Resistance to targeted therapy in metastatic colorectal cancer:Current status and new developments

Colorectal cancer(CRC)is one of the most lethal and common malignancies in the world.Chemotherapy has been the conventional treatment for metastatic CRC(mCRC)patients.However,the effects of chemotherapy have been unsatisfactory.With the advent of targeted therapy,the survival of patients with CRC have been prolonged.Over the past 20 years,targeted therapy for CRC has achieved substantial progress.However,targeted therapy has the same challenge of drug resistance as chemotherapy.Consequently,exploring the resistance mechanism and finding strategies to address the resistance to targeted therapy,along with searching for novel effective regimens,is a constant challenge in the mCRC treatment,and it is also a hot research topic.In this review,we focus on the current status on resistance to existing targeted therapies in mCRC and discuss future developments.

Intellectual Property Protection and New Development Pattern Construction of Xinjiang Jujube

"Three new developments"is the guiding ideology of Chinese-style high-quality development in the new era.Jujube(Zizyphus jujube Mill.)is a plant of Zizyphus of Rhamnaceae,which originated in China and has been listed as one of the"five fruits"since ancient times.Xinjiang is the most important jujube producing area in China,and its yield has accounted for 50%of the national jujube yield.In the five prefectures and cities of southern Xinjiang,as well as the regimental farms of southern and eastern Xinjiang of Xinjiang Production and Construction Corps,the jujube industry is an advantageous characteristic industry in agriculture.This paper studied Xinjiang jujube industry and its agricultural intellectual property resources,analyzed six major issues to be further implemented,such as the"three new developments"thinking and the strategy of building an intellectual property power,and puts forward eight strategies such as coordinating the two markets and two resources to accelerate the construction of a new development pattern and dual circulation of jujube.

China’s Industrial Upgrading and Value Chain Restructuring Under the New Development Pattern

Global industrial chains(GICs)have become a hallmark of the world economy underpinning the global production cycle.Since the reform and opening up was introduced in 1978,China has taken an active role in global value chains(GVCs)and become the world’s factory floor.Under the external shocks to GICs,such as US trade frictions with China and the COVID-19 pandemic,China’s traditional comparative advantages in manufacturing which include its labor force and costs are waning.This has manifested in a wave of industrial relocations from China to other countries as well as China’s weakening international competitiveness.We took stock of the concepts and journey of GVCs and elaborated the intrinsic relationship between GVCs and the new development pattern of“dual circulations”.We also analyzed the trends of GVCs,the current status and problems of China’s industrial chains,and China’s market heft,complete industrial chains and the digital economy as new strengths for industrial chain upgrade.In our conclusion,this paper put forth some policy recommendations for China’s industrial chain upgrade in the context of dual circulations.

Construction of China Osmanthus City and Intellectual Property Right Protection in Xianning City in the Context of Three New Developments

Xianning City of Hubei Province is one of the five major traditional osmanthus producing areas in the world and the hometown of osmanthus in China. Xianning is constructing China Osmanthus City in the whole city. This paper first introduces the main characteristics of the osmanthus industry in Xianning City, and analyzes the characteristics of traditional knowledge, biological genetic resources, new plant varieties, patents, geographical indications, and trademarks. Then, it studies the intellectual property resources of the osmanthus industry, and analyzes the main problems existing in the construction of China Osmanthus City and intellectual property right protection. Finally, it comes up with constructive recommendations including applying for China and Globally Important Agricultural Heritage Systems, developing colored-leaf osmanthus varieties, creating a regional public brand of osmanthus specialty products, and building a new development pattern of osmanthus industry.

Pathways for Elevating China’s Opening-up under the New Development Paradigm

Due to the superimposed impacts of new industrial revolution,the changing trade policy and the COVID-19 pandemic,the world has seen setbacks in globalization,contractions in the global value chain(GVC),and the risk of a fragmented global system.The once-in-a-century changes in our world today highlight the need for China to explore a new development paradigm based on new concepts.In the new era,China must not only come to terms with a backlash against globalization and challenges from the reshaping of international rules,but also breathe life into the“dual circulations,”i.e.domestic and international economic circulations.China must open up wider to the outside world to keep abreast with changes in today’s global governance system.In the complex and volatile international environment,we should explore new areas of development spearheaded by institutional opening up,create new gateways and platforms for opening up and cooperation for mutual benefit,contribute to new global governance and security systems,and promote synergy between domestic and international circulations.In building a great modern socialist country,China must open up wider and be more inclusive to the outside world.

New Developments on Existence and Uniqueness of Solutions to Some Models in Atmospheric Dynamics

This survey is concerned with the new developments on existence and uniqueness of solutions of some basic models in atmospheric dynamics, such as two-and three-dimensional quasi-geostrophic models and three-dimensional balanced model. The main aim of this paper is to introduce some results about the global and local (with respect to time) existence of solutions given by the authors in recent years, but others' important contributions and the literature on this subject are also quoted. We discuss briefly the relationships among the existence and uniqueness, physical instability and computational instability. In the appendixes, some key mathematical techniques in obtaining our results are presented, which are of vital importance to other problems in geophysical fluid dynamics as well.

