Remnant Paleoproterozoic Subduction or Lithospheric Drip Initiation at the Yilgarn Craton Margin:Constraints from P-wave Tomography

The Paleoproterozoic was a critical time in whether modern-style plate tectonics had become globally dominant(e.g.,Wan et al.,2020).The Capricorn Orogen witnessed the assembly of the Pilbara and Yilgarn Cratons and an exotic microcontinent,the Glenburgh Terrane,to form the West Australia Craton(WAC)through two collisional orogenic events,the 2215–2145 Ma Ophthalmian and 2005–1950 Ma Glenburgh Orogenies(Johnson et al.,2013;Fig.1).Compared to other Proterozoic orogenic belts in Australia,the Capricorn Orogen preserves‘complete'opposing continental margin successions,together with intervening arc fragments associated with oceanic closure and foreland basins associated with collisional loading(Cawood et al.,2009).

Differences in Precipitation and Related Wind Dynamics and Moisture and Heat Features in Separate Areas of the South China Sea before and after Summer Monsoon Onset

Using surface and balloon-sounding measurements, satellite retrievals, and ERA5 reanalysis during 2011–20, this study compares the precipitation and related wind dynamics, moisture and heat features in different areas of the South China Sea(SCS) before and after SCS summer monsoon onset(SCSSMO). The rainy sea around Dongsha(hereafter simply referred to as Dongsha) near the north coast, and the rainless sea around Xisha(hereafter simply referred to as Xisha) in the western SCS, are selected as two typical research subregions. It is found that Dongsha, rather than Xisha, has an earlier and greater increase in precipitation after SCSSMO under the combined effect of strong low-level southwesterly winds, coastal terrain blocking and lifting, and northern cold air. When the 950-h Pa southwesterly winds enhance and advance northward, accompanied by strengthened moisture flux, there is a strong convergence of wind and moisture in Dongsha due to a sudden deceleration and rear-end collision of wind by coastal terrain blocking. Moist and warm advection over Dongsha enhances early and deepens up to 200 h Pa in association with the strengthened upward motion after SCSSMO, thereby providing ample moisture and heat to form strong precipitation. However, when the 950-h Pa southwesterly winds weaken and retreat southward, Xisha is located in a wind-break area where strong convergence and upward motion centers move in. The vertical moistening and heating by advection in Xisha enhance later and appear far weaker compared to that in Dongsha, consistent with later and weaker precipitation.

A Comparison between Late Preterm and Term Infants with Respiratory Distress Syndrome, Early-Onset Sepsis, and Neonatal Jaundice in Ecuadorian Newborns

Background: To examine the differences in prevalence of respiratory distress syndrome, early-onset sepsis and jaundice, between late preterm infants versus term infants in Ecuadorian newborns. Methods: Study design: Epidemiological, observational, and cross-sectional, with two cohorts of patients. Settings: IESS Quito Sur Hospital at Quito, Ecuador, from February to April of 2020. Participants: This study included 204 newborns, 102 preterm infants, 102 term infants. Results: There are significant differences between late preterm infants and term infants, with a p-value of 0.000 in the prevalence of early sepsis, 70.59% vs. 35.29%. In respiratory distress syndrome between late and term premature infants, significant differences were observed with a p-value of 0.000, the proportion being 55.58% vs. 24.51% respectively. The prevalence of jaundice is higher in term infants with a p value of 0.002, 72.55%, versus 51.96% in late preterm infants, and the mean value of bilirubins in mg/dL was higher in term infants 14.32 versus 12.33 in late preterm infants;this difference is statistically significant with a p value of 0.004. Admission to the NICU is more frequent in late preterm infants with a p-value of 0.000, being 42.16% for late preterm infants vs. 7.84% in term infants;the mean of the hospital days with p-value 0.005, was higher in late preterm infants 4.97 days vs. 3.55 days for term newborns. Conclusion: Due to the conditions of their immaturity, late preterm infants are 2.86 times more likely to present early sepsis than full-term newborns. It is shown that late preterm infants are 2.69 times more likely to have respiratory distress syndrome compared to term infants, therefore, late preterm infants have a longer hospital stay of 4.97 days versus 3.55 days in term infants. Jaundice and mean bilirubin levels are higher in term infants due to blood group incompatibility and insufficient breastfeeding.

