Environmental cleaning is an important aspect of bacteria control.Ethyl cellulose microcapsules containing potassium monopersulfate(PMCM)were prepared by emulsified solvent diffusion method.The chemical structure and ...Environmental cleaning is an important aspect of bacteria control.Ethyl cellulose microcapsules containing potassium monopersulfate(PMCM)were prepared by emulsified solvent diffusion method.The chemical structure and microstructure of the obtained PMCM was characterized by methods of Fourier transform infrared spectroscopy(FT-IR),optical microscopy,scanning electron microscopy and X-ACT energy dispersive X-ray spectroscopy.The SEM micrographs of the PMCM containing 21.6%of C,46.8%of O,10.7%of S and 19.4%of K was relatively smooth.Thermal stability,sustained release performance,and antimicrobial activity of PMCM were investigated.The results showed that the drug loading and encapsulation efficiency of PMCM were 30.3%and 42.6%respectively.Potassium monopersulfate was fully released after 8 h,following a Fickian diffusion mechanism.Results showed that the microcapsules prepared with a high concentration of potassium monopersulfate solution showed a good antimicrobial effect.The microcapsule wall of the resulting PMCM increased with increasing ethyl cellulose content and had high thermal stability from the data of 69%residue rate.The excellent thermal stability and high sustained release performance of PMCM showed high application value.展开更多
Ammonium fixation and adsorption experiments were conducted to study the effect of potassium on ammonium fixation into interlayer of vermiculite and ammonium adsorption at the surface of vermiculite both in the binary...Ammonium fixation and adsorption experiments were conducted to study the effect of potassium on ammonium fixation into interlayer of vermiculite and ammonium adsorption at the surface of vermiculite both in the binary (NH-4~(+)-Ca~(2+)) and ternary (NH-4~(+)-K~(+)-Ca~(2+)) systems. In the ammonium fixation experiment, 5 mmol NH-4~(+) kg~(-1) was added alone, or after, before or simultaneously with 5 mmol K~(+) kg~(-1) to the vermiculite (vermiculite:solution = 1:1), and the incubation was conducted for 3 days under constant 20℃. In the adsorption experiment, after addition of 10 mmol Ca~(2+) L~(-1) as matrix ions, either NH-4~(+) alone with a concentration series from 0.1 to 5.0 mmol NH-4~(+) L~(-1) (binary exchange system of NH-4~(+) and Ca~(2+) or NH-4~(+) together with 5 mmol K~(+) L~(-1) (ternary exchange system of NH-4 ~(+), K~(+) and Ca~(2+) was added to vermiculite at a vermiculite to solution ratio of l:10 for 24-h equilibrium. The results of the fixation experiment showed that the presence of K~(+) increased NH-4~(+) fixation for all the treatments, regardless of the addition orders. For ammonium adsorption a linear relationship between activity ratios of NH-4~(+) to Ca~(2+) and Mg~(2+) in the equilibrium solutions (ARNH-4) and increases of exchangeable NH-4~(+) at the surface of vermiculite after 24- h equilibrium (△Ex-NH-4) was shown for almost the whole concentration ranges tested. Compared with the binary system, the slope of the curve of the ternary system was steeper, indicating a more intensive adsorption of NH-4~(+) in the presence of K~(+). It was demonstrated that K ~(+) did not reduce the ammounium fixation into the interlayer and ammonium adsororption at the surface of vermiculite, which indicated that, under the experimental conditions of this study, K~(+) did neither occupy the sites for NH-4~(+)-fixation in the interlayer nor the sites for NH-4~(+)-adsorption at the surface of vermiculite.展开更多
The purposes of this study are to prepare the generic extended release tablet of potassiumchloride(PC) 600 mg and to compare the absorption of potassium ion from the experimen-tal tablets to that of Kaleorid? LP 600 m...The purposes of this study are to prepare the generic extended release tablet of potassiumchloride(PC) 600 mg and to compare the absorption of potassium ion from the experimen-tal tablets to that of Kaleorid? LP 600 mg(Leo Pharmaceutical Products, Denmark). Car-nauba wax was used as retardant in the matrix core tablets. The core tablets were coatedwith blends of ethyl cellulose(EC) and hydroxypropyl methyl cellulose(HPMC) to modulatethe drug release. Results of a selective two-level, three-factor experiment design revealedthat a blend of 41.75% of EC and 58.25% of HPMC at 4.5% weight gained could produce thecoated tablets having dissolution profiles similar to those of Kaleorid?. A two-treatment,two-period, two-sequence crossover bioequivalence