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Snapshot of HIV pathogenesis in China 被引量:4
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作者 Nitin K SAKSENA Bin WANG +2 位作者 Megan STEAIN Rong Ge YANG Lin Qi ZHANG 《Cell Research》 SCIE CAS CSCD 2005年第11期953-961,共9页
Several reviews have focused on the nature of HIV infection and its spread in various geographical regions of China. In contrast, this review provides a comprehensive update on the prevalence of multiple HIV- 1 subtyp... Several reviews have focused on the nature of HIV infection and its spread in various geographical regions of China. In contrast, this review provides a comprehensive update on the prevalence of multiple HIV- 1 subtypes, consequent emergence of recombinant and novel forms of HIV- 1 in China, and the implications this may have on HIV diversity and the development of effective vaccines. In addition it also examines the dissemination of primary drug resistance in therapy naive patients, as well as co-infections with two other important viruses-hepatitis B and C. The main purpose of this review is to provide a current snapshot of HIV-1 pathogenesis in China and possibly shed some light on the future of HIV evolution, and potential challenges for future vaccine and anti-retroviral therapeutics against HIV strains in this area. 展开更多
关键词 HIV recombination circulating recombinant forms CO-INFECTIONS AIDS
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HIV/AIDS in Asia:The Shape of Epidemics and Their Molecular Epidemiology 被引量:4
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作者 Rie Uenishi Saiki Hase +2 位作者 Tee Kok Keng Shigeru Kusagawa Yutaka Takebe 《Virologica Sinica》 SCIE CAS CSCD 2007年第6期426-433,共8页
The Asia-Pacific region is a home to 60% of the population in the world and to approximately one quarter of people with HIV/AIDS. Close to a million of people has been infected and a half million people died of AIDS a... The Asia-Pacific region is a home to 60% of the population in the world and to approximately one quarter of people with HIV/AIDS. Close to a million of people has been infected and a half million people died of AIDS annually in Asia,becoming the second largest epicenter of global AIDS epidemic. Molecular epidemiology has been useful tool to track a course of HIV spread. In-depth knowledge from the studies on molecular epidemiology elucidates the dynamics of HIV spread and the interrelationship of epidemics in the different regions in Asia. 展开更多
关键词 Molecular epidemiology Genetic variability Circulation recombinant form (CRF) Unique recombinant form (URF)
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