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Eosinophilic solid and cystic renal cell carcinoma with aggressive behavior:Two case reports
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作者 Hui-Hui Cao Hong Li +2 位作者 Xiao-Hong Guo Zhi-Xing Cao Bo-Hui Zhang 《World Journal of Clinical Cases》 SCIE 2024年第22期5124-5130,共7页
BACKGROUND Eosinophilic solid and cystic(ESC)renal cell carcinoma(RCC),a unique and emerging subtype of RCC,has an indolent nature;in some rare instances,it may exhibit metastatic potential.Current cases are inadequat... BACKGROUND Eosinophilic solid and cystic(ESC)renal cell carcinoma(RCC),a unique and emerging subtype of RCC,has an indolent nature;in some rare instances,it may exhibit metastatic potential.Current cases are inadequate to precisely predict the clinical outcome of ESC RCC and determine treatment choices.CASE SUMMARY Herein,we report two patients with ESC RCC.Patient 1 was a young woman with classical pathological characteristics.Patient 2 was a 52-year-old man with multifocal metastases,involving the pulmonary hilar and mediastinal lymph nodes,liver,brain,mesosternum,vertebra,rib,femur,and symphysis pubis.Awareness of ESC RCC,along with its characteristic architecture and immunophenotype,would contribute to making a definitive diagnosis,even on core biopsy samples.CONCLUSION The discovery of ESC RCC molecular signatures may provide new therapeutic strategies in the future. 展开更多
关键词 Eosinophilic solid and cystic renal cell carcinoma Solid and cystic growth pattern CK20 TSC1 mutations TSC2 mutations Case report
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Multilocular Cystic Renal Cell Carcinoma:A Series of 8 Cases and Review of the Literature 被引量:9
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作者 Shuo Liu Guang Sun Zhanjun Guo Xiaodong Li 《Chinese Journal of Clinical Oncology》 CSCD 2007年第2期133-136,共4页
OBJECTIVE To study the clinical, pathologic and imaging features of multilocular cystic renal cell carcinoma (MCRCC) and to review the diagnosis and treatment of this subtype of renal cell carcinoma (RCC). METHODS... OBJECTIVE To study the clinical, pathologic and imaging features of multilocular cystic renal cell carcinoma (MCRCC) and to review the diagnosis and treatment of this subtype of renal cell carcinoma (RCC). METHODS The data from 8 cases (mean age, 49.4; 5 men and 3 women) who had been treated from 2004 to 2006, were reviewed retrospectively. Radiologic and pathologic documents were evaluated. For treatments, radical nephrectomy was conducted in 4 patients, partial nephrectomy in 2 and laparoscopic nephrectomy in 2. RESULTS Postoperative pathological findings confirmed the diagnosis of MCRCC. The stage of all 8 cases was pT1. For pathologic grade, 7 cases were G1 and 1 case was G2. Seven patients available for follow-up had survived tumor-free during the mean time of 8 months. CONCLUSION MCRCC is an uncommon subtype of RCC, it has a lower malignant potential and a better prognosis compared with other types of RCC. Nephron-sparing surgery may be an appropriate treatment options for MCRCC. 展开更多
关键词 renal cell carcinoma multilocular cystic renal cell carcinoma DIAGNOSTIC TREATMENT
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Recurrent renal cell carcinoma leading to a misdiagnosis of polycystic liver disease: A case report
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作者 Chen Liang Kazuhiro Takahashi +3 位作者 Masanao Kurata Shingo Sakashita Tatsuya Oda Nobuhiro Ohkohchi 《World Journal of Gastroenterology》 SCIE CAS 2019年第18期2264-2270,共7页
BACKGROUND Polycystic liver disease(PCLD) with a large cystic volume deteriorates the quality of life of patients through substantial effects on the adjacent organs,recurrent cyst infections, cyst rupture, and hemorrh... BACKGROUND Polycystic liver disease(PCLD) with a large cystic volume deteriorates the quality of life of patients through substantial effects on the adjacent organs,recurrent cyst infections, cyst rupture, and hemorrhage. Surgical or radiological intervention is usually needed to alleviate these symptoms. We report a rare case of the cystic metastasis of renal cell carcinoma(RCC), which was misdiagnosed as PCLD, as a result of the clinical