study was carried out on 24 healthyvolunteers to compare the absorption of potassium ion from experimental tablets to thatfrom Kaleorid?. The potassium ion in the urine was measured by a selective electrode of theADVIA 1650 system(Bayer) and used to calculate cumulative urinary excretion and urinaryexcretion rate. Results of 90 percent confidence interval analysis showed that the limits fornatural log-transformed cumulative urinary potassium excretion(Ln Ae 0-24) of test productwere in the range of 3.73–3.79 mEq, corresponding to 99.08%–100.92% of Kaleorid ?, respec-tively, and the limits for natural log-transformed maximal potassium excretion rate( R max) oftest product were in the range of 1.72–1.82 mEq/h, corresponding to 97.34%–102.66% of refer-ence product, respectively. Both of them fell within the bioequivalence interval(80%–125%)of reference product, proving that experimental product is bioequivalent to Kaleorid ?.展开更多
Soil potassium (K) deficiency has been increasing over recent decades as a result of higher inputs of N and P fertilizers concomitant with lower inputs of K fertilizers in China; however, the effects of interactions b...Soil potassium (K) deficiency has been increasing over recent decades as a result of higher inputs of N and P fertilizers concomitant with lower inputs of K fertilizers in China; however, the effects of interactions between N, P, and K of fertilizers on K status in soils have not been thoroughly investigated for optimizing N, P, and K fertilizer use effciency. The influence of ammonium sulfate (AS), monocalcium phosphate (MCP), and potassium chloride application on K fractions in three typical soils of China was evaluated during 90-d laboratory soil incubation. The presence of AS significantly altered the distribution of native and added K in soils, while addition of MCP did not significantly affected K equilibrium in most cases. Addition of AS significantly increased water-soluble K (WSK), decreased exchangeable K (EK) in almost all the soils except the paddy soil that contained considerable amounts of 2:1 type clay minerals with K added, retarded the formation of fixed K in the soils with K added, and suppressed the release of fixed K in the three soils without K added. These interactions might be expected to influence the K availability to plants when the soil was fertilized with AS. To improve K fertilizer use effciency, whether combined application of AS and K was to be recommended or avoided should depend on K status of the soil, soil properties, and cropping systems.展开更多
Potassium permanganate (KMnO<sub>4</sub>) has been used widely as an oxidant for remediation of contaminated soil and water systems. The present study evaluates the release of this oxidant from Polycaprola...Potassium permanganate (KMnO<sub>4</sub>) has been used widely as an oxidant for remediation of contaminated soil and water systems. The present study evaluates the release of this oxidant from Polycaprolactone (PCL) polymer as part of a patented controlled release process (CRP) to be applied for targeted removal of contaminants from water. KMnO<sub>4</sub> was encapsulated into PCL at a 1:5 oxidant to polymer ratio and placed in batch reactor systems with reagent water to be evaluated over a 96 hour period. SEM images showed that over time, the number of cavities and their sizes increased on the waxy surface of the PCL polymer. The experimental data from the release of KMnO<sub>4</sub> from PCL was found to fit non-Fickian diffusion model after dissolution (R<sup>2</sup> = 0.93) similar to other systems that describe the dispersal of other oxidants from wax matrices. In addition, the model parameters for data of this present study were also found to be comparable to previous release studies with the same oxidant encapsulated in different wax matrices at similar ratios. Overall, the similarity of release data between the diversity of polymers shows that the controlled release biodegradable polymer utilizing PCL provides effective release of the KMnO<sub>4</sub> with the added benefit biodegradable nature of PCL.展开更多
