A mine-used multi-function serial signal converter is introduced.This converter is based on Ethernet.The core of this design is embedded microprocessor STM32F107VCT6.Embedded operation system μC/OS-Ⅱ is transplanted...A mine-used multi-function serial signal converter is introduced.This converter is based on Ethernet.The core of this design is embedded microprocessor STM32F107VCT6.Embedded operation system μC/OS-Ⅱ is transplanted into this converter,and light-weight Internet protocal （LwIP） stack is also embedded to realize mutual conversion of serial signals such as meter bus （M-Bus） signal,RS485 signal,RS232 signal and Ethernet signal.Interconnection between all kinds of monitoring system interfaces under coal mine can be formed easily,which can solve compatibility problem between monitoring system and communication system and improve overall performance of safety monitoring system.The designed multi-function serial signal converter is of great value for application,which is worthy to be popularized in coal mine safety production.展开更多
Non-alcoholic fatty liver disease(NAFLD)is associated with mutations in lipopolysaccharide-binding protein(LBP),but the underlying epigenetic mechanisms remain understudied.Herein,LBP^(-/-)rats with NAFLD were establi...Non-alcoholic fatty liver disease(NAFLD)is associated with mutations in lipopolysaccharide-binding protein(LBP),but the underlying epigenetic mechanisms remain understudied.Herein,LBP^(-/-)rats with NAFLD were established and used to conduct integrative targetingactive enhancer histone H3 lysine 27 acetylation(H3K27ac)chromatin immunoprecipitation coupled with high-throughput and transcriptomic sequencing analysis to explore the potential epigenetic pathomechanisms of active enhancers of NAFLD exacerbation upon LBP deficiency.Notably,LBP^(-/-)reduced the inflammatory response but markedly aggravated high-fat diet(HFD)-induced NAFLD in rats,with pronounced alterations in the histone acetylome and regulatory transcriptome.In total,1128 differential enhancer-target genes significantly enriched in cholesterol and fatty acid metabolism were identified between wild-type(WT)and LBP^(-/-)NAFLD rats.Based on integrative analysis,CCAAT/enhancer-binding proteinβ(C/EBPβ)was identified as a pivotal transcription factor(TF)and contributor to dysregulated histone acetylome H3K27ac,and the lipid metabolism gene SCD was identified as a downstream effector exacerbating NAFLD.This study not only broadens our understanding of the essential role of LBP in the pathogenesis of NAFLD from an epigenetics perspective but also identifies key TF C/EBPβand functional gene SCD as potential regulators and therapeutic targets.展开更多
随着国家大力发展城市轨道交通,不间断电源(uninterruptible power supply,UPS)系统作为关键供电装置,具有重要的研究意义和价值。为了满足相关电能质量法规的要求,集成功率因数校正(power factor correction,PFC)输入级是保证轨道交通...随着国家大力发展城市轨道交通,不间断电源(uninterruptible power supply,UPS)系统作为关键供电装置,具有重要的研究意义和价值。为了满足相关电能质量法规的要求,集成功率因数校正(power factor correction,PFC)输入级是保证轨道交通基础设施设备供电的UPS系统的重要要求。三电平Boost PFC在采用传统载波调制时,在一定的输入电压范围内输入电流始终为零,导致变换器功率因数校正效果较差。因此,提出一种基于k值调制的变占空比控制的方法,不仅可以解决高输入电压下传统载波调制存在的问题,且可进一步抑制输入电流的畸变从而提高输入电流波形质量。首先介绍了这种k值调制方法,分析了其原理以及k值对变换器功率因数和电感电流有效值的影响。在此基础上,结合电压平衡策略对k值进行优化,解决直流侧输出电容电压上下不均衡问题。最后,针对高输入电压下输入电流仍然严重畸变的问题,提出一种基于k值调制的可变占空比控制方法,分析了变占空比控制对变换器功率因数、输出功率、电压纹波以及电感电流峰值的影响。最后通过仿真和搭建小功率实验平台,验证了所提控制方法的正确性和有效性。展开更多
A discrete iterative map model of V^2C control boost converter was established to study the dynamical behaviors of the converter. By using parameter space map and bifurcation diagram, the effects of circuit parameters...A discrete iterative map model of V^2C control boost converter was established to study the dynamical behaviors of the converter. By using parameter space map and bifurcation diagram, the effects of circuit parameters on the bifurcation behaviors of V^2C control and current-mode control boost converters were analyzed. The phase portraits and time-domain waveforms of the V^2C control boost converter were obtained by Runge-Kutta algorithm through piecewise smooth switching model. The research results indicate that V^2C control boost converters can evolve into periodic and chaotic behaviors, and show weaker nonlinear behaviors than current-mode control boost converters.展开更多
