The burden of depression,anxiety and schizophrenia among the older population in ageing and aged countries:an analysis of the Global Burden of Disease Study 2019

Background Depression,anxiety and schizophrenia among older persons have become global public health challenges.However,the burden of these disorders in ageing and aged countries has not been analysed.Aims To investigate the burden of depression,anxiety and schizophrenia among older adults in ageing and aged countries.Methods Using data from the Global Burden of Disease Study 2019,we calculated the estimated annual percentage change(EAPC)in the age-standardised incidence rates(ASiR)and age-standardised disability-adjusted life years(DALYs)rates(ASDR)for depression,anxiety and schizophrenia of older people in ageing countries(China,India,Indonesia)and aged countries(Japan,Italy,Portugal)between 1990 and 2019.Trends in incidence and DALYs were analysed by gender and age.Results In 2019,the highest incidence of depression,anxiety and schizophrenia in the older population in aged countries was in Japan(927271.3(752552.3-1125796.5),51498.2(37625.7-70487.3)and 126.0(61.0-223.2),respectively),while the highest incidence in ageing countries was in China(5797556.9(4599403.4-7133006.5),330256.1(246448.9-445987.4)and 1067.7(556.2-1775.9),respectively).DALYs for these disorders were similar,with the highest in Japan and China.From 1990 to 2019,the ASIR for depressive disorders decreased in aged countries but increased in ageing countries;the ASIR for anxiety disorders and schizophrenia declined in both ageing and aged countries.The ASDR for depressive disorders was consistent with the ASIR but not for anxiety disorders and schizophrenia.The ASIR for depressive disorders was higher in older women,while the opposite was observed in anxiety disorders and schizophrenia.Notably,the conditions of burden of depressive disorders,anxiety disorders and schizophrenia in the 65-70-year-old age group were the most burdensome.Conclusions The incidence and DALYs of these three mental disorders increased while exhibiting differences between ageing and aged countries.Raising awareness about formulating health policies for preventing and treating mental disorders in the older population is necessary to reduce the future burden posed by the ageing challenge.

Influence of Non-Natural Ageing Temperature on the Microstructural Characteristics and Mechanical Properties of Cast Aluminum 6063 Alloy

This research considered the effect of non-natural aging on the microstructural characteristics and mechanical properties of as-cast aluminum 6063 alloys. The samples were developed through a sand casting process and machined into tensile and impact test samples before carrying out solution heat treatment at 550?C (0.83 Tm) on two parts of the samples while retaining one part as the control. The two parts were further divided into sets denoted A and B and were aged at 180?C (0.27 Tm) and 160?C (0.24 Tm), respectively, for 12 hours. The results showed that sample A has the optimal yield strength and ultimate tensile strength of 192 and 206 MPa, respectively. Likewise, the sample gave the highest impact strength value of about 9.63 J/mm2. The observed results were supported by the optical micrograph, which revealed that the sample has evenly dispersed precipitates in its microstructure. This is deemed responsible for the observed increase in strength of the sample.

Mitigating the negative catalytic effect of CuO by FAS-17 coated Al nanopowder:Isothermal ageing of Al/CuO nanothermite at 71°C and 60%relative humidity

The safety and reliability of weapon systems would be significantly affected by changes in the performance of energetic materials due to ambient temperature and humidity.Nanothermites have promising applications due to their excellent reactivity.Therefore it becomes extremely important to understand their aging and failure process in the environment before using them.Here,the aging and failure process of Al/CuO in 71°C/60%RH were investigated,and showed that CuO nanoparticles negatively catalyze Al nanopowders,resulting in rapid hydration.The anti-aging effect of FAS-17-coated Al nanopowder was also examined.The aging process of Al,Al/CuO,and Al@FAS-17/CuO in high humidity and heat environment were revealed by quasi-in situ SEM and TEM methods.Compared with the aging of pure Al,the Al nanopowder in the nanothermites strongly agglomerated with the CuO nanopowder and hydrated earlier.This may be caused by CuO catalyzed hydration of Al nanopowder.The energy release experiments showed that the performance of Al/CuO decreased rapidly and failed to ignite after 4 h of aging.In contrast,the Al@FAS-17/CuO thermite can achieve long-term stability of up to 60 h in the same environment by simple cladding of FAS-17.It is found that FAS-17 coated Al nanopowder can prevent both particle agglomeration and water erosion,which is an effective means to make nanothermites application in high humidity and heat environment.

