BACKGROUND A few reports have revealed induction of rhabdomyolysis by a red yeast rice(RYR)supplement or by RYR in combination with abiraterone(an androgen biosynthesis inhibitor).CASE SUMMARY A 76-year-old man presen...BACKGROUND A few reports have revealed induction of rhabdomyolysis by a red yeast rice(RYR)supplement or by RYR in combination with abiraterone(an androgen biosynthesis inhibitor).CASE SUMMARY A 76-year-old man presented with progressive limb weakness,muscle soreness,and acute kidney injury(AKI).He had been taking the anti-prostate cancer drug abiraterone for 14 mo and had added a RYR supplement 3 mo before symptom onset.After being diagnosed with rhabdomyolysis-induced AKI,the patient discontinued these drugs and responded well to hemodialysis and hemoperfusion.After 23 d of treatment,creatine kinase levels returned to normal and serum creatinine levels decreased.CONCLUSION We speculate that statins,the main lipid-lowering component of RYR,or a combination of statins and abiraterone,will increase the risk of rhabdomyolysis.展开更多
Aim To establish a sensitive and specific liquid chromatography-mass spectrometry (HPLC-MS) method for measuring lovastatin level in human plasma and the relative bioavailability. Methods Lovastatin in the plasma was ...Aim To establish a sensitive and specific liquid chromatography-mass spectrometry (HPLC-MS) method for measuring lovastatin level in human plasma and the relative bioavailability. Methods Lovastatin in the plasma was extracted with acetoacetate. Simvastatin was added as internal standard (IS). Samples were separated on a C_ 18 column with a mobile phase consisting of methanol and 50 mmol·L~ -1 sodium acetate (88 ∶ 12). The flow rate was 1 mL·min~ -1 . Sample was detected using an electrospray ionization (ES...展开更多
A morphologically structured model is proposed to describe the batch fermentation of lovastatin according to the growth kinetics of filamentous microorganisms. Three kinds of hyphae are considered in the model: active...A morphologically structured model is proposed to describe the batch fermentation of lovastatin according to the growth kinetics of filamentous microorganisms. Three kinds of hyphae are considered in the model: actively growing hyphae, non-growing hyphae and deactivated hyphae. Furthermore, actively growing hyphae consist of three morphological compartments: apical compartment which gives rise to hyphal tip extension; subapical compartment which is related to hyphal branching; and hyphal compartment which is only responsible for secondary metabolite formation. The kinetics of mycelial growth mechanism is summarized and applied in modeling lovastatin fermentation. A Michaelis-Menten kinetic model with substrate inhibition is proposed for product formation. As expected, the model simulations fit well with experimental data obtained either from a laboratory scale 10L fer-menter or from a pilot-plant scale fermenter.展开更多
基金Supported by the Natural Science Foundation of Shandong Province,No.ZR2021QH110.
文摘BACKGROUND A few reports have revealed induction of rhabdomyolysis by a red yeast rice(RYR)supplement or by RYR in combination with abiraterone(an androgen biosynthesis inhibitor).CASE SUMMARY A 76-year-old man presented with progressive limb weakness,muscle soreness,and acute kidney injury(AKI).He had been taking the anti-prostate cancer drug abiraterone for 14 mo and had added a RYR supplement 3 mo before symptom onset.After being diagnosed with rhabdomyolysis-induced AKI,the patient discontinued these drugs and responded well to hemodialysis and hemoperfusion.After 23 d of treatment,creatine kinase levels returned to normal and serum creatinine levels decreased.CONCLUSION We speculate that statins,the main lipid-lowering component of RYR,or a combination of statins and abiraterone,will increase the risk of rhabdomyolysis.
文摘Aim To establish a sensitive and specific liquid chromatography-mass spectrometry (HPLC-MS) method for measuring lovastatin level in human plasma and the relative bioavailability. Methods Lovastatin in the plasma was extracted with acetoacetate. Simvastatin was added as internal standard (IS). Samples were separated on a C_ 18 column with a mobile phase consisting of methanol and 50 mmol·L~ -1 sodium acetate (88 ∶ 12). The flow rate was 1 mL·min~ -1 . Sample was detected using an electrospray ionization (ES...
文摘A morphologically structured model is proposed to describe the batch fermentation of lovastatin according to the growth kinetics of filamentous microorganisms. Three kinds of hyphae are considered in the model: actively growing hyphae, non-growing hyphae and deactivated hyphae. Furthermore, actively growing hyphae consist of three morphological compartments: apical compartment which gives rise to hyphal tip extension; subapical compartment which is related to hyphal branching; and hyphal compartment which is only responsible for secondary metabolite formation. The kinetics of mycelial growth mechanism is summarized and applied in modeling lovastatin fermentation. A Michaelis-Menten kinetic model with substrate inhibition is proposed for product formation. As expected, the model simulations fit well with experimental data obtained either from a laboratory scale 10L fer-menter or from a pilot-plant scale fermenter.
