Hepatitis B virus (HBV) infection is a major public health problem worldwide. The aim of this study was to document the dynamics of HBV viral load during the follow-up of chronic hepatitis B patients at the Saint Cami...Hepatitis B virus (HBV) infection is a major public health problem worldwide. The aim of this study was to document the dynamics of HBV viral load during the follow-up of chronic hepatitis B patients at the Saint Camille Hospital in Ouagadougou (HOSCO) from 2017 to 2021. This descriptive retrospective study was carried out in the Hepato-Gastro-Enterology Department of HOSCO and focused on patients who were undergoing treatment for chronic viral hepatitis B. A total of 260 cases of chronic hepatitis B were included in the study. The most affected age group was 21 to 30 years, accounting for 48.08% of the cases. Lifestyle factors included alcohol consumption (3.08%) and tobacco use (2.69%). Major risk factors for transmission included lack of vaccination (98.46%), family history of HBV infection (68.00%) and engagement in high-risk activities (28.00%). Patients requiring treatment were prescribed Tenofovir 300 mg tablets. FibroScan<sup>®</sup> showed the presence of stage F3-F4 fibrosis (2.14%) and S3 steatosis (13.33%). After one year of follow-up, 6.92% of patients achieved an undetectable viral load with normalized transaminase levels. The majority of other patients had a detectable viral load but below 20,000 IU/mL. The prevalence of viral hepatitis B remains significant worldwide. Although effective and well-monitored treatment can lead to undetectable viremia, prevention remains the most effective strategy for successful management of this disease.展开更多
为准确模拟桥址随机车流荷载,提出基于可变元胞与跟驰理论的元胞自动机(cellular automata,CA)模型。首先,重新定义元胞构成,提出以车辆为核心的动态可变元胞,并将精确的轴间距和轴重信息融入车辆元胞,实现车辆荷载的精确模拟;然后,引...为准确模拟桥址随机车流荷载,提出基于可变元胞与跟驰理论的元胞自动机(cellular automata,CA)模型。首先,重新定义元胞构成,提出以车辆为核心的动态可变元胞,并将精确的轴间距和轴重信息融入车辆元胞,实现车辆荷载的精确模拟;然后,引入跟驰理论,提出基于跟驰理论的状态演化规则,推导每辆车的专有加速度,实现车辆微观交互的模拟;最后,提出基于实测动态称重系统(weigh in motion,WIM)数据的发车规则,依据WIM数据,重构任意时段的实际车队,并建立基于车头时距的发车规则,重现车辆通过WIM时的运动状态。基于所提出的发车规则和动态演化规则,实现车辆从进入道路到驶离道路全过程时空位置的准确模拟,结合融入精确轴载的车辆元胞,实现随机车流荷载的模拟。基于实测WIM数据验证所提模型的可行性和先进性。结果表明:可变元胞可以精确模拟车辆荷载;提出的状态演化规则可以根据不同车辆的运动状态计算得到每辆车的专属加速度,准确模拟每辆车在自由行驶和跟驰行驶时的不同运动状态;新发车规则可以重构任意时段的实测车队,结合新状态演化规则,可以实现桥址任意时段随机车流的模拟。结合精细化车辆荷载模拟和合理的车流模拟,可实现桥址随机车流荷载模拟。展开更多
The non-linear dynamic behaviors of thermoelastic circular plate with varying thickness subjected to radially uniformly distributed follower forces are considered. Two coupled non-linear differential equations of moti...The non-linear dynamic behaviors of thermoelastic circular plate with varying thickness subjected to radially uniformly distributed follower forces are considered. Two coupled non-linear differential equations of motion for this problem are derived in terms of the transverse deflection and radial displacement component of the mid-plane of the plate. Using the Kantorovich averaging method, the differential equation of mode shape of the plate is derived, and the eigenvalue problem is solved by using shooting method. The eigencurves for frequencies and critical loads of the circular plate with unmovable simply supported edge and clamped edge are obtained. The effects of the variation of thickness and temperature on the frequencies and critical loads of the thermoelastic circular plate subjected to radially uniformly distributed follower forces are then discussed.展开更多
