Stability of the Stratification of Water Bodies in the North Passage of the Yangtze River Estuary Based on the EFDC Model

To study the stratified stability of a water column in the North Passage of the Yangtze River Estuary,a numerical model of the hydrodynamics of this estuary is established using the EFDC model.On the basis of EFDC results,this paper derives and pro-vides the discriminative index of water body stability caused by salinity and analyzes the along-range variation in water body strati-fication stability in the North Passage of the Yangtze River Estuary and the periodic variation at a key location(bend area)based on the simulation results of the numerical model.This work shows that the water body in the bend area varies between mixed and strati-fied types,and the vertical average flow velocity has a good negative correlation with the differential velocity between the surface and bottom layers of the water body.The model simulation results validate the formulae for the stratified stability discriminant during spring tides.

Effects of high glucose and severe hypoxia on the biological behavior of mesenchymal stem cells at various passages

BACKGROUND Mesenchymal stem cells(MSCs)have been extensively studied for therapeutic potential,due to their regenerative and immunomodulatory properties.Serial passage and stress factors may affect the biological characteristics of MSCs,but the details of these effects have not been recognized yet.AIM To investigate the effects of stress factors(high glucose and severe hypoxia)on the biological characteristics of MSCs at different passages,in order to optimize the therapeutic applications of MSCs.METHODS In this study,we investigated the impact of two stress conditions;severe hypoxia and high glucose on human adipose-tissue derived MSCs(hAD-MSCs)at passages 6(P6),P8,and P10.Proliferation,senescence and apoptosis were evaluated measuring WST-1,senescence-associated beta-galactosidase,and annexin V,respectively.RESULTS Cells at P6 showed decreased proliferation and increased apoptosis under conditions of high glucose and hypoxia compared to control,while the extent of senescence did not change significantly under stress conditions.At P8 hAD-MSCs cultured in stress conditions had a significant decrease in proliferation and apoptosis and a significant increase in senescence compared to counterpart cells at P6.Cells cultured in high glucose at P10 had lower proliferation and higher senescence than their counterparts in the previous passage,while no change in apoptosis was observed.On the other hand,MSCs cultured under hypoxia showed decreased senescence,increased apoptosis and no significant change in proliferation when compared to the same conditions at P8.CONCLUSION These results indicate that stress factors had distinct effects on the biological processes of MSCs at different passages,and suggest that senescence may be a protective mechanism for MSCs to survive under stress conditions at higher passage numbers.

Factors and Cut-Off Predicting Stone Passage under Medical Expulsive Therapy (MET)

Background: Ureteral stones are the most common leading cause of acute flank pain. This study aimed to identify sociodemographic and clinical variables predicting spontaneous ureteral stone passage and determine the optimal size cut-off for predicting such passage. Method: We conducted a retrospective evaluation of patients presenting with acute renal colic at a urology outpatient clinic. Patients with ureteral stones ≤ 10 mm and no surgical intervention post-initial diagnosis, who attended follow-up visits, were included. Exclusion criteria comprised stone size > 1 cm, fever due to obstructive pyelonephritis, acute kidney injury, single kidney status, or bilateral ureteral obstruction. Results: Of 124 included patients, the spontaneous stone passage rate was 57.3%, with a mean passage time of 11.1 (SD 6.25) days. Bivariate analysis revealed that factors predicting spontaneous passage were stone size (p Conclusions: Stone size < 7 mm, UVJ or distal ureter location, emerged as key predictors of stone passage in nephrolithiasis, and stone size below 6.85 mm is a reasonable cut off to initiate MET rather than 10 mm.