Effect of the mixing of s-wave and chiral p-wave pairings on electrical shot noise properties of normal metal/superconductor tunnel junctions

We study theoretically the electrical shot noise properties of tunnel junctions between a normal metal and a superconductor with the mixture of singlet s-wave and chiral triplet p-wave pairing due to broken inversion symmetry. We investigate how the shot noise properties vary as the relative amplitude between the two parity components in the pairing potential is changed. It is demonstrated that some characteristics of the electrical shot noise properties of such tunnel junctions may depend sensitively on the relative amplitude between the two parity components in the pairing potential, and some significant changes may occur in the electrical shot noise properties when the relative amplitude between the two parity components is varied from the singlet s-wave pairing dominated regime to the chiral triplet p-wave pairing dominated regime. In the chiral triplet p-wave pairing dominated regime, the ratio of noise power to electric current is close to 2e both in the in-gap and in the out-gap region. In the singlet s-wave pairing dominated regime, the value of this ratio is close to 4e in the inner gap region but may reduce to about 2e in the outer gap region as the relative amplitude of the chiral triplet pairing component is increased. The variations of the differential shot noise with the bias voltage also exhibit some significantly different features in different regimes. Such different features can serve as useful diagnostic tools for the determination of the relative magnitude of the two parity components in the pairing potential.

Clinical characteristics of patients with early-and late-onset optic neuromyelitis optica spectrum disease

Objective:To analyze the different clinical features of patients with early-onset(EO-NMOSDs)and late-onset neuromyelitis optica spectrum diseases(LO-NMOSDs).Methods:A total of 51patients with neuromyelitis optica spectrum disease who were diagnosed in our hospital for the first time from January 2015 to December 2022 were included in the First Affiliated Hospital of Hainan Medical College and divided into 22 cases in the EO-NMOSDs group and 29 cases in the LO-NMOSDs group according to whether the age of onset was 50 years old.The basic data,Extended Disability Status Scale(EDSS)score,blood and cerebrospinal fluid test indicators of the two groups were statistically analyzed.Results:There were no significant differences in demographic characteristics,clinical features and serum AQP-4 antibody positivity rate between the two groups(all P>0.05),and there were significant differences in triglycerides(TG),low-density lipoprotein(LDL),apolipoprotein A(APOA),apolipoprotein B(APOB)and lipoprotein a(P=0.010,P=0.048,P=0.014,P=0.061,P=0.001,respectively),and cerebrospinal fluid LDH,There were significant differences between microprotein quantification and EDSS score(P=0.018,P=0.034,P=0.025,respectively),and the level of microprotein quantification in cerebrospinal fluid of LO-NMOSDs had a certain correlation with the degree of disability(r=0.52,P<0.03).Conclusion:LO-NMOSDs and EO-NMOSDs group patients have similar demographic characteristics,serum AQP-4 antibody positive rate and clinical features,but compared with EO-NMOSDs,patients in LO-NMOSDs group are prone to abnormal lipid metabolism,higher trace proteins in cerebrospinal fluid and more likely to be disabled,and among LO-NMOSDs,the higher the trace protein in the cerebrospinal fluid,the more severe the disability status of patients.

