An organocatalytic asymmetric branching sequence was realized in the presence of 10 mol% of （DHQD）2AQN, affording the sequential products with three stereocentres, including two quaternary carbon centres, in 47%-79%...An organocatalytic asymmetric branching sequence was realized in the presence of 10 mol% of （DHQD）2AQN, affording the sequential products with three stereocentres, including two quaternary carbon centres, in 47%-79% yields with 85%-99% ee.展开更多
The enantioselective O-allylic alkylation of acetophenone oxime with various Morita-Baylis-Hillman (MBH) carbonates has been accomplished by the catalysis of a commercially available cinchona alkaloid (DHQD)2PHAL. The...The enantioselective O-allylic alkylation of acetophenone oxime with various Morita-Baylis-Hillman (MBH) carbonates has been accomplished by the catalysis of a commercially available cinchona alkaloid (DHQD)2PHAL. The corresponding O-allylic products were obtained in moderate to excellent yields up to 96% ee.展开更多
The asymmetric allylic alkylation reaction of sulfonylimidates with various Morita-Baylis-Hillman (MBH) carbonates was accomplished by the catalysis of commercially available cinchona alkaloids catalyst (DHQD)2AQN.The...The asymmetric allylic alkylation reaction of sulfonylimidates with various Morita-Baylis-Hillman (MBH) carbonates was accomplished by the catalysis of commercially available cinchona alkaloids catalyst (DHQD)2AQN.The corresponding allylic alkylation products were obtained in good yields with high stereoselectivities (up to 99% ee,89:11 dr).展开更多
基金Acknowledgement This work was supported financially by the National Natural Science Foundation of China （Nos. 20972110 and 20902067）.
文摘An organocatalytic asymmetric branching sequence was realized in the presence of 10 mol% of （DHQD）2AQN, affording the sequential products with three stereocentres, including two quaternary carbon centres, in 47%-79% yields with 85%-99% ee.
基金Supported by the National Natural Science Foundation of China (Grant No. 20772084)
文摘The enantioselective O-allylic alkylation of acetophenone oxime with various Morita-Baylis-Hillman (MBH) carbonates has been accomplished by the catalysis of a commercially available cinchona alkaloid (DHQD)2PHAL. The corresponding O-allylic products were obtained in moderate to excellent yields up to 96% ee.
基金financially Supported by the National Natural Science Foundation of China (20772084)
文摘The asymmetric allylic alkylation reaction of sulfonylimidates with various Morita-Baylis-Hillman (MBH) carbonates was accomplished by the catalysis of commercially available cinchona alkaloids catalyst (DHQD)2AQN.The corresponding allylic alkylation products were obtained in good yields with high stereoselectivities (up to 99% ee,89:11 dr).
