从一块腐烂的鲸鱼骨头分离鉴定了一株真菌Penicillium sp. S2014503。利用大米固体发酵培养技术从该菌产物中获得10个化合物,通过核磁共振波谱数据比对分析结合质谱数据分析,手性化合物测定旋光值或者进行X-射线单晶衍射分析后将这10个...从一块腐烂的鲸鱼骨头分离鉴定了一株真菌Penicillium sp. S2014503。利用大米固体发酵培养技术从该菌产物中获得10个化合物,通过核磁共振波谱数据比对分析结合质谱数据分析,手性化合物测定旋光值或者进行X-射线单晶衍射分析后将这10个化合物分别鉴定为emodin(1)、citreorosein(2)、tetrahydroaltersolanolB(3)、conioxanthoneA(4)、chrysogine(5)、pyramidamycin B (6)、germicidin O (7)、2-(6-hydroxy-5,7-dimethylbenzefuranone-4-yl) acetaldehyde (8)、astrophenone (9)和chenopodolans A (10)。经生物活性测试发现,化合物1和2对藤黄微球菌具有弱的抑制活性,化合物1、2和4对卤虫幼虫具有显著的致死毒性。此外,化合物1是中药大黄和虎杖的主要致泻成分。文章首次报道了来源于海洋动物样品鲸鱼骨的真菌Penicillium sp.能够生产大黄素类等活性天然产物。展开更多
Eight compounds are isolated from the ferment liquid of mangrove fungus(No.zzf33) by silica gel column chromatography.Their structures are determined to be ramlusin(1),monodictyxanthone(2),8-hydroxy-6-methyl-9-oxo-9H-...Eight compounds are isolated from the ferment liquid of mangrove fungus(No.zzf33) by silica gel column chromatography.Their structures are determined to be ramlusin(1),monodictyxanthone(2),8-hydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylic acid methyl ester(3),(E)-dec-2-enedioic acid(4),succinic acid(5),urail(6),thymine(7) and nonacosanoic acid(8) on the basis of comprehensive spectroscopic analysis and chemical method.Compounds 1-3 are isolated from Penicillium sp.for the first time.Compound 8 is first found in marine fungus.In the primary bioassay,compound 2 and 3 exhibit high inhibition to hep2 and hepG2 cells lines.展开更多
文摘从一块腐烂的鲸鱼骨头分离鉴定了一株真菌Penicillium sp. S2014503。利用大米固体发酵培养技术从该菌产物中获得10个化合物,通过核磁共振波谱数据比对分析结合质谱数据分析,手性化合物测定旋光值或者进行X-射线单晶衍射分析后将这10个化合物分别鉴定为emodin(1)、citreorosein(2)、tetrahydroaltersolanolB(3)、conioxanthoneA(4)、chrysogine(5)、pyramidamycin B (6)、germicidin O (7)、2-(6-hydroxy-5,7-dimethylbenzefuranone-4-yl) acetaldehyde (8)、astrophenone (9)和chenopodolans A (10)。经生物活性测试发现,化合物1和2对藤黄微球菌具有弱的抑制活性,化合物1、2和4对卤虫幼虫具有显著的致死毒性。此外,化合物1是中药大黄和虎杖的主要致泻成分。文章首次报道了来源于海洋动物样品鲸鱼骨的真菌Penicillium sp.能够生产大黄素类等活性天然产物。
文摘Eight compounds are isolated from the ferment liquid of mangrove fungus(No.zzf33) by silica gel column chromatography.Their structures are determined to be ramlusin(1),monodictyxanthone(2),8-hydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylic acid methyl ester(3),(E)-dec-2-enedioic acid(4),succinic acid(5),urail(6),thymine(7) and nonacosanoic acid(8) on the basis of comprehensive spectroscopic analysis and chemical method.Compounds 1-3 are isolated from Penicillium sp.for the first time.Compound 8 is first found in marine fungus.In the primary bioassay,compound 2 and 3 exhibit high inhibition to hep2 and hepG2 cells lines.