Climate prediction of the seasonal sea-ice early melt onset in the Bering Sea

基于大尺度环流异常对海冰消融的影响过程,本文采用年际增量预测方法研制了白令海季节性海冰早期消融开始日期(EMO)的统计预测模型.预测模型选取了3个具有明确物理意义的预测因子:1月波弗特高压,前期11月东西伯利亚地区海平面气压,以及11月东欧平原积雪覆盖率。1月波弗特高压可以通过海气相互作用影响白令海地区海温异常,该海温异常能够从1月持续到3月,进而影响白令海EMO.11月东西伯利亚地区海平面气压与11月至次年2月北太平洋中纬度东部海温密切相关。伴随着北太平洋中纬度东部冷海温异常的出现,白令海地区会出现暖海温异常,进而导致白令海海冰范围减少,EMO较晚.1月北极偶极子异常是11月东欧平原积雪覆盖率影响次年白令海EMO的桥梁之一.1981-2022年的交叉检验结果表明:统计模型对白令海EMO具有较好的预测能力,预测与观测的EMO之间时间相关系数达到了0.45,超过了99%的置信水平.统计模型对白令海EMO正常年份和异常年份的预测准确率分别为60%和41%.

Impacts of anisotropy coefficient and porosity on the thermal conductivity and P-wave velocity of calcarenites used as building materials of historical monuments in Morocco

It is essential to study the porosity,thermal conductivity,and P-wave velocity of calcarenites,as well as the anisotropy coefficients of the thermal conductivity and P-wave velocity,for civil engineering,and conservation and restoration of historical monuments.This study focuses on measuring the thermal conductivity using the thermal conductivity scanning(TCS)technique and measuring the P-wave ve-locity using portable equipment.This was applied for some dry and saturated calcarenite samples in the horizontal and vertical directions(parallel and perpendicular to the bedding plane,respectively).The calcarenites were selected from some historical monuments in Morocco.These physical properties were measured in the laboratory to find a reliable relationship between all of these properties.As a result of the statistical analysis of the obtained data,excellent linear relationships were observed between the porosity and both the thermal conductivity and porosity.These relationships are characterized by relatively high coefficients of determination for the horizontal and vertical samples.Based on the thermal conductivity and P-wave velocity values in these two directions,the anisotropy coefficients of these two properties were calculated.The internal structure and the pore fabric of the calcarenite samples were delineated using scanning electron microscopy(SEM),while their chemical and mineral compositions were studied using the energy dispersive X-ray analysis(EDXA)and X-ray diffraction(XRD)techniques.

Detection of Alzheimer’s disease onset using MRI and PET neuroimaging:longitudinal data analysis and machine learning

The scientists are dedicated to studying the detection of Alzheimer’s disease onset to find a cure, or at the very least, medication that can slow the progression of the disease. This article explores the effectiveness of longitudinal data analysis, artificial intelligence, and machine learning approaches based on magnetic resonance imaging and positron emission tomography neuroimaging modalities for progression estimation and the detection of Alzheimer’s disease onset. The significance of feature extraction in highly complex neuroimaging data, identification of vulnerable brain regions, and the determination of the threshold values for plaques, tangles, and neurodegeneration of these regions will extensively be evaluated. Developing automated methods to improve the aforementioned research areas would enable specialists to determine the progression of the disease and find the link between the biomarkers and more accurate detection of Alzheimer’s disease onset.

Influences of MJO-induced Tropical Cyclones on the Circulation-Convection Inconsistency for the 2021 South China Sea Summer Monsoon Onset

The South China Sea Summer Monsoon(SCSSM)onset is characterized by an apparent seasonal conversion of circulation and convection.Accordingly,various indices have been introduced to identify the SCSSM onset date.However,the onset dates as determined by various indices can be very inconsistent.It not only limits the determination of onset dates but also misleads the assessment of prediction skills.In 2021,the onset time as identified by the circulation criteria was 20 May,which is 12 days earlier than that deduced by also considering the convection criteria.The present study mainly ascribes such circulation-convection inconsistency to the activities of tropical cyclones(TCs)modulated by the Madden-Julian Oscillation(MJO).The convection of TC“Yaas”(2021)acted as an upper-level diabatic heat source to the north of the SCS,facilitating the circulation transition.Afterward,TC“Choi-wan”(2021)over the western Pacific aided the westerlies to persist at lower levels while simultaneously suppressing moist convection over the SCS.Accurate predictions using the ECMWF S2S forecast system were obtained only after the MJO formation.The skillful prediction of the MJO during late spring may provide an opportunity to accurately predict the establishment of the SCSSM several weeks in advance.