Irvingia Fat Ageing: Study of Chemical Characteristics Related to MIR Spectroscopy

The Irvingia gabonensis kernels, which have been extensively studied for their numerous virtues, including the ability to act against the accumulation of fats in the body[1], contain an oil. The aging of this oil under two different conditions of conservation was the subject of our work. One of the results was an increase in the content of long-chain carbonaceous fatty acids during aging for 11 months of storage at low temperature (6℃) and at 30℃. This behavior does not find a concordant explanation by the comparative analysis of the chemical indices. Hence, there is the need to use the Medium Infra-Red spectroscopy (MIR) which allowed to clarify the information of the saponification index, to justify the weakness of the formation of peroxides in the case of the conservation at 30℃ and to confirm the information given by the peroxide index. It also allowed to understand the formation of the long carbon chains by the “cis-trans” isomerization and the homolytic cuts which intervene within the matrix of the fat by the analysis of the number of -CH2 and -CH3 groups in the two conditions of conservation. This study reveals that the rapid solidification of Irvingia gabonensis oil at room temperature[2] is an advantage for its preservation at room temperature but a great weakness when the fat is stored at low temperature.

Review of ultraviolet ageing mechanisms and anti-ageing methods for asphalt binders

Asphalt binder is inevitably aged by ultraviolet(UV)light during its service period.UV ageing can significantly decrease the technical properties of asphalt binder.The sensitivity of asphalt to UV ageing and thermal-oxidative ageing differs,such that the UV ageing performance cannot be determined based on the thermal-oxidative ageing performance.Previous researches mainly focused on the chemical composite and technical performance changes of asphalt binder during UV ageing,and the UV light parameters effect on the ageing rate of asphalt binder.However,the theory for characterizing and explaining the development of UV ageing depth does not get too much attentions,and the UV ageing mechanism of asphalt binder is not very clear.Therefore,it cannot guide to develop or select the good methods or anti-UV ageing additives for asphalt binders.This paper focuses on the latest researches of the mechanisms and anti-ageing methods of asphalt binders.With the increase of UV ageing time,the UV ageing of asphalt binder develops gradually from the surface to inner part.There are various methods,such as low-penetration grade asphalt,less air void ratio,UV stabilizers and UV light absorbers,that can improve the UV ageing resistance of asphalt binders.A new theory of sensitive wavelengths of asphalt UV ageing is proposed,which can enrich the basic theory of asphalt UV ageing.Depending on this theory,different wavelengths of UV light have different ageing effects on asphalt binder.The composite anti-UV ageing additives with barrier and specific absorption effects on UV light is proposed,and may have better improvement effect on the anti-UV ageing performance of asphalt binder.

Effects of stress and physical ageing on nonlinear creep behavior of poly(methyl methacrylate)

The effects of stress,ageing time and ageing temperature on creep behavior of poly(methyl methacrylate) were studied.After annealing above its glass transition temperature for a period of time to eliminate the stress and thermal history,the specimens were quenched and aged at various ageing temperatures for different ageing time,and then the short-term creep tests under different stress levels were carried out at room temperature.The creep strains were modeled by means of time-ageing time equivalence and time-stress equivalence,and the master creep curves were constructed via ageing time shift factors and stress shift factors.The results indicate that the creep rate increases with stress,while decreases with ageing time,and the ageing temperature history obviously affects the creep rate.For linear viscoelastic material,the ageing shift rate is independent on imposed stress,while for nonlinear viscoelastic material,the ageing shift rate decreases with increasing stress.The unified master creep curve up to 540 d at reference state was constructed by shifting the creep curves horizontally along the logarithmic time axis to overlap each other.It is demonstrated that the time-stress equivalence,united with the time-ageing time equivalence,provides an effective accelerated characterization technique in the laboratory to evaluate the long-term creep behavior of physical ageing polymers.

Gender Differences in Attitudes to Ageing among Norwegian Older Adults

Increased life expectancy has led to policy interest in adding quality to years of life and in related concepts such as attitudes to ageing. Improving attitudes to ageing is regarded as one means of improving the participation and contribution of older people within society. In considering age- related attitudes in the dynamic nature of social identity, age is not just one social category that may or may not constitute a part of one’s identity. Other identities such as gender may be more salient in attitudes to ageing. The purpose of this study was to explore Norwegian gender differences in attitudes to ageing among 282 females and 200 males living in the community. Attitudes to ageing were measured using the Attitudes to Ageing Questionnaire (AAQ;Laidlaw, Power, Schmidt, & the WHOQOL-OLD Group, 2007). Both genders in this study had positive attitudes toward their ageing, in spite of acknowledging loss with problems of exclusion, making friends and talking about difficult feelings. Compared to men, women perceived ageing as a time of greater loss, however, they felt more strongly that ageing brought wisdom and that their life had made a difference. On the other hand, men felt more strongly that physical problems did not hold them back from doing what they wanted to do and believed more strongly that they passed on their experiences to others. Both genders felt that their identity was not defined by age, they didn’t feel old, aging was a privilege, and appraised the importance of exercising. Attitudes to ageing are becoming increasingly important in ageing societies. Such positive attitudes should be regarded with importance to health professionals, leaders and policy makers in planning interventions to buffer the detrimental aspects of ageing.