文摘A mine-used multi-function serial signal converter is introduced.This converter is based on Ethernet.The core of this design is embedded microprocessor STM32F107VCT6.Embedded operation system μC/OS-Ⅱ is transplanted into this converter,and light-weight Internet protocal （LwIP） stack is also embedded to realize mutual conversion of serial signals such as meter bus （M-Bus） signal,RS485 signal,RS232 signal and Ethernet signal.Interconnection between all kinds of monitoring system interfaces under coal mine can be formed easily,which can solve compatibility problem between monitoring system and communication system and improve overall performance of safety monitoring system.The designed multi-function serial signal converter is of great value for application,which is worthy to be popularized in coal mine safety production.
基金supported by the National Natural Science Foundation of China(81971875,82300661)Natural Science Foundation of Anhui province(2308085QH246)+3 种基金Natural Science Foundation of the Anhui Higher Education Institutions(KJ2021A0205)Basic and Clinical Cooperative Research Program of Anhui Medical University(2019xkjT002,2019xkjT022,2022xkjT013)Talent Training Program,School of Basic Medical Sciences,Anhui Medical University(2022YPJH102)National College Students Innovation and Entrepreneurship Training Program of China(202210366024)。
文摘Non-alcoholic fatty liver disease(NAFLD)is associated with mutations in lipopolysaccharide-binding protein(LBP),but the underlying epigenetic mechanisms remain understudied.Herein,LBP^(-/-)rats with NAFLD were established and used to conduct integrative targetingactive enhancer histone H3 lysine 27 acetylation(H3K27ac)chromatin immunoprecipitation coupled with high-throughput and transcriptomic sequencing analysis to explore the potential epigenetic pathomechanisms of active enhancers of NAFLD exacerbation upon LBP deficiency.Notably,LBP^(-/-)reduced the inflammatory response but markedly aggravated high-fat diet(HFD)-induced NAFLD in rats,with pronounced alterations in the histone acetylome and regulatory transcriptome.In total,1128 differential enhancer-target genes significantly enriched in cholesterol and fatty acid metabolism were identified between wild-type(WT)and LBP^(-/-)NAFLD rats.Based on integrative analysis,CCAAT/enhancer-binding proteinβ(C/EBPβ)was identified as a pivotal transcription factor(TF)and contributor to dysregulated histone acetylome H3K27ac,and the lipid metabolism gene SCD was identified as a downstream effector exacerbating NAFLD.This study not only broadens our understanding of the essential role of LBP in the pathogenesis of NAFLD from an epigenetics perspective but also identifies key TF C/EBPβand functional gene SCD as potential regulators and therapeutic targets.
基金The National Natural Science Foundation of China (No.50677056)the Natural Science Foundations of Jiangsu Province (No.BK2009105)
文摘A discrete iterative map model of V^2C control boost converter was established to study the dynamical behaviors of the converter. By using parameter space map and bifurcation diagram, the effects of circuit parameters on the bifurcation behaviors of V^2C control and current-mode control boost converters were analyzed. The phase portraits and time-domain waveforms of the V^2C control boost converter were obtained by Runge-Kutta algorithm through piecewise smooth switching model. The research results indicate that V^2C control boost converters can evolve into periodic and chaotic behaviors, and show weaker nonlinear behaviors than current-mode control boost converters.