Atypical Symptoms of Early Onset Bipolar Disorder

Juvenile bipolar disorder can be a challenging diagnosis, given its atypical presentation and tendency to have other comorbid psychiatric disorders. In this case study, we describe a case of a young patient with some atypical symptoms of early-onset bipolar disorder.

The Inter-Annual Variability of Rainfall Onset and Its Implication on Crop Planting in Selected East Africa Countries

The inter-annual variability of rainfall onset and crop replanting in East Africa (EA) was assessed using daily estimated rainfall data from climate hazard group infrared precipitation (CHIRPS Ver2.0) and monthly Sea Surface Temperature (SST) indices [Indian Ocean Dipole (IOD) and El-Ni?o Southern Oscillation (ENSO) at NINO3.4 region] from the National Center for Environmental Prediction (NCEP) and the National Center for Atmospheric Research (NCAR). The data covered a period of 40 years from1981 to 2020. The methods of cumulative of daily mean rainfall, percentage of onset date departure (PODD), Mann-Kendall (MK) trend test, student t-test, and correlation were applied in the analysis. The results showed that early onset with dry spell (WDS) consideration frequently occurs in Uganda between the first and second dekads of September, while late rainfall onset WDS occurs in the first and second dekads of December over central and Northern Kenya as well as in the Northeastern highlands, parts of the northern coast and unimodal regions in Tanzania. Rainfall onset with no dry spell (WnDS) portrayed an average of 10 days before the occurrence of true onset WDS, with maximum onset departure days (ODD) above 30 days across the Rift Valley area in Kenya and the Northeastern highlands in Tanzania. The high chance of minimum ODD is seen over entire Uganda and the area around Lake Victoria. However, few regions, such as Nakuru (Kenya) Gulu and Kibale (Uganda), and Gitega (Burundi), revealed a slight positive linear trend while others showed negative trend. Significant positive patterns for correlation between onset WDS and SST indices (IOD and NINO 3.4) were discovered in Northern and Northeastern Kenya, as well as areas along the Indian Ocean (over Tanzania’s Northern Coast). Inter-annual relationship between onset dates WDS and IOD (NINO3.4) indices exhibits a high correlation coefficient r = 0.23 (r = 0.48) in Uganda and r = 0.44 (r = 0.36) in Kenya. On the other hand, a negative correlation was revealed over Burundi and Tanzania (over a unimodal region). A high percentage of PODD was observed, ranging from 40% to 70% over the Rift Valley in Kenya and at the Northeastern highlands in Tanzania. However, a strong PODD above 70% was observed over Tanga and the Northern Pwani Region in Tanzania. These findings will help farmers to understand the appropriate time for crop planting, as well as help other socio-economic activities that strongly depend on rainfall.

P-wave velocity structure beneath reservoirs and surrounding areas in the lower Jinsha River

