The synthesis of a continuous IMF zeolite membrane was fabricated on tubular substrates by seeded growth for the first time. The straight channels of IMF zeolite with diameters of 0.53–0.59 nm are distinguishable for...The synthesis of a continuous IMF zeolite membrane was fabricated on tubular substrates by seeded growth for the first time. The straight channels of IMF zeolite with diameters of 0.53–0.59 nm are distinguishable for p-xylene from o-xylene molecules. Pure IMF-phase high-silica IM-5 zeolite seeds with uniform and fine crystal size were fabricated by a new sonication-assisted aging process. The seeds were coated on the support by dipcoating and induced the formation of continuous membrane. Separation performance in p-/o-xylene mixture was investigated at various temperature and pressure. The typical IM-5zeolite membrane had p-/o-xylene separation factor of 3.7. Our results suggest that IM-5 zeolite is a potentially good membrane material for the separation of xylene mixtures.展开更多
Metal ions doping is a typical approach for tuning sensing properties of metal oxide semiconductors based gas sensors.Herein,hierarchical flower-like pure and In-doped Co_(3)O_(4) nanostructures assembled by porous tw...Metal ions doping is a typical approach for tuning sensing properties of metal oxide semiconductors based gas sensors.Herein,hierarchical flower-like pure and In-doped Co_(3)O_(4) nanostructures assembled by porous two-dimensional(2D)nanosheets are synthesized via a solvothermal method and annealing process.The sensing measurements display that the In@Co_(3)O_(4)-4 based sensor possesses high response value of 55.9 toward 100 ppm xylene at 150 ℃,which is nearly 3.8times larger than that of pure Co_(3)O_(4) sensor.Furthermore,it possesses good selectivity and anti-humidity properties.Combined with the results of DFT calculations,the mechanism of enhanced gas sensing performance is analyzed systematically.展开更多
目的探讨甲基转移酶5(methyltransferase-like 5,METTL5)在三阴乳腺癌(triple-negative breast cancer,TNBC)中的作用和潜在机制。方法采用免疫组织化学方法和Western blot检测TNBC肿瘤组织和细胞系中METTL5的表达情况。用靶向METTL5的s...目的探讨甲基转移酶5(methyltransferase-like 5,METTL5)在三阴乳腺癌(triple-negative breast cancer,TNBC)中的作用和潜在机制。方法采用免疫组织化学方法和Western blot检测TNBC肿瘤组织和细胞系中METTL5的表达情况。用靶向METTL5的shRNA(shRNA-METTL5)转染TNBC细胞后,用CCK-8、集落形成、伤口愈合以及Transwell实验分别检测细胞增殖活性、迁移与侵袭,Western blot检测Wnt/β-catenin信号关键蛋白的表达。构建异种移植瘤模型,验证敲降METTL5对TNBC细胞在体内生长以及Wnt/β-catenin信号活性的影响。结果METTL5在TNBC肿瘤组织和细胞系中表达上调(P<0.01)。敲降METTL5可抑制TNBC细胞的增殖、迁移和侵袭并降低了Wnt/β-catenin信号分子β-catenin、细胞周期蛋白(Cyclin)D1、基质金属蛋白酶(MMP)-2和MMP-7的表达(均P<0.01)。体内实验显示,敲降METTL5减缓了移植瘤生长和Wnt/β-catenin信号活性。结论敲降METTL5能抑制TNBC细胞的增殖、迁移与侵袭,其作用可能与抑制Wnt/β-catenin信号通路有关。展开更多
基金the financial supports that are from the National Natural Science Foundation of China (21921006, U22A20414 and 21938007)the Natural Science Foundation of Jiangsu Province (BK20220002)the open project of the State Key Laboratory of China (KL21-04 and D2021FK055)。
文摘The synthesis of a continuous IMF zeolite membrane was fabricated on tubular substrates by seeded growth for the first time. The straight channels of IMF zeolite with diameters of 0.53–0.59 nm are distinguishable for p-xylene from o-xylene molecules. Pure IMF-phase high-silica IM-5 zeolite seeds with uniform and fine crystal size were fabricated by a new sonication-assisted aging process. The seeds were coated on the support by dipcoating and induced the formation of continuous membrane. Separation performance in p-/o-xylene mixture was investigated at various temperature and pressure. The typical IM-5zeolite membrane had p-/o-xylene separation factor of 3.7. Our results suggest that IM-5 zeolite is a potentially good membrane material for the separation of xylene mixtures.
文摘Metal ions doping is a typical approach for tuning sensing properties of metal oxide semiconductors based gas sensors.Herein,hierarchical flower-like pure and In-doped Co_(3)O_(4) nanostructures assembled by porous two-dimensional(2D)nanosheets are synthesized via a solvothermal method and annealing process.The sensing measurements display that the In@Co_(3)O_(4)-4 based sensor possesses high response value of 55.9 toward 100 ppm xylene at 150 ℃,which is nearly 3.8times larger than that of pure Co_(3)O_(4) sensor.Furthermore,it possesses good selectivity and anti-humidity properties.Combined with the results of DFT calculations,the mechanism of enhanced gas sensing performance is analyzed systematically.