Effects of the two-step ageing treatment on the microstructure and properties of 7B04 alloy pre-stretched thick plates

The effects of the two-step ageing parameters （temperature and time） on the mechanical properties and electrical conductivity of 7B04 （A1-Zn-Mg-Cu） pre-stretched thick plates were studied. The results reveal that the initial T1 ageing contributes a major increase of the tensile strength, and the 0.2% proof stress value reaches 482 MPa after ageing for 7 h at 115℃. Behavioral differences in the tensile properties of the alloy after the two-step ageing treatment were less with the first-step ageing at 115~C for different time periods （7, 14, and 21 h）. The effects of the second ageing parameters on the properties and microstructure of the 7B04 alloy were remarkable. TEM analysis of the samples aged at Temper I （7 h at 115℃ ＋ 12 h at 160℃） and Temper II （7 h at 115℃ ＋ 16 h at 165℃） indicates that two kinds of phases, i.e. 11＇ and 11 phases, precipitate from the matrix and efficiently improve the tensile strength of the alloy, and the grain boundary precipitates are coarse and discrete. There are obvious precipitate free zones （PFZs） along the grain boundary in the microstructure of the alloy after the two-step ageing treatment.

Effect of tankyrase 1 on autophagy in the corpus cavernosum smooth muscle cells from ageing rats with erectile dysfunction and its potential mechanism

This study compared tankyrase 1 expression and autophagy quantity between erectile dysfunction （ED） and non-ED rats＇ corpus cavernosum smooth muscle cells （CSMCs）. This study aslo explored the effect and possible mechanism of tankyrase 1 on autophagy and cell proliferation in ageing ED rats＇ CSMCs. The intracavernous pres- sure and mean systemic arterial pressure were measured to investigate erectile function so that eight 24-month-old ED and eight 8-month-old male Wistar rats were choosed respectively. The rat CSMCs were isolated and cultured by enzyme digestion, in which tankyrase 1 expression and autophagy quantity were compared. Tankyrase 1 over-expression was induced with plasmid transfection by Lipofectamine^TM. The effect of tankyrase 1 overexpression on proliferation, autophagy and mTOR pathway in 24-month-old ED rats＇ CSMCs was measured by the cell growth curve in MTT assay, cell cycle analysis in flow cytometry （FCM）, key protein expression in Western blot, autophagy quantity in transmission electron microscopy, monodansylcadaverine staining and GFP-LC3 fluorescence. The primary CSMCs were confirmed by immunofluorescence, and the purity was 99.1% in FCM. Compared with that of 8-month-old rats, tankyrase 1 expression and autophagy quantity significantly decreased in 24-month-old ED rats＇ primary CSMCs （P 〈 0.01）. Tankyrase 1 overexpression significantly increased the growth rate （P 〈 0.05） and increased the S phase of cell cycle （P 〈 0.01）. The autophagosome quantity was remarkably increased （P 〈 0.01）, LC3-Ⅰ/Ⅱ and Beclin 1 were upregulated （P 〈 0.01 and P 〈 0.05）, and p-p70S6K （Thr389） was downregulated in 24-month-old ED rat CSMCs （P 〈 0.05）. In conclusion, Tankyrase 1 and autophagy decrease in the CSMCs from aging rats with ED, and tankyrase 1 may have a positive effect on proliferation by enhancing autophagy and regulating the mTOR signalling pathway.

Microstructure and mechanical properties of forged Al-7.1Zn-1.1Mg-1.6Cu-0.14Zr alloy after two-step ageing treatment at 120 and 170℃

The tensile properties, electrical conductivity, and microstructure of the forged A1-7.1Zn-1.1Mg-1.6Cu-0.14Zr alloy were investigated after a two-step ageing treatment at 120 and 170℃. The results indicate that the strength of the alloy reaches the peak value at 170~C for 1 h during the second step ageing and then decreases sharply. However, the electrical conductivity value increases continuously with the second ageing time increasing. The fracture mechanism of the alloy is intergranular fracture for 1 h and then changes to dimple transgranular fracture later, and the toughness of the alloy is improved significantly. The phases of rl＇ and 1＂1 are major precipitates in the alloy under the two-step ageing condition. Discontinuous grain boundary precipitates and precipitate-flee zones along the grain boundary are clearly observed.