温控负荷(thermostatically controlled loads,TCLs)集群作为一种灵活的可调度资源,已成为促进电网经济运行和帮助电网恢复稳定的有力手段之一。然而,由于温控负荷单体功率小、位置分散且参数各异,给调度带来了困难。为了灵活利用数量...温控负荷(thermostatically controlled loads,TCLs)集群作为一种灵活的可调度资源,已成为促进电网经济运行和帮助电网恢复稳定的有力手段之一。然而,由于温控负荷单体功率小、位置分散且参数各异,给调度带来了困难。为了灵活利用数量庞大的负荷侧资源进行负荷跟随控制,该文建立温控负荷的虚拟电池模型和负荷集群的聚合模型,并提出基于双层分布式通信网络的控制策略。上层利用分布式交替方向乘子法(alternating direction method of multipliers,ADMM)来解决不同负荷聚合器的最佳跟随功率问题,以确保跟随效益最优;下层提出基于快速分布式平均一致性算法的深度神经网络(deep neural networks,DNN)的方法,使得聚合器内部的所有温控负荷以相等的虚拟电池荷电状态(state of charge,SoC)快速共享上层得到的跟随功率,并有效减少了通信数据量。不同时间尺度的算例验证提出的控制策略能够实现快速的负荷跟随,并保证用户侧的效益。展开更多
文摘Hepatitis B virus (HBV) infection is a major public health problem worldwide. The aim of this study was to document the dynamics of HBV viral load during the follow-up of chronic hepatitis B patients at the Saint Camille Hospital in Ouagadougou (HOSCO) from 2017 to 2021. This descriptive retrospective study was carried out in the Hepato-Gastro-Enterology Department of HOSCO and focused on patients who were undergoing treatment for chronic viral hepatitis B. A total of 260 cases of chronic hepatitis B were included in the study. The most affected age group was 21 to 30 years, accounting for 48.08% of the cases. Lifestyle factors included alcohol consumption (3.08%) and tobacco use (2.69%). Major risk factors for transmission included lack of vaccination (98.46%), family history of HBV infection (68.00%) and engagement in high-risk activities (28.00%). Patients requiring treatment were prescribed Tenofovir 300 mg tablets. FibroScan<sup>®</sup> showed the presence of stage F3-F4 fibrosis (2.14%) and S3 steatosis (13.33%). After one year of follow-up, 6.92% of patients achieved an undetectable viral load with normalized transaminase levels. The majority of other patients had a detectable viral load but below 20,000 IU/mL. The prevalence of viral hepatitis B remains significant worldwide. Although effective and well-monitored treatment can lead to undetectable viremia, prevention remains the most effective strategy for successful management of this disease.
文摘为准确模拟桥址随机车流荷载,提出基于可变元胞与跟驰理论的元胞自动机(cellular automata,CA)模型。首先,重新定义元胞构成,提出以车辆为核心的动态可变元胞,并将精确的轴间距和轴重信息融入车辆元胞,实现车辆荷载的精确模拟;然后,引入跟驰理论,提出基于跟驰理论的状态演化规则,推导每辆车的专有加速度,实现车辆微观交互的模拟;最后,提出基于实测动态称重系统(weigh in motion,WIM)数据的发车规则,依据WIM数据,重构任意时段的实际车队,并建立基于车头时距的发车规则,重现车辆通过WIM时的运动状态。基于所提出的发车规则和动态演化规则,实现车辆从进入道路到驶离道路全过程时空位置的准确模拟,结合融入精确轴载的车辆元胞,实现随机车流荷载的模拟。基于实测WIM数据验证所提模型的可行性和先进性。结果表明:可变元胞可以精确模拟车辆荷载;提出的状态演化规则可以根据不同车辆的运动状态计算得到每辆车的专属加速度,准确模拟每辆车在自由行驶和跟驰行驶时的不同运动状态;新发车规则可以重构任意时段的实测车队,结合新状态演化规则,可以实现桥址任意时段随机车流的模拟。结合精细化车辆荷载模拟和合理的车流模拟,可实现桥址随机车流荷载模拟。
基金Natural Science Research Project of Education Department of Shaanxi Province,China(No.08JK394).
文摘The non-linear dynamic behaviors of thermoelastic circular plate with varying thickness subjected to radially uniformly distributed follower forces are considered. Two coupled non-linear differential equations of motion for this problem are derived in terms of the transverse deflection and radial displacement component of the mid-plane of the plate. Using the Kantorovich averaging method, the differential equation of mode shape of the plate is derived, and the eigenvalue problem is solved by using shooting method. The eigencurves for frequencies and critical loads of the circular plate with unmovable simply supported edge and clamped edge are obtained. The effects of the variation of thickness and temperature on the frequencies and critical loads of the thermoelastic circular plate subjected to radially uniformly distributed follower forces are then discussed.
文摘温控负荷(thermostatically controlled loads,TCLs)集群作为一种灵活的可调度资源,已成为促进电网经济运行和帮助电网恢复稳定的有力手段之一。然而,由于温控负荷单体功率小、位置分散且参数各异,给调度带来了困难。为了灵活利用数量庞大的负荷侧资源进行负荷跟随控制,该文建立温控负荷的虚拟电池模型和负荷集群的聚合模型,并提出基于双层分布式通信网络的控制策略。上层利用分布式交替方向乘子法(alternating direction method of multipliers,ADMM)来解决不同负荷聚合器的最佳跟随功率问题,以确保跟随效益最优;下层提出基于快速分布式平均一致性算法的深度神经网络(deep neural networks,DNN)的方法,使得聚合器内部的所有温控负荷以相等的虚拟电池荷电状态(state of charge,SoC)快速共享上层得到的跟随功率,并有效减少了通信数据量。不同时间尺度的算例验证提出的控制策略能够实现快速的负荷跟随,并保证用户侧的效益。