This work investigates the impact of biomechanical wear and abrasion on the antibiotic release profiles of hydroxyapatite (HA) coated fixation pins during their insertion into synthetic bone. Stainless steel fixation ...This work investigates the impact of biomechanical wear and abrasion on the antibiotic release profiles of hydroxyapatite (HA) coated fixation pins during their insertion into synthetic bone. Stainless steel fixation pins are coated with crystalline TiO2 by cathodic arc evaporation forming the bioactive layer for biomimetic deposition of Tobramycin containing HA. Tobramycin is either introduced by co-precipitation during HA formation or by adsorption-loading after HA deposition. The samples containing antibiotics are inserted into bone mimicking polyethylene foam after which the drug release is monitored using high performance liquid chromatography. This analysis shows that HA coating wear and delamination significantly decrease the amount of drug released during initial burst, but only marginally influence the sustained release period. Spalled coating fragments are found to remain within the synthetic bone material structure. The presence of HA within this structure supports the assumption that the local release of Tobramycin is not only expected to eliminate bacteria growth directly at the pin interface but as well at some distance from the implant. Furthermore, no negative effect of gamma sterilization could be observed on the drug release profile. Overall, the observed results demonstrate the feasibility of a multifunctional implant coating that is simultaneously able to locally deliver clinically relevant doses of antibiotics and an HA coating capable of promoting osteoconduction. This is a potentially promising step toward orthopaedic devices that combine good fixation with the ability to treat and prevent post-surgical infections.展开更多
After the first research with this technique done by the first author, ten operations on the foot and ankle were performed on five patients (two boys and three girls) suffering from severe club foot deformity all with...After the first research with this technique done by the first author, ten operations on the foot and ankle were performed on five patients (two boys and three girls) suffering from severe club foot deformity all with bilateral foot affection. Their ages ranged from five to fourteen years. All of them were treated by soft tissue release, skin flap (rotational flap), supplemented with Alkhooly external fixator. The follow up period ranged from two to seven years. The results according to Mittal (1987) [1] were excellent in eight feet (80%) and good in two feet (20%).展开更多
Because of both ozone gas and ozone solution are instable which limits the application of ozone, to solve the storage problem, it is necessary to find a kind ofideal ozone carrier which can combine ozone as an "ozoni...Because of both ozone gas and ozone solution are instable which limits the application of ozone, to solve the storage problem, it is necessary to find a kind ofideal ozone carrier which can combine ozone as an "ozonic compound" in which the bond strength between ozone and carrier should not be too high or too low, to appropriately release ozone from the ozonic compound. Combining Criegee’s three-step reaction mechanism of ozone and olefins, the charge, covalent bond levels and energy levels of ozone, ethylene, butadiene and their ozonic compounds were calculated by the first-principles calculation method based on density functional theory methods. The stability of the ozonide, or the bond strength between ozone and ions of carrier were controlled felicitously to release ozone from the ozonide with proper velocity. Ozone antimicrobial was composed on the above principle. It can be used conveniently, especially for common families.展开更多
The application of controlled release materials in tandem with chemical oxidants has become an emerging topic within the field of environmental treatment. The controlled release kinetic and mechanistic relationship be...The application of controlled release materials in tandem with chemical oxidants has become an emerging topic within the field of environmental treatment. The controlled release kinetic and mechanistic relationship between these components is important to understand a controlled release system. Potassium permanganate (KMnO<sub>4</sub>) was used as the encapsulated material integrated into polycaprolactone (PCL) producing controlled release biodegradable polymer (CRBP) pellets. In this study, batch experiments were used to examine the release kinetics from the discharge of the pelletized encapsulated oxidant into aqueous systems at various KMnO<sub>4</sub>:PCL ratios of 1:5, 2:5, and 3:5 by mass. Experimental results indicated as the amount of KMnO<sub>4</sub> in the PCL polymer pellets increased, a greater fraction of the oxidant was released as a function of time. The resultant data best fit a linearized diffusion model equation. Additionally, a comparison-controlled release study was conducted that contained the same oxidant at similar mass ratios. Release kinetics determined from this study could lead to effective implementation of CRBP systems and could suggest that CRBP encapsulated with KMnO<sub>4</sub> could serve as a promising controlled release technology in a long-term and controlled manner.展开更多