The lower reaches of the Jinsha River are rich in hydropower resources because of the high mountains,deep valleys,and swift currents in this area.This region also features complex tectonic structures and frequent earthquakes.After the impoundment of the reservoirs,seismic activity increased significantly.Therefore,it is necessary to study the P-wave velocity structure and earthquake locations in the lower reaches of the Jinsha River and surrounds,thus providing seismological support for subsequent earthquake prevention and disaster reduction work in reservoir areas.In this study,we selected the data of 7.670 seismic events recorded by the seismic networks in Sichuan.Yunnan,and Chongqing and the temporary seismic arrays deployed nearby.We then applied the double-difference tomography method to this data,to obtain the P-wave velocity structure and earthquake locations in the lower reaches of the Jinsha River and surrounds.The results showed that the Jinsha River basin has a complex lateral P-wave velocity structure.Seismic events are mainly distributed in the transition zones between high-and low-velocity anomalies,and seismic events are particularly intense in the Xiluodu and Baihetan reservoir areas.Vertical cross-sections through the Xiangjiaba and Xiluodu reservoir areas revealed an apparent high-velocity anomaly at approximately 6 km depth:this high-velocity anomaly plays a role in stress accumulation,with few earthquakes distributed inside the high-velocity body.After the impoundment of the Baihetan reservoir,the number of earthquakes in the reservoir area increased significantly.The seismic events in the reservoir area north of 27°N were related to the enhanced activity of nearby faults after impoundment:the earthquakes in the reservoir area south of 27°N were probably induced by additional loads(or regional stress changes),and the multiple microseismic events may have been caused by rock rupture near the main faults under high pore pressure.

Elabela is a reliable biomarker for predicting early onset preeclampsia:A comparative study

BACKGROUND Preeclampsia(PE)is a multisystemic metabolic disease with an undetermined etiology.PE is a worldwide cause of maternal and perinatal morbidity,subdivided into early(EoPE)and late-onset(LoPE)according to 34 wk of gestation as a divider.Many researchers investigated biomarkers for predicting PE to halt its consequences on the feto-maternal outcome.Elabela(Ela)is a newly discovered peptide hormone that was implicated in PE pathogenesis.Earlier rodent studies discussed Ela’s role in controlling blood pressure.Moreover,Ela deficiency was associated with PE development.AIM To test whether plasma Ela could serve as a reliable marker for predicting PE based on the time of onset(EoPE vs LoPE)compared to age and body mass matched healthy controls since no definitive treatment exists for PE but to terminate a pregnancy.METHODS This case-control study recruited(n=90)pregnant who fulfilled inclusion criteria;they were allocated into three groups:EoPE(30/90)(<34 wk of gestation);LoPE(30/90)(≥34 wk of gestation);and healthy pregnant(30/90).Demographic criteria;biochemical,hematological,and maternal plasma Ela levels were recorded for comparison.RESULTS Serum Ela was significantly reduced in EoPE compared to LoPE and healthy controls(P=0.0023).The correlation confirmed a strong inverse relationship with mean atrial blood pressure(r=-0.7,P<0.001),while gestational age and platelets count showed a moderate correlation with(r=0.4 with P<0.0001).No correlation was confirmed between the body mass index(BMI)and urine albumin.The predictive ability of 25 centile serum Ela had an Odds ratio of 5.21,95%confidence interval(1.28,21.24),P=0.02 for predicting EoPE.The receiver operator characteristic curve defined the Ela cutoff value at>9.156 with 96.7%and 93.3%sensitivity and specificity,P<0.0001 in predicting EoPE.CONCLUSION A strong correlation of serum Ela with PE parameters with excellent sensitivity and specificity in distinguishing EoPE independent of the BMI,age,and blood pressure which makes Ela a recommendable marker in screening.Further research is warranted to explore prognostic and therapeutic applications for Ela in PE.

Timing of Elective Repeat Cesarean Delivery at 38 Weeks versus 39 Weeks: Rate of Spontaneous Onset of Labor before Planned Cesarean Section and Impact on Maternal Outcome: A Retrospective Cohort Study

