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Phlorizin alleviates deltamethrin-induced oxidative stress in brine shrimp Artemia
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作者 Dandan MA Qingli ZHOU +5 位作者 Liying SUI Qingbin GUO Huanhuan LIU Honghe LIANG Zhenjing LI Zhongna SANG 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2024年第1期163-173,共11页
Deltamethrin(DEL),a commonly used pyrethroid pesticide,results in higher reactive oxygen species(ROS)levels in aquatic animals,which consequently unbalance the redox state.Phlorizin(PHL)is a flavonoid and a natural pr... Deltamethrin(DEL),a commonly used pyrethroid pesticide,results in higher reactive oxygen species(ROS)levels in aquatic animals,which consequently unbalance the redox state.Phlorizin(PHL)is a flavonoid and a natural product promising to prevent or reduce pesticide-induced oxidative stress.Artemia is a micro-crustacean widely used in marine hatcheries and an experimental aquatic organism for environmental toxicology research.This research aimed to evaluate the toxicity of DEL on Artemia and the antioxidative effect of PHL against the toxicity.Results show that 0.08-mg/mL PHL exerted its antioxidative effects on hatching percentage of the cysts in 24-h incubation and on body length and survival rate of Artemia in 12-d culture.After 12-d culture,12-,24-,and 36-h DEL exposure showed significant drops in SOD,CAT,and GSH-Px enzyme activities,and significant increases in ROS and malondialdehyde(MDA)levels in Artemia(P<0.05).On the contrary,0.08-mg/mL PHL application improved the enzyme activities and decreased the ROS and MDA levels(P<0.05).Moreover,0.08-mg/mL PHL significantly increased mRNA expression levels of Cu/Zn SOD,CAT,GST,HO-1,NQO1,and Nrf2,and decreased mRNA expression level of Keap1 in the DEL-exposed Artemia(P<0.05).Therefore,DEL is toxic to Artemia,while PHL alleviates DEL-induced oxidative damage by possibly regulating the Nrf2signaling pathway.This study provided a theoretical basis for PHL to reduce pesticide-induced toxicity in aquatic animals. 展开更多
关键词 ARTEMIA deltamethrin PHLORIZIN oxidative stress
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Acute Single and Joint Toxicity Effects of Deltamethrin and Lambda-cyhalothrin on Zebrafish(Danio rerio)
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作者 Robert Kamutambuko Mingxiao Li Shunlong Meng 《Agricultural Biotechnology》 2024年第5期19-21,27,共4页
In this research,the single and combined toxicity effects of two commonly used pesticides,lambda-cyhalothrin and deltamethrin,were investigated on zebrafish at 20℃,with a weight of(1±0.1)g and a length of(3.5... In this research,the single and combined toxicity effects of two commonly used pesticides,lambda-cyhalothrin and deltamethrin,were investigated on zebrafish at 20℃,with a weight of(1±0.1)g and a length of(3.5±0.35)cm.The study revealed that lambda-cyhalothrin exhibited higher toxicity compared to deltamethrin.Additionally,when used together,these pesticides showed significantly increased toxic effects on zebrafish.The 96-h LC 50 values were determined to be 3.059μg/L(confidence limits 0.077-0.351μg/L)for lambda-cyhalothrin and 1.304μg/L(confidence limits;0.046-0.228μg/L)for deltamethrin,both demonstrating a significant positive correlation(P<0.05).These results underscore the importance of regulating and managing pesticide use to safeguard aquatic organisms and uphold environmental sustainability. 展开更多
关键词 Acute toxicity Joint toxicity LAMBDA-CYHALOTHRIN deltamethrin Zebrafish(Danio rerio)
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Screening of Deltamethrin Resistant Strain of Bombyx Mandarina 被引量:3
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作者 赵华强 刘海涛 +3 位作者 王东 李兵 许雅香 沈卫德 《Agricultural Science & Technology》 CAS 2009年第2期138-141,共4页
[ Objective ] The aim of the study was to explore the resistance development of deltamethrin through selection of dettamethrin resistant strain of wild silkworm ( Bombyx Mandarina), thus providing the basis for scie... [ Objective ] The aim of the study was to explore the resistance development of deltamethrin through selection of dettamethrin resistant strain of wild silkworm ( Bombyx Mandarina), thus providing the basis for scientific pesticide application and resistance management. [ Method] The wild silkworms collected from three different regions were reared indoors, and the sensitivity of their parents to deltamethrin was detected by topical application. The larvae in each generation were treated with deltamethdn in median lethal dose or so by.topical application. The mortality of larva was analyzed for the establishment of toxicity regression equations and the calculation of the multiple or increased multiple of deltamethdn resistance.[Result] After the Qidong Bornbyx Mandarina (YQD) fed with mulberry leaves were selected for three generations indoors, the multiple of deltamethdn resistance of F, was 14.26, 1.2 times as great as that of Fo ; after the Bombyx Mandarina from mulberry garden of Soochow University (YSD) fed with mulberry leaves were selected for three generations indoors, the multiple of deltamethrin resistance of F4 was 16.48, 1.9 times as great as that of Fo ; after the Wujiang Bombyx Mandarina (YWJ) fed with artificial diets were selected for three generations indoors during six generations, the multiple of deltamethrin resistance of Fe was 18.67, 1.2 times as great as that of Fo. [ Conclusioa] With the selection in same dose, the resistance multiple of YSD increases more rapidly than that of YQD; under double selection of artificial diets and insecticide, the resistance multiple of YWJ increases more slowly than that of YQD. 展开更多
关键词 Bombyx Mandarina deltamethrin RESISTANCE
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Effects of Spraying Deltamethrin on Agronomic Traits and Yield of Soybean
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作者 戴海英 张礼凤 +4 位作者 李伟 王彩洁 张彦威 孟维伟 徐冉 《Agricultural Science & Technology》 CAS 2016年第5期1181-1182,1213,共3页
At the seedling and beginning flowering stages,2.5% deltamethrin EC was sprayed to control the pests in summer soybean,and its effects on agronomic traits and yield of soybean were analyzed.The results showed that com... At the seedling and beginning flowering stages,2.5% deltamethrin EC was sprayed to control the pests in summer soybean,and its effects on agronomic traits and yield of soybean were analyzed.The results showed that compared with the control,the plant height,branch number,effective pod number,grain number per plant,grain weight per plant,100-grain weight and yield of Qihuang 34 significantly increased by 9.3%,25.8%,15.8%,26.8%,33.2%,9.1% and 33.0%,respectively,while those of Qihuang 35 increased by 13.8%,10.0%,15.8%,16.9%,11.6%,6.0%and 16.9%,respectively;the noneffective pod number of Qihuang 34 and Qihuang35 significantly decreased by 18.5% and 38.7%,respectively.The spraying of 2.5%deltamethrin EC showed no significant effects on the other agronomic traits of the two cultivars. 展开更多
关键词 SOYBEAN deltamethrin Agronomic traits YIELD
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Sensitive determination of fenpropathrin,cyhalothrin and deltamethrin in environmental water samples using multiwalled carbon nanotubes cartridge prior to HPLC 被引量:3
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作者 Qing Xiang Zhou Guo Hong Xie +2 位作者 Jun Ping Xiao Wei Dong Wang Yu Jie Ding 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第1期95-98,共4页
This paper described a new method for the trace determination of fenpropathrin, cyhalothrin and deltamethrin using multiwalled carbon nanotubes (MWCNTs) cartridge. Important parameters, such as the sample pH, eluent... This paper described a new method for the trace determination of fenpropathrin, cyhalothrin and deltamethrin using multiwalled carbon nanotubes (MWCNTs) cartridge. Important parameters, such as the sample pH, eluent and its volume, sample flow rate and sample volume were investigated in detail. The linear ranges, the detection limits, and precisions (R.S.D.) were in the range of 0.1- 40 μg L^-11, 1.34.3 ng L^-1 and 2.3-2.8%, respectively. The performance of the proposed method was validated with real water samples, and the spiked recoveries were in the range of 91.7-117.8%, respectively. The experimental results demonstrated that the proposed method was an excellent alternative for the routine analysis of such pollutants in environmental samples. 2007 Qing Xiang Zhou. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. 展开更多
关键词 Multiwalled carbon nanotubes FENPROPATHRIN CYHALOTHRIN deltamethrin High performance liquid chromatography
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Oxidative Stress, Biochemical and Histopathological Alterations in the Liver and Kidney of Female Rats Exposed to Low Doses of Deltamethrin (DM):A Molecular Assessment 被引量:2
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作者 CHARGUI Issam GRISSA Intissar +4 位作者 BENSASSI Fatma HRIRA Mohamed Yahia HAOUEM Samir HAOUAS Zohra BENCHEIKH Hassen 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2012年第6期672-683,共12页
Objective To evaluate histopathological alterations of the liver and kidney of female rats exposed to low doses of DM and its potential genotoxic activity. Methods Female Wistar rats were randomly assigned to control ... Objective To evaluate histopathological alterations of the liver and kidney of female rats exposed to low doses of DM and its potential genotoxic activity. Methods Female Wistar rats were randomly assigned to control (3 groups, 6 rats in each) and treatment groups (3 groups, 6 rats in each). They were subjected to subcutaneous injections of DM (at doses of 0.003, 0.03, and 0.3 mg/kg bw/d) after 30, 45, and 60 d, respectively. Results Significant alterations were recorded in liver parenchyma induced by hepatic vacuolization, fragmented chromatin in nuclei, dilatation of sinusoids and congestions. Lesions within proximal and distal tubules were observed in the kidneys. Tissue congestions and severe alterations within glomeruli were visible. DM as a pyrethroid insecticide induced significant increase (P〈_O.05) of plasma MDA concentrations after 45 d. A significant increase (P_〈0.05) in plasma ALT (after 45 and 60 d) and AST (after 60 d) concentrations was recorded as compared to controls. During the whole experimental period the toxic agent provoked significant DNA damages (P〈0.05), especially in the dominance of classes 3 and 4 of obtained comet. Conclusion DM even at a very low dose displays harmful effects by disrupting hepatic and renal function and causing DNA damages in puberscent female rats. Low doses of DM are hepatotoxic and nephrotoxic. 展开更多
关键词 deltamethrin Rats LIVER KIDNEY HISTOPATHOLOGY Comet assay DNA damage.
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Susceptibility to temephos,permethrin and deltamethrin of Aedes aegypti(Diptera:Culicidae) from Muang district,Phitsanulok Province,Thailand 被引量:1
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作者 Damrongpan Thongwat Nophawan Bunchu 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2015年第1期14-18,共5页
Objective:To investigate the susceptibility to temephos.permethrin and deltamethrin of Aedes aegypti Ae.aegypti),collected from areas with high incidence of dengue hemorrhagic fever cases in Phitsanulok Province.Thail... Objective:To investigate the susceptibility to temephos.permethrin and deltamethrin of Aedes aegypti Ae.aegypti),collected from areas with high incidence of dengue hemorrhagic fever cases in Phitsanulok Province.Thailand.Methods:The F1 progenies of Ae.aegypti colony,originated from five sub-districts including Aranyik.Hua Ro,Nai Muang.Ban Krang and Tha Pho,were used in the bioassays following the procedures of World Heath Organization.For larval bioassay.the late third or early fourth-instar lanae were tested with different concentrations of temephos.For adult bioassay.the females were exposed to 0.75%permethrin or 0.05%deltamethrin.LC_(50)value and mortality rate were analyzed to compare the insecticide susceptibility of the larvae and the adults in each area,respectively.Results:The LC_(50) value of temephos for the larvae from Aranyik.Hua Ro.Nai Muang,Ban Krang and Tha Pho sub-districts was 0.017.0.017.0.026.0.061.and 0.113 ppm,respectively.For permethrin,the highest morlalitv rate(86.84%) was found in the mosquitoes from Aranyik but the others were more resistant with the lower morlality rates(16.00-42.67%).The adult morlality rates after exposing to dellaiiielhrin were higher(82.34-98.67%) in all areas.Conclusions:Ae.acgypti larvae were still susceptible to temephos.Conversely,most tested adults tended to resist the penmethrin and deltamethrin. 展开更多
关键词 AEDES aegypti Insecticide SUSCEPTIBILITY TEMEPHOS PERMETHRIN deltamethrin
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Deltamethrin:Promising mosquito control agent against adult stage of Aedes aegypti L. 被引量:1
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作者 Sarita Kumar Anita Thomas Pillai MKK 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2011年第6期430-435,共6页
Objective:To evaluate the effects of deltamethrin against field-collected adults of Aedes aegypti L(Ae.aegypti).Methods:The adults were selected with 0.025%deltamethrin for 40 successive generations.The selected adult... Objective:To evaluate the effects of deltamethrin against field-collected adults of Aedes aegypti L(Ae.aegypti).Methods:The adults were selected with 0.025%deltamethrin for 40 successive generations.The selected adults were tested with 4%DDT and the emerging larvae were tested with various insecticides to study the cross-resistance spectrum.The knockdown and irritability studies were carried out in adult mosquitoes to investigate their behavioural response to deltamethrin.Results:Forty generations of selection with deltamethrin resulted in only 3.8-fold resistance in the adults of Ae.aegypti.The adults of parent(PS) and selected strains (DAS) exhibited only 0.8-fold cross resistance to 4%DDT.The larvae emerging from the PS and DAS strains did not develop appreciable levels of resistance to various insecticides tested.The knockdown studies revealed KTSO of 14.4 min in PS adults with no signs of recovery even after 24 h. The DAS strains could develop only 1.2 to 1.3-fold knockdown resistance(KDR).The knockdown response of DDT was though 5-6 times slower than deltamethrin but the continued response in deltamethrin-selected adults caused only 1.2-fold KDR.The PS and DAS strains exhibited significant irritability response towards deltamethrin and DDT.The DAS strains showed 5-6 fold increased irritability to deltamethrin as compared to the PS strain.Conclusions:The above results suggest the prolonged effective use of deltamethrin against Ae.aegypti as an adulticide. 展开更多
关键词 deltamethrin KNOCKDOWN IRRITABILITY Resistance CROSS-RESISTANCE
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Effects of deltamethrin on the activation or expression of Nrf2 and on the GCS-HS protein level in primary astrocytes with laser scanning confocal microscope 被引量:2
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作者 Huangyuan Li Nian Shi +1 位作者 Yufang Zhong Linlin Liu 《Journal of Nanjing Medical University》 2006年第1期1-7,共7页
Objective: To examine the effects of deltamethrin(DM) and tBHQ on the activation of Nrt2 and expression of GCS-HS in primary astrocytes. Methods: Rat primary astrocytes were treated with DM (10μmol/L) and tBHQ ... Objective: To examine the effects of deltamethrin(DM) and tBHQ on the activation of Nrt2 and expression of GCS-HS in primary astrocytes. Methods: Rat primary astrocytes were treated with DM (10μmol/L) and tBHQ (40μmol/L), for 1 and 6 h respectively. Results: Analysis using immunofluorescent confocal microscopy revealed that tBHQ treatment led to a dramatic increase in the level of Nrt2. The ratio of cytoplasmic Nrt2 protein to nuclear Nrt2 protein was markedly reduced in astrocytes by either tBHQ or DM treatment. The level of Nrf2 was reduced by combined tBHQ with DM treatment for 1 h, but treatment the ratio of cytoplasmic Nrf2 protein to nuclear Nrf2 protein was increased compared with that of the tBHQ only. The expression of GCS-HS in astrocytes was not altered by DM or tBHQ or both in astrocytes. Conclusion: These findings demonstrated for the first time that Nrf2 was activated by pesticides and antioxidants in astrocytes, implicating a tote of Nrf2 in response to pesticide neurotoxicity ingla. 展开更多
关键词 deltamethrin NF-E2 related factor 2 gmmm-glutamylcysteine synthetase LSCM ASTROCYTE
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Long Term Perinatal Deltamethrin Exposure Alters Electrophysiological Properties of Embryonic Ventricular Cardiomyocyte 被引量:1
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作者 Hong-yan LUO Jacob Masika +6 位作者 Xiu-wen Guan Li NIE Dong-hui AO Yu QI Rui SHI Jurgen Hescheler Ying ZENG 《Current Medical Science》 SCIE CAS 2019年第1期21-27,共7页
Increased use of pyrethroids and the exposure to pyrethroids for pregnant women and children have raised the concerns over the potential effect of pyrethroids on developmental cardiotoxicity and other abnormalities.Th... Increased use of pyrethroids and the exposure to pyrethroids for pregnant women and children have raised the concerns over the potential effect of pyrethroids on developmental cardiotoxicity and other abnormalities.The purpose of this study was to investigate whether long tenn peri natal deltamethrin exposure altered embryonic cardiac electrophysiology in mice.Pregnant mice were administered with 0 or 3 mg/kg of deltamethrin by gavage daily from gestational day(gd)10.5 to gd 17.5.Whole cell patch-clamp technique was used in electrophysiological study,and real time RT-PCR was applied to analyze the molecular changes for the electrophysiological properties.Deltamethrin exposure resulted in increased mortality of pregnant mice and decreased viability of embryos.Moreover,deltamethrin slowed the maximum depolarization velocity(Vmax),prolonged the action potential duration(APD)and depolarized the maximuin diastolic potential(MDP)of embryonic cardiomyocytes.Additionally,perinatal deltamethrin exposure decreased the mRNA expression of Na^+channel regulatory subunit Navpl,inward rectifier K^+channel subunit Kir2.1,and delayed rectifier K^+channel subunit MERG while the L-type Ca^2+channel subunit,Cavl.2 expression was increased.On the contraiy,deltamethrin administration did not significantly alter the regulation ofβ-adrenergic or muscarinic receptor on embryonic cardiomyocytes.In conclusion,deltamethrin exposure at perinatal stage significantly alters mRNA expression of embryonic cardiac ion channels and therefore influences embryonic cardiac electrophysiological properties.This highlights the need to understand the persistent effects of pyrethroid exposure on cardiac function during embryonic development due to potential for cardiac arrhythmogenicity. 展开更多
关键词 PYRETHROID deltamethrin EMBRYONIC cardiomyocytes action potential developmental CARDIOTOXICITY
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Impact of Indoor Residual-Sprayed Deltamethrin on Different Surfaces in a Malaria Endemic Area in Balai Ringin, Sarawak 被引量:1
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作者 Ahmad Rohani Ismail Zamree +4 位作者 Wan Najdah Wan Mohamad Ali Azahari Abdul Hadi Matusop Asmad Zurainee Mohamed Nor Lee Han Lim 《Advances in Entomology》 2014年第3期151-160,共10页
Malaria control programme utilizing indoor residual spraying of chemical insecticide is only effective if a high coverage of targeted area is achieved. The effectiveness of the residual spraying, on the other hand, re... Malaria control programme utilizing indoor residual spraying of chemical insecticide is only effective if a high coverage of targeted area is achieved. The effectiveness of the residual spraying, on the other hand, relies on the efficacy and residual activity of the insecticides applied, which to a certain extent are influenced by the nature of the sprayed surfaces. The bioefficacy of indoor residual-sprayed deltamethrin wettable granule (WG) formulation for the control of malaria was compared with the current dose of deltamethrin wettable powder (WP) in malaria endemic areas in Balai Ringin, Sarawak. Doses of 20 mg/m2 WP (control), 20 mg/m2 WG, 30 mg/m2 WG and 40 mg/m2 WG were sprayed separately on different surfaces namely, wooden, rough-bamboo, smooth-bamboo and brick surfaces. Residual activity of WP and WG formulations was tested against lab-bred Anopheles maculatus using WHO standard procedure. Deltamethrin at 30 mg/m2 WG exhibited the highest sustainable level of effectiveness against An. maculatus (An. maculatus mortality was between 95% - 100%) up to week 60 post-spraying when sprayed on smooth- bamboo surface. These results indicated that 30 mg/m2 WG could be an ideal concentration for controlling malaria vector effectively up to 15 months of which long-lasting residual spraying was envisaged. The usual two spraying cycles per year with 20 mg/m2 deltamethrin WP could be replaced with 30 mg/m2 deltamethrin WG since the long residual activity was achieved by employing a single spraying only. 展开更多
关键词 Component INDOOR Residual-Sprayed deltamethrin Wettable GRANULE An. maculatus
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Studies on the Effects of Deltamethrin on Sodium Net Transport Through the in vivo Amphibian Skin 被引量:3
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作者 ALFREDO SALIBIAN AND JOSE L. MARAZZO(Programa de Ecofisiologia Aplicada, Departamento de Ciencias Basicas,Universidad Nacional de Lujan, Casilla de Correo 221, 6700-Lujaan (B),Argentina)(Comision de Investigaciones Cientificas, Provincia de Buenos Aires, 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1995年第2期164-168,共5页
The action of micromolar concentrations of Deltamethrin on sodium net transport through the in vivo skin of the South American toad Bufo arenarum was studied. The effect of pure ethanolic insecticide solutions and com... The action of micromolar concentrations of Deltamethrin on sodium net transport through the in vivo skin of the South American toad Bufo arenarum was studied. The effect of pure ethanolic insecticide solutions and commercial formulations when applied on the mucosal surface was assayed. Deltamethrin provoked a concentration-independent inhibition; the highest inhibition was found at the lowest concentrations. At highest concentrations of the insecticide the J Na was not altered 展开更多
关键词 Studies on the Effects of deltamethrin on Sodium Net Transport Through the in vivo Amphibian Skin
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First investigation of deltamethrin pyrethroid susceptibility and resistance status of Anopheles labranchiae(Falleroni, 1926), potential malaria vector in Tunisia
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作者 Ahmed Tabbabi Jabeur Daaboub 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2017年第12期1067-1070,共4页
Objective: To evaluate the deltamethrin pyrethroid insecticides against Anopheles labranchiae, potential malaria vector in Tunisia.Methods: Six field populations of Anopheles labranchiae mosquitoes were collected from... Objective: To evaluate the deltamethrin pyrethroid insecticides against Anopheles labranchiae, potential malaria vector in Tunisia.Methods: Six field populations of Anopheles labranchiae mosquitoes were collected from six localities in Northern and Central Tunisia between October and November 2016.Different bioassays were performed to estimate the level of resistance in each collected population. Two synergists were used to estimate the involvement of detoxification enzymes in insecticide resistance.Results: All studied strains were resistant and the RR50 ranged from 12.5 in sample #1 to72.5 in sample #6. Synergist tests using piperonyl butoxide indicated the involvement of monoxygenases enzymes in the recorded resistance. In contrast, the increase of deltamethrin mortality was not significant in presence of S,S,sributyl phosphorothioate(0.8 < SR < 1.2), suggesting no role of esterases(and/or GST) in the resistance phenotype. The correlation recorded between mortality due to DDT and the LC50 of deltamethrin insecticide indicated an insensitive sodium channel affected by Kdr mutation(Spearman rank correlation, r =-0.59, P < 0.01).Conclusions: These results should be considered in the current mosquitoes control programs in Tunisia. The use of pesticides and insecticides by both agricultural and public health departments in Tunisia should be more rational to reduce the development of resistance in populations. Different insecticide applications should be implemented alternately. 展开更多
关键词 RESISTANCE Anopheles labranchiae deltamethrin pyrethroid Synergism Kdr mutation Tunisia
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Application of Gas Chromatography-mass Spectrometry in Analyzing Pharmacokinetics and Distribution of Deltamethrin in Miniature Pig Tissues
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作者 ZHU Pan FAN Sai +4 位作者 ZOU Jian Hong MIAO Hong LI Jing Guang ZHANG Guo Wen WU Yong Ning 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2014年第6期426-435,共10页
Objective To characterize the pharmacokinetics and distribution profiles of deltamethrin in miniature pig tissues by gas chromatography-mass spectrometry (GC-MS). Methods Pharmacokinetics and distribution of deltame... Objective To characterize the pharmacokinetics and distribution profiles of deltamethrin in miniature pig tissues by gas chromatography-mass spectrometry (GC-MS). Methods Pharmacokinetics and distribution of deltamethrin in blood and tissues of 30 miniature pigs were studied by GC-MS after oral administration of deltamethrin (5 mg/kg bw). Data were processed by 3P97 software. Results The serum deltamethrin level was significantly lower in tissues than in blood of miniature pigs.The AUC0-72 h, Cmax, of deltamethrin were 555.330±316.987 ng h/mL and 17.861±11.129 ng/mL, respectively. The Tmax, of deltamethrin was 6.004±3.131 h.Conclusion The metabolism of deltamethrin in miniature pigs is fit for a one-compartment model with a weighting function of I/C^2. Deltamethrin is rapidly hydrolyzed and accumulated in miniature pig tissues. 展开更多
关键词 deltamethrin Miniature pig PHARMACOKINETICS Tissue distribution GC-MS
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Tyrosine Hydroxylase as a Target for Deltamethrin in the Nigrostriatal Dopaminergic Pathway
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作者 GONG-PING LIU QIANG MA NIAN SHI 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2006年第1期27-34,共8页
Objective To study the effects of deltamethrin on tyrosine hydroxylase in nigrostriatum of male rats. Methods Sprague-Dawley rats were daily treated with deltamethrin at 6.25 or 12.5 mg/kg body weight by gavage for 10... Objective To study the effects of deltamethrin on tyrosine hydroxylase in nigrostriatum of male rats. Methods Sprague-Dawley rats were daily treated with deltamethrin at 6.25 or 12.5 mg/kg body weight by gavage for 10 days. Then HPLC-fluorescence detection was used to analyze the contents of dopamine (DA), 3,4-dihydmxyphenylacetic acid (DOPAC) and homoranillic acid (HVA) in substantial nigra and striatum. The activities of tyrosine hydroxylase (TH) were also detected by HPLC-fluorescence detection. TH mRNA or TH protein levels were measured by RT-PCR and immunohistochemistry method. Results The content of DA in stfiatum was significantly decreased by the treatments, suggesting an inhibition of DA synthesis by deltamethrin. The contents of DA metabolites DOPAC and HVA increased, indicating increased dopamine turnover. Furthermore, deltamethrin significantly decreased the activity, as well as the mRNA and protein levels of TH. Conclusions These findings reveal a novel aspect of deltamethfin neurotoxicity and suggest tyrosine hydroxylase as a molecular target of deltamethin on dopamine metabolism in the nigrostriatal pathway. 展开更多
关键词 deltamethrin Nigrostriatum DOPAMINE Tyrosine hydroxylase Parkinson's disease
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Distribution and Significance of Nitric Oxide Synthase in Brain Tissues of Rats Exposed to Deltamethrin Insecticide
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作者 ZHAO Xi-Long, ZHU Xiao-Feng, YUAN De-Xin, LIU Yu-GuDepartment of Environmental Toxicology, Laboratory of Brain Research,Tongji Medical University, Wuhan 430030, China JiamusiMedical College, Jiamusi 154002, China 《中国组织化学与细胞化学杂志》 CAS CSCD 1996年第2期231-235,共5页
The distribution of nitric oxide synthase(NOS)in brain tissues of rats exposed to deltamethrininsecticide has been examined by histochemical NADPH-diaphorase staining techniques on frozen sec-tions.After injection of ... The distribution of nitric oxide synthase(NOS)in brain tissues of rats exposed to deltamethrininsecticide has been examined by histochemical NADPH-diaphorase staining techniques on frozen sec-tions.After injection of deltamethrin(12.5mg/kg,i.p.),a reproducible sequence of toxic signs ofhyperexcitability were elicited.The observation and image analysis showed that,within brain sec-tions of rats exposed to deltamethrin,the numbers and the total staining areas of the NOS positiveneurons were greatly increased,especially in cerebral cortex,hippocampal formation and paraventric-ular nucleus.In addition,the density of single neuron and the processes were also increased.The re-sults suggested that deltamethrin may induce the NOS expression or activate the NOS activity.TheNOS activation may involve in the chains responsible for the excitatory neurotoxicities induced bydeltamethrin. 展开更多
关键词 NITRIC OXIDE NITRIC OXIDE SYNTHASE deltamethrin Neurotoxicity
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Variability of Deltamethrin-Resistant <i>Metarhizium anisopliae</i>Aggressive Strains Group to a Population of the Cossid Moth from <i>Eucalyptus nitens</i>
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作者 Pedro Romón Hardus Hatting +1 位作者 Arturo Goldarazena Juan Carlos Iturrondobeitia 《Open Journal of Forestry》 2018年第2期196-204,共9页
Random amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR) was used to examine the genetic variability among Metarhizium anisopliae isolates tested to the cossid moth, Coryphodema tristis. All the isolates ... Random amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR) was used to examine the genetic variability among Metarhizium anisopliae isolates tested to the cossid moth, Coryphodema tristis. All the isolates tightly clustered into one or the other of two groups that diverged at 12%. Results suggested that certain genotypes of the fungus, that grouped together, were able to infect moth larvae while others did not. A fragment of 760 bp, which presents high homology with a host-adaptation related protein coding gene, distinguished between aggressive and non-aggressive isolates. Neither mycelial growth nor sporulation rate or presence of known virulence genes was correlated with mortality values. Some isolates, including the most aggressive isolate ARSEF2518, were compatible with deltamethrin. Deltamethrin treatment killed all the larvae after seven days whereas fungal and mixed treatments respectively reached the same mortality after 28 and 21 days. 展开更多
关键词 Coryphodema tristis METARHIZIUM anisopliae Assays Compatibility with deltamethrin RAPDS
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Metabolism of Deltamethrin in Rats
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作者 S.EL-MAGHRABY 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2007年第3期212-216,共5页
Objective To study the metabolism of 14^C-deltamethrin in rats. Methods Rats were dosed orally and i.p. with a single dose of 14^C-deltamethrin (0.64 mg/Kg) body weight. The required dose was applied daily for 3 day... Objective To study the metabolism of 14^C-deltamethrin in rats. Methods Rats were dosed orally and i.p. with a single dose of 14^C-deltamethrin (0.64 mg/Kg) body weight. The required dose was applied daily for 3 days. At the end of the experiment, selected organs, such as liver, kidney, fat, intestine, and blood were excised for radioassay of 14^C-content. Results Deltamethrin was almost eliminated from the body within 1-3 days. The main portion of 14^C-residues was extracted from urine (38%, 32%) and feces (20%, 24%) with a little amount remained in various organs. Conclusion The elimination and distribution of 14^C-radioactivity in rats treated orally and intraperitoneally signify that deltamethrin is bioavallable in urine and feces. 展开更多
关键词 Pyrethroid insecticide 14C-deltamethrin Oral and intraperitoneally treatment BIOAVAILABILITY
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Ameliorative Effects of Spirulina platensis on Deltamethrin-Induced Biochemical Alterations and Oxidative Stress in the African Catfish;Clarias gariepinus
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作者 Heba S. Hamed 《Open Journal of Marine Science》 2016年第1期1-10,共10页
The present study was carried out to determine LC<sub>50</sub> of deltamethrin (DM) in the African catfish;Clarias gariepinus, investigate its effects on the biochemical parameters and the antioxidant stat... The present study was carried out to determine LC<sub>50</sub> of deltamethrin (DM) in the African catfish;Clarias gariepinus, investigate its effects on the biochemical parameters and the antioxidant status of various tissues, and assess the protective role of Spirulina platensis (SP) against DM induced toxicity in C. gariepinus. The fish were distributed into seven groups of 10 fish/each for 30 days as follows: Group 1, control;Group 2, orally administered saline;Group 3, oral SP (150 mg/kg b.w.);Group 4, exposed to 5.19 μg/l DM;Group 5, exposed to 5.19 μg/l DM and orally administered SP (150 mg/kg b.w.);Group 6, exposed to 12.97 μg/l DM;and Group 7, exposed to 12.97 μg/l DM and orally administered SP (150 mg/kg b.w.). Results revealed marked elevation in serum AST, ALT, ALP, creatinine, urea and uric acid. Significant decrease in serum total protein and albumin was recorded. At the same time, the level of malondialdehyde (MDA) was significantly increased in liver, kidney and gills. While, tissue level ofGSHand, SOD,CATandGSH-Px activities were reduced. Treatment with SP improved the biochemical parameters and attenuated the DM induced oxidative damage. Therefore, this study confirmed the protective role of SP as an antioxidant against the toxicity of DM in catfish. 展开更多
关键词 Clarias gariepinus deltamethrin BIOCHEMISTRY Oxidative Stress SPIRULINA
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Photodegradation mechanism of deltamethrin and fenvalerate 被引量:8
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作者 Pengyan Liu Yujie Liu +1 位作者 Qingxue Liu Jinwei Liu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2010年第7期1123-1128,共6页
To understand the degradation and environmental fate of pyrethroids, the process of their photodegradation under simulated natural conditions was investigated. The results showed that the degradation process follows f... To understand the degradation and environmental fate of pyrethroids, the process of their photodegradation under simulated natural conditions was investigated. The results showed that the degradation process follows first-order kinetics. The degradation intermediates were identified with gas chromatography-mass spectrometry. A plausible mechanism was discussed to explain the process. Several influences on degradation process were investigated and reported such as the effects of initial concentration of pyrethroids, total time of light irradiation, solvents, and light source, as well as the effect of a few substances that exist in the environment. This study could be a good reference for the degradation of pyrethroids in practical circumstances. 展开更多
关键词 PYRETHROIDS deltamethrin FENVALERATE PHOTODEGRADATION
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