Development potential of the Northeast Passage based on a multinomial-logit-based stochastic user equilibrium model

We developed a multinomial-logit-based stochastic user equilibrium(MNL SUE)model incorporating time value of cargo to investigate future proportions of cargo flow through the Northeast Passage(NEP)and the Suez Canal Route between representative ports.We studied navigation during the ice-free and ice-covered seasons using sea ice projections for 2070 based on 1991–2021 NEP ice data.Sailing distance and time between selected ports are lower via the NEP than the Suez Canal Route.Under the scenario of year-round operation of the NEP,the proportion of cargo flow through the NEP is estimated to be 68.5%,which represents considerable commercial potential.Proportions are higher for the ice-free season and for ports at high latitudes.We also assessed flow under different scenarios.Under the scenario of fuel price increase,proportion of flow through the NEP in the ice-covered season is expected to increase.If time value is ignored,flow through the NEP is expected to increase all year round.If shippers become more cost-conscious,flow through the NEP is also expected to increase.

《詩經》的國際化:域外漢學家呈現的光陰推移(temporal passage)和心理反應

一、引言《詩經》之中,“慆慆”指時間長久的感覺。“慆”用作動詞,指逝去,意思與“滔”同((1))。書中表示一天内的時間用語有:昧、旦、夙、朝、辰、晝、莫、昏、夕、宵、夜((2))。這些詞語都不能指涉很精確的時刻。不過,周王朝可能有洩水型計時器——漏壺((3))。到了春秋時代,墨家有計時之學((4))。東漢王充《論衡》記載了“日(太陽)行天十六道”。先秦時期,民衆没有自鳴鐘.

Optimization of transport passage with dragline system in thick overburden open pit mine

According to the characteristics of opencast coal resources and dragline technology system application in China,the structure and shifting step of transport passage are optimized in this paper.Typical coal transport passage is analyzed in aspects such as the internal dump occupation,dragline operation efficiency,coal transport distance,upper stripping distance and shifting quantities.The middle passage should be given priority in thick overburden open pit mine because the dragline system is only responsible for part stripping task.According to characteristics of middle passage,the transport passage is divided into parallel climbing,vertical climbing and horizontal transport.In addition,the transport passage structure optimization model and shifting distance optimization model are established in this paper.The case study in Heidaigou open pit mine shows that,the parallel climbing height is accounted for about 60%of the total height,and reasonable shifting distances of the first mining area and the second mining area are 240 and 320 m.Sensitivity analysis shows that,the total passage height has important influence on the shifting step,so it is with the stripping height and passage construction cost to the passage structure.

Failure of Aspired Understanding Among the Human Race——On the Theme of A Passage to India

The author attempts to interpret the theme of A Passsage to India by analyzing the major events and characterization. It is indicated in the thesis that E.M.Forster highlights the failure of aspired understanding between different races, different people and even within a person. In other words, in many cases people have aspirations for understanding, but in reality the real understanding is very difficult to fulfill.

An Analysis of the Performance of Orientalism in A Passage to India and the Exorcization of Orientalism in Maxine Hong Kingston's Works

This thesis tries to study two novels:firstly,the performance of Orientalism in the novel A Passage to India;secondly the Exorcization of Orientalism in the novel the Woman Warrior written by Maxine Hong Kingston.

Three-Dimensional Quantum State Transferring Between Two Remote Atoms by Adiabatic Passage under Dissipation

Recently, Zhou et al. [Phys. Rev. A 79 （2009） 044304] proposed a scheme for transferring three-dimensional quantum states between remote atomic qubits confined in cavities connected by fibers through adiabatic passage. In order to avoid the decoherence due to spontaneous emission, Zhou et al. utilized the large detuning atom-field interaction. In the present paper, we discuss the influence of dissipation on the scheme in both the resonant atom-field interaction case and the large detuning case. We numerically analyze the success probability and the transferring fidelity. It is shown that the resonant case is a preferable choice for the technique of the stimulated Raman adiabatic passage （STIRAP） due to the shorter operation time and the smaller probability of dissipation.

