Impact of an Active Pharmacovigilance Program in a Third-Level Clinic in Barranquilla, Colombia

The objective of this study is to assess the impact of APV （active pharmacovigilance） and PPV （passive pharmacovigilance） by detection of ADEs （adverse drug events）, through PIs （pharmaceutical interventions）. Authors have used observational pre-post intervention study. Dader methodology was used in 123 patients with data obtained from medical records and pharmaceutical interview. Detection of ADE was made by direct observation and laboratory tests, with statistical significance 0.05. In PPV, 47 ADEs were detected： nausea, vomiting, skin rash and skin redness. In APV, 100 ADEs are presented, similar to those described in the PPV, in which Dipyrone produced 26.2%. The causes of DRPs （drug related problems） were： probability of adverse events 36%, personal characteristics 30%, and dose regimen and/or inadequate duration 22%. Out of 127 PIs performed, 91.34% were accepted and resolved. The patient satisfaction rate was 82.7% for APV and doctor satisfaction 90.4% with high impact, surpassing the 80%. The impact of APV was 93.6% and 53% in PPV for PIs and ADEs. PIs were performed to the ADEs with a high percentage of accepted and solved ones. Evaluation of satisfaction of patients and doctors in APV had a high impact. The assessment of APV generated a high impact on compliance and PPV a low one.

Optimizing polypharmacy interventions and evaluating their impact on elderly inpatients using dual criteria and medication appropriateness index

With the acceleration of society’s aging process,the widespread phenomenon of polypharmacy among the elderly has become a significant concern.This research aimed to analyze potential inappropriate medication among 178 inpatients in the geriatric general department of our hospital from January 2022 to September 2022.The participants were randomly assigned to an observation group and a control group.The observation group received pharmaceutical intervention,whereas the control group did not.The objective was to explore the impact of pharmaceutical intervention on polypharmacy in this population.The results revealed that after pharmaceutical intervention,there were no significant differences in medication adherence,medication appropriateness index(MAI),quantity of medicine,and potentially inappropriate medication(PIM)in the control group compared to before the intervention(P>0.05).However,the observation group showed significant improvement(P<0.05).The proportion of patients with good adherence increased from 57%to 78%,and the percentage of patients with MAI scores over 10 decreased from 60%to 40%.Moreover,there was a reduction in the number of medications prescribed,with only 47%of patients receiving more than five different types compared to the initial rate of 64%.Additionally,the occurrence of PIM declined from an initial rate of 64%to just 44%,surpassing that observed in the control group.Therefore,the implementation of pharmaceutical intervention can effectively enhance medication adherence and appropriateness among elderly patients,mitigate the risk of PIM,and promote rational medicine utilization.

Impact of pharmaceutical intervention on the rational use of antibiotics in primary hospital

Evidence based pharmaceutical interventions focusing on the characteristics of antibiotics use in primary hospitals were investigated to optimize the use of antibiotics. Four pharmaceutical interventions were set up in this study： 1） different levels of antibiotic management system were developed; 2） usage of antibiotics was reported in a monthly journal for the entire hospital; 3） early antibiotics warning system was started; 4） communication between pharmacists and physicians was strengthened. Use of antibiotics in 2007 （before intervention） and 2008 （after intervention） in department of respiratory medicine was analyzed. Significant differences （P〈0.01） in antibiotics use before and after intervention were observed. Use of antibiotics was changed from focusing on one category of drugs to a rotation of a wide range of agents. Evidence based, sound pharmaceutical interventions were effective means to ensure the rational use of antibiotics.