and radiological similarity between these disorders.CASE SUMMARY A 74-year-old female who had undergone nephrectomy for papillary-type RCC(PRCC) was suffering from abdominal pain and the recurrent intracystic hemorrhage of multiple cysts in the liver. Imaging studies and aspiration cytology of the cysts showed no evidence of malignancy. With a diagnosis of autosomal dominant polycystic liver disease, the patient received hepatectomy for the purpose of mass reduction and infectious cyst removal. Surgery was performed without complications, and the patient was discharged on postoperative day 14. Postoperatively, the pathology revealed a diagnosis of recurrent PRCC with cystic formation.CONCLUSION This case demonstrates the importance of excluding the cystic metastasis of a cancer when liver cysts are observed. 展开更多
关键词 POLYcystic liver DISEASE POLYcystic kidney DISEASE cystic metastasis renal cell carcinoma Case report
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A clinical analysis of multilocular cystic renal cell carcinoma and its correlation with mutation of the von Hippel-Lindau gene
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作者 赵伟平 《外科研究与新技术》 2011年第4期239-240,共2页
Objective To discuss the diagnosis and surgical management of multilocular cystic renal cell carcinoma ( MCRCC) and to evaluate the gene function of the mutation of von Hippel-Lindau ( VHL) gene in MCRCC. Methods Seve... Objective To discuss the diagnosis and surgical management of multilocular cystic renal cell carcinoma ( MCRCC) and to evaluate the gene function of the mutation of von Hippel-Lindau ( VHL) gene in MCRCC. Methods Seventeen MCRCC cases ( 11 men and 展开更多
关键词 A clinical analysis of multilocular cystic renal cell carcinoma and its correlation with mutation of the von Hippel-Lindau gene cell
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Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy:A case report
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作者 Saori Kondo Takashi Suzuki +4 位作者 Kanato Yoshiike Sakura Yamanaka Kenta Sonehara Hiroshi Nabeshima Osamu Oguchi 《World Journal of Clinical Cases》 SCIE 2025年第1期56-61,共6页
BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced cases.Concurrent chemoradiotherapy(CCRT)has an inhibitory effect on MT.CASE SUMMARY Herein,we present a ... BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced cases.Concurrent chemoradiotherapy(CCRT)has an inhibitory effect on MT.CASE SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our hospital.Computed tomography revealed right hydronephrosis and a 6-cm pelvic mass.Endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell carci-noma.The patient was diagnosed with MT of MCT.Due to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse effects.After CCRT,her performance status improved,and the tumor size was reduced;surgery was performed.Five months postoperatively,the patient developed dis-semination and lymph node metastases.Palliative chemotherapy was ineffective.She died 18 months after treatment initiation.CONCLUSION EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life. 展开更多
关键词 Mature cystic teratoma Malignant transformation Squamous cell carcinoma Concurrent chemoradiotherapy Endoscopic ultrasound-guided fine-needle biopsy Case report
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Primary small cell carcinoma of kidney after renal transplantation:a case report and literature review 被引量:4
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作者 Hsiang-Ying Lee Wen-Jeng Wu +5 位作者 Kun-Bow Tsai Jung-Tsung Shen Mei-Yu Jang Hsun-Shuan Wang Shu-Fang Chang Li-Jiun Tsai 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2013年第5期608-611,共4页
