Despite a decrease in incidence over past decades,gastric cancer remains a major global health problem. In the more recent period, survival has shown only minor improvement, despite significant advances in diagnostic ...Despite a decrease in incidence over past decades,gastric cancer remains a major global health problem. In the more recent period, survival has shown only minor improvement, despite significant advances in diagnostic techniques, surgical and chemotherapeutic approaches, the development of novel therapeutic agents and treatment by multidisciplinary teams. Because multiple genetic mutations, epigenetic alterations, and aberrant molecular signalling pathways are involved in the development of gastric cancers, recent research has attempted to determine the molecular heterogeneity responsible for the processes of carcinogenesis, spread and metastasis. Currently, some novel agents targeting a part of these dysfunctional molecular signalling pathways have already been integrated into the standard treatment of gastric cancer, whereas others remain in phases of investigation within clinical trials. It is essential to identify the unique molecular patterns of tumours and specific biomarkers to develop treatments targeted to the individual tumour behaviour. This review analyses the global impact of gastric cancer, as well as the role of Helicobacter pylori infection and the efficacy of bacterial eradication in preventing gastric cancer development. Furthermore, the paper discusses the currently available targeted treatments and future directions of research using promising novel classes of molecular agents for advanced tumours.展开更多
In recent years,despite the global economic recession and steel oversupply,the demand for high strength steel( HSS) and advanced high strength steel( AHSS) sheets has robustly increased. To supply the materials needed...In recent years,despite the global economic recession and steel oversupply,the demand for high strength steel( HSS) and advanced high strength steel( AHSS) sheets has robustly increased. To supply the materials needed for automotive manufacturing,various AHSS products and application technologies have been developed by Baosteel,including the 1st,2nd,and 3rd Gen. AHSS,which makes Baosteel the world’s first steel maker to commercially provide all three generations of AHSS. Recently,the new Gen.( the 2nd and 3rd Gen. combined)AHSS products,which feature ultra-high strength and enhanced ductility,have drawn great attention from both steel makers and the automotive industry as these products can be used to produce auto parts with complicated shapes by cold forming and have great potential for manufacturing car bodies that are lighter in weight and have higher crash resistance. In this article,the concepts,properties,and applications of Baosteel’s new Gen. AHSS products,including quenching and partitioning( QP) steels,twinning-induced-plasticity( TWIP) steels,and Medium-Mn( Mn-TRIP)steels,are described and reviewed. Moreover,the progress of the Baosteel light-weight steel car body( BCB) was reported.展开更多
Regeneration in the central nervous system （CNS） is limited, and CNS damage often leads to cognitive impairment or permanent functional motor and sensory loss. Impaired regenerative capacity is multifactorial and in...Regeneration in the central nervous system （CNS） is limited, and CNS damage often leads to cognitive impairment or permanent functional motor and sensory loss. Impaired regenerative capacity is multifactorial and includes inflammation, loss of the blood-brain barrier, and alteration in the extracellular matrix （ECM）. One of the main problems is the formation of a glial scar and the production of inhibitory ECM, such as proteoglycans, that generates a physical and mechanical barrier, impeding axonal regrowth （Figure 1A）.展开更多
Recently, switched control systems have been attracting much attention m the control community because the problems are not only academically challenging for the inherent complexity, but also of practical importance d...Recently, switched control systems have been attracting much attention m the control community because the problems are not only academically challenging for the inherent complexity, but also of practical importance due to its wide ranges of applications in nature, engineering, and social sciences.展开更多
The use of solar energy to drive the chemical and energy processes,and the chemical storage of solar energy are the key elements to move to a low-carbon economy,sustainable society and to foster energy transition.For ...The use of solar energy to drive the chemical and energy processes,and the chemical storage of solar energy are the key elements to move to a low-carbon economy,sustainable society and to foster energy transition.For this reason,there is a fast-growing scientific interest on this subject,which is part of the general effort for a solar-driven chemistry and energy,the chemistry of the future.To realize this展开更多
As guest editors, it is our great honor to bring this special issue of the Journal of Control Theory and Applications devoted to Recent Advances and New Directions in Switched Control Systems.