Ageing behavior of an Al-Zn-Mg-Cu alloy pre-stretched thick plate

The ageing behavior of a pre-stretched thick plate of Al-Zn-Mg-Cu alloy was systemically studied including one-step ageing, two-step ageing, and retrogression and reageing treatment （RRA）. One-step ageing of the alloy resulted in peak ultimate tensile strengths of 595 and 575 MPa after 22 and 6 h at 120 and 135°C, respectively. The strengthening phase in peak aged （T6 temper） alloy contained GP zones and the η′ phase predominantly. After two-step ageing, the electrical conductivity was increased markedly, but the pre-stretched thick plate sacrificed a great loss of strength. RRA treatment provided a method for maintaining the strength close to that obtained by T6 temper and for obtaining the high electrical conductivity close to that obtained by T7 temper; the ultimate tensile strength and electrical conductivity were 583 MPa and 21.0 MS/m, respectively. TEM analysis of T7 and RRA specimens revealed two types of precipitates that contributed to age strengthening i.e. the η′ and η phases.

Experimental study on thermal decomposition kinetics of natural ageing AP/HTPB base bleed composite propellant

The kinetics of the thermal decomposition for a naturally ageing ammonium perchlorate(AP) and hydroxyl-terminated-polybutadiene(HTPB) base bleed composite propellant were investigated using a differential scanning calorimetry(DSC). The naturally ageing AP/HTPB base bleed propellant samples have been stored in a sealed plastic bag at room temperature(5-25 ℃) for more than 20 years. The experimental DSC results were obtained by placing samples(each about 1.5 mg) in a sealed pan under non-isothermal condition under different heating rates, 5.0, 10.0, 15.0, 20.0 and 30.0 ℃·min^(-1). The activation energy and pre-exponential factor were estimated based on the relationship between the exothermic peak temperature and the heating rate by Ozawa and Kissinger methods, respectively. The decomposition kinetic parameters is lower the values under laboratorial aging condition.

Chronic stress induces ageing-associated degeneration in rat Leydig cells

Several studies have suggested that stress and ageing exert inhibitory effects on rat Leydig cells. In a pattern similar to the normal process of Leydig cell ageing, stress-mediated increases in glucocorticoid levels inhibit steroidogenic enzyme expression that then results in decreased testosterone secretion. We hypothesized that chronic stress accelerates the degenerative changes associated with ageing in Leydig cells. To test this hypothesis, we established a model of chronic stress to evaluate stress-induced morphological and functional alterations in Brown Norway rat Leydig cells; additionally, intracellular lipofuscin levels, reactive oxygen species （ROS） levels and DNA damage were assessed. The results showed that chronic stress accelerated ageing-related changes： ultrastructural alterations associated with ageing, cellular lipofuscin accumulation, increased ROS levels and more extensive DNA damage were observed. Additionally, testosterone levels were decreased. This study sheds new light on the idea that chronic stress contributes to the degenerative changes associated with ageing in rat Leydig cells in vivo.

Epithermal Ageing Mechanism of Gussasphalt

The normal asphalt index test, DSR test, FTIR and the GPC distribution analysis of molecular weight on the extraction and recovery of asphalt of the gussasphalt, SMA extraction and recovery of asphalt and the rotary-thin-film-oven-aged asphalt above 240 ℃ were introduced. The results indicate the rutting factor and fatigue factor of the extraction and recovery of asphalt of the gussasphalt are greatly improved, and an obvious absorption peak of carbonyl and a further decrease of the SBS molecular weight of the gussasphalt are found.

Ageing Effect on Hardness and Microstructure of Al-Zn-Mg Alloys

Experimental results of the investigation on the hardness of two Al-Zn-Mg alloys [Al-10.0 Zn-4.0 Mg and Al-8.5 Zn-3.0 Mg (wt pct)] aged in the temperature range 60～310℃ for different intervals of time from 1/4 h to 168 h are presented. Both the alloys were found to show identical behaviour of hardness with ageing time. Alloy with higher Zn and Mg content had higher hardness than the alloy with lower solute content. There were three ranges of temperature in which different types of precipitates formed and affected the hardness. Some of the grain boundaries were found to migrate and precipitate free zone has been observed.