A Preliminary Study on Historical Evolution and Spatial Characteristics of Traditional Settlements along the Feihu Passage Based on GIS

The eight Taihang passages are important cultural routes in the northern region,and a large number of traditional settlements with northern residential characteristics are distributed along the passages.Traditional settlements along the Feihu passage are studied in the paper,and the temporal and spatial distribution of traditional settlements is sorted out via ArcGIS platform,to explore its historical evolution in time and distribution rule in space.

Efficient Coherent Population Transfer of D2 Molecules by Stark-induced Adiabatic Raman Passage

Preparation of a high flux of hydrogen molecules in a specific vibrationally excited state is the major prerequisite and challenge in scattering experiments that use vibrationally excited hydrogen molecules as the target. The widely used scheme of stimulated Raman pumping suffers from coherent population return which severely limits the excitation efficiency. Re- cently we successfully transferred D2 molecules in the molecular beam from （v=0, J=0） to （v=1, J=0） level, with the scheme of Stark-induced adiabatic Raman passage. As high as 75% of the excitation efficiency was achieved. This excitation technique promise to be a unique tool for crossed beam and beam-surface scattering experiments which aim to reveal the role of vibrational excitation of hydrogen molecules in the chemical reaction.

Effects of Meridional Flow Passage Shape on Hydraulic Performance of Mixed-flow Pump Impellers

During the process of designing the mixed-flow pump impeller, the meridional flow passage shape directly affects the obtained meridional flow field, which then has an influence on the three-dimensional impeller shape. However, the meridional flow passage shape is too complicated to be described by a simple formula for now. Therefore, reasonable parameter selection for the meridional flow passage is essential to the investigation. In order to explore the effects of the meridional flow passage shape on the impeller design and the hydraulic performance of the mixed-flow pump, the hub and shroud radius ratio (HSRR) of impeller and the outlet diffusion angle (ODA) of outlet zone are selected as the meridional flow passage parameters. 25 mixed-flow pump impellers, with specific speed of 496 under the design condition, are designed with various parameter combinations. Among these impellers, one with HSRR of 1.94 and ODA of 90° is selected to carry out the model test and the obtained experimental results are used to verify accuracies of the head and the hydraulic efficiency predicted by numerical simulation. Based on SIMPLE algorithm and standard k-ε two-equation turbulence model, the three-dimensional steady incompressible Reynolds averaged Navier-Stokes equations are solved and the effects of different parameters on hydraulic performance of mixed-flow pump impellers are analyzed. The analysis results demonstrate that there are optimal values of HSRR and ODA available, so the hydraulic performance and the internal flow of mixed-flow pumps can be improved by selecting appropriate values for the meridional flow passage parameters. The research on these two parameters, HSRR and ODA, has further illustrated influences of the meridional flow passage shape on the hydraulic performance of the mixed-flow pump, and is beneficial to improving the design of the mixed-flow pump impeller.

Anisodamine accelerates spontaneous passage of single symptomatic bile duct stones ≤ 10 mm

AIM:To investigate the rate of spontaneous passage of single and symptomatic common bile duct(CBD)stones≤10 mm in diameter in 4 wk with or without a2-wk course of anisodamine.METHODS:A multicenter,randomized,placebocontrolled trial was undertaken.A total of 197 patients who met the inclusion criteria were enrolled.Ninetyseven patients were assigned randomly to the control group and the other 100 to the anisodamine group.The anisodamine group received intravenous infusions of anisodamine(10 mg every 8 h)for 2 wk.The control group received the same volume of 0.9%isotonic saline for 2 wk.Patients underwent imaging studies and liver-function tests every week for 4 wk.The rate of spontaneous passage of CBD stones was analyzed.RESULTS:The rate of spontaneous passage of CBD stones was significantly higher in the anisodamine group than that in the control group(47.0%vs 22.7%).Most(87.2%,41/47)stone passages in the anisodamine group occurred in the first 2 wk,and passages in the control group occurred at a comparable rate each week.Factors significantly increasing the possibility of spontaneous passage by univariate logistic regression analyses were stone diameter(<5 mm vs≥5 mm and≤10 mm)and anisodamine therapy.Multivariate logistic regression analyses revealed that these two factors were significantly associated with spontaneous passage.CONCLUSION:Two weeks of anisodamine administration can safely accelerate spontaneous passage of single and symptomatic CBD stones≤10 mm in diameter,especially for stones<5 mm.

Changes in sea ice kinematics in the Arctic outflow region and their associations with Arctic Northeast Passage accessibility

Amplification of climate warming in the Arctic is causing a dramatic retreat of sea ice, which means the Arctic sea routes are becoming increasingly accessible. This study used a satellite-derived sea ice motion product to quantify the kinematic features of sea ice in the Arctic outflow region which specially referred to the Fram Strait and to the north of the Northeast Passage(NEP). An observed trend of increased southward sea ice displacement from the central Arctic to the Fram Strait indicated enhancement of the Transpolar Drift Stream(TDS). In the regions to the north of the NEP, the long-term trend of northward sea ice speed in the Kara sector was +0.04 cm/s per year in spring. A significant statistical relationship was found between the NEP open period and the northward speed of the sea ice to the north of the NEP. The offshore advection of sea ice could account for the opening of sea routes by 33% and 15% in the Kara and Laptev sectors, respectively. The difference in sea level pressure across the TDS,i.e., the Central Arctic Index(CAI), presented more significant correlation than for the Arctic atmospheric Dipole Anomaly index with the open period of the NEP, and the CAI could explain the southward displacement of sea ice toward the Fram Strait by more than 45%. The impact from the summer positive CAI reinforces the thinning and mechanical weakening of the sea ice in the NEP region, which improves the navigability of the NEP.

Sequence Variation in the Gp120 region of SHIV-CN97001 during in vivo Passage

SHIV-CN97001 played an important role in assessing the immune effect and strategy of the AIDS vaccine which included genes of the predominant prevalent HIV-1 strain in China. In this study, SHIV-CN97001 was in vivo passaged serially to construct pathogenic SHIV-CN97001/rhesus macaques model. To identify variation in the gp120 region of SHIV-CN97001 during passage, the fragments of gp120 gene were amplified by RT-PCR from the plasma of SHIV-CN97001 infected animals at the peak viral load time point and the gene distances (divergence, diversity) were calculated using DISTANCE. The analysis revealed that the genetic distances of SHIV-CN97001 in the third passage animals were the highest during in vivo passage. It had a relationship between viral divergence from the founder strain and viral replication ability. The nucleic acid sequence of the V3 region was highly conservative. All of the SHIV-CN97001 strains had V3 loop central motif (GPGQ) and were predicted to be using CCR5 co-receptor on the basis of the critical amino acids within V3 loop. These results show that there was no significant increase in the genetic distance during serial passage, and SHIV-CN97001 gp120 gene evolved toward ancestral states upon transmission to a new host. This could partly explain why there was no pathogenic viral strain obtained during in vivo passage.

Flow measurement and parameter optimization of right-angled flow passage in hydraulic manifold block

This study was conducted to investigate the flow field characteristics of right-angled flow passage with various cavities in the typical hydraulic manifold block.A low-speed visualization test rig was developed and the flow field of the right-angled flow passage with different cavity structures was measured using 2D-PIV technique.Numerical model was established to simulate the three-dimensional flow field.Seven eddy viscosity turbulence models were investigated in predicting the flow field by comparing against the particle image relocimetry(PIV)measurement results.By defining the weight error function K,the S-A model was selected as the appropriate turbulence model.Then,a three-factor,three-level response surface numerical test was conducted to investigate the influence of flow passage connection type,cavity diameter and cavity length-diameter ratio on pressure loss.The results show that the Box-Benhnken Design(BBD)model can predict the total pressure loss accurately.The optimal factor level appeared in flow passage connection type II,14.64 mm diameter and 67.53%cavity length-diameter ratio.The total pressure loss decreased by 11.15%relative to the worst factor level,and total pressure loss can be reduced by 64.75%when using an arc transition right-angled flow passage,which indicates a new direction for the optimization design of flow passage in hydraulic manifold blocks.

