When working at K(?)tzting Hospital of Traditional Chinese Medicine near Munich, Germany from March 1991 to May 1993, the author had treated 9 cases of phantom limb pain by means of acupuncture with satisfactory thera...When working at K(?)tzting Hospital of Traditional Chinese Medicine near Munich, Germany from March 1991 to May 1993, the author had treated 9 cases of phantom limb pain by means of acupuncture with satisfactory therapeutic effect as reported in the following. Clinical Data In this series, all the 9 cases were male, aged 60-79 years, with the course of disease ranging from 3-49 years. Five cases were amputated because of wound in war, 1 case embolism of femoral artery, 1 case tumor in the knee joint, 1 case comminuted展开更多
目的探讨临床药师在截肢术后残端痛合并幻肢痛患者治疗过程中发挥的作用。方法针对1例因“左下肢残端痛6年”入院的64岁女性患者,临床药师详细询问用药史及用药细节,结合微创介入治疗过程疼痛变化情况,制订用药方案,并进行全程药物治疗...目的探讨临床药师在截肢术后残端痛合并幻肢痛患者治疗过程中发挥的作用。方法针对1例因“左下肢残端痛6年”入院的64岁女性患者,临床药师详细询问用药史及用药细节,结合微创介入治疗过程疼痛变化情况,制订用药方案,并进行全程药物治疗监护及用药教育。结果患者发生药品不良反应后,临床药师结合其病史、用药史及视觉模拟评分法(VAS)评分,及时调整镇痛治疗方案为普瑞巴林(75 mg,口服,每天2次)+曲马多(50 mg,口服,每12 h 1次),医师采纳,患者残端痛及幻肢痛均明显缓解。结论临床药师利用药学专业知识可协助医师制订截肢术后残端痛并幻肢痛的个体化治疗方案,并及时进行药学监护及跟踪随访,有助于提高患者的用药依从性和疗效。展开更多
Deer antlers are the only known mammalian organ that,once lost,can fully grow back naturally.Hence,the antler offers a unique opportunity to learn how nature has solved the problem of mammalian epimorphic regeneration...Deer antlers are the only known mammalian organ that,once lost,can fully grow back naturally.Hence,the antler offers a unique opportunity to learn how nature has solved the problem of mammalian epimorphic regeneration(EpR).Comprehensive comparisons amongst different types of EpR reveal that antler renewal is fundamentally different from that in lower vertebrates such as regeneration of the newt limb.Surprisingly,antler renewal is comparable to wound healing over a stump of regeneration-incompetent digit/limb,bone fracture repair,and to a lesser extent to digit tip regeneration in mammals.Common to all these mammalian cases of reaction to the amputation/mechanical trauma is the response of the periosteal cells at the distal end/injury site with formation of a circumferential cartilaginous callus(CCC).Interestingly,whether the CCC can proceed to the next stage to transform to a blastema fully depends on the presence of an interactive partner.The actual form of the partner can vary in different cases with the nail organ in digit tip EpR,the opposing callus in bone fracture repair,and the closely associated enveloping skin in antler regeneration.Due to absence of such an interactive partner,the CCC of a mouse/rat digit/limb stump becomes involuted gradually.Based on these discoveries,we created an interactive partner for the rat digit/limb stump through surgically removal of the interposing layers of loose connective tissue and muscle between the resultant CCC and the enveloping skin after amputation and by forcefully bonding two tissue types tightly together.In so doing partial regeneration of the limb stump occurred.In summary,if EpR in humans is to be realized,then I envisage that it would be more likely in a manner akin to antler regeneration rather to that of lower vertebrates such as newt limbs.展开更多
文摘When working at K(?)tzting Hospital of Traditional Chinese Medicine near Munich, Germany from March 1991 to May 1993, the author had treated 9 cases of phantom limb pain by means of acupuncture with satisfactory therapeutic effect as reported in the following. Clinical Data In this series, all the 9 cases were male, aged 60-79 years, with the course of disease ranging from 3-49 years. Five cases were amputated because of wound in war, 1 case embolism of femoral artery, 1 case tumor in the knee joint, 1 case comminuted
文摘目的探讨临床药师在截肢术后残端痛合并幻肢痛患者治疗过程中发挥的作用。方法针对1例因“左下肢残端痛6年”入院的64岁女性患者,临床药师详细询问用药史及用药细节,结合微创介入治疗过程疼痛变化情况,制订用药方案,并进行全程药物治疗监护及用药教育。结果患者发生药品不良反应后,临床药师结合其病史、用药史及视觉模拟评分法(VAS)评分,及时调整镇痛治疗方案为普瑞巴林(75 mg,口服,每天2次)+曲马多(50 mg,口服,每12 h 1次),医师采纳,患者残端痛及幻肢痛均明显缓解。结论临床药师利用药学专业知识可协助医师制订截肢术后残端痛并幻肢痛的个体化治疗方案,并及时进行药学监护及跟踪随访,有助于提高患者的用药依从性和疗效。
基金supported by National Natural Science Foundation of China(Regional Joint Funds,No.U20A20403).
文摘Deer antlers are the only known mammalian organ that,once lost,can fully grow back naturally.Hence,the antler offers a unique opportunity to learn how nature has solved the problem of mammalian epimorphic regeneration(EpR).Comprehensive comparisons amongst different types of EpR reveal that antler renewal is fundamentally different from that in lower vertebrates such as regeneration of the newt limb.Surprisingly,antler renewal is comparable to wound healing over a stump of regeneration-incompetent digit/limb,bone fracture repair,and to a lesser extent to digit tip regeneration in mammals.Common to all these mammalian cases of reaction to the amputation/mechanical trauma is the response of the periosteal cells at the distal end/injury site with formation of a circumferential cartilaginous callus(CCC).Interestingly,whether the CCC can proceed to the next stage to transform to a blastema fully depends on the presence of an interactive partner.The actual form of the partner can vary in different cases with the nail organ in digit tip EpR,the opposing callus in bone fracture repair,and the closely associated enveloping skin in antler regeneration.Due to absence of such an interactive partner,the CCC of a mouse/rat digit/limb stump becomes involuted gradually.Based on these discoveries,we created an interactive partner for the rat digit/limb stump through surgically removal of the interposing layers of loose connective tissue and muscle between the resultant CCC and the enveloping skin after amputation and by forcefully bonding two tissue types tightly together.In so doing partial regeneration of the limb stump occurred.In summary,if EpR in humans is to be realized,then I envisage that it would be more likely in a manner akin to antler regeneration rather to that of lower vertebrates such as newt limbs.