Neurovascular ageing:transcriptomic readout and implications on therapeutic targeting in Alzheimer’s disease

Ageing is one of the greatest risk factors for neurodegenerative diseases.How the complex biological changes in ageing increase the brain’s susceptibility to neurodegeneration remains incompletely understood.Research into neurodegenerative disorders has shifted from a neuron-centric approach,to the contributing roles of age-related neurovascular and glial cell dysfunction.

Effects of Ultraviolet Radiation,High Temperature and Alkaline Chemicals on Ageing of Silicone Sealants Used in Ballastless Track Expansion Joints

Expansion joints silicone sealants used in high speed railway construction suffer from ultraviolet radiation（UV）, high temperature combined with the alkaline environment. To evaluate the durability and analyse the ageing mechanism, six one-component silicone sealants from different companies were selected and subjected to accelerated ageing tests including UV, thermal and alkali ageing treatments. The ageing effects on the performance of the sealants were evaluated via the appearance and the mechanical property changes. The changes in molecular structure were studied by means of Fourier transform infrared spectroscopy（FTIR）, differential scanning calorimetry（DSC） and thermogravimetry（TG）. This study revealed that different materials displayed different sensibilities to the ageing methods, in which 15 %-20 % decreases of mechanical properties could be observed under UV radiation test, owning the most significant effects. Structure analysis showed that the physical changes of aggregative states were the principal factors to the performance, along with the chemical slight changes. The glossiness dropped significantly in ageing test, which could be used as one of the effective evaluation parameters for ageing conditions in the field.

Formation of advanced glycation end products in raw and subsequently boiled broiler muscle:biological variation and effects of postmortem ageing and storage

The study aimed to investigate and compare the contents of carboxymethyllysine(CML)in two kinds of broilers during postmortem ageing and storage.The contents of CML in raw and boiled(100℃,30 min)broiler briskets and legs which were from white feather broilers(n=8)and yellow feather broilers(n=8)with ageing and storage at 4℃for 0-168 h were determined.Postmortem ageing and storage had a significant(P<0.05)effect on the color and A;in both boiled broilers meat.In addition,with the ageing and storage time increasing,CML content in raw white feather broiler brisket meat had no significant(P>0.05)change,while that in boiled brisket meat significantly(P<0.05)increased during 0-6 h,then decreased during 6-24 h,finally increased again.CML content in leg meat increased significantly(P<0.05)with the ageing and storage time prolonging.But postmortem ageing and storage had no significant(P>0.05)effect on the CML contents in raw/boiled yellow feather broilers.Meanwhile,CML contents in white feather broilers were much higher than that in yellow feather broilers.Thus,white feather broilers can be selected as the research object to study the mechanism of ageing and storage on CML content in the postmortem broiler in the future.

Over-relaxation effect of deformed austenite on ageing behavior of an Nb-bearing microalloyed steel

The ageing behavior of an Nb-bearing microalloyed steel at 525℃ was investigated by thermo-simulation test, hardness measurements and transmission electron microscopy (TEM). Prior to ageing, the steel was deformed in austenite zone followed by a long relaxation. Experimental results indicate that the hardness decreases gradually in the initial stage until ageing for 120 min, and then increases continuously until 1200 min. The coarsened precipitates (>10 nm) formed in deformed austenite remain nearly unchanged in size, even after ageing for long time, while the further precipitates, which nucleate in a phase, contribute to the increasing of hardness. By comparison, the undeformed samples in austenite subjected to the same ageing process display a very similar hardness change trend to that of over-relaxation ones and have higher hardness values at each corresponding period.

Effect of ageing on fatigue properties of asphalt

The fatigue properties of asphalts were investigated after various laboratory simulation ageing tests and outdoor natural exposure ultraviolet radiation ageing,by dynamic shear rheometer(DSR) time sweep fatigue test in constant strain model and a new type of specimen which was introduced to avoid the problem of adhesion failure between rotor and asphalt binder.The results show that outdoor natural exposure ageing(NEA) causes the decrease of retained fatigue life distinctly,and photodegradation caused by outdoor NEA of 1 250 μm thin films asphalt for three months,is found to be severer than pressure ageing vessel(PAV) with respects to retained fatigue life.The effect of photodegradation increases as the time of outdoor NEA increases.DSR time sweep fatigue test in constant strain indicates that the aged styrene-butadiene-styrene(SBS) modified asphalt still displays better fatigue properties than the corresponding base asphalt after ageing.