Extrapulmonary small cell carcinoma (EPSCC) is a rare neoplasm comprising 2.5% to 5% of small cell carcinomas (SCCs).Bladder SCC is the most common site of genitourinary tract.Primary renal SCC is extremely rare... Extrapulmonary small cell carcinoma (EPSCC) is a rare neoplasm comprising 2.5% to 5% of small cell carcinomas (SCCs).Bladder SCC is the most common site of genitourinary tract.Primary renal SCC is extremely rare.We report a case of primary SCC of the kidney which is rarely reported in the urinary tract and presents an aggressive clinical picture.A 59-year-old female visited a urologic clinic with complaint of persistent left flank soreness 10 years after undergoing renal transplantation.Abdominal computed tomography showed a left renal pelvis tumor.After the patient received left nephroureterectomy with bladder cuff resection,her pathology results showed SCC.After surgery,she received adjuvant systemic chemotherapy,and her recovery has been uneventful as of 8 months.Primary renal SCC presents with an advanced tumor stage and a short median survival period,therefore early intervention and close follow-up are recommended. 展开更多
关键词 KIDNEY small cell carcinoma (SCC) EXTRAPULMONARY renal pelvis carcinoma
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SONOGRAPHIC PATTERNS AND DIFFERENTIAL DIAGNOSIS OF CYSTIC RENAL CARCINOMAS 被引量:2
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作者 蔡胜 李建初 +2 位作者 姜玉新 谭莉 张缙熙 《Chinese Medical Sciences Journal》 CAS CSCD 2002年第3期164-167,共4页
OBJECTIVE: To study the sonographic features and patterns of cystic renal carcinomas. METHODS: Thirteen cases of cystic renal carcinoma confirmed by operation and pathology were examined by ultrasonography, and the cy... OBJECTIVE: To study the sonographic features and patterns of cystic renal carcinomas. METHODS: Thirteen cases of cystic renal carcinoma confirmed by operation and pathology were examined by ultrasonography, and the cystic walls, septa and solid mural nodules were studied. RESULTS: Solid mural nodules of some cases and irregular thickening of the cystic walls and septa were characteristic findings for the ultrasonic diagnosis of cystic renal carcinomas. According to their pathologic mechanisms and sonographic features, cystic renal carcinomas were classified into 3 patterns: unilocular cystic mass, multiloculated cystic mass and cystic-solid mass. CONCLUSIONS: Typical cystic renal carcinomas can be well diagnosed, while atypical cases may be misdiagnosed as benign renal cysts by ultrasonography. Color Doppler ultrasonography and needle aspiration guided by ultrasonography are helpful in the diagnosis of these atypical cases. 展开更多
关键词 cystic renal carcinoma ultrasonography Objective. To study the sonographic features and patterns of cystic renal carcinomas. Methods. Thirteen cases of cystic renal carcinoma confirmed by operation and pathology were examined by ultrasonogra
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Comparison of biological behavior of lacrimal gland adenoid cystic carcinoma with high-grade transformation cells 被引量:2
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作者 Chuan-Li Zhang Li-Min Zhu +3 位作者 Xun Liu Mei-Xia Jiang Ting-Ting Lin Yan-Jin He 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第2期163-171,共9页
AIM:To evaluate the differences between human lacrimal gland adenoid cystic carcinoma with high-grade transformation(LACC-HGT)primar y cells cultured by high-grade transformation tissue and non-high-grade transformati... AIM:To evaluate the differences between human lacrimal gland adenoid cystic carcinoma with high-grade transformation(LACC-HGT)primar y cells cultured by high-grade transformation tissue and non-high-grade transformation(non-HGT)primary cells cultured by non-highgrade transformation tissue in proliferation,metastasis,drug susceptibility,and genes.METHODS:LACC-HGT primary cells were established by tissue block culture,and the 4^(th)to 10^(th)generation primary cells were selected as research objects.The cells were preliminarily identified by immunofluorescent staining.The differences between non-HGT and LACC-HGT primary cells in terms of proliferation,metastasis,and drug susceptibility were compared by cell counting kit-8(CCK-8)assay,wound healing,and drug sensitivity experiments.Differentially expressed genes were screened using mRNA array.Gene expression was analyzed using real-time quantitative polymerase chain reaction(RT-qPCR).RESULTS:LACC-HGT primary cells were successfully cultured by tissue block culture.Immunofluorescence staining results showed that cytokeratin(CK)and CK7 expression levels were positive in LACC-HGT primary cells.CCK-8 results showed that the proliferation ability of LACCHGT cells was significantly higher