This paper introduces the importance of synthesis and study of new nuclides far from the stability line. Following the example of new nuclides 208Hg, 185Hf and 237Th, which were synthesized for the first time by the s...This paper introduces the importance of synthesis and study of new nuclides far from the stability line. Following the example of new nuclides 208Hg, 185Hf and 237Th, which were synthesized for the first time by the scientists in the Institute of Modern Physics, the progress of physics and technology in this aspect in our country are summarized. This paper also outlines a proposal about farther development of the synthesis and study of new nuclides and the construction of relevant key facilities in our country at the beginning of the next century.展开更多
One of the significant theoretical contributions of the Report to the 20th National Congress of the Communist Party of China(CPC)is a well-conceived systematic Chinese modernization theory,which is developed based on ...One of the significant theoretical contributions of the Report to the 20th National Congress of the Communist Party of China(CPC)is a well-conceived systematic Chinese modernization theory,which is developed based on the profound summarization of the successful experience of Chinese modernization,and on the modernization theories of China and other countries.Chinese modernization of the rule of law,a section of the lawbased Chinese modernization,focuses on the subject of rule of law.Breaking the myth of Western centralism,it creates a new model of modernization of the rule of law and produces a revolutionary effect on the modernization of the rule of law modernization in the world.It presents distinctive Chinese features and Chinese vision.Led by the CPC,it is an independent exploration,people-centered,organized,and planned,and has lofty value goals.Driven by modern science and technology forworld peace and development,the principal task of Chinese modernization of the rule of law is to create a system of socialist rule of law with Chinese characteristics and a new form of human advancement of the rule of law.Its great mission is to build China into a modern socialist country in all respects under the rule of law,ensuring that the rule of law runs through all areas and aspects of national governance and construction,so that building China into a great modern socialist country with the high-quality rule of law can be guaranteed.展开更多
Recently,switched control systems have been attracting much attention in the control community because the problems are not only academically challenging for the inherent complexity, but also of practical importance d...Recently,switched control systems have been attracting much attention in the control community because the problems are not only academically challenging for the inherent complexity, but also of practical importance due to its wide ranges of applications in nature,engineering,and social sciences. For survival,natural biological systems switch in strategies in accordance to environmental changes. For improved perfor-mance , switching has been extensively utilized/exploited in many engineering systems such as electronics, power systems, and traffic control,among others.In addition,switched behaviors exhibit in social systems.展开更多
The global collisional orogenic events (e.g. Grenvil-lian or Pan-African event) have occurred for several times since 2.5 billion years (Ga) ago, which has led Earth scientists to speculate that continental landmasses...The global collisional orogenic events (e.g. Grenvil-lian or Pan-African event) have occurred for several times since 2.5 billion years (Ga) ago, which has led Earth scientists to speculate that continental landmasses have periodically assembled and dispersed, resulting in the assembly and breakup of supercontinent. In the last decade, the reconstruction of ancient supercontinents has been focused on Rodinia, a defined supercontinent that was assembled along the -1.0 Ga "Grenvillian" oro-gens. In reconstructing Rodinia, however, Earth scientists have noticed that not all continental blocks in the supercontinent were welded by the -1.0 Ga orogenic belts (fig. 1(a)), and that most blocks welded by the 1.0 Ga orogens contain abundant evidence that they are a展开更多
Prosthetic hands are becoming more and more popular among people without a hand and it is able to perform certain manual operations in function.In biology,action potentials trigger muscle contractions,and surface elec...Prosthetic hands are becoming more and more popular among people without a hand and it is able to perform certain manual operations in function.In biology,action potentials trigger muscle contractions,and surface electromyography（sEMG）signals are the sum of action potentials under the skin exposed by the electrodes（via sebum and solution conduction）.展开更多
EXCITING reports on paleontological discoveries from western Liaoning Province, northeastern China have frequently been released in the past few years. From Confuciusornis to Sinosauropteryx, from Protarchaeopteryx to...EXCITING reports on paleontological discoveries from western Liaoning Province, northeastern China have frequently been released in the past few years. From Confuciusornis to Sinosauropteryx, from Protarchaeopteryx to the primitive mammal, Zhangheotherium, and most recently, to the possibly earliest known flower, Archaefructus liaoningensis, these founds have astounded the world, and this miracle land has drawn increasing interests of scholars all over the world. Two world-famed展开更多
