In recent scenario of Wireless Sensor Networks(WSNs),there are many application developed for handling sensitive and private data such as military information,surveillance data,tracking,etc.Hence,the sensor nodes of W...In recent scenario of Wireless Sensor Networks(WSNs),there are many application developed for handling sensitive and private data such as military information,surveillance data,tracking,etc.Hence,the sensor nodes of WSNs are distributed in an intimidating region,which is non-rigid to attacks.The recent research domains of WSN deal with models to handle the WSN communications against malicious attacks and threats.In traditional models,the solution has been made for defending the networks,only to specific attacks.However,in real-time applications,the kind of attack that is launched by the adversary is not known.Additionally,on developing a security mechanism for WSN,the resource constraints of sensor nodes are also to be considered.With that note,this paper presents an Enhanced Security Model with Improved Defensive Routing Mechanism(IDRM)for defending the sensor network from various attacks.Moreover,for efficient model design,the work includes the part of feature evaluation of some general attacks of WSNs.The IDRM also includes determination of optimal secure paths and Node security for secure routing operations.The performance of the proposed model is evaluated with respect to several factors;it is found that the model has achieved better security levels and is efficient than other existing models in WSN communications.It is proven that the proposed IDRM produces 74%of PDR in average and a minimized packet drop of 38%when comparing with the existing works.展开更多
The pine wood nematode(PWN),Bursaphelenchus xylophilus(Steiner & Buhrer) Nickle,is the pathogen of pine wilt disease(PWD) which can devastate forests.PWN can be of hi gh or low severity and the mechanisms underlyi...The pine wood nematode(PWN),Bursaphelenchus xylophilus(Steiner & Buhrer) Nickle,is the pathogen of pine wilt disease(PWD) which can devastate forests.PWN can be of hi gh or low severity and the mechanisms underlying the differences in virulence are unclear.Therefore,it is necessary to study the relationship between differentiation of PWN severity and its resistance to the main defensive substances of pine species(i.e.,α-pinene and H_(2)O_(2)).The feeding rate and fecundity of PWN was examined at different levels of virulence under conditions of a-pinene and H_(2)O_(2) stress.Moreover,the expression patterns of the main resistance genes of PWN with different virulence were determined under conditions of α-pinene and H_(2)O_(2) stress.The feeding rate and fecundity of the high virulence strain AMA3 were higher than those of the low virulence strain YW4.The expression levels of the autophagy gene BxATG5,cytochrome P450 gene BxCYP33 D3,and glutathione S-transferase genes BxGST1 and BxGST3 in AMA3 increased significantly upon exposure to α-pinene for 2 h,while these genes showed smaller degrees of upregulation in YW4.Under conditions of H_(2)O_(2) stress,the expression levels of BxATG5,catalase genes Bxy-ctl-1 and Bxy-ctl-2,and the 2-cysteine peroxiredoxin gene BxPrx in AMA3 were higher than those in YW4.These findings suggest that high virulence PWN has greater resistance to pine defensive substances α-pinene and H_(2)O_(2) than low virulence PWN,and resistance genes mediate the differential resistance of PWN strains.This study will contribute to the clarification of the mechanism underlying virulence differentiation of PWN and will advance understanding of the pathogenic mechanism of PWD.展开更多
A lightning strike accident of a residential house in the rural areas of Neijiang is analyzed through on-site investigation,and the causes are discussed. Defensive measures of lightning disasters are proposed to provi...A lightning strike accident of a residential house in the rural areas of Neijiang is analyzed through on-site investigation,and the causes are discussed. Defensive measures of lightning disasters are proposed to provide reference for the prevention of lightning disasters in the construction of new countryside.展开更多
The advancement of technology and the digitization of organizational functions and services have propelled the world into a new era of computing capability and sophistication. The proliferation and usability of such c...The advancement of technology and the digitization of organizational functions and services have propelled the world into a new era of computing capability and sophistication. The proliferation and usability of such complex technological services raise several security concerns. One of the most critical concerns is cross-site scripting (XSS) attacks. This paper has concentrated on revealing and comprehensively analyzing XSS injection attacks, detection, and prevention concisely and accurately. I have done a thorough study and reviewed several research papers and publications with a specific focus on the researchers’ defensive techniques for preventing XSS attacks and subdivided them into five categories: machine learning techniques, server-side techniques, client-side techniques, proxy-based techniques, and combined approaches. The majority of existing cutting-edge XSS defensive approaches carefully analyzed in this paper offer protection against the traditional XSS attacks, such as stored and reflected XSS. There is currently no reliable solution to provide adequate protection against the newly discovered XSS attack known as DOM-based and mutation-based XSS attacks. After reading all of the proposed models and identifying their drawbacks, I recommend a combination of static, dynamic, and code auditing in conjunction with secure coding and continuous user awareness campaigns about XSS emerging attacks.展开更多
Defensive medicine is widespread and practiced the world over, with serious consequences for patients, doctors, and healthcare costs. Even students and resi-dents are exposed to defensive medicine practices and taught...Defensive medicine is widespread and practiced the world over, with serious consequences for patients, doctors, and healthcare costs. Even students and resi-dents are exposed to defensive medicine practices and taught to take malpractice liability into consideration when making clinical decisions. Defensive medicine is generally thought to stem from physicians' perception that they can easily be sued by patients or their relatives who seek compensation for presumed medical errors. However, in our view the growth of defensive medicine should be seen in the context of larger changes in the conception of medicine that have taken place in the last few decades, undermining the patient–physician trust, which has traditionally been the main source of professional satisfaction for physicians. These changes include the following: time directly spent with patients has been overtaken by time devoted to electronic health records and desk work; family doctors have played a progressively less central role; clinical reasoning is being replaced by guidelines and algorithms; the public at large and a number of young physicians tend to believe that medicine is a perfect science rather than an imperfect art, as it continues to be; and modern societies do not tolerate the inevitable morbidity and mortality. To finally reduce the increasing defensive behavior of doctors around the world, the decriminalization of medical errors and the assurance that they can be dealt with in civil courts or by medical organizations in all countries could help but it would not suffice. Physicians and surgeons should be allowed to spend the time they need with their patients and should give clinical reasoning the importance it deserves. The institutions should support the doctors who have experienced adverse patient events, and the media should stop reporting with excessive evidence presumed medical errors and subject physicians to "public trials" before they are eventually judged in court.展开更多
Glandular trichomes of plants produce a wide variety of secondary metabolites which are considered as major defensive chemicals. The capitate glandular trichomes of Oenothera glazioviana(Onagraceae) were collected wit...Glandular trichomes of plants produce a wide variety of secondary metabolites which are considered as major defensive chemicals. The capitate glandular trichomes of Oenothera glazioviana(Onagraceae) were collected with laser microdissection and analyzed by gas chromatography-mass spectrometry. The volatile compound 4-hydroxy-4-methylpentan-2-one(1) was identified. We found that compound 1 displays antimicrobial, insecticidal, and phytotoxic activities. These results suggest that compound 1 might function as a defensive compound in the capitate glandular trichomes of O. glazioviana against pathogens, insect herbivores, and presumably competitive plants as well.展开更多
Model predictive control(MPC)has been widely used in process industry,but its appli-cations to missile guidance law are relatively rare.In this paper,MPC is introduced to design defen-sive guidance law in a three-body...Model predictive control(MPC)has been widely used in process industry,but its appli-cations to missile guidance law are relatively rare.In this paper,MPC is introduced to design defen-sive guidance law in a three-body engagement,where a defending missile(i.e.,defender)is employed to protect a target aircraft from an attacking missile.Based on nonlinear kinematic equa-tions,an explicit linear discrete-time model is derived as the predictive model.Then the defensive guidance problem is formulated as a quadratic programming problem,and a fast algorithm for the MPC guidance law is developed.The advantages of the MPC guidance law include the applicabil-ity to scenarios with unknown guidance strategy of attacking missile,nonlinear kinematics and mul-tiple constraints.Another key feature is that the proposed approach does not require alteration in the target maneuver.Simulation results show that the MPC guidance law works well and can meet real-time requirements.展开更多
Oligosaccharins are potent biomolecules which activate defense responses and resistance in tobacco plants. However, it is not known the systemic behavior of defensive enzymes activated by these elicitors. In this work...Oligosaccharins are potent biomolecules which activate defense responses and resistance in tobacco plants. However, it is not known the systemic behavior of defensive enzymes activated by these elicitors. In this work, the dynamic behavior of key defensive enzymes was evaluated in tobacco plant leaves previously treated through the roots with chitosan polymer (CH), chitosan (COS) and pectic (OGAS) oligosaccharides and Spermine (Sp). All macromolecules tested activated protein levels and defense enzymatic activity in tobacco leaves but with different response dynamics among them and depending on the biochemical variable evaluated. Defense response above control levels were detected since 12 hours after treatments and it consisted in a biphasic behavior with two peaks for PAL (EC 4.3.1.5) and β 1 - 3 glucanase (EC 3.2.1.6) enzymatic activities. The highest enzymatic levels for these enzymes were achieved at 48 hours in plantlets elicited with COS and at 72 hours for those plants treated with chitosan polymer, while the highest POD (EC 1.11.1.6) activity was detected with CH between 48 and 72 hours. These results demonstrated systemic defense activation by oligosaccharins in tobacco whose dynamic of defense response is affected by the kind of oligosaccharins tested. When applying OGAS by foliar spray on tobacco, systemic resistance against Phytoththora nicotianae was induced and plantlets were protected with the low concentration tested by 46% under the bioassays conditions performed. Moreover, enzymatic determinations on roots and leaves previous to plant-pathogen interaction showed increments above 30% of control levels for PAL and POD activities. It means that oligosaccharins activate local and systemic defense responses in plants in the absent of pathogen infection.展开更多
Kaiping Diaolou is a special and unique architectural style of Chinese countryside dwellings. It is famous for the rare and complex fusion of Chinese and Western architectural styles. The Diaolou is also an important ...Kaiping Diaolou is a special and unique architectural style of Chinese countryside dwellings. It is famous for the rare and complex fusion of Chinese and Western architectural styles. The Diaolou is also an important historic and cultural site as it shows China’s embrace of foreign culture in a transitional period. On June 28, 2007, Kaiping Diaolou was inscribed into the world cultural heritage list.展开更多
Animals promote their survival by avoiding rapidly approaching objects that indicate threats.It is believed that looming cues are detected by retinal ganglion cells(RGCs)that project to the superior colliculus(SC).How...Animals promote their survival by avoiding rapidly approaching objects that indicate threats.It is believed that looming cues are detected by retinal ganglion cells(RGCs)that project to the superior colliculus(SC).However,the exact type of RGC that transmits looming-related signals remains unclear.Here we identify a specific transient type of RGCs that controls mouse looming-evoked defensive response by sending axonal collaterals to the dorsal raphe nucleus(DRN)and SC.Looming signals transmitted by DRN-projecting RGCs activate DRN GABA neurons and in turn inhibit serotonin neurons.Moreover,optogenetically stimulating serotonin neurons reduces looming-evoked defensive behaviors.Thus,a dedicated population of RGCs detects rapidly approaching visual threats and their input to the DRN controls a serotonergic self-gating mechanism that regulates innate defensive responses.Our study provides new insights into how DRN and SC work in concert to extract and translate visual threats into defensive behavioral responses.展开更多
The experiment was carried out to assess the reaction of different categories of rice genotypes viz., resistant, susceptible, hybrid, scented, popular and wild in response to the infestation by rice leaffolder (RLF)...The experiment was carried out to assess the reaction of different categories of rice genotypes viz., resistant, susceptible, hybrid, scented, popular and wild in response to the infestation by rice leaffolder (RLF), Cnaphalocrocis medinalis (Guenee) and to explore the possible use of these genotypes in developing RLF-resistant rice varieties. The changes of various biochemical constituents such as leaf soluble protein, phenol, ortho-dihydroxy phenol, tannin and enzymes viz., peroxidase, phenyl alanine ammonia lyase (PAL) were assessed spectrophotometrically in all the rice genotypes before and after RLF infestation. The protein profile was analyzed using sodium dodecyl sulphate-poly acrylamide gel electrophoresis (SDS-PAGE) method. A significant constituent of biochemical content such as tannin, phenol and ortho-dihydroxy phenol has been increased along with enzyme activities of peroxidase and PAL in the infested resistant (Ptb 33, TKM6 and LFR831311) and wild rice genotypes (Oryza minuta and O. rhizomatis). A decrease in leaf protein content was evident invariably in all the infested rice genotypes. It is also evident that the contents of biochemicals such as phenol, ortho- dihydroxy phenol and tannin were negatively correlated with leaffolder damage. However, leaf protein content was positively correlated with the damage by rice leaffolder. SDS-PAGE analysis for total protein profiling of healthy and C. medinalis-infested genotypes revealed the enhanced expression of a high molecular weight (〉 97 kDa) protein in all the genotypes. Besides, there was also an increased induction of a 38 kDa protein in C. medinalis infested resistant genotypes, which was absent in uninfested plants. The present investigation proved that the elevated levels of biochemicals and enzymes may play a vital role in rice plants resistance to RLF.展开更多
Objective: The objective of this study was to reduce or avoid the occurrence of the cases of osteofascial compartment syndrome induced by a radial artery puncture for arterial blood gas analysis. Methods: We analyze...Objective: The objective of this study was to reduce or avoid the occurrence of the cases of osteofascial compartment syndrome induced by a radial artery puncture for arterial blood gas analysis. Methods: We analyzed an adverse event using cheese model analysis, "fish bone" analysis, root cause analysis, and other methods. Results: There are three root causes leading to an adverse event: operation technique, assessment of the disease, and informing patient families. However, there are many reasons to promote the occurrence and development of the event. Conclusions: We should analyze and manage the adverse events in patients from the point of view of a system. Developing the measures of a system defense can enhance patient safety and create a good safety culture.展开更多
This study evaluated the expression of defense compounds from the secondary metabolism of Eucalyptus globulus plants, subjected to direct and indirect stimuli by the insect Ctenarytaina eucalypti (blue gum Psyllid). R...This study evaluated the expression of defense compounds from the secondary metabolism of Eucalyptus globulus plants, subjected to direct and indirect stimuli by the insect Ctenarytaina eucalypti (blue gum Psyllid). Results showed that defense responses were activated in plants in all tested cases. Were detected and identified thirty-two compounds in the leaves of treated plants, of which five compounds differed with the control, and all are part of the chemical defenses from the plants, three of them were oxygenated monoterpenes (borneol, exo-2-hydroxy cineole and thymol), a aromatic carboxylic acid (benzoic acid) and a quinone (6-acethyl-flaviolin). The plants induced by volatile compounds and by indirect entomological manner, showed its capability to synthesize defensive compounds without a wound that promotes these responses. Were also found some constitutive secondary metabolites over expressed in the different inductions compared with the control.展开更多
The key successful for seed priming technique was the management of seed imbibition process. This study was aimed to indicate the seed moisture sorption characteristics of Hordeum vulgare L. cv. Samerng 2 in relation ...The key successful for seed priming technique was the management of seed imbibition process. This study was aimed to indicate the seed moisture sorption characteristics of Hordeum vulgare L. cv. Samerng 2 in relation to the seed priming technique and its effect on the seed qualities. The experiment was designed by Completely Randomized Design (CRD) with four replications. Seed hydro-priming technique was done under 25 degree Celsius, and 40% - 60% RH. Barley seed moisture content was determined every hour after imbibition for 24 hours. Then, primed barley seed qualities were evaluated at 6, 8, 10, 12, 14, and 16 hours of hydrotime. The results revealed that barley seeds were imbibed rapidly from 10.55% to 37.69% seed moisture content during 0 - 9 hours of imbibition. The constantly seed moisture content was continued until 17 hours of imbibition. Radicle was protruded with 42.74% seed moisture content. Seed moisture sorption characteristic equation was Y = 0.0055x3- 0.267x2 + 4.5931x + 13.348. Coefficient of determination (R2) was 0.916. Primed seed germination was not affected by hydrotime. Primed seeds were improved in speed of germination and seedling growth rate. The best primed barley seed vigorous was noted at 14 - 16 hours of hydrotime. In addition, catalase activity (CAT) and superoxide dismutase activity (SOD) were not significantly different for non-primed and 14 - 16 hours primed seeds. However, lipoxygenase activity (LOX) was increased and malondialdehyde (MDA) content was decreased for 14 - 16 hours primed seeds. Subsequently, 14 - 16 hours primed barley seeds can maintain high seed germination and vigor for 8 - 12 months under 5 degree Celsius. Thus, it could be concluded that hydro-priming for 14 - 16 hours enhances barley seed quality by reducing germination time, induced defenses mechanism, and could be stored for 8 - 12 months.展开更多
Parvalbumin-positive retinal ganglion cells(PV+RGCs)are an essential subset of RGCs found in various species.However,their role in transmitting visual information remains unclear.Here,we characterized PV+RGCs in the r...Parvalbumin-positive retinal ganglion cells(PV+RGCs)are an essential subset of RGCs found in various species.However,their role in transmitting visual information remains unclear.Here,we characterized PV+RGCs in the retina and explored the functions of the PV+RGC-mediated visual pathway.By applying multiple viral tracing strategies,we investigated the downstream of PV+RGCs across the whole brain.Interestingly,we found that the PV+RGCs provided direct monosynaptic input to PV+excitatory neurons in the superficial layers of the superior colliculus(SC).Ablation or suppression of SC-projecting PV+RGCs abolished or severely impaired the flight response to looming visual stimuli in mice without affecting visual acuity.Furthermore,using transcriptome expression profiling of individual cells and immunofluorescence colocalization for RGCs,we found that PV+RGCs are predominant glutamatergic neurons.Thus,our findings indicate the critical role of PV+RGCs in an innate defensive response and suggest a non-canonical subcortical visual pathway from excitatory PV+RGCs to PV+SC neurons that regulates looming visual stimuli.These results provide a potential target for intervening and treating diseases related to this circuit,such as schizophrenia and autism.展开更多
Defensive behaviors induced by innate fear or Pavlovian fear conditioning are crucial for animals to avoid threats and ensure survival.The zona incerta(ZI)has been demonstrated to play important roles in fear learning...Defensive behaviors induced by innate fear or Pavlovian fear conditioning are crucial for animals to avoid threats and ensure survival.The zona incerta(ZI)has been demonstrated to play important roles in fear learning and fear memory,as well as modulating auditory-induced innate defensive behavior.However,whether the neuronal subtypes in the ZI and specific circuits can mediate the innate fear response is largely unknown.Here,we found that somatostatin(SST)-positive neurons in the rostral ZI of mice were activated by a visual innate fear stimulus.Optogenetic inhibition of SST-positive neurons in the rostral ZI resulted in reduced flight responses to an overhead looming stimulus.Optogenetic activation of SST-positive neurons in the rostral ZI induced fear-like defensive behavior including increased immobility and bradycardia.In addition,we demonstrated that manipulation of the GABAergic projections from SST-positive neurons in the rostral ZI to the downstream nucleus reuniens(Re)mediated fear-like defensive behavior.Retrograde trans-synaptic tracing also revealed looming stimulus-activated neurons in the superior colliculus(SC)that projected to the Re-projecting SST-positive neurons in the rostral ZI(SC-ZIrSST-Re pathway).Together,our study elucidates the function of SST-positive neurons in the rostral ZI and the SC-ZIrSST-Re tri-synaptic circuit in mediating the innate fear response.展开更多
Defensive traditional architecture research is critical to the understanding of the ethnic history and multiethnic villages.Currently,there are few studies on the combination of traditional architecture and multiethni...Defensive traditional architecture research is critical to the understanding of the ethnic history and multiethnic villages.Currently,there are few studies on the combination of traditional architecture and multiethnicity,and most of the defensive traditional buildings in multiethnic villages of Guangxi are facing the plight of being destroyed and abandoned.The aim of this research is to identify the spatial characteristics,commonalities,and differences of Guangxi’s defensive traditional architecture with Mozhuang Village and Guxietun Village as the examples,in order to preserve the architectural and ethnic components of these villages.This research uses the four research methods:literature review,field research,observation and space syntax analysis,and it summarizes the three results from the five aspects:plan,elevation,construction material,masonry and decoration.Results showed that the spatial characteristics are dominated by the ethnic group with the higher technological,cultural or economic level,and there are both commonalities and differences in defensive traditional architecture in multiethnic villages.Based on the three study results,this research proposes some overall suggestions toward traditional villages and architecture improvement in ethnic areas.展开更多
What recurring pattern did the interactions between imperial China and the sur-rounding regimes follow?When imperial China was economically prosperous,what kind of policies did it generally adopt toward others?The&quo...What recurring pattern did the interactions between imperial China and the sur-rounding regimes follow?When imperial China was economically prosperous,what kind of policies did it generally adopt toward others?The"Confucian long peace"continuously proclaimed by many international relations scholars and some historians may not stand up to empirical testing.The research finds that the rela-tionship between the four major dynasties of imperial China,i.e.,the Han,Tang,Ming,and Qing dynasties,and their surrounding regimes as well as their relation-ship with nomadic empires were not always peaceful.During the prosperous age of each dynasty,defensive realism more or less explained the state behavior of impe-rial China.As its economic power increased,the frequency of China's use of force also increased dramatically.As the frequency of wars greatly decreased with the end of the prosperous age,the long peace between imperial China and the surrounding regimes can be explained by the theory of hegemonic stability.This research helps us understand contemporary China's foreign relations and state behavior.展开更多
Painful stimuli elicit first-line reflexive defensive reactions and,in many cases,also evoke second-line recuperative behaviors,the latter of which reflects the sensing of tissue damage and the alleviation of sufferin...Painful stimuli elicit first-line reflexive defensive reactions and,in many cases,also evoke second-line recuperative behaviors,the latter of which reflects the sensing of tissue damage and the alleviation of suffering.The lateral parabrachial nucleus(lPBN),composed of external-(elPBN),dorsal-(dlPBN),and central/superior-subnuclei(jointly referred to as slPBN),receives sensory inputs from spinal projection neurons and plays important roles in processing affective information from external threats and body integrity disruption.However,the organizational rules of lPBN neurons that provoke diverse behaviors in response to different painful stimuli from cutaneous and deep tissues remain unclear.In this study,we used region-specific neuronal depletion or silencing approaches combined with a battery of behavioral assays to show that slPBN neurons expressing substance P receptor(NK1R)(lPBNNK1R)are crucial for driving pain-associated self-care behaviors evoked by sustained noxious thermal and mechanical stimuli applied to skin or bone/muscle,while elPBN neurons are dispensable for driving such reactions.Notably,lPBNNK1R neurons are specifically required for forming sustained somatic pain-induced negative teaching signals and aversive memory but are not necessary for fear-learning or escape behaviors elicited by external threats.Lastly,both lPBNNK1R and elPBN neurons contribute to chemical irritant-induced nocifensive reactions.Our results reveal the functional organization of parabrachial substrates that drive distinct behavioral outcomes in response to sustained pain versus external danger under physiological conditions.展开更多
Integration of primary and secondary devices are impelled by the development of smart grid. Based on the ideology of primary and secondary device integration, an all-in-one device and its concept, configuration and fu...Integration of primary and secondary devices are impelled by the development of smart grid. Based on the ideology of primary and secondary device integration, an all-in-one device and its concept, configuration and function are proposed. Then, an all-in-one device framework of distributed substation area protection is proposed. Point-topoint model and virtual local area network(VLAN) based network-to-network model are adopted in this framework.The dual redundancy on hardware and software level is realized by modularization and protection information mirroring storage/overwriting. Considering the fact that the sampling, logic judgment and information sharing processes of protection may fail in atrocious conditions, a distributed cooperative all-in-one device cluster based substation area joint defensive protection strategy is proposed. The adaptability of sectional component failure in secondary system is strengthened by reusing module function, setting value mirroring storage and dynamic load balancing computing ability to constitute strong intelligent outdoor secondary device integrated network. Finally, the simulation examples based on EPOCHS which consider various system failure conditions are presented to verify the validity and rationality of the proposed architecture and strategy.展开更多
文摘In recent scenario of Wireless Sensor Networks(WSNs),there are many application developed for handling sensitive and private data such as military information,surveillance data,tracking,etc.Hence,the sensor nodes of WSNs are distributed in an intimidating region,which is non-rigid to attacks.The recent research domains of WSN deal with models to handle the WSN communications against malicious attacks and threats.In traditional models,the solution has been made for defending the networks,only to specific attacks.However,in real-time applications,the kind of attack that is launched by the adversary is not known.Additionally,on developing a security mechanism for WSN,the resource constraints of sensor nodes are also to be considered.With that note,this paper presents an Enhanced Security Model with Improved Defensive Routing Mechanism(IDRM)for defending the sensor network from various attacks.Moreover,for efficient model design,the work includes the part of feature evaluation of some general attacks of WSNs.The IDRM also includes determination of optimal secure paths and Node security for secure routing operations.The performance of the proposed model is evaluated with respect to several factors;it is found that the model has achieved better security levels and is efficient than other existing models in WSN communications.It is proven that the proposed IDRM produces 74%of PDR in average and a minimized packet drop of 38%when comparing with the existing works.
基金funded partly by the National Key Research and Development Program of China(No.2018YFD0600203)the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)+1 种基金Innovation and Entrepreneurship Training Program for Students of Jiangsu Higher Education Institutions (SPITP)Innovation and Entrepreneurship Training Program for Students of Nanjing Forestry University (No.201710298047Z)。
文摘The pine wood nematode(PWN),Bursaphelenchus xylophilus(Steiner & Buhrer) Nickle,is the pathogen of pine wilt disease(PWD) which can devastate forests.PWN can be of hi gh or low severity and the mechanisms underlying the differences in virulence are unclear.Therefore,it is necessary to study the relationship between differentiation of PWN severity and its resistance to the main defensive substances of pine species(i.e.,α-pinene and H_(2)O_(2)).The feeding rate and fecundity of PWN was examined at different levels of virulence under conditions of a-pinene and H_(2)O_(2) stress.Moreover,the expression patterns of the main resistance genes of PWN with different virulence were determined under conditions of α-pinene and H_(2)O_(2) stress.The feeding rate and fecundity of the high virulence strain AMA3 were higher than those of the low virulence strain YW4.The expression levels of the autophagy gene BxATG5,cytochrome P450 gene BxCYP33 D3,and glutathione S-transferase genes BxGST1 and BxGST3 in AMA3 increased significantly upon exposure to α-pinene for 2 h,while these genes showed smaller degrees of upregulation in YW4.Under conditions of H_(2)O_(2) stress,the expression levels of BxATG5,catalase genes Bxy-ctl-1 and Bxy-ctl-2,and the 2-cysteine peroxiredoxin gene BxPrx in AMA3 were higher than those in YW4.These findings suggest that high virulence PWN has greater resistance to pine defensive substances α-pinene and H_(2)O_(2) than low virulence PWN,and resistance genes mediate the differential resistance of PWN strains.This study will contribute to the clarification of the mechanism underlying virulence differentiation of PWN and will advance understanding of the pathogenic mechanism of PWD.
文摘A lightning strike accident of a residential house in the rural areas of Neijiang is analyzed through on-site investigation,and the causes are discussed. Defensive measures of lightning disasters are proposed to provide reference for the prevention of lightning disasters in the construction of new countryside.
文摘The advancement of technology and the digitization of organizational functions and services have propelled the world into a new era of computing capability and sophistication. The proliferation and usability of such complex technological services raise several security concerns. One of the most critical concerns is cross-site scripting (XSS) attacks. This paper has concentrated on revealing and comprehensively analyzing XSS injection attacks, detection, and prevention concisely and accurately. I have done a thorough study and reviewed several research papers and publications with a specific focus on the researchers’ defensive techniques for preventing XSS attacks and subdivided them into five categories: machine learning techniques, server-side techniques, client-side techniques, proxy-based techniques, and combined approaches. The majority of existing cutting-edge XSS defensive approaches carefully analyzed in this paper offer protection against the traditional XSS attacks, such as stored and reflected XSS. There is currently no reliable solution to provide adequate protection against the newly discovered XSS attack known as DOM-based and mutation-based XSS attacks. After reading all of the proposed models and identifying their drawbacks, I recommend a combination of static, dynamic, and code auditing in conjunction with secure coding and continuous user awareness campaigns about XSS emerging attacks.
文摘Defensive medicine is widespread and practiced the world over, with serious consequences for patients, doctors, and healthcare costs. Even students and resi-dents are exposed to defensive medicine practices and taught to take malpractice liability into consideration when making clinical decisions. Defensive medicine is generally thought to stem from physicians' perception that they can easily be sued by patients or their relatives who seek compensation for presumed medical errors. However, in our view the growth of defensive medicine should be seen in the context of larger changes in the conception of medicine that have taken place in the last few decades, undermining the patient–physician trust, which has traditionally been the main source of professional satisfaction for physicians. These changes include the following: time directly spent with patients has been overtaken by time devoted to electronic health records and desk work; family doctors have played a progressively less central role; clinical reasoning is being replaced by guidelines and algorithms; the public at large and a number of young physicians tend to believe that medicine is a perfect science rather than an imperfect art, as it continues to be; and modern societies do not tolerate the inevitable morbidity and mortality. To finally reduce the increasing defensive behavior of doctors around the world, the decriminalization of medical errors and the assurance that they can be dealt with in civil courts or by medical organizations in all countries could help but it would not suffice. Physicians and surgeons should be allowed to spend the time they need with their patients and should give clinical reasoning the importance it deserves. The institutions should support the doctors who have experienced adverse patient events, and the media should stop reporting with excessive evidence presumed medical errors and subject physicians to "public trials" before they are eventually judged in court.
基金supported financially by the National Science Fund for Distinguished Young Scholars(31525005)the NSFC-Yunnan Joint Fund (U1202263)+1 种基金the National Basic Research Program of China (973 Program) on Biological Control of Key Crop Pathogenic Nematodes (2013CB127505)the "Hundred Talents Program" of the Chinese Academy of Sciences (awarded to S.-H. Li)
文摘Glandular trichomes of plants produce a wide variety of secondary metabolites which are considered as major defensive chemicals. The capitate glandular trichomes of Oenothera glazioviana(Onagraceae) were collected with laser microdissection and analyzed by gas chromatography-mass spectrometry. The volatile compound 4-hydroxy-4-methylpentan-2-one(1) was identified. We found that compound 1 displays antimicrobial, insecticidal, and phytotoxic activities. These results suggest that compound 1 might function as a defensive compound in the capitate glandular trichomes of O. glazioviana against pathogens, insect herbivores, and presumably competitive plants as well.
基金supported by the National Natural Science Foundation of China(No.61673146)Zhejiang Provincial University Research Foundation(GK209907299001-021).
文摘Model predictive control(MPC)has been widely used in process industry,but its appli-cations to missile guidance law are relatively rare.In this paper,MPC is introduced to design defen-sive guidance law in a three-body engagement,where a defending missile(i.e.,defender)is employed to protect a target aircraft from an attacking missile.Based on nonlinear kinematic equa-tions,an explicit linear discrete-time model is derived as the predictive model.Then the defensive guidance problem is formulated as a quadratic programming problem,and a fast algorithm for the MPC guidance law is developed.The advantages of the MPC guidance law include the applicabil-ity to scenarios with unknown guidance strategy of attacking missile,nonlinear kinematics and mul-tiple constraints.Another key feature is that the proposed approach does not require alteration in the target maneuver.Simulation results show that the MPC guidance law works well and can meet real-time requirements.
文摘Oligosaccharins are potent biomolecules which activate defense responses and resistance in tobacco plants. However, it is not known the systemic behavior of defensive enzymes activated by these elicitors. In this work, the dynamic behavior of key defensive enzymes was evaluated in tobacco plant leaves previously treated through the roots with chitosan polymer (CH), chitosan (COS) and pectic (OGAS) oligosaccharides and Spermine (Sp). All macromolecules tested activated protein levels and defense enzymatic activity in tobacco leaves but with different response dynamics among them and depending on the biochemical variable evaluated. Defense response above control levels were detected since 12 hours after treatments and it consisted in a biphasic behavior with two peaks for PAL (EC 4.3.1.5) and β 1 - 3 glucanase (EC 3.2.1.6) enzymatic activities. The highest enzymatic levels for these enzymes were achieved at 48 hours in plantlets elicited with COS and at 72 hours for those plants treated with chitosan polymer, while the highest POD (EC 1.11.1.6) activity was detected with CH between 48 and 72 hours. These results demonstrated systemic defense activation by oligosaccharins in tobacco whose dynamic of defense response is affected by the kind of oligosaccharins tested. When applying OGAS by foliar spray on tobacco, systemic resistance against Phytoththora nicotianae was induced and plantlets were protected with the low concentration tested by 46% under the bioassays conditions performed. Moreover, enzymatic determinations on roots and leaves previous to plant-pathogen interaction showed increments above 30% of control levels for PAL and POD activities. It means that oligosaccharins activate local and systemic defense responses in plants in the absent of pathogen infection.
文摘Kaiping Diaolou is a special and unique architectural style of Chinese countryside dwellings. It is famous for the rare and complex fusion of Chinese and Western architectural styles. The Diaolou is also an important historic and cultural site as it shows China’s embrace of foreign culture in a transitional period. On June 28, 2007, Kaiping Diaolou was inscribed into the world cultural heritage list.
文摘Animals promote their survival by avoiding rapidly approaching objects that indicate threats.It is believed that looming cues are detected by retinal ganglion cells(RGCs)that project to the superior colliculus(SC).However,the exact type of RGC that transmits looming-related signals remains unclear.Here we identify a specific transient type of RGCs that controls mouse looming-evoked defensive response by sending axonal collaterals to the dorsal raphe nucleus(DRN)and SC.Looming signals transmitted by DRN-projecting RGCs activate DRN GABA neurons and in turn inhibit serotonin neurons.Moreover,optogenetically stimulating serotonin neurons reduces looming-evoked defensive behaviors.Thus,a dedicated population of RGCs detects rapidly approaching visual threats and their input to the DRN controls a serotonergic self-gating mechanism that regulates innate defensive responses.Our study provides new insights into how DRN and SC work in concert to extract and translate visual threats into defensive behavioral responses.
文摘The experiment was carried out to assess the reaction of different categories of rice genotypes viz., resistant, susceptible, hybrid, scented, popular and wild in response to the infestation by rice leaffolder (RLF), Cnaphalocrocis medinalis (Guenee) and to explore the possible use of these genotypes in developing RLF-resistant rice varieties. The changes of various biochemical constituents such as leaf soluble protein, phenol, ortho-dihydroxy phenol, tannin and enzymes viz., peroxidase, phenyl alanine ammonia lyase (PAL) were assessed spectrophotometrically in all the rice genotypes before and after RLF infestation. The protein profile was analyzed using sodium dodecyl sulphate-poly acrylamide gel electrophoresis (SDS-PAGE) method. A significant constituent of biochemical content such as tannin, phenol and ortho-dihydroxy phenol has been increased along with enzyme activities of peroxidase and PAL in the infested resistant (Ptb 33, TKM6 and LFR831311) and wild rice genotypes (Oryza minuta and O. rhizomatis). A decrease in leaf protein content was evident invariably in all the infested rice genotypes. It is also evident that the contents of biochemicals such as phenol, ortho- dihydroxy phenol and tannin were negatively correlated with leaffolder damage. However, leaf protein content was positively correlated with the damage by rice leaffolder. SDS-PAGE analysis for total protein profiling of healthy and C. medinalis-infested genotypes revealed the enhanced expression of a high molecular weight (〉 97 kDa) protein in all the genotypes. Besides, there was also an increased induction of a 38 kDa protein in C. medinalis infested resistant genotypes, which was absent in uninfested plants. The present investigation proved that the elevated levels of biochemicals and enzymes may play a vital role in rice plants resistance to RLF.
文摘Objective: The objective of this study was to reduce or avoid the occurrence of the cases of osteofascial compartment syndrome induced by a radial artery puncture for arterial blood gas analysis. Methods: We analyzed an adverse event using cheese model analysis, "fish bone" analysis, root cause analysis, and other methods. Results: There are three root causes leading to an adverse event: operation technique, assessment of the disease, and informing patient families. However, there are many reasons to promote the occurrence and development of the event. Conclusions: We should analyze and manage the adverse events in patients from the point of view of a system. Developing the measures of a system defense can enhance patient safety and create a good safety culture.
文摘This study evaluated the expression of defense compounds from the secondary metabolism of Eucalyptus globulus plants, subjected to direct and indirect stimuli by the insect Ctenarytaina eucalypti (blue gum Psyllid). Results showed that defense responses were activated in plants in all tested cases. Were detected and identified thirty-two compounds in the leaves of treated plants, of which five compounds differed with the control, and all are part of the chemical defenses from the plants, three of them were oxygenated monoterpenes (borneol, exo-2-hydroxy cineole and thymol), a aromatic carboxylic acid (benzoic acid) and a quinone (6-acethyl-flaviolin). The plants induced by volatile compounds and by indirect entomological manner, showed its capability to synthesize defensive compounds without a wound that promotes these responses. Were also found some constitutive secondary metabolites over expressed in the different inductions compared with the control.
文摘The key successful for seed priming technique was the management of seed imbibition process. This study was aimed to indicate the seed moisture sorption characteristics of Hordeum vulgare L. cv. Samerng 2 in relation to the seed priming technique and its effect on the seed qualities. The experiment was designed by Completely Randomized Design (CRD) with four replications. Seed hydro-priming technique was done under 25 degree Celsius, and 40% - 60% RH. Barley seed moisture content was determined every hour after imbibition for 24 hours. Then, primed barley seed qualities were evaluated at 6, 8, 10, 12, 14, and 16 hours of hydrotime. The results revealed that barley seeds were imbibed rapidly from 10.55% to 37.69% seed moisture content during 0 - 9 hours of imbibition. The constantly seed moisture content was continued until 17 hours of imbibition. Radicle was protruded with 42.74% seed moisture content. Seed moisture sorption characteristic equation was Y = 0.0055x3- 0.267x2 + 4.5931x + 13.348. Coefficient of determination (R2) was 0.916. Primed seed germination was not affected by hydrotime. Primed seeds were improved in speed of germination and seedling growth rate. The best primed barley seed vigorous was noted at 14 - 16 hours of hydrotime. In addition, catalase activity (CAT) and superoxide dismutase activity (SOD) were not significantly different for non-primed and 14 - 16 hours primed seeds. However, lipoxygenase activity (LOX) was increased and malondialdehyde (MDA) content was decreased for 14 - 16 hours primed seeds. Subsequently, 14 - 16 hours primed barley seeds can maintain high seed germination and vigor for 8 - 12 months under 5 degree Celsius. Thus, it could be concluded that hydro-priming for 14 - 16 hours enhances barley seed quality by reducing germination time, induced defenses mechanism, and could be stored for 8 - 12 months.
基金supported by grants from the National Key R&D Program of China(2017YFE0103400)the National Nature Science Foundation of China(81470628).
文摘Parvalbumin-positive retinal ganglion cells(PV+RGCs)are an essential subset of RGCs found in various species.However,their role in transmitting visual information remains unclear.Here,we characterized PV+RGCs in the retina and explored the functions of the PV+RGC-mediated visual pathway.By applying multiple viral tracing strategies,we investigated the downstream of PV+RGCs across the whole brain.Interestingly,we found that the PV+RGCs provided direct monosynaptic input to PV+excitatory neurons in the superficial layers of the superior colliculus(SC).Ablation or suppression of SC-projecting PV+RGCs abolished or severely impaired the flight response to looming visual stimuli in mice without affecting visual acuity.Furthermore,using transcriptome expression profiling of individual cells and immunofluorescence colocalization for RGCs,we found that PV+RGCs are predominant glutamatergic neurons.Thus,our findings indicate the critical role of PV+RGCs in an innate defensive response and suggest a non-canonical subcortical visual pathway from excitatory PV+RGCs to PV+SC neurons that regulates looming visual stimuli.These results provide a potential target for intervening and treating diseases related to this circuit,such as schizophrenia and autism.
基金supported by the Science and Technology Innovation 2030-Major Project of Brain Science and Brain-like Research(2021ZD0202700,2021ZD0202702)the Key-Area Research and Development Program of Guangdong Province(2019B030335001,2018B030334001)+6 种基金the Major Program of the National Natural Science Foundation of China(82090030,82090031)the CAMS Innovation Fund for Medical Sciences(2019-12M-5-057)the Ministry of Science and Technology(2019YFA0110103)the National Natural Science Foundation of China(81870898)the Fundamental Research Funds for the Central Universities(2021FZZX001-37)the Zhejiang Provincial Natural Science Foundation(LR18H090002)the Young Scientist Program of the National Natural Science Foundation of China(82001135).
文摘Defensive behaviors induced by innate fear or Pavlovian fear conditioning are crucial for animals to avoid threats and ensure survival.The zona incerta(ZI)has been demonstrated to play important roles in fear learning and fear memory,as well as modulating auditory-induced innate defensive behavior.However,whether the neuronal subtypes in the ZI and specific circuits can mediate the innate fear response is largely unknown.Here,we found that somatostatin(SST)-positive neurons in the rostral ZI of mice were activated by a visual innate fear stimulus.Optogenetic inhibition of SST-positive neurons in the rostral ZI resulted in reduced flight responses to an overhead looming stimulus.Optogenetic activation of SST-positive neurons in the rostral ZI induced fear-like defensive behavior including increased immobility and bradycardia.In addition,we demonstrated that manipulation of the GABAergic projections from SST-positive neurons in the rostral ZI to the downstream nucleus reuniens(Re)mediated fear-like defensive behavior.Retrograde trans-synaptic tracing also revealed looming stimulus-activated neurons in the superior colliculus(SC)that projected to the Re-projecting SST-positive neurons in the rostral ZI(SC-ZIrSST-Re pathway).Together,our study elucidates the function of SST-positive neurons in the rostral ZI and the SC-ZIrSST-Re tri-synaptic circuit in mediating the innate fear response.
文摘Defensive traditional architecture research is critical to the understanding of the ethnic history and multiethnic villages.Currently,there are few studies on the combination of traditional architecture and multiethnicity,and most of the defensive traditional buildings in multiethnic villages of Guangxi are facing the plight of being destroyed and abandoned.The aim of this research is to identify the spatial characteristics,commonalities,and differences of Guangxi’s defensive traditional architecture with Mozhuang Village and Guxietun Village as the examples,in order to preserve the architectural and ethnic components of these villages.This research uses the four research methods:literature review,field research,observation and space syntax analysis,and it summarizes the three results from the five aspects:plan,elevation,construction material,masonry and decoration.Results showed that the spatial characteristics are dominated by the ethnic group with the higher technological,cultural or economic level,and there are both commonalities and differences in defensive traditional architecture in multiethnic villages.Based on the three study results,this research proposes some overall suggestions toward traditional villages and architecture improvement in ethnic areas.
文摘What recurring pattern did the interactions between imperial China and the sur-rounding regimes follow?When imperial China was economically prosperous,what kind of policies did it generally adopt toward others?The"Confucian long peace"continuously proclaimed by many international relations scholars and some historians may not stand up to empirical testing.The research finds that the rela-tionship between the four major dynasties of imperial China,i.e.,the Han,Tang,Ming,and Qing dynasties,and their surrounding regimes as well as their relation-ship with nomadic empires were not always peaceful.During the prosperous age of each dynasty,defensive realism more or less explained the state behavior of impe-rial China.As its economic power increased,the frequency of China's use of force also increased dramatically.As the frequency of wars greatly decreased with the end of the prosperous age,the long peace between imperial China and the surrounding regimes can be explained by the theory of hegemonic stability.This research helps us understand contemporary China's foreign relations and state behavior.
基金supported by the Shenzhen Key Laboratory of Drug Addiction (ZDSYS20190902093601675)CAS Key Laboratory of Brain Connectome and Manipulation (2019DP173024)+2 种基金National Natural Science Foundation of China (82274358)Shenzhen-Hong Kong Institute of Brain ScienceGuangdong Basic and Applied Basic Research Foundation (2023B1515040009)
文摘Painful stimuli elicit first-line reflexive defensive reactions and,in many cases,also evoke second-line recuperative behaviors,the latter of which reflects the sensing of tissue damage and the alleviation of suffering.The lateral parabrachial nucleus(lPBN),composed of external-(elPBN),dorsal-(dlPBN),and central/superior-subnuclei(jointly referred to as slPBN),receives sensory inputs from spinal projection neurons and plays important roles in processing affective information from external threats and body integrity disruption.However,the organizational rules of lPBN neurons that provoke diverse behaviors in response to different painful stimuli from cutaneous and deep tissues remain unclear.In this study,we used region-specific neuronal depletion or silencing approaches combined with a battery of behavioral assays to show that slPBN neurons expressing substance P receptor(NK1R)(lPBNNK1R)are crucial for driving pain-associated self-care behaviors evoked by sustained noxious thermal and mechanical stimuli applied to skin or bone/muscle,while elPBN neurons are dispensable for driving such reactions.Notably,lPBNNK1R neurons are specifically required for forming sustained somatic pain-induced negative teaching signals and aversive memory but are not necessary for fear-learning or escape behaviors elicited by external threats.Lastly,both lPBNNK1R and elPBN neurons contribute to chemical irritant-induced nocifensive reactions.Our results reveal the functional organization of parabrachial substrates that drive distinct behavioral outcomes in response to sustained pain versus external danger under physiological conditions.
基金supported by the Science and Technology Project of State Grid Corporation of China(research and development of novel framework based protection adaptive to the evolution of substation and power grid)
文摘Integration of primary and secondary devices are impelled by the development of smart grid. Based on the ideology of primary and secondary device integration, an all-in-one device and its concept, configuration and function are proposed. Then, an all-in-one device framework of distributed substation area protection is proposed. Point-topoint model and virtual local area network(VLAN) based network-to-network model are adopted in this framework.The dual redundancy on hardware and software level is realized by modularization and protection information mirroring storage/overwriting. Considering the fact that the sampling, logic judgment and information sharing processes of protection may fail in atrocious conditions, a distributed cooperative all-in-one device cluster based substation area joint defensive protection strategy is proposed. The adaptability of sectional component failure in secondary system is strengthened by reusing module function, setting value mirroring storage and dynamic load balancing computing ability to constitute strong intelligent outdoor secondary device integrated network. Finally, the simulation examples based on EPOCHS which consider various system failure conditions are presented to verify the validity and rationality of the proposed architecture and strategy.