than that of non-HGT cells.Wound healing experiment showed that the migration ability of LACC-HGT cells was significantly higher than that of non-HGT cells.LACC-HGT cells were also less sensitive to cisplatin and paclitaxel than non-HGT cells.Compared with non-HGT cells,9566 differentially expressed genes were found in LACC-HGT primary cells,of which 5162 were upregulated and 4404 were down-regulated.The expression of N-acetylneuraminate pyruvate lyase(NPL),MARVEL domain containing 3(MARVELD3),syntabulin(SYBU),and allograft inflammatory factor 1(AIF1)was higher in LACCHGT cells than in non-HGT cells,whereas that of periostin(POSTN)was lower.CONCLUSION:LACC-HGT primary cells have faster proliferation,stronger migration ability,and poorer sensitivity to chemotherapy drugs than non-HGT primary cells.The expression of mRNAs in non-HGT and LACC-HGT primary cells are significantly different.These features are speculated to be the reasons why high-grade transformation tissues exhibit higher malignant degree and poorer prognosis than their counterparts. 展开更多
关键词 lacrimal gland lacrimal gland adenoid cystic carcinoma high-grade transformation primary cell culture biological behavior mRNA array
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Spindle cell carcinoma of the breast as complex cystic lesion: a case report 被引量:6
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作者 Masahiro Kitada Satoshi Hayashi +3 位作者 Yoshinari Matsuda Kei Ishibashi Keisuke Oikawa Naoyuki Miyokawa 《Cancer Biology & Medicine》 SCIE CAS CSCD 2014年第2期130-133,共4页
Spindle cell carcinoma of the breast is a rare tumor. This tumor can proliferate rapidly and cause cystic changes because of internal tissue necrosis. We evaluated a 54-year-old woman with right breast lump. Mammograp... Spindle cell carcinoma of the breast is a rare tumor. This tumor can proliferate rapidly and cause cystic changes because of internal tissue necrosis. We evaluated a 54-year-old woman with right breast lump. Mammography showed a category four mass with a diameter of 2.5 cm. Ultrasonography(US) revealed a complex cystic lesion, and fine-needle aspiration(FNA) cytology demonstrated bloody fluid and malignant cells. Partial breast resection and sentinel lymph node biopsy were performed. Immunohistology revealed spindle cells with positive results for cytokeratin(AE1/AE3) and vimentin, partially positive results for s-100, and negative results for desmin and α-actin. The pathological stage was IIA, and biochemical characterization showed that the tumor was triple negative. Six courses of FEC-100 chemotherapy(5-fluorouracil 500 mg/m2, epirubicin 100 mg/m2, and cyclophosphamide 500 mg/m2) were administered. Radiotherapy was performed. This case is discussed with reference to the literature. 展开更多
关键词 Breast cancer spindle cell carcinoma cystic lesion
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Lung squamous cell carcinoma presenting as rare clustered cystic lesions:A case report and review of literature 被引量:1
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作者 Yu-Yao Shen Jing Jiang +1 位作者 Jing Zhao Jie Song 《World Journal of Clinical Cases》 SCIE 2022年第35期13006-13014,共9页
BACKGROUND Lung cancer is the leading cause of cancer-related death.Early diagnosis is critical to improving a patient’s chance of survival.However,lung cancer associated with cystic airspaces is often misdiagnosed o... BACKGROUND Lung cancer is the leading cause of cancer-related death.Early diagnosis is critical to improving a patient’s chance of survival.However,lung cancer associated with cystic airspaces is often misdiagnosed or underdiagnosed due to the absence of clinical symptoms,poor imaging specificity,and high risk of biopsy-related complications.CASE SUMMARY We report an unusual case of cancer in a 55-year-old man,in which the lesion evolved from a small solitary thin-walled cyst to lung squamous cell carcinoma(SCC)with metastases in both lungs.The SCC manifested as rare clustered cystic lesions,detected on chest computed tomography.There were air-fluid levels,compartments,and bronchial arteries in the cystic lesions.Additionally,there was no clear extrathoracic metastasis.After chemotherapy,the patient achieved a partial response,type I respiratory failure was relieved,and the lung lesions became a clustered thin-walled cyst.CONCLUSION Pulmonary cystic lesions require regular imaging follow-up.Lung SCC should be a diagnostic consideration in cases of thin-walled cysts as well as multiple clustered cystic lesions. 展开更多