The uremic symptoms of advanced chronic kidney disease(CKD)can severely impair physical function,psychological health and social life.Some patients,especially for the older,chose conservative kidney management(CKM)and...The uremic symptoms of advanced chronic kidney disease(CKD)can severely impair physical function,psychological health and social life.Some patients,especially for the older,chose conservative kidney management(CKM)and Traditional Chinese medicine(TCM)but not dialysis in this stage.To measure the patients-reported outcome(PRO)from these people,Advanced Chronic Kidney展开更多
文摘Despite a decrease in incidence over past decades,gastric cancer remains a major global health problem. In the more recent period, survival has shown only minor improvement, despite significant advances in diagnostic techniques, surgical and chemotherapeutic approaches, the development of novel therapeutic agents and treatment by multidisciplinary teams. Because multiple genetic mutations, epigenetic alterations, and aberrant molecular signalling pathways are involved in the development of gastric cancers, recent research has attempted to determine the molecular heterogeneity responsible for the processes of carcinogenesis, spread and metastasis. Currently, some novel agents targeting a part of these dysfunctional molecular signalling pathways have already been integrated into the standard treatment of gastric cancer, whereas others remain in phases of investigation within clinical trials. It is essential to identify the unique molecular patterns of tumours and specific biomarkers to develop treatments targeted to the individual tumour behaviour. This review analyses the global impact of gastric cancer, as well as the role of Helicobacter pylori infection and the efficacy of bacterial eradication in preventing gastric cancer development. Furthermore, the paper discusses the currently available targeted treatments and future directions of research using promising novel classes of molecular agents for advanced tumours.
文摘In recent years,despite the global economic recession and steel oversupply,the demand for high strength steel( HSS) and advanced high strength steel( AHSS) sheets has robustly increased. To supply the materials needed for automotive manufacturing,various AHSS products and application technologies have been developed by Baosteel,including the 1st,2nd,and 3rd Gen. AHSS,which makes Baosteel the world’s first steel maker to commercially provide all three generations of AHSS. Recently,the new Gen.( the 2nd and 3rd Gen. combined)AHSS products,which feature ultra-high strength and enhanced ductility,have drawn great attention from both steel makers and the automotive industry as these products can be used to produce auto parts with complicated shapes by cold forming and have great potential for manufacturing car bodies that are lighter in weight and have higher crash resistance. In this article,the concepts,properties,and applications of Baosteel’s new Gen. AHSS products,including quenching and partitioning( QP) steels,twinning-induced-plasticity( TWIP) steels,and Medium-Mn( Mn-TRIP)steels,are described and reviewed. Moreover,the progress of the Baosteel light-weight steel car body( BCB) was reported.
文摘Regeneration in the central nervous system （CNS） is limited, and CNS damage often leads to cognitive impairment or permanent functional motor and sensory loss. Impaired regenerative capacity is multifactorial and includes inflammation, loss of the blood-brain barrier, and alteration in the extracellular matrix （ECM）. One of the main problems is the formation of a glial scar and the production of inhibitory ECM, such as proteoglycans, that generates a physical and mechanical barrier, impeding axonal regrowth （Figure 1A）.
文摘Recently, switched control systems have been attracting much attention m the control community because the problems are not only academically challenging for the inherent complexity, but also of practical importance due to its wide ranges of applications in nature, engineering, and social sciences.
文摘The use of solar energy to drive the chemical and energy processes,and the chemical storage of solar energy are the key elements to move to a low-carbon economy,sustainable society and to foster energy transition.For this reason,there is a fast-growing scientific interest on this subject,which is part of the general effort for a solar-driven chemistry and energy,the chemistry of the future.To realize this
文摘As guest editors, it is our great honor to bring this special issue of the Journal of Control Theory and Applications devoted to Recent Advances and New Directions in Switched Control Systems.
文摘This paper introduces the importance of synthesis and study of new nuclides far from the stability line. Following the example of new nuclides 208Hg, 185Hf and 237Th, which were synthesized for the first time by the scientists in the Institute of Modern Physics, the progress of physics and technology in this aspect in our country are summarized. This paper also outlines a proposal about farther development of the synthesis and study of new nuclides and the construction of relevant key facilities in our country at the beginning of the next century.