Background: The timing of elective repeat cesarean delivery at 38 weeks versus 39 weeks is still a debatable subject, both regarding maternal and neonatal outcomes. In the Saudi context, there is lack of local data to aid decision-making regarding the timing of elective repeat cesarean delivery. Objectives: To estimate the rate of spontaneous onset of labor before the planned gestational age for repeat cesarean section in women who were booked at gestational age of (39 0/7 - 39 6/7) weeks (W39) versus (38 0/7 - 38 6/7) weeks (W38) and to compare the rate of maternal composite outcome between these groups. Design: Retrospective cohort. Setting: This study was conducted at King Abdulaziz Medical City, Jeddah, KSA. Method: Delivery registry books were reviewed to identify all deliveries from 1 January 2014 to 31 December 2016 (3 years). All low-risk pregnant women who had 2 or more cesarean deliveries and who met the inclusion criteria were included. Results: A total of 440 women were included of whom 318 (72.3%) were planned for elective cesarean section at W38 gestational age and 122 women at W39 gestational age. Mothers planned at W39 had higher rate of emergency cesarean deliveries versus those planned at W38 (18.0% versus 10.4%, p = 0.030;RR = 13.06), most frequently due to early onset of contractions (16.4% versus 8.2%, p = 0.012;RR = 12.17) or cervical dilatation (11.6% versus 5.4%, p = 0.024, RR = 16.15). No difference in the incidence of individual or composite maternal complications was noted between the two groups. Mother’s age (OR 0.93, p = 0.018) and schedule date at W39 (OR = 1.94, p = 0.028) were independently associated with spontaneous onset of labor before the scheduled gestational age, while no association was found with parity, previous number of spontaneous vaginal deliveries, number of previous cesarean deliveries or interval from last cesarean delivery. Conclusion: Elective cesarean section scheduled at 39 weeks of gestation or beyond carries a higher risk of emergency cesarean section, with no significant increase in maternal complications. The identification of factors associated with spontaneous onset of labor before the planned gestational age should be carefully identified to determine the optimal timing.

高原地区卒中后癫痫的临床及预后特征

目的探讨高原地区居民卒中后癫痫(post-stroke epilepsy,PSE)的临床、治疗和预后特征,并分析影响PSE预后的风险因素,为制定高原地区PSE临床诊疗策略提供一定依据。方法回顾性连续纳入2019年1月—2023年6月在西藏自治区人民医院住院治疗的高原地区PSE患者。根据PSE类型分为早发性(卒中后≤7 d)PSE组和迟发性(卒中后>7 d)PSE组,于2023年9月通过电话和门诊相结合的方式进行随访,获取患者的功能预后(mRS评分)情况。比较两组患者的性别、年龄、卒中类型分布、卒中严重程度(发病时mRS评分)、实验室检查等基线资料,以及随访功能预后的差异,分析预后不良(随访mRS评分≥3分)的影响因素。结果共纳入符合入组标准的PSE患者89例,占同期住院高原卒中患者的4.2%,患者发病年龄中位数为55(44~69)岁,男性59例(66.3%),藏族87例(97.8%),发病时mRS评分为3(1~4)分。入组患者中早发性PSE组49例(55.1%),迟发性PSE组40例(44.9%)。卒中亚型分布中脑出血所占比例最高,为39.3%(35例)。最常见的癫痫发作类型为全面起源性发作,共69例(77.5%)。36例(40.4%)PSE患者合并癫痫持续状态。影像学检查显示卒中病灶中最常见的为皮质病灶,共48例(53.9%)。治疗方面85例(95.5%)PSE患者接受了抗癫痫药物治疗,其中79例(88.8%)患者接受单药治疗,最常应用的抗癫痫药物是奥卡西平/卡马西平(36例,40.4%)。PSE患者的院内死亡率为10.1%(9例)。随访时间中位数为27(15~40)个月,预后不良患者占56.7%(38/67),死亡率为35.8%(24/67)。与早发性PSE组相比,迟发性PSE组男性比例更高(78.6%vs.56.6%,P=0.043)且有癫痫家族史比例更高(10.0%vs.0,P=0.037)。两组间的卒中类型分布(P=0.040)和应用抗癫痫药物类型分布(P=0.047)差异有统计学意义。多因素回归分析显示,卒中症状严重(发病时mRS评分高)是PSE预后不良的独立危险因素(OR 1.691,95%CI 1.245~2.297,P<0.001)。结论PSE在高原地区住院卒中患者中的发生率为4.2%。高原地区PSE患者发病时临床症状重,40.4%的患者合并癫痫持续状态。高原地区PSE患者预后不良,致残率和死亡率高。

Clinical implication of platelet to lymphocyte ratio in early onset preeclampsia:A single-center experience

BACKGROUND Preeclampsia(PE)is a pregnancy syndrome of undetermined etiology;inflammation was one of the proposed theories for its development.AIM To examine the platelet to lymphocyte ratio(PLR),an inflammatory biomarker,as a marker to predict poor maternal-neonatal outcomes in early-onset PE(EoPE).METHODS A cross-sectional study enrolled 60 pregnant women with EoPE(at 32-30 wk of gestation)at a university hospital.Demographic criteria and hematological indices were collected,including platelet counts and indices(mean platelet volume and platelet distribution width),PLR,and the Doppler study,which calculated estimated fetal weight(EFW),amniotic fluid index(AFI),resistance index(RI),and pulsatility index(PI).Participants were followed until delivery,where maternal outcomes were recorded,including;delivery mode and reason for cesarean section,and neonatal outcomes,including fetal growth restriction(FGR),meconium-stained liquid,the 5-min Apgar score,and admission to the intensive care unit.RESULTS There was a trend of insignificant increases in cesarean sections.Sixty-one-point two percent(37/60)fetuses were admitted to the neonatal care unit;70.0%of admitted fetuses were meconium-stained liquor,and 56.7%of them had FGR.PLR was positively correlated with AFI and EFW as r=0.98,0.97,P<0.001;PLR showed negative correlations with PI and RI as r=-0.99,-0.98,P<0.001.The Apgar score and the number of days admitted to the intensive care unit had a positive and negative correlation(0.69,-0.98),P<0.0001,respectively.Receiver operating characteristic calculated a PLR cutoff value(7.49)that distinguished FGR at 100%sensitivity and 80%specificity.CONCLUSION Strong,meaningful relationships between PLR and FGR parameters and a poor neonatal outcome with a significant P value make it a recommendable biomarker for screening EoPE-related complications.Further studies are suggested to see the impact on maternal-neonatal health.

基于FAERS数据库的喹硫平不良事件信号挖掘与分析

目的基于美国食品药品监督管理局(FDA)不良事件报告系统(FAERS)数据库挖掘喹硫平的药物不良事件(ADE)信号,为该药的临床安全使用提供参考。方法检索FAERS数据库中2004年至2023年共79个季度关于喹硫平的不良反应报告,同时采用报告比值比法、比例报告比值法、贝叶斯置信区间神经网络传播法、多重伽马-泊松收缩估计法,按药物不良事件术语集的首选术语(PT)和系统器官分类(SOC)对纳入的ADE报告进行分类并计算风险信号。结果共收集主要怀疑药物为喹硫平的ADE报告261725份,涉及的患者有68012例,其中以女性(37495份,55.13%)及老年患者(>65岁)(35312份,占51.9%)居多,报告国家以美国为主,结局多为其他严重后果、住院、死亡和危及患者生命。共挖掘出喹硫平阳性风险信号PT 713个,涉及SOC 27个,所得信号基本与药品说明书一致,其中报告数最多的ADE为糖尿病,且信号强度较高。报告数超过500例的ADE中,共挖掘47个阳性风险信号PT,其中横纹肌溶解为说明书中未收载的ADE。喹硫平引起ADE发生的时间不一,常在用药后30 d内或用药一年以上发生。结论临床在使用喹硫平时除应在全程关注药品说明书收录的ADE外,还应警惕说明书未提及的ADE,并且根据性别、年龄等制订个体化的用药监护方案。

不同首发年龄精神分裂症患者临床特征及影响因素

目的:探讨不同首发年龄精神分裂症患者的临床特征,以及社会人口学影响因素。方法:根据美国精神障碍诊断与统计手册第5版的精神分裂症诊断标准,选取15~70岁患者2016例,由精神科医生采用简明国际神经精神访谈、精神症状维度评定量表(CRDPSS)和阳性与阴性症状量表(PANSS)进行诊断和评估。以18岁和25岁作为精神分裂症早发、中发及晚发的分组界值。采用方差分析、多重相关分析和多重线性回归的方法进行统计分析。结果:早发型患者的PANSS量表总分(73.8±28.0)和CRDPSS量表总分(11.7±5.4)均为最高。女性、受教育程度高、汉族、首发年龄较早、起病形式较慢等特征与PANSS量表和CRDPSS量表总分及其各维度分数正关联(标化回归系数:0.04~0.47),收入水平和吸烟与PANSS量表和CRDPSS量表总分及其各维度分数负关联(标化回归系数:-0.04~-0.14)。结论:早发型精神分裂症患者的症状严重程度更高,女性、受教育水平高、早发病、慢性起病是精神分裂症患者症状严重的危险因素。

基于共同养育理念的剖宫产产妇泌乳分期护理方案构建及实施

目的探讨基于共同养育理念的泌乳分期护理在剖宫产产妇母乳喂养中的应用效果。方法将200对行剖宫产手术的产妇及配偶按照住院时间分为对照组和试验组各100对。对照组给予常规护理,试验组采用基于共同养育理念的泌乳分期护理,将泌乳过程分为乳腺分化期、乳腺活化期、泌乳建立、泌乳维持4个阶段给予针对性的主题教育及干预措施。结果对照组和试验组分别95对和97对产妇及配偶完成研究及随访。试验组首次母乳喂养得分显著高于对照组,泌乳启动时间显著早于对照组(均P<0.05);试验组中配偶母乳喂养知识水平、出院时纯母乳喂养率、产后6周产妇感知配偶母乳喂养支持总分及各维度得分显著高于对照组(均P<0.05)。结论基于共同养育理念的泌乳分期护理可提高首次母乳喂养得分、新生儿父亲母乳喂养知识水平,缩短泌乳启动时间,提升出院时纯母乳喂养率,改善产妇感知配偶母乳喂养支持情况,从而促进母乳喂养。

Rationale of a Cross-Sectional Descriptive Study on Associated Factors and Prognosis Maternal-Fetal Links to Early Onset Preeclampsia at the University Clinics of Kinshasa, DR Congo

Background: Preeclampsia (PE) is one of the forms of hypertensive diseases that occur during pregnancy. Early-onset preeclampsia (EOP), which occurred before 34 weeks, proved to be the deadliest. Indeed, it is characterized by a poor maternal and fetal prognosis. EOP has a disparate incidence in the world varying between 0.9% and 31%. Several risks factors are associated with the occurrence of EOP, which is responsible of several adverse obstetrical outcomes. Complications can affect up to 85% of pregnant women with EOP, especially when EOP appears very early, before 28 or even 25 weeks’ gestation. Objectives: To determine frequency of EOP at the University Clinics of Kinshasa, to describe sociodemographic and clinical characteristics of pregnant women with EOP and to identify its risks factors and its association adverse obstetrical outcomes. Methods: The study will be a cross-sectional analytical study in University Clinics of Kinshasa from January 2016 to December 2022. The minimal size will be 119. Our study population will consist of pregnant women who consult for antenatal best care and are neonates in our Clinic. Result will be presented as percentage proportion. Comparison and proportion means between groups will be made using Student’s test and Pearson’s chi-square test, respectively. Our test will be statistically significant for a p-value ≤ than less 0.05. Data will be collected and analysed anonymously and confidentiality. Conclusion: We believe that our study should enable us to identify profile of gestational carriers at risk of EOP in our environment, as well as prognosis associated with this entity, with a view to arousing particular interest in EOP.