The First Congress of New Development on Molecular Imaging Dec 22 to 24,2011,Guangzhou,China

"The First Congress of New Development on Molecular Imaging" will be held in Guangdong Hotel in Guangzhou, Guangdong province, Dec 22 to 24, 2011. This conference is hosted by Ultrasound Medical Branch of Guangdong Medical Association, Ultrasound Medical Branch of Guangzhou Medical Association, is undertaken by

Domestic Welfare Industry Expects New Development

China has 85.02 million disabled people,and 39%of them have needs for rehabilitation technical aids,while only 7.31%of them have been equipped with such aids.According to data from the National Working Commission on Aging,the demands of Chinese pension services market are valued at more than RMB 3trillion,and will reach RMB 5 trillion by the year 2050.

New Developments of Tungsten Technology in China

I.IntroductionIt is well known that China is rich in natural resources of tungsten.Before 1949 there was al-most no tungsten industry in our country except mining and ore dressing.Tremendous changeshave taken place after 1949.We have built our metallurgical industry of tungsten.Especially start-ing from the last decade much progress has been made not only in production technologies and

NEW DEVELOPMENTS IN WESTERN POPULIST POLITICS IN 2016

For Westerners,2016 was a year of frequent 'black swan' events.Following a referendum held on June 23,Britain decided to leave the European Union.On November 8,Donald Trump won the U.S.presidential election unsurprisingly.Another referendum was held in Italy on December

New development in risk assessment of genotoxic carcinogens in foods

The no-observed-effect level (NOEL) in a study of carcinogenicity for compounds that are both genotoxic and carcinogenic represents the limit of detection in that bioassay, rather than an estimate of a possible threshold. Therefore, for those genotoxic and carcinogenic contaminants (e.g. acrylamides, PAHs, etc.) in foods it is not possible to develop health-based guidance values (e.g. ADI or PTWI) using the traditional NOEL and safety/uncertainty factors.

New Development of Foreign-Funded Enterprises

Since 1979, China’s foreign capital utilization has made renewed progress in a steady sound way, invigorating China’s social progress and economic prosperity. The year 1994 witnessed 47,390 foreign-funded projects approved in China with direct foreign investment reaching US$33.8 billion, some 22.8 percent higher than in the previous year. By April 1995 from 1980, there were 230,000 foreign-funded projects approved with contractual foreign investment exceeding US$300 billion and actually about US$104

New DevelopmenTrends of the China-Africa Relationship

THE scorching weather in Beijing could not deter a group of young Africans from visiting the myriad of high-tech companies scattered across the city’s Zhongguancun Science Park （Z-Park） in late June. Tese youth representatives from 53 African countries and the African Union （AU） are also members of the Forum on China-Africa Cooperation （FOCAC）. Since its establishment in 2000, FOCAC has become a vital platform to coordinate and strengthen cooperation between China and African countries.

New development of whey protein products as nutritional food ingredients

Whey protein products provided ideal ingredients for nutritional food applications.Whey proteins are known to have high nutritional quality due to their high content of essential amino acids,high digestibility and biological value.Research in the past decades has shown that many of the whey protein fractions and peptides derived from them possess various biological activities.The technology developments in the last decade,such as those in the areas of protein fractionation technologies have made industrial scale production of fractionated whey protein products commercially feasible.The development in hydrolysis technology and the peptide analytical capability allowed production of whey protein hydrolysates with designed bioactivity and functionalities.People are continuously finding new biological activities of the various whey protein fractions or their hydrolysis products.Significant amount of research has also been carried out to study the clinical benefits of some of the whey protein fractions and whey protein derived peptides.Examples of these studies will be reviewed and discussed.

New Developments in Drug Therapy and Research of Cerebral Vasospasm

In this manuscript a comprehensive coverage of recent developments in the drug therapy of vasospasm while providing the background information that neuroscientists need to understand its rationale. The range of new agents available for treatment of cerebral vasospasm is expanding rapidly along with rapid advances in pharmacology and physiology that are uncovering the mechanisms of this disease. Although there are many publications for treatment of cerebral vaso-spasm, most are focusing on different aspects of vasospasm treatment and many have limited value due to insufficient quality. Moreover, the complexity of this, in many cases deleterious condition, is enormous and the information needed to understand drug effects is accordingly often not readily available in a single source. A number of pharmacological and medical therapies are currently in use or being investigated in an attempt to reverse cerebral vasospasm, but only a few have proven to be useful. Current research efforts promise the eventual production of new medical therapies. At last, recommendations for the use of different treatment stages based on currently available clinical data are provided.

New development of men's wear in the new era

The 3rd China Men’s Wear Summit Forum is held in Ningbo Recently,the 3rd China Men’s Wear Summit Forum which was sponsored by China National Garment Association and Ningbo People’s Government and jointly organized by Men’s Wear Specialized Committee of China National Garment Association,Ningbo Economy