Experimental Study of the Influence of Flow Passage Subtle Variation on Mixed-flow Pump Performance

In the mixed-flow pump design, the shape of the flow passage can directly affect the flow capacity and the internal flow, thus influencing hydraulic performance, cavitation performance and operation stability of the mixed-flow pump. However, there is currently a lack of experimental research on the influence mechanism. Therefore, in order to analyze the effects of subtle variations of the flow passage on the mixed-flow pump performance, the frustum cone surface of the end part of inlet contraction flow passage of the mixed-flow pump is processed into a cylindrical surface and a test rig is built to carry out the hydraulic performance experiment. In this experiment, parameters, such as the head, the efficiency, and the shaft power, are measured, and the pressure fluctuation and the noise signal are also collected. The research results suggest that after processing the inlet flow passage, the head of the mixed-flow pump significantly goes down; the best efficiency of the mixed-flow pump drops by approximately 1.5%, the efficiency decreases more significantly under the large flow rate; the shaft power slightly increases under the large flow rate, slightly decreases under the small flow rate. In addition, the pressure fluctuation amplitudes on both the impeller inlet and the diffuser outlet increase significantly with more drastic pressure fluctuations and significantly lower stability of the internal flow of the mixed-flow pump. At the same time, the noise dramatically increases. Overall speaking, the subtle variation of the inlet flow passage leads to a significant change of the mixed-flow pump performance, thus suggesting a special attention to the optimization of flow passage. This paper investigates the influence of the flow passage variation on the mixed-flow pump performance by experiment, which will benefit the optimal design of the flow passage of the mixed-flow pump.

Is ERCP really necessary in case of suspected spontaneous passage of bile duct stones?

AIM:To investigate the usefulness of magnetic resonance cholangiopancreatography (MRCP) and the need for endoscopic retrograde cholangiopancreatography (ERCP) in cases of suspected spontaneous passage of stones into the common bile duct.METHODS:Thirty-six patients with gallbladder stones were clinically suspected of spontaneous passage of stones into the common bile duct because they presented with clinical symptoms such as abdominal pain and fever,and showed signs of inflammatory reaction and marked rise of hepatobiliary enzymes.These symptoms resolved and they showed normalized values of blood biochemical parameters after conservative treatment without evidence of stones in the common bile duct on MRCP.All these patients were subjected to ERCP within 3 d of MRCP to check for the presence of stones.RESULTS:No stones were detected by ERCP in any patient,confi rming the results of MRCP.CONCLUSION:When clinical symptoms improve,blood biochemical parameters have normalized,and MRCP shows there are no stones in the common bile duct,it can be considered the stone has spontaneously passed and thus ERCP is not necessary.

Development and Application of a Shaft-type Tubular Pumping System with a Siphon Discharge Passage

Based on the characteristics of large flow rate , low head , short annual operation time , and high reliability of the city flood-control pumping stations , a new-type shaft tubular pumping system featuring a shaft suction box and a siphon-type discharge passage with a vacuum breaker as the cutoff device was developed , which possesses such advantages as simple structure , reliable cutoff , and high energy performance.Taking some pumping stations as the case studies , in the light of the specified operation conditions , the hydraulic optimal design of the shaft-type tubular pumping system was determined and the optimized shape of the system was recommended.The performance prediction based on the computational fluid dynamics methodology was determined and the model test verification was conducted.The results show that the predicted data agree with the experimental head and efficiency so that both methods can be used to determine the performance of a real pumping station.Finally , the in-situ measurements of a pumping station during the commissioning period further verified that the shaft-type tubular pumping station with a siphon discharge passage is of higher efficiency , more reliable and stable.