The Effect of a Novel Complex, Composed of Ceramide, Energizing Peptide and Camu Camu Extract, on Epidermal Barrier Function and Dermal Antiaging Properties in Ex Vivo Human Skin Small Live Cohort

The skin’s primary function is to protect the body against a spectrum of environmental stressors, including mechanical insults, microorganisms, chemicals, and allergens. Located in the outermost layers, the primary structures and components responsible for the skin’s barrier function are susceptible to environmental variables, dermatological conditions, and the aging process. The ensuing alterations to structure, composition, and organizational attributes of the epidermal barrier can impact its integrity and functionality. The aim of this study was to assess the effect of a novel complex composed of a ceramide, energizing peptide, and Camu Camu extract (SUPCERATTM complex) on specific markers of epidermal barrier integrity, as well as epidermal and dermal function. All the experiments were conducted on fresh human abdominal skin explants. Intradermal production of hyaluronic acid, epidermal claudin-1, and ceramide synthase 3 expressions, as well as epidermal lipids content were assessed using specific fluorescent stainings on ex vivo skin after the application of the complex or placebo. Additionally, dermal elastase and collagenase activities were assessed using in tubo enzymatic assays. Lastly, the effect of a cosmetic cream containing SUPCERATTM complex was assessed using subjective Global Aesthetic Improvement Scale (GAIS) in a small cohort of patients after 60 days of use. The application of the SUPCERATTM complex on ex vivo skin led to significant increase in dermal hyaluronic acid content and epidermal activity of claudin-1, ceramide synthase 3 and epidermal ceramide content. Furthermore, in tubo enzymatic assays demonstrated inhibition of both dermal elastase and collagenase activities. In addition, the patient-reported results indicated significant improvements in skin quality and appearance. .

Antiaging agents: safe interventions to slow aging and healthy life span extension

Human longevity has increased dramatically during the past century.More than 20%of the 9 billion population of the world will exceed the age of 60 in 2050.Since the last three decades,some interventions and many preclinical studies have been found to show slowing aging and increasing the healthy lifespan of organisms from yeast,flies,rodents to nonhuman primates.The interventions are classified into two groups:lifestyle modifications and pharmacological/genetic manipulations.Some genetic pathways have been characterized to have a specific role in controlling aging and lifespan.Thus,all genes in the pathways are potential antiaging targets.Currently,many antiaging compounds target the calorie-restriction mimetic,autophagy induction,and putative enhancement of cell regeneration,epige-netic modulation of gene activity such as inhibition of histone deacetylases and DNA methyltransferases,are under development.It appears evident that the exploration of new targets for these antiaging agents based on biogeron-tological research provides an incredible opportunity for the healthcare and pharmaceutical industries.The present review focus on the properties of slow aging and healthy life span extension of natural products from various biologi-cal resources,endogenous substances,drugs,and synthetic compounds,as well as the mechanisms of targets for antiaging evaluation.These bioactive compounds that could benefit healthy aging and the potential role of life span extension are discussed.

Antiaging activity of low molecular weight peptide from Paphia undulate

Low molecular weight peptide (LMWP) was prepared from clam Paphia undulate and its antiaging effect on D-galactose-induced acute aging in rats, aged Kunming mice, ultraviolet-exposed rats, and thermally injured rats was investigated. P. undulate flesh was homogenized and digested using papain under optimal conditions, then subjected to Sephadex G-25 chromatography to isolate the LMWP. Administration of LMWP significantly reversed D-galactose-induced oxidative stress by increasing the activities of glutathione peroxidase (GPx) and catalase (CAT), and by decreasing the level of malondialdehyde (MDA). This process was accompanied by increased collagen synthesis. The LMWP prevented photoaging and promoted dermis recovery and remission of elastic fiber hyperplasia. Furthermore, treatment with the LMWP helped to regenerate elastic fibers and the collagen network, increased superoxide dismutase (SOD) in the serum and significantly decreased MDA. Thermal scald-induced inflammation and edema were also relieved by the LWMP, while wound healing in skin was promoted. These results suggest that the LMWP from P. undulate could serve as a new antiaging substance in cosmetics.

Antiaging cosmeceuticals from pigmented rice

Cosmeceuticals are cosmetic products claimed to have medicinal or drug-like benefits.The term was created in 1990s from cosme(tics)and(pharma)ceuticals.These products are marketed as cosmetics but formulated with biologically active ingredients to promote them to have the benefits beyond the traditional moisturizer.Cosmeceuticals,however,are not recognized under any categories of the Food,Drug,and Cosmetic Act.In consideration on rice,it is the most widely consumed staple food for large parts of the world’s human population,especially in Asia,as the source of nutrition and caloric intake.

East to west:research progress in traditional Chinese medicine for antiaging strategies

Delaying the onset of aging is considered an important tool for dealing with the global crisis of the aging population.Accordingly,several antiaging studies have been conducted using strategies of modern medicine and traditional Chinese medicine(TCM).In this review,we summarize the current state of antiaging research related to both modern medicine and TCM and provide suggestions for further research.Various theories related to the aging process have been proposed,including the free radical theory,mitochondrial DNA damage theory,telomere theory,cross-linking theory,and intestinal flora theory,and a number of antiaging chemical treatments have been developed using modern medicine.These theories and achievements have resulted in major advancements in antiaging research.TCM is based on practical experience and has a long history with unique advantages in antiaging research.Some antiaging practices such as moderate diet consumption,acupuncture,Tai Chi(a traditional Chinese martial art that can relax the nerves to slow down the aging process),and Wuqin Xi(a traditional Chinese exercise to strengthen the body)have been adopted to maintain health.Several TCMs and prescriptions,particularly those related to medicine food homology,have been used in antiaging treatment,and their antiaging properties have been demonstrated to be effective based on pharmacological experiments and clinical applications.

纳溪茯砖茶的微量元素研究

纳溪茯砖茶产于四川南部纳溪县山区。该茶有稳定血压、防治心脑血管疾病,调节新陈代谢的作用,有益于健康长寿。我们以该茶为研究组,以泸州名茶玉蟾抗衰茶作对照组进行了铜、锌、铁、锰、镉、镍、铅、硒、钙、镁、钾、钠十二种元素的含量测定,对其中部分元素的含量分布特点加以对比分析,并就它们与人体健康的关系进行探讨。

Study on the Anti-aging Efficacy of the Active Ingredients in Aqueous Extract of Ganoderma lucidum

[ Objective ] The research aimed to develop anti-aging masks with aqueous extracts of Ganoderma lucidum and to study the clinical efficacy on the delaying of skin aging. [Method] The anti-aging efficacy of the aqueous extract of C.anoderrna luciclum was evaluated by sensory evaluation, safety evaluation, instrumental measurements, etc. [ Result] The results of sensory evaluation showed that after continuous application of the test materials for 12 weeks, the skin dryness, elasticity, surface sheen, fine wrinkles and smoothness were well improved, and the improvement rates were 9l. 17%, 91.17% , 94.12% , 11.76% and 91.18% , respectively. The measurement results by specialized instrument showed that the skin hydration on the target site increased continuously with the prolonging of the using time. Significant differences existed between each time point after using the products and the time before using. There was no signiScant difference existed in elasticity index 112 and R5 compared with before using. [Result] Clinical data showed that the active ingredients in aqueous extract of Ganoderma lucidum had a certain effect on the delaying of skin aging.