关键词 Squamous cell carcinoma Lung cancer cystic airspaces Thin-walled cyst Computed tomography Case report
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Small bowel obstruction caused by secondary jejunal tumor from renal cell carcinoma: A case report 被引量:1
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作者 Gao-Chen Bai Yue Mi +3 位作者 Yi Song Jin-Rui Hao Zhi-Song He Jie Jin 《World Journal of Clinical Cases》 SCIE 2021年第19期5339-5344,共6页
BACKGROUND Secondary jejunal tumor from renal cell carcinoma(RCC)is extremely rare in clinical practice and is easily missed and misdiagnosed because of the low incidence and atypical symptoms.CASE SUMMARY A 38-year-o... BACKGROUND Secondary jejunal tumor from renal cell carcinoma(RCC)is extremely rare in clinical practice and is easily missed and misdiagnosed because of the low incidence and atypical symptoms.CASE SUMMARY A 38-year-old male patient was diagnosed pathologically with left RCC after radical nephrectomy in 2012.The patient then suffered multiple lung metastases 2 years later and was treated with oral sorafenib without progression for 6 years.In 2020,an emergency intestinal segmental resection due to intestinal obstruction was required,and postoperative pathology confirmed a jejunal secondary tumor from RCC.The patient had a smooth recovery following surgery.Three months after surgery,the patient was diagnosed with left adrenal metastasis,and subsequent sintilimab therapy has stabilized his condition.CONCLUSION This report is written to remind urologists and pathologists of the potential for small intestinal secondary tumors when a patient with a history of RCC seeks treatment for digestive symptoms.Enteroscopy and abdominal contrast-enhanced computed tomography are essential means of examination,but severe cases require immediate surgical intervention despite the lack of a preoperative examination to distinguish tumor attributes. 展开更多
关键词 small bowel obstruction Secondary jejunal tumor renal cell carcinoma SURGERY Tumor metastasis Case report
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Effects of Genistein on Proliferation and Cell Cycle of Salivary Adenoid Cystic Carcinoma Cells
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作者 马杰 王洁 +1 位作者 钟鸣 王兆元 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2007年第1期64-67,共4页
Objective: To investigate the growth inhibiting effect of tyrosine protein kinase inhibitor, genistein, on human salivary adenoid cystic carcinoma SACC-83 cell line in vitro, and its effects on the expression of Cycl... Objective: To investigate the growth inhibiting effect of tyrosine protein kinase inhibitor, genistein, on human salivary adenoid cystic carcinoma SACC-83 cell line in vitro, and its effects on the expression of CyclinB1 protein and cell cycle. Methods: Effects of genistein on the growth of SACC-83 cells in vitro were measured with MTr assay. Cell cycle was detected with flow cytometry. The expressions of CyclinB1 and Cdkl proteins were measured with Western blot method, and the results of protein expression were quantitatively analyzed by FluorChem V2.0 software. The results were statistically analyzed by SPSSI 1.5 software. Results: Genistein inhibited the cell proliferation in a dose-dependant and time-dependant manner. The genistein-treated SACC-83 cells were arrested in the G2/M phase and had lower contents of CyclinB1 and Cdkl proteins compared with the control group. Conclusion: The growth inhibiting effect of genistein on SACC-83 cells may be associated with the regulations of genistein on the CyclinB1 and Cdk1 protein expressions and the cell cycle. 展开更多
关键词 Adenoid cystic carcinoma GENISTEIN CYCLINB1 cell cycle
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Effect of Exogenous bFGF on the Proliferation of Human Adenoid Cystic Carcinoma ACC-2 Cells
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作者 丁蕾 朱声荣 +1 位作者 谢三祥 吴祥冰 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2008年第2期227-229,共3页