BACKGROUND Adult distal humeral fractures(DHF)comprise 2%-5%of all fractures and 30%of all elbow fractures.Treatment of DHF may be technically demanding due to fracture complexity and proximity of neurovascular struct...BACKGROUND Adult distal humeral fractures(DHF)comprise 2%-5%of all fractures and 30%of all elbow fractures.Treatment of DHF may be technically demanding due to fracture complexity and proximity of neurovascular structures.Open reduction and internal fixation(ORIF)are often the treatment of choice,but arthroplasty is considered in case of severe comminution or in elderly patients with poor bone quality.Ulnar nerve affection following surgical treatment of distal humerus fractures is a well-recognized complication.AIM To report the risk of ulnar nerve affection after surgery for acute DHFs.METHODS We retrospectively identified 239 consecutive adult patients with acute DHFs who underwent surgery with ORIF,elbow hemiarthroplasty(EHA)or total elbow arthroplasty(TEA)between January 2011 and December 2019.In all cases,the ulnar nerve was released in situ without anterior transposition.We used our institutional database to review patients’medical records for demographics,fracture morphology,type of surgery and ulnar nerve affection immediately;records were reviewed after surgery and at 2 wk and 12 wk of routine clinical outpatient follow-up.Twenty-nine percent patients were excluded due to pre-or postoperative conditions.Final follow-up examination was a telephone interview in which ulnar nerve affection was reported according to the McGowen Classification Score.A total of 210 patients were eligible for interview,but 13 patients declined participation and 17 patients failed to respond.Thus,180 patients were included.RESULTS Mean age at surgery was 64 years(range 18-88 years);121(67.3%)patients were women;59(32.7%)were men.According to the AO/OTA classification system,we recorded 47 patients with type A3,55 patients with type B and 78 patients with type C fractures.According to the McGowen Classification Score,mild ulnar nerve affection was reported in nine patients;severe affection,in two.A total of 69 patients were treated with ORIF of whom three had mild temporary ulnar nerve affection and one had severe ulnar nerve affection.In all,111 patients were treated with arthroplasty(67 EHA,44 TEA)of whom seven had mild ulnar nerve affection and one had severe persistent ulnar nerve affection.No further treatment was provided.CONCLUSION The risk of ulnar nerve affection after surgical treatment for acute DHF is low when the ulnar nerve is released in situ without nerve transposition,independently of the treatment provided.展开更多
To improve drug utilization,reduce the drug administration frequency,increase the release time,and reduce the drug side effects in the human body,we prepared(KHA/CMC-Fe^(3+))@CS hydrogel spheres using green and natura...To improve drug utilization,reduce the drug administration frequency,increase the release time,and reduce the drug side effects in the human body,we prepared(KHA/CMC-Fe^(3+))@CS hydrogel spheres using green and natural potassium humate(KHA),carboxymethyl cellulose(CMC),and chitosan(CS)as raw materials and Fe3+as a crosslinking agent,and loaded them with riboflavin for drug sustainedrelease study using the drop ball method.The tests with FTIR,SEM,TG,and X-ray diffractometer showed that the coordination among KHA,CMC,and Fe^(3+)formed a three-dimensional network structure,where cs was encapsulated on the surface of the hydrogel spheres via noncovalent bonding,resulting in good thermal stability.The stability,drug loading,swelling,and in vitro release of the(KHA/CMC-Fe^(3+))@CS hydrogel spheres were investigated.The results showed that the hydrogel spheres were significantly pH-sensitive,with 11.16 g/g higher swelling in an alkaline environment(pH=7.4)than that in an acidic environment(pH=1.2).The swelling and drug release process of the hydrogel spheres were analyzed using mathematical models,concluding that the hydrogel swelling follows Schott second-order swelling kinetics,and the drug release mechanism was Fickian delivery mode.展开更多
基金support From the Open Fund Project of Key Lab.of Biomass Energy and Material,Jiangsu Province(JSBEM201907)the Ordinary University Young Innovative Talents Project of Guangdong Province(2018KQNCX119).
