期刊文献+
共找到3篇文章
< 1 >
每页显示 20 50 100
Intestinal NK/T cell lymphoma: A case report 被引量:1
1
作者 Hui Li Wen Lyu 《World Journal of Gastroenterology》 SCIE CAS 2020年第27期3989-3997,共9页
BACKGROUND The incidence of intestinal NK/T cell lymphoma(NKTCL)is extremely low,and the clinical symptoms are atypical,which makes it difficult to distinguish this disorder from Crohn's disease(CD),T lymphocyte p... BACKGROUND The incidence of intestinal NK/T cell lymphoma(NKTCL)is extremely low,and the clinical symptoms are atypical,which makes it difficult to distinguish this disorder from Crohn's disease(CD),T lymphocyte proliferative disease,and other immune disorders.The misdiagnosis rate is high,and the patient's prognosis is poor.CASE SUMMARY In this case,the patient had repeated high fever,colonoscopy revealed multiple ulcers,and the initial diagnosis was CD.The patient’s condition did not improve after treatment with hormones and infliximab,and she eventually died.Positron emission tomographic-computed tomographic and B-ultrasound were performed in our hospital and showed that multiple lymph nodes were enlarged.Immunohistochemi-stry showed that CD3 and Epstein-Barr virus encoded RNA expression was positive.Colonoscopy,tissue biopsy,and histopathology showed intestinal focal mucosal infiltration of heterotypic lymphocytes with an abnormal immune phenotype.On the basis of the patient’s medical history,auxiliary examination,and pathological findings,digestive physicians and pathologists gave the diagnosis of NKTCL.CONCLUSION Clinicians need to improve their comprehensive knowledge of NKTCL,and combination of clinical symptoms,histological characteristics,as well as colonoscopy biopsies should be considered to improve the diagnosis and thereby reduce misdiagnosis. 展开更多
关键词 nk/t cell lymphoma Indolent t lymphocyte proliferative disease Crohn's disease ENDOSCOPY MISDIAGNOSIS Case report
下载PDF
The significance and features of apoptosis and proliferation of NK/T cell lymphoma
2
作者 Dabin Wang Meng Ming +2 位作者 Junhua Liu Jianhua Yi Dianding Zou 《The Chinese-German Journal of Clinical Oncology》 CAS 2011年第5期286-289,共4页
Objective:The aim was to study the features and clinical significance of cell apoptosis and proliferation of NK/T cell lymphoma.Methods:TdT-mediated dUTP nick end labeling and immunohistochemical Streptavidin-peroxida... Objective:The aim was to study the features and clinical significance of cell apoptosis and proliferation of NK/T cell lymphoma.Methods:TdT-mediated dUTP nick end labeling and immunohistochemical Streptavidin-peroxidase method were used to study cell apoptosis and the expression of proliferation cell nuclear antigen in 25 NK/T cell lymphoma and 10 reactive lymphoid tissues.Results:Apoptotic index(AI) and proliferative index(PI) averaged(1.92%±0.86%) and(41.48%±5.10%) respectively in the 25 NK/T cell lymphomas and(6.70%±1.89%) and(20.10%±2.77%) in the 10 reactive lymphoid tissues.Compared with reactive lymphoid tissues,AI was significantly reduced in NK/T cell lymphoma(t=10.80,P<0.01) while PI significantly increased(t=12.39,P<0.01).In addition,in NK/T cell lymphoma,AI and PI were positively related(r=0.69,P<0.01).Conclusion:In NK/T cell lymphoma,cell apoptosis is reduced while cell proliferation increased.The imbalance between cell apoptosis and cell proliferation is closely related to the development and progression of NK/T cell lymphoma. 展开更多
关键词 nk/t cell lymphoma APOPtOSIS proliferation cell nuclear antigen
下载PDF
Role of natural killer T cells in Graves' disease
3
作者 雒文田 郭辉 +1 位作者 青才文江 矢野明彦 《Chinese Medical Journal》 SCIE CAS CSCD 2002年第8期63-65,151,共4页
Objective To explore the role of natural killer T (NK T) cells in the pathogenesis of Graves’ disease.Methods NK T cell deficient mice and wild BALB/c mice were immunized with cells expressing TSH receptor once eve... Objective To explore the role of natural killer T (NK T) cells in the pathogenesis of Graves’ disease.Methods NK T cell deficient mice and wild BALB/c mice were immunized with cells expressing TSH receptor once every two weeks 6 times. Two weeks after the final immunization, the mice were killed and serum thyroxine levels, anti-TSH receptor antibodies and thyroid pathological changes were examined.Results The mean levels of TT 4 and TRAb in the immunized NK T cell deficient group were slightly elevated but significantly different from those of the non-immunized control group, while comparable to those in the immunized wild group. There were no significant changes of the activity levels of TSAb or TSBAb in the immunized NK T cell deficient mice compared to those in immunized wild control mice. Thyroids from immunized NK T cell deficient mice showed mild hypertrophy of some follicles as compared with non-immunized control mice. This change was comparable to immunized wild control mice.Conclusion NK T cells may not be involved in the pathogenesis of Graves’ disease. 展开更多
关键词 nk t cell · Graves’ disease · thyroid · tRAb
全文增补中
上一页 1 下一页 到第
使用帮助 返回顶部