基金a phased achievement of the Philosophy and Social Science Major Project of the Ministry of Education of China in 2022,"Studies on the Practices for Building a Chinese-Style Socialist Rule of Law System and Developing the Comprehensive Rule of Law"(2022JZDZ002).
文摘One of the significant theoretical contributions of the Report to the 20th National Congress of the Communist Party of China(CPC)is a well-conceived systematic Chinese modernization theory,which is developed based on the profound summarization of the successful experience of Chinese modernization,and on the modernization theories of China and other countries.Chinese modernization of the rule of law,a section of the lawbased Chinese modernization,focuses on the subject of rule of law.Breaking the myth of Western centralism,it creates a new model of modernization of the rule of law and produces a revolutionary effect on the modernization of the rule of law modernization in the world.It presents distinctive Chinese features and Chinese vision.Led by the CPC,it is an independent exploration,people-centered,organized,and planned,and has lofty value goals.Driven by modern science and technology forworld peace and development,the principal task of Chinese modernization of the rule of law is to create a system of socialist rule of law with Chinese characteristics and a new form of human advancement of the rule of law.Its great mission is to build China into a modern socialist country in all respects under the rule of law,ensuring that the rule of law runs through all areas and aspects of national governance and construction,so that building China into a great modern socialist country with the high-quality rule of law can be guaranteed.
文摘Recently,switched control systems have been attracting much attention in the control community because the problems are not only academically challenging for the inherent complexity, but also of practical importance due to its wide ranges of applications in nature,engineering,and social sciences. For survival,natural biological systems switch in strategies in accordance to environmental changes. For improved perfor-mance , switching has been extensively utilized/exploited in many engineering systems such as electronics, power systems, and traffic control,among others.In addition,switched behaviors exhibit in social systems.
基金This work was supported by Hong Kong RGC (Grant Nos. HKU7115/00P and HKU7090/01P) the National Natural Science Foundation of China (Grant No. 40072061).
文摘The global collisional orogenic events (e.g. Grenvil-lian or Pan-African event) have occurred for several times since 2.5 billion years (Ga) ago, which has led Earth scientists to speculate that continental landmasses have periodically assembled and dispersed, resulting in the assembly and breakup of supercontinent. In the last decade, the reconstruction of ancient supercontinents has been focused on Rodinia, a defined supercontinent that was assembled along the -1.0 Ga "Grenvillian" oro-gens. In reconstructing Rodinia, however, Earth scientists have noticed that not all continental blocks in the supercontinent were welded by the -1.0 Ga orogenic belts (fig. 1(a)), and that most blocks welded by the 1.0 Ga orogens contain abundant evidence that they are a
基金supported by the National Natural Science Foundation of China(Grant No.51575020)the National Key Technology R&D Program(Grant No.2015BAI02B00)Open Foundation of the State Key Laboratory of Fluid Power and Mechatronic Systems
文摘Prosthetic hands are becoming more and more popular among people without a hand and it is able to perform certain manual operations in function.In biology,action potentials trigger muscle contractions,and surface electromyography（sEMG）signals are the sum of action potentials under the skin exposed by the electrodes（via sebum and solution conduction）.
文摘EXCITING reports on paleontological discoveries from western Liaoning Province, northeastern China have frequently been released in the past few years. From Confuciusornis to Sinosauropteryx, from Protarchaeopteryx to the primitive mammal, Zhangheotherium, and most recently, to the possibly earliest known flower, Archaefructus liaoningensis, these founds have astounded the world, and this miracle land has drawn increasing interests of scholars all over the world. Two world-famed
基金supported by MOST/SATCM of the People's Republic of China grant2013BAI02B04
文摘The uremic symptoms of advanced chronic kidney disease(CKD)can severely impair physical function,psychological health and social life.Some patients,especially for the older,chose conservative kidney management(CKM)and Traditional Chinese medicine(TCM)but not dialysis in this stage.To measure the patients-reported outcome(PRO)from these people,Advanced Chronic Kidney