文摘Environmental cleaning is an important aspect of bacteria control.Ethyl cellulose microcapsules containing potassium monopersulfate(PMCM)were prepared by emulsified solvent diffusion method.The chemical structure and microstructure of the obtained PMCM was characterized by methods of Fourier transform infrared spectroscopy(FT-IR),optical microscopy,scanning electron microscopy and X-ACT energy dispersive X-ray spectroscopy.The SEM micrographs of the PMCM containing 21.6%of C,46.8%of O,10.7%of S and 19.4%of K was relatively smooth.Thermal stability,sustained release performance,and antimicrobial activity of PMCM were investigated.The results showed that the drug loading and encapsulation efficiency of PMCM were 30.3%and 42.6%respectively.Potassium monopersulfate was fully released after 8 h,following a Fickian diffusion mechanism.Results showed that the microcapsules prepared with a high concentration of potassium monopersulfate solution showed a good antimicrobial effect.The microcapsule wall of the resulting PMCM increased with increasing ethyl cellulose content and had high thermal stability from the data of 69%residue rate.The excellent thermal stability and high sustained release performance of PMCM showed high application value.
基金Project (No. 39770427) supported by the National Natural Science Foundation of China.
文摘Ammonium fixation and adsorption experiments were conducted to study the effect of potassium on ammonium fixation into interlayer of vermiculite and ammonium adsorption at the surface of vermiculite both in the binary (NH-4~(+)-Ca~(2+)) and ternary (NH-4~(+)-K~(+)-Ca~(2+)) systems. In the ammonium fixation experiment, 5 mmol NH-4~(+) kg~(-1) was added alone, or after, before or simultaneously with 5 mmol K~(+) kg~(-1) to the vermiculite (vermiculite:solution = 1:1), and the incubation was conducted for 3 days under constant 20℃. In the adsorption experiment, after addition of 10 mmol Ca~(2+) L~(-1) as matrix ions, either NH-4~(+) alone with a concentration series from 0.1 to 5.0 mmol NH-4~(+) L~(-1) (binary exchange system of NH-4~(+) and Ca~(2+) or NH-4~(+) together with 5 mmol K~(+) L~(-1) (ternary exchange system of NH-4 ~(+), K~(+) and Ca~(2+) was added to vermiculite at a vermiculite to solution ratio of l:10 for 24-h equilibrium. The results of the fixation experiment showed that the presence of K~(+) increased NH-4~(+) fixation for all the treatments, regardless of the addition orders. For ammonium adsorption a linear relationship between activity ratios of NH-4~(+) to Ca~(2+) and Mg~(2+) in the equilibrium solutions (ARNH-4) and increases of exchangeable NH-4~(+) at the surface of vermiculite after 24- h equilibrium (△Ex-NH-4) was shown for almost the whole concentration ranges tested. Compared with the binary system, the slope of the curve of the ternary system was steeper, indicating a more intensive adsorption of NH-4~(+) in the presence of K~(+). It was demonstrated that K ~(+) did not reduce the ammounium fixation into the interlayer and ammonium adsororption at the surface of vermiculite, which indicated that, under the experimental conditions of this study, K~(+) did neither occupy the sites for NH-4~(+)-fixation in the interlayer nor the sites for NH-4~(+)-adsorption at the surface of vermiculite.
基金Financial support for bioequivalence study from The Department of Science and Technology (grant number 209/HDSKHCN) of Ho chi Minh city (DOST)
文摘The purposes of this study are to prepare the generic extended release tablet of potassiumchloride(PC) 600 mg and to compare the absorption of potassium ion from the experimen-tal tablets to that of Kaleorid? LP 600 mg(Leo Pharmaceutical Products, Denmark). Car-nauba wax was used as retardant in the matrix core tablets. The core tablets were coatedwith blends of ethyl cellulose(EC) and hydroxypropyl methyl cellulose(HPMC) to modulatethe drug release. Results of a selective two-level, three-factor experiment design revealedthat a blend of 41.75% of EC and 58.25% of HPMC at 4.5% weight gained could produce thecoated tablets having dissolution profiles similar to those of Kaleorid?. A two-treatment,two-period, two-sequence crossover bioequivalence study was carried out on 24 healthyvolunteers to compare the absorption of potassium ion from experimental tablets to thatfrom Kaleorid?. The potassium ion in the urine was measured by a selective electrode of theADVIA 1650 system(Bayer) and used to calculate cumulative urinary excretion and urinaryexcretion rate. Results of 90 percent confidence interval analysis showed that the limits fornatural log-transformed cumulative urinary potassium excretion(Ln Ae 0-24) of test productwere in the range of 3.73–3.79 mEq, corresponding to 99.08%–100.92% of Kaleorid ?, respec-tively, and the limits for natural log-transformed maximal potassium excretion rate( R max) oftest product were in the range of 1.72–1.82 mEq/h, corresponding to 97.34%–102.66% of refer-ence product, respectively. Both of them fell within the bioequivalence interval(80%–125%)of reference product, proving that experimental product is bioequivalent to Kaleorid ?.