To observe the effects of basic fibroblast growth factor (bFGF) on human adenoid cystic carcinoma ACC-2 cell line proliferation and ERK, cyclin D1/p21^waf/cip1 signaling pathways, human adenoid cystic carcinoma cel... To observe the effects of basic fibroblast growth factor (bFGF) on human adenoid cystic carcinoma ACC-2 cell line proliferation and ERK, cyclin D1/p21^waf/cip1 signaling pathways, human adenoid cystic carcinoma cells (ACC-2) were cultured and the influence of bFGF of different concentrations on cell proliferation was determined by MTT. Protein was detected by immuno-precipitation and ERK activity by using ERK agent kit. p-ERK1/2 and down-stream cyclin D1, p21^waf/cip1 expression were detected by Western blotting and the interfering role of mitogen protein-activated kinase (MEK) suppressor U0126 in the afore-mentioned indicators was examined. MTT demonstrated ACC-2 cell proliferation was substantially enhanced by bFGF, immuo-precipitation displayed ERK activity was up-regulated by bFGF, and immuno-imprinting also showed p-ERK1/2, cyclin D1 expression was greatly enhanced and p21^waf/cip1 expression was inhibited by bFGE U0126 suppressed the effect of bFGF. It is concluded that bFGF can promote the proliferation of human adenoid cystic carcinoma ACC-2 cells, and its pathways are associated with the up-regulated activity and expression of p-ERK1/2, inhibited p21waf/cip1 expression and enhanced cyclin D1 expression. 展开更多
关键词 basic fibroblast growth factor adenoid cystic carcinoma extracellular signal-regulated kinase cell cycle phase protein D1
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Granulocyte-colony stimulating factor-producing squamous cell carcinoma arising in ovarian mature cystic teratoma: A case report
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作者 Satoshi Ichigo Hiroshi Takagi +3 位作者 Kazutoshi Matsunami Takayuki Murase Tsuneko Ikeda Atsushi Imai 《Open Journal of Obstetrics and Gynecology》 2013年第9期686-689,共4页
Granulocyte-colony stimulating factor (G-CSF)-producing cancer has been reported to occur in various organs. It has an aggressive nature and shows resistance to conventional treatments, however, its clinical features ... Granulocyte-colony stimulating factor (G-CSF)-producing cancer has been reported to occur in various organs. It has an aggressive nature and shows resistance to conventional treatments, however, its clinical features are not well known because of the small number or reported cases. We report G-CSF-producing squamous cell carcinoma arising in malignant-transformed ovarian mature cystic teratoma. An 80-year-old woman underwent suboptimal surgical excision of stage IIIC ovarian cancer. Prior to the treatment, the patient presented severe granulocytosis and elevated serum G-CSF concentration. With the help of histopathological and immunohistochemical studies, we diagnosed this case to be a poorly differentiated squamous cell carcinoma developed in ovarian mature cystic teratoma, which highly expressed G-CSF. During radiation therapy, the patient died from rapid growth of residual tumor and peritoneal dissemination 2 months after surgery. This is the first case of G-CSF-producing squamous cell carcinoma arising in malignant-transformed ovarian mature cystic teratoma, and its prognosis was very poor. 展开更多
关键词 G-CSF-Producing CANCER Malignant Transformation of MATURE cystic TERATOMA SQUAMOUS cell carcinoma OVARIAN CANCER
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EXPRESSIONS OF P_(53), PROLIFERATING CELL NUCLEAR ANITIGEN,BCL-2 PROTEIN AND THEIR SIGNIFICANCE IN SALIVARY ADENOID CYSTIC CARCINOMA
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作者 张引成 朱艳梅 金晓明 《Academic Journal of Xi'an Jiaotong University》 2000年第1期67-69,80,共4页
Objective To study the effects of P53, PCNA, Bc1-2 protein and their relationship in salivary adenoid cystic carclnoma(SACC). Methods These protelns were examlned by lmmunohistochemistry. Results overexpressions of Ps... Objective To study the effects of P53, PCNA, Bc1-2 protein and their relationship in salivary adenoid cystic carclnoma(SACC). Methods These protelns were examlned by lmmunohistochemistry. Results overexpressions of Ps, and PCNA were revealed in ACC samples, they were higher than those in (polymorphous adenomas) PA, but expression of Bc1-2 protein was not different between ACC and PA. In 3 subtypes of ACC, expressions of 3 proteins were different. Conciusion Mutations of P53, Bc1-2 may be involed in the occurrence of SACC, expression of PCNA and mutation of P53 may coexist in the development of the SACC. 展开更多
关键词 adenoid cystic carcinoma (ACC) P53 protein proliferating cell nuclear antigen (PCNA) Bc1-2 protein
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Nephron-sparing surgery for small renal cell carcinoma
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作者 Yongsheng Li Shaoxing Zhu Weizhong Cai Shiping Chen Qiyong Li 《Journal of Nanjing Medical University》 2009年第3期207-211,共5页
Objective:To investigate the method and effect of nephron-sparing surgery in the treatment of small renal cell carcinoma. Methods: From August 1 997 to October 2008, 48 cases of small renal cell carcinomas were conf... Objective:To investigate the method and effect of nephron-sparing surgery in the treatment of small renal cell carcinoma. Methods: From August 1 997 to October 2008, 48 cases of small renal cell carcinomas were confirmed by surgery and pathology, and reviewed retrospectively. Of the 48 cases, there was 1 patient with bilateral tumors, 8 with solitary kidney tumors, 1 with unilateral tumor and a damaged contralateral kidney, and 38 with unilateral tumors and a normal contralateral kidney; 9 underwent tumor enucleation and the remaining patients received partial nephrectomy. Results:There were no local tumor recurrences and/or tumor metastasis at a mean followup of 60 months. Conclusion: Confirming conclusions from other centers, we have found that nephron-sparing surgery is an effective treatment for small renal cell carcinomas. 展开更多
关键词 small renal cell carcinoma nephron-sparing surgery kidney neoplasms
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Renal cell carcinoma: Evolving and emerging subtypes 被引量:7
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作者 Suzanne M Crumley Mukul Divatia +3 位作者 Luan Truong Steven Shen Alberto G Ayala Jae Y Ro 《World Journal of Clinical Cases》 SCIE 2013年第9期262-275,共14页
Our knowledge of renal cell carcinoma(RCC) is rapidly expanding. For those who diagnose and treat RCC, it is important to understand the new developments. In recent years, many new renal tumors have been described and... Our knowledge of renal cell carcinoma(RCC) is rapidly expanding. For those who diagnose and treat RCC, it is important to understand the new developments. In recent years, many new renal tumors have been described and defined, and our understanding of the biology and clinical correlates of these tumors is changing. Evolving concepts in Xp11 translocation carcinoma, mucinous tubular and spindle cell carcinoma, multilocular cystic clear cell RCC, and carcinoma associated with neuroblastoma are addressed within this review. Tubulocystic carcinoma, thyroid-like follicular carcinoma of kidney, acquired cystic disease-associated RCC, and clear cell papillary RCC are also described. Finally, candidate entities, including RCC with t(6;11) translocation, hybrid oncocytoma/chromophobe RCC, hereditary leiomyomatosis and RCC syndrome, and renal angiomyoadenomatous tumor are reviewed. Knowledge of these new entities is important for diagnosis, treatment and subsequent prognosis. This review provides a targeted summary of new developments in RCC. 展开更多
关键词 renal cell carcinoma SUBTYPES Xp11 TRANSLOCATION Mucinous tubular and spindle cell Multilocular cystic clear cell carcinoma associated with neuroblastoma recently described entities Clear cell papillary renal cell carcinoma Acquired cystic kidney disease Hereditary leiomyomatosis Candidate entities renal cell carcinoma with t(6 11)translocation
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Inhibition of Salidroside on Salivary Gland Adenoid Cystic Carcinoma
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作者 LI Mei-hua ZHOU Hong-lan +1 位作者 WANG Wei QIU Xin-ru 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2010年第6期969-973,共5页
To evaluate the role of salidroside on proliferation,apoptosis and invasiveness of salivary gland adenoid cystic carcinoma cells(SACC),immunocytochemical staining was employed to detect proliferating cell nuclear an... To evaluate the role of salidroside on proliferation,apoptosis and invasiveness of salivary gland adenoid cystic carcinoma cells(SACC),immunocytochemical staining was employed to detect proliferating cell nuclear antigen(PCNA),caspase 3 and caspase 8 expression in SACC-2 cells.Modified Boyden chamber assay combined with laser confocal microscopy(LSCM) was used to evaluate the invasion and migration abilities of SACC-2 cells at different time point.Immunohistochemistry staining revealed that the expression of PCNA was significantly decreased(P0.01) after salidroside treatment.In contrast,salidroside treatment led to increased caspase 3 and caspase 8 in SACC-2 cells.Cell migration depth and number of cells that penetrated Boyden chamber were also decreased by salidroside.Salidroside potently inhibits the proliferation and simultaneously induces the apoptosis of SACC-2 cells.Migration and invasion of SACC-2 cells are also inhibited.Our data throw light on potential clinical application of salidroside to the patients with SACC. 展开更多
关键词 IMMUNOHISTOCHEMISTRY SALIDROSIDE Salivary gland adenoid cystic carcinoma cell SACC-2 Boyden chamber Proliferating cell nuclear antigen
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STUDIES OF TISSUE CULTURE ON THE ADENOID CYSTIC CARCINOMA OF SALIVARY GLANDS
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作者 何荣根 王峥 +1 位作者 周晓健 张秀丽 《Medical Bulletin of Shanghai Jiaotong University》 CAS 1991年第2期22-27,共6页
In this paper, the authors gave a synthetic report about sutdies of tissue culture on adenoid cystic carcinomas from human salivary glands. It includes the process of establishment of Acc-2 and Acc-3 cell lines, obser... In this paper, the authors gave a synthetic report about sutdies of tissue culture on adenoid cystic carcinomas from human salivary glands. It includes the process of establishment of Acc-2 and Acc-3 cell lines, observations to the cellular morphostructures, chromosome analysis, proliferative kinetics and some cellular physiological functions. All of these observations confirm that two cell lines have obvious malignant natures, epithelial and glandulous cellular features as well as. Both of cell lines have provided the useful experimental models in vitro for research on histogenesis and biological behaviours at adenoid cystic carcinoma and seeking new methods of clinical treatment. 展开更多
关键词 ADENOID cystic carcinoma tissue culture cell line SALIVARY GLAND
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左上腭腺样囊性癌复发并发腭部大出血救治1例及文献回顾
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作者 章旺茹 陈媛媛 +1 位作者 李志萍 孟箭 《口腔疾病防治》 2025年第1期60-67,共8页
目的探讨多学科诊疗(multi-disciplinary treatment,MDT)在上腭腺样囊性癌(adenoid cystic carcinoma,ACC)复发转移的诊疗及并发腭部大出血的救治中的应用,为晚期口腔癌患者的诊疗及大出血的救治提供参考。方法报道1例左上腭腺样囊性癌... 目的探讨多学科诊疗(multi-disciplinary treatment,MDT)在上腭腺样囊性癌(adenoid cystic carcinoma,ACC)复发转移的诊疗及并发腭部大出血的救治中的应用,为晚期口腔癌患者的诊疗及大出血的救治提供参考。方法报道1例左上腭腺样囊性癌手术及放疗后颅底复发及肺部转移的患者、并发腭部大出血时多学科救治的过程,并结合相关文献对ACC复发伴大出血患者进行分析。患者为36岁女性,左腭部ACC,2013年初诊时临床分期为T3N0M0。患者接受腭部病损扩大切除术,随后在放射治疗计划系统(treatment planning system,TPS)及数字化导板引导下行放射性粒子125I植入治疗。术后持续随访4年,期间未见肿瘤复发。随访至第5年时,患者出现复发并肺转移(T4N0M1)。经口腔颌面外科、放疗科、肿瘤内科、胸外科多学科会诊,患者接受了“左侧上颌骨次全切术+自体游离皮瓣移植+胸腔镜下肺转移灶切除”手术。术后患者接受60 Gy剂量的放疗,并口服靶向药物盐酸安罗替尼胶囊,以控制肿瘤生长。继续随访31个月时,患者主诉口腔内偶有轻微渗血。颅颌面CT提示肿瘤侵袭性生长,破坏颅底,患者再次入院,入院第2天突发口腔大出血,床旁压迫止血仍渗血不止,紧急气管切开以解除患者呼吸道梗阻,输注红细胞悬液,以纠正失血性休克。经血管介入外科紧急会诊,紧急采用超选择介导栓塞术进一步止血,实现快速有效的血管闭塞,并在MDT下制定术后补充放疗、靶向免疫药物以控制肿瘤的个体化治疗计划。结果通过MDT模式的高效协作,成功实现了为患者紧急止血,恢复正常生命体征;经补充放疗及免疫靶向药物的治疗,有效控制了肿瘤进展,患者的生活质量得以改善,截止2024年7月,已成功实现带瘤生存129个月。回顾相关文献表明,MDT在ACC的诊治过程中展现出显著优势。在手术方式选择方面,MDT团队可以综合考虑患者的年龄、身体状况、肿瘤的位置、大小以及侵犯范围等因素,制定个性化的治疗计划。根治性手术切除是ACC常用的治疗方案。术后的组织缺损可以通过自体组织重建,如腓骨肌皮瓣、髂骨肌皮瓣等,或植入人工材料等手段来恢复相应的功能和美观。对于切缘阳性、复发及转移等复杂情况,MDT模式通过跨学科协作,制定包括再次手术、放疗、化疗在内的综合治疗方案,旨在降低ACC的复发风险和控制远处转移。晚期口腔癌引起的大量出血是一种复杂的医疗挑战,涉及的风险因素包括肿瘤类型、转移情况、治疗方案以及患者的全身状况等。早期识别出血风险,通过支持性护理、内科治疗、外科干预和介入治疗等方法,减轻出血对疾病进展的负面影响,有益于改善患者的生活质量。结论MDT模式为晚期口腔癌伴大出血患者提供全面、精准、个性化的治疗方案,有效提高治疗策略的有效性。 展开更多
关键词 腺样囊性癌 小唾液腺 局部扩大切除 放射性粒子植入 上颌骨次全切除 复发 肺转移 出血 多学科联合诊疗 气管切开 超选择性动脉内栓塞术
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