A myriad of medicinal effects has been attributed to Thymoquinone (TQ), the major biological-active component of Nigella sativa. TQ has been shown to exhibit potent anti-tumor activities. The present work was undertak...A myriad of medicinal effects has been attributed to Thymoquinone (TQ), the major biological-active component of Nigella sativa. TQ has been shown to exhibit potent anti-tumor activities. The present work was undertaken to further explore TQ’s chemopreventive efficacy against 1, 2-dimethylhydrazine (DMH)-induced colon carcinogenesis in the rat model through a two-phase study (initiation and post-initiation) and to evaluate its potential impact on tumor progression and invasion in vivo. TQ treatment in the initiation phase significantly reduced tumor incidence, multiplicity and mean tumor volume. However, although mean tumor volume and multiplicity were decreased upon TQ treatment in the post-initiation phase, TQ did not reduce incidence significantly. Cellular proliferation, as assessed by expression of colonic PCNA, was shown to be inhibited in consequence to TQ treatment in both phases, with a more pronounced reduction in the initiation phase. In addition, our results demonstrated an appreciable negative impact of TQ on vascular endothelial growth factor (VEGF) production in tumor-bearing rats. Furthermore, we provided evidence that TQ-treatment, in both phases, tended to considerably suppress tumor progression and invasion. Taken together, the present study demonstrated that TQ, at an orally daily dose of 10 mg/kg, has a chemopreventive effect in the initiation phase, and has the potential to attenuate tumor burden, suppress progression of pre-neoplastic lesions and to inhibit tumor growth in the post-initiation phase of DMH-induced colon carcinogenesis, We surmise that such effects of TQ may be due to suppression of cellular proliferation and inhibition of VEGF production. The results could provide an effective chemopreventive approach in the primary prevention of colon cancer in humans in the next future, and illuminate a promising horizon to combat progression of benign colonic pre-neoplastic lesions into malignant metastatic tumors and to manage colon cancer.展开更多
The pictures from the James Webb Space Telescope (JWST) suggest that massive galaxies were already at the beginning of the expansion of the Universe because there was too short time to create them. It is consistent wi...The pictures from the James Webb Space Telescope (JWST) suggest that massive galaxies were already at the beginning of the expansion of the Universe because there was too short time to create them. It is consistent with the new cosmology presented within the Scale-Symmetric Theory (SST). The phase transitions of the initial inflation field described in SST lead to the Protoworld—its core was built of dark matter (DM). We show that the DAMA/LIBRA annual-modulation amplitude forced by the change of the Earth’s velocity (i.e. baryonic-matter (BM) velocity) in relation to the spinning DM field in our Galaxy’s halo should be very low. We calculated that in the DM-BM weak interactions are created single and entangled spacetime condensates with a lowest mass/energy of 0.807 keV—as the Higgs boson they can decay to two photons, so we can indirectly detect DM. Our results are consistent with the averaged DAMA/LIBRA/COSINE-100 curve describing the dependence of the event rate on the photon energy in single-hit events. We calculated the mean dark-matter-halo (DMH) mass around quasars, we also described the origin of the plateaux in the rotation curves for the massive spiral galaxies, the role of DM-loops in magnetars, the origin of CMB, the AGN-jet and galactic-halo production, and properties of dark energy (DE).展开更多
文摘A myriad of medicinal effects has been attributed to Thymoquinone (TQ), the major biological-active component of Nigella sativa. TQ has been shown to exhibit potent anti-tumor activities. The present work was undertaken to further explore TQ’s chemopreventive efficacy against 1, 2-dimethylhydrazine (DMH)-induced colon carcinogenesis in the rat model through a two-phase study (initiation and post-initiation) and to evaluate its potential impact on tumor progression and invasion in vivo. TQ treatment in the initiation phase significantly reduced tumor incidence, multiplicity and mean tumor volume. However, although mean tumor volume and multiplicity were decreased upon TQ treatment in the post-initiation phase, TQ did not reduce incidence significantly. Cellular proliferation, as assessed by expression of colonic PCNA, was shown to be inhibited in consequence to TQ treatment in both phases, with a more pronounced reduction in the initiation phase. In addition, our results demonstrated an appreciable negative impact of TQ on vascular endothelial growth factor (VEGF) production in tumor-bearing rats. Furthermore, we provided evidence that TQ-treatment, in both phases, tended to considerably suppress tumor progression and invasion. Taken together, the present study demonstrated that TQ, at an orally daily dose of 10 mg/kg, has a chemopreventive effect in the initiation phase, and has the potential to attenuate tumor burden, suppress progression of pre-neoplastic lesions and to inhibit tumor growth in the post-initiation phase of DMH-induced colon carcinogenesis, We surmise that such effects of TQ may be due to suppression of cellular proliferation and inhibition of VEGF production. The results could provide an effective chemopreventive approach in the primary prevention of colon cancer in humans in the next future, and illuminate a promising horizon to combat progression of benign colonic pre-neoplastic lesions into malignant metastatic tumors and to manage colon cancer.
文摘The pictures from the James Webb Space Telescope (JWST) suggest that massive galaxies were already at the beginning of the expansion of the Universe because there was too short time to create them. It is consistent with the new cosmology presented within the Scale-Symmetric Theory (SST). The phase transitions of the initial inflation field described in SST lead to the Protoworld—its core was built of dark matter (DM). We show that the DAMA/LIBRA annual-modulation amplitude forced by the change of the Earth’s velocity (i.e. baryonic-matter (BM) velocity) in relation to the spinning DM field in our Galaxy’s halo should be very low. We calculated that in the DM-BM weak interactions are created single and entangled spacetime condensates with a lowest mass/energy of 0.807 keV—as the Higgs boson they can decay to two photons, so we can indirectly detect DM. Our results are consistent with the averaged DAMA/LIBRA/COSINE-100 curve describing the dependence of the event rate on the photon energy in single-hit events. We calculated the mean dark-matter-halo (DMH) mass around quasars, we also described the origin of the plateaux in the rotation curves for the massive spiral galaxies, the role of DM-loops in magnetars, the origin of CMB, the AGN-jet and galactic-halo production, and properties of dark energy (DE).