基金Supported by the Knowledge Innovative Program of the Chinese Academy of Sciences (No.KSCX2-YW-N-002)the National Key Basic Research Program of China(No.2007CB109301)+1 种基金the National Natural Science Foundation of China(No.40971176)the International Potash Institute China Project
文摘Soil potassium (K) deficiency has been increasing over recent decades as a result of higher inputs of N and P fertilizers concomitant with lower inputs of K fertilizers in China; however, the effects of interactions between N, P, and K of fertilizers on K status in soils have not been thoroughly investigated for optimizing N, P, and K fertilizer use effciency. The influence of ammonium sulfate (AS), monocalcium phosphate (MCP), and potassium chloride application on K fractions in three typical soils of China was evaluated during 90-d laboratory soil incubation. The presence of AS significantly altered the distribution of native and added K in soils, while addition of MCP did not significantly affected K equilibrium in most cases. Addition of AS significantly increased water-soluble K (WSK), decreased exchangeable K (EK) in almost all the soils except the paddy soil that contained considerable amounts of 2:1 type clay minerals with K added, retarded the formation of fixed K in the soils with K added, and suppressed the release of fixed K in the three soils without K added. These interactions might be expected to influence the K availability to plants when the soil was fertilized with AS. To improve K fertilizer use effciency, whether combined application of AS and K was to be recommended or avoided should depend on K status of the soil, soil properties, and cropping systems.
文摘Potassium permanganate (KMnO<sub>4</sub>) has been used widely as an oxidant for remediation of contaminated soil and water systems. The present study evaluates the release of this oxidant from Polycaprolactone (PCL) polymer as part of a patented controlled release process (CRP) to be applied for targeted removal of contaminants from water. KMnO<sub>4</sub> was encapsulated into PCL at a 1:5 oxidant to polymer ratio and placed in batch reactor systems with reagent water to be evaluated over a 96 hour period. SEM images showed that over time, the number of cavities and their sizes increased on the waxy surface of the PCL polymer. The experimental data from the release of KMnO<sub>4</sub> from PCL was found to fit non-Fickian diffusion model after dissolution (R<sup>2</sup> = 0.93) similar to other systems that describe the dispersal of other oxidants from wax matrices. In addition, the model parameters for data of this present study were also found to be comparable to previous release studies with the same oxidant encapsulated in different wax matrices at similar ratios. Overall, the similarity of release data between the diversity of polymers shows that the controlled release biodegradable polymer utilizing PCL provides effective release of the KMnO<sub>4</sub> with the added benefit biodegradable nature of PCL.
文摘This work investigates the impact of biomechanical wear and abrasion on the antibiotic release profiles of hydroxyapatite (HA) coated fixation pins during their insertion into synthetic bone. Stainless steel fixation pins are coated with crystalline TiO2 by cathodic arc evaporation forming the bioactive layer for biomimetic deposition of Tobramycin containing HA. Tobramycin is either introduced by co-precipitation during HA formation or by adsorption-loading after HA deposition. The samples containing antibiotics are inserted into bone mimicking polyethylene foam after which the drug release is monitored using high performance liquid chromatography. This analysis shows that HA coating wear and delamination significantly decrease the amount of drug released during initial burst, but only marginally influence the sustained release period. Spalled coating fragments are found to remain within the synthetic bone material structure. The presence of HA within this structure supports the assumption that the local release of Tobramycin is not only expected to eliminate bacteria growth directly at the pin interface but as well at some distance from the implant. Furthermore, no negative effect of gamma sterilization could be observed on the drug release profile. