To evaluate the comparative activity of seven oral antimicrobial agents against 100 strains of Streptococcus pneumoniae (S pneumoniae) Methods Total 100 strains of S pneumoniae were collected from gener...To evaluate the comparative activity of seven oral antimicrobial agents against 100 strains of Streptococcus pneumoniae (S pneumoniae) Methods Total 100 strains of S pneumoniae were collected from general hospitals in Beijing from June 1996 to June 1997 E test method was used to detect the minimum inhibitory concentration (MIC) values of the following seven drugs against S pneumoniae : penicillin, amoxicillin/clavulanate, cefaclor, cefuroxime, ceftriaxone, azithromycin and ofloxacin The breakpoint of susceptibility categories was defined according to NCCLS Results 74% of isolates were susceptible (S, MIC 0 06?mg/L) to penicillin, and 5% were penicillin resistant (R, MIC 2?mg/L). The intermediately resistant (I, MIC 0 1-1?mg/L) rate to penicillin was 21% The total rates of R or I were 26% for penicillin, 6% for both amoxicillin/clavulanate and ceftriaxone, 9% for cefuroxime, 66% and 68% for azithromycin and ofloxacin respectively Overall 94%, 94% and 91% of the pneumococcal isolates were susceptible to amoxicillin/clavulanate, ceftriaxone and cefuroxime respectively S pneumoniae was highly resistant to azithromycin tested as a representative of macrolides (MIC 50 and MIC 90 both >256?mg/L, R rate 66%), and had a highly intermediately resistant rate to ofloxacin (I rate 62%) Conclusions Our data suggest that in vitro activity of oral amoxicillin/clavulanate was as good as ceftriaxone and cefuroxime It can be considered as an alternative compound in the treatment of community acquired pneumoniae and other respiratory tract infections caused by multiresistant S pneumoniae展开更多
文摘To evaluate the comparative activity of seven oral antimicrobial agents against 100 strains of Streptococcus pneumoniae (S pneumoniae) Methods Total 100 strains of S pneumoniae were collected from general hospitals in Beijing from June 1996 to June 1997 E test method was used to detect the minimum inhibitory concentration (MIC) values of the following seven drugs against S pneumoniae : penicillin, amoxicillin/clavulanate, cefaclor, cefuroxime, ceftriaxone, azithromycin and ofloxacin The breakpoint of susceptibility categories was defined according to NCCLS Results 74% of isolates were susceptible (S, MIC 0 06?mg/L) to penicillin, and 5% were penicillin resistant (R, MIC 2?mg/L). The intermediately resistant (I, MIC 0 1-1?mg/L) rate to penicillin was 21% The total rates of R or I were 26% for penicillin, 6% for both amoxicillin/clavulanate and ceftriaxone, 9% for cefuroxime, 66% and 68% for azithromycin and ofloxacin respectively Overall 94%, 94% and 91% of the pneumococcal isolates were susceptible to amoxicillin/clavulanate, ceftriaxone and cefuroxime respectively S pneumoniae was highly resistant to azithromycin tested as a representative of macrolides (MIC 50 and MIC 90 both >256?mg/L, R rate 66%), and had a highly intermediately resistant rate to ofloxacin (I rate 62%) Conclusions Our data suggest that in vitro activity of oral amoxicillin/clavulanate was as good as ceftriaxone and cefuroxime It can be considered as an alternative compound in the treatment of community acquired pneumoniae and other respiratory tract infections caused by multiresistant S pneumoniae
基金基金项目：国家重点基础研究发展计划（973计划）资助项目（2011CB933202）中围科学院战略性先导科技专项课题资助项目（XDA06020101）+3 种基金国家杰出青年自然基金资助项目（61125105）国家高技术研究发展计划（863计划）资助项目（2009AA03Z411）中国科学院科研装备研制资助项目（Y2010015）国家自然科学基金资助项目（61027001,61002037）.Acknowledgements This work was supported by the Major National Scientific Research Plan （No.2011CB933202）, ＂Strategic Priority Research Program＂ of the Chinese Academy of Sciences （No.XDA06020101）, the National Science Fund for Distinguished Young Scholar （No. 61125105）, the Hi-Tech R＆D Program of China （No. 2009AA03Z411）, the CAS Program （No.Y2010015） and the National Natural Science Foundation of China （No. 61027001, No. 61002037）.
