FC between right BA17 and right middle occipital gyrus(BA19, 37).CONCLUSION: Our findings show that CE involves abnormal FC in primary visual cortex in many regions, which may underlie the pathologic mechanism of impaired fusion and stereoscopic vision in CEs. 展开更多
关键词 comitant exotropia functional connectivity primary visual cortex spontaneous activity
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Altered relationship between thickness and intrinsic activity amplitude in generalized tonic–clonic seizures 被引量:3
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作者 Wei Liao Jue Wang +10 位作者 Ting Xu Zhiqiang Zhang Gong-Jun Ji Qiang Xu Zhengge Wang Fang Yang Xi-Nian Zuo Anqi Qiu Yu-Feng Zang Guangming Lu Huafu Chen 《Science Bulletin》 SCIE EI CAS CSCD 2016年第24期1865-1875,共11页
A thinner cortex has higher potential for binding GABA receptor A which is associated with larger amplitudes of intrinsic brain activity(i BA). However, the relationship between cortical thickness and i BA is unknown ... A thinner cortex has higher potential for binding GABA receptor A which is associated with larger amplitudes of intrinsic brain activity(i BA). However, the relationship between cortical thickness and i BA is unknown in intact and epileptic brains. To this end, we investigated the relationship between cortical thickness measured by highresolution MRI and surface-based i BA derived from resting-state functional MRI in normal controls(n = 82) andpatients with generalized tonic–clonic seizures(GTCS)only(n = 82). We demonstrated that the spatial distribution of cortical thickness negatively correlated with surface-based i BA amplitude at both whole-brain and within independent brain functional networks. In GTCS patients,spatial coupling between thickness and i BA amplitude decreased in the default mode, dorsal attention, and somatomotor networks. In addition, the vertex-wise acrosssubject thickness–i BA amplitude correspondence altered in the frontal and temporal lobes as well as in the precuneus in GTCS patients. The relationship between these two modalities can serve as a brain-based marker for detecting epileptogenic changes. 展开更多
关键词 cortex thickness - Generalized tonicclonic seizures - Intrinsic brain activity amplitude -Morphometric-functional relationship ~ Resting state
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