Subchronic Toxicity of Lanthanum Nitrate on Liver in Rats

Young Wistar rats were divided into six groups,the experimental groups were given La(NO 3) 3 at dose of 20,10,2,0.2,0.1 mg·kg -1 and the control group was given physiological saline respectively for six months. The animalswere weighed and the ratios of the liver to body weight were counted. Pathological changes of liver were observed by light microscope and transmission electron microscope. Glutamic oxalacetic transaminase(GOT), glutamic pyruvic transaminase (GPT),gamma glutamyl transferase(γ GT) and alkline phosphatase(ALP) in the serum were measured. The results indicate that the body weight of animals gaines slowly in the group of 20 mg·kg -1 La(NO 3) 3 , but it gained quickly in the rats fed with 0.1 mg·kg -1 La(NO 3) 3. Biochemical indexes have no abnormal changes. In the group of 20 mg·kg -1 La(NO 3) 3, there were lipid droplets and decrease of glycogen in the hepatocytes, denser matrix of the mitochondria, deformation of the nuclei of some hepatocytes to different degree and infiltration of inflammatory cells at portal area. The more the dose of La(NO 3) 3 were given to the rats, the more the number of bodies containing highly electronic dense gravel like granules and the secondary lysosomes with dense bodies. The rats fed with 20 mg·kg -1 La(NO 3) 3 for six months shows injurious effects on the hepatocytes.

Mechanism of Effect of Lanthanum Nitrate on Vigor of Aged Rice Seeds

The effect of La(NO3)(3) on natural or artificial aged rice seeds vigor was studied. The results show that the germination rate, germination index and vigor index of aged rice seed increase. Activities of superoxide dismutase, catalase and peroxidase are enhanced. . O-2(-) and malond ialdehyde contents decrease in germinating stage of aged rice seed, and cell membrane permeability of aged rice seeds reduces by treating with La(NO3)(3). The vigor increase of rice natural aged seed is greater than that of artificial aged rice seeds by treating with La(NO3)(3).

A Thermochemical Study of the Reaction of Lanthanum Nitrate with Alanine

The standard molar reaction enthalpy of the solid-solid coordination reaction La(NO3)3. 6H2O (s) +4Ala(s) (Ala is Alanine)=La(NO3)3·(Ala)4·H2O(s) + 5H2O(1) was studied by using classical solution calorimetry. The molar dissolution enthalpies of the reactants and the product of the solid-solid coordination reaction in 2 mol/L HCl were measured by using an isoperibol calorimeter. From the results and other auxiliary quantities, the standard molar formation enthalpy of [La (NO3)3·(Ala)4·H2O, s, 298. 15 K] has been determined to be △fHm[La(NO3)3·(Ala)4·H2O, s, 298. 15 K]=-3 864. 248 kJ/mol.

Stimulatory effect of lanthanum nitrate on the root tuber yield of Pseudostellaria heterophylla via improved photosynthetic characteristics

The stimulatory effects and associated mechanism of lanthanum nitrate on the root tuber yield of the traditional Chinese medicinal plant Pseudostellaria heterophylla, by means of improved photosynthetic characteristics, were investigated. Field experiments were conducted and the foliage was sprayed with varying concentrations of lanthanum nitrate. The results indicated that growth indexes, chlorophyll and carotenoid contents initially increased, and then decreased in a dose-dependent manner with increasing concentrations of lanthanum nitrate. The fresh and dry weights of root tuber yield per unit area significantly increased by 58.34% and 56.87% with a lanthanum nitrate concentration of 100 mg/L, respectively, compared with the control. Appropriate concentrations of lanthanum nitrate were found to alleviate photosynthetic depression at midday, as well as improve the mean values of photosynthetic rate（Pn）, stomatal conductance（Gs） and transpiration rate（Tr） associated with the diurnal variation in photosynthetic parameters, while reducing intercellular CO2 concentration（Ci）. During the experiment, the chlorophyll fluorescence parameters Fv/Fm, Fv＇/Fm＇, ΦPSII and qP increased initially and then decreased along with the increasing concentration of lanthanum nitrate, while NPQ followed the opposite trend. Correlation analysis revealed that Pn had a significantly positive relationship with seedling height, ground diameter, chlorophyll and carotenoid contents, Gs and ΦPSII, while a negative relationship was observed with Ci and NPQ. Grey relational analysis（GRA） indicated that photosynthetic pigments, ΦPSII and qP were the primary factors impacting photosynthesis. These results suggested that the application of an appropriate concentration of lanthanum nitrate（100 mg/L） was effective in improving growth, root tuber yield and photosynthetic characteristics of Psendoste llaria（P） heterophylla. The regulatory effect of lanthanum nitrate on photosynthesis was related to the promotion of light energy absorption and conversion, improvement in photochemical efficiency and the alleviation of photoinhibition. The improvement of the non-stomatal limitation factor was the primary basis for the mitigation of midday photosynthetic depression.

