AIM: To investigate the relationship between clinicopathological features and bone turnover markers in castration-resistant prostate cancer(CRPC) patients treated with docetaxel.METHODS: Thirty-three patients were enr...AIM: To investigate the relationship between clinicopathological features and bone turnover markers in castration-resistant prostate cancer(CRPC) patients treated with docetaxel.METHODS: Thirty-three patients were enrolled in this study. Serum levels of carboxyterminal cross-linked telopeptide of type 1 collagen generated by metalloproteinases(1CTP) and alkaline phosphatase(ALP) were measured at the start of docetaxel chemotherapy. We examined the relationship between clinicopathological features and serum levels of 1CTP and ALP levels in CRPC patients treated with docetaxel.RESULTS: For the total patient group, the mean ± standard deviation(SD) values for docetaxel chemotherapy dose, dose intensity, dosage interval, and num-ber of cycles were 59.3 ± 10.6 mg/m2, 13.9 ± 5.2 mg/m2 per week, 4.7 ± 1.2 wk, and 11.2 ± 7.4, respectively. Fourteen patients died from prostate cancer. Patients were divided into two groups according to mean + SD of serum 1CTP(8.2 ng/m L) and ALP(538.2 IU/L) levels at the start of docetaxel chemotherapy. Patients with lower levels of serum 1CTP and ALP had significantly better survivals than those with higher serum levels(P < 0.05).CONCLUSION: Serum levels of 1CTP and ALP are predictors of survival in patients with CRPC who are treated with docetaxel.展开更多
目的分析北京地区健康绝经期前女性不同年龄阶段血清I型原胶原氨基端肽(procollagen type 1 N-terminal propeptide,P1NP)和I型胶原羧基端肽交联(βcross-linked C-telopeptide of type 1 collagen,β-CTX)水平的分布趋势差异并初步建...目的分析北京地区健康绝经期前女性不同年龄阶段血清I型原胶原氨基端肽(procollagen type 1 N-terminal propeptide,P1NP)和I型胶原羧基端肽交联(βcross-linked C-telopeptide of type 1 collagen,β-CTX)水平的分布趋势差异并初步建立两者的参考区间。方法以北京地区健康绝经期前女性作为研究对象,应用罗氏电化学发光免疫分析技术,对符合入组标准的272名30~54岁女性血清P1NP和β-CTX水平进行检测。以5岁为一年龄段进行分组:30~34岁,35~39岁,40~44岁,45~49岁,50~54岁;运用局部加权回归散点平滑法和Kolmogorov-Smirnov Z检验比较不同年龄段两者的组间分布趋势差异,确定参考人群的特异年龄段,并应用非参数方法建立参考区间。结果 272名入组受试者的平均年龄为(39.51±5.85)岁,总体P1NP与β-CTX水平呈非正态分布。35~39岁与40~44岁的血清P1NP与β-CTX水平分布趋势比较差异无统计学意义(P>0.05);进一步将30~34岁及45~49岁水平分别与35~44岁水平的分布趋势比较,差异有统计学意义(P<0.05)。因此将35~44岁年龄段的健康绝经期前女性作为参考人群,由此所建立的血清P1NP参考区间为:17.95~65.60 ng/m L,血清β-CTX参考区间为0.10~0.49 ng/m L。结论北京地区35~44岁健康绝经期前女性血清骨转换标志物P1NP和β-CTX水平分布趋势相对平稳,受变异因素影响最小,两者在此年龄段人群的测定结果适宜作为建立参考区间的参考值。展开更多
基金Supported by Grants-in-Aid from the Ministry of Education,Culture,Sports,Science and Technology,Tokyo,Japan,No.22591761,No.23791792
文摘AIM: To investigate the relationship between clinicopathological features and bone turnover markers in castration-resistant prostate cancer(CRPC) patients treated with docetaxel.METHODS: Thirty-three patients were enrolled in this study. Serum levels of carboxyterminal cross-linked telopeptide of type 1 collagen generated by metalloproteinases(1CTP) and alkaline phosphatase(ALP) were measured at the start of docetaxel chemotherapy. We examined the relationship between clinicopathological features and serum levels of 1CTP and ALP levels in CRPC patients treated with docetaxel.RESULTS: For the total patient group, the mean ± standard deviation(SD) values for docetaxel chemotherapy dose, dose intensity, dosage interval, and num-ber of cycles were 59.3 ± 10.6 mg/m2, 13.9 ± 5.2 mg/m2 per week, 4.7 ± 1.2 wk, and 11.2 ± 7.4, respectively. Fourteen patients died from prostate cancer. Patients were divided into two groups according to mean + SD of serum 1CTP(8.2 ng/m L) and ALP(538.2 IU/L) levels at the start of docetaxel chemotherapy. Patients with lower levels of serum 1CTP and ALP had significantly better survivals than those with higher serum levels(P < 0.05).CONCLUSION: Serum levels of 1CTP and ALP are predictors of survival in patients with CRPC who are treated with docetaxel.