Effects of Lanthanum on Liquid Culture and Contents of Amino Acids ofNostoc Commune Flagelliforme Cells

The effects of La(NO3)(3) on the liquid culture and the contents of amino acids of Nostoc commune flagelliforme cells were studied. It is indicated from the experimental results that the growth of Nostoc commune flagelliforme cells can be stimulated by La(NO3)(3) at the concentrations from 1 to 200 mg.L-1, and among them the treatment of 100 mg.L-1 La(NO3)(3) has the largest A(670) and dry weight which increased by 64.9% and 61.1%, respectively as compared with the control, and La(NO3)(3) can also influence the contents of some kinds of amino acids in Nostoc commune flagelliforme cells. The contents of aspartic acid and glutamic acid decreased by 59.9% and 57.9%, respectively, and that of proline increased by 24.5% with the treatment of 200 mg.L-1 La(NO3)(3).

Phase Equilibrium of Ternary Systems LaX_3-C_(18)H_(16)N_3O_2Cl-H_2O

Solubilities and refractive indices of saturated solutions of the ternary systems LaX 3 C 18 H 16 N 3O 2Cl(4 ( p chlorobenzoyl) aminoantipyrine H 2O(30 ℃; X=NO 3 -, Cl -) were determined. The incongruent compound, LaL 3(NO 3) 3 was discovered in the system LaL 3(NO 3) 3 L H 2O, while LaCl 3 L H 2O(L=4 ( p chlorobenzoyl) aminoantipyrine H 2O) is a simple eutonic system.

The Ultracytochemical Effects of High Energy Shock Wave on Rabbit Liver

The ultracytochemical effects in the liver of rabbit undergoing high energy shock wave (HESW) were studied with electron microscope. The application of lanthanum as a tracer for ultrastructural study demonstrated that intracellular lanthanum could be observed, most of which entered the hepatocytes and its mitochondria. The lanthanum granules were also found to deposite in the zone of tight junctions of bile canaliculi, which indicated that the tight junctions had been damaged. The activities of succinate dehydrogenase (SDH) in liver cells, alkaline phosphatase (ALP) and thiamine pyrophosphatase (TPPase) on the wall of bile canaliculi became diminished obviously. Both the activites and localizations of TPPase had changed. Some TPPase from the damaged lysosome like vesicles and Golgi saccules of liver cells discharged into cytoplasm. TPPase reaction production in some bile canaliculi decreased. In the intercellular space of the liver cells and the tight junctions of bile canaliculi TPPase reaction could be seen. Ultrastructurally, the changes commonly seen were hydropic mitochondria and dilatation of rough endoplasmic reticulum. Serologic test demonstrated that there was an abnormal change of SGPT, SGOT and ALP. The results showed that HESW can damage the ultrastructure and function of liver.

New steroid dimer derived from cholic acid as receptor for lanthanum(Ⅲ) and calcium(Ⅱ) nitrates

New steroid dimer,ethylene bridged bis-carbamate(3) was synthesized from cholic acid in few steps. Complexes of 3 with lanthanum(Ⅲ) and calcium(Ⅱ) nitrates were prepared in reaction of 3 and appropriate metal salts. They were characterized by spectral data(Infrared(IR) ,ultraviolet-visible(UV/Vis) ,nuclear magnetic resonance(NMR) spectroscopy and fast-atom bombardment(FAB) ,electrospray(ESI) and matrix-assisted laser desorption/ionization mass spectrometry(MALDI-MS)) and elemental analysis. The similarity in complexing behavior of steroidal dimer toward calcium and lanthanum ions was observed.

Synthesis,characterization,and antimicrobial properties of Cu-inorganic antibacterial material containing lanthanum

In this paper a kind of new inorganic antibacterial material:Cu-antibacterial white carbon black containing lanthanum was synthesized.The characterization and antimicrobial effect of the Cu-antibacterial white carbon black containing lanthanum was investigated.Inorganic antibiotic materials comprised the carrier,the antibacterial ion and the additive.In this study,we choosed white carbon black as the carrier,which was compound by a sol-gel method.Copper ion was selected to be the antibacterial ion,and lanthanum nitrate was selected to be the additive.The as-synthesized Cu-La-antibacterial white carbon black was characterized by inductively coupled plasma(ICP),laser particle size analyzer,Fourier transform infra-red spectroscopy(FT-IR) and antibacterial activity test(Escherichia coli as experimental bacterium).Results showed that the amount of antibacterial ions of the Cu-La-antibacterial white carbon black was higher than that for the general Cu-antibacterial white carbon black.Its bacteriostasis rate was about 98%(when the content of Cu2+ was about 3%),and corresponded to Ag-antibacterial white carbon black(99%).The particle size of Cu-La-antibacterial white carbon black was under 30 μm with a narrow size distribution.Copper ion was bound to white carbon black by ion exchange process.Moreover,this new inorganic antibacterial material showed promising result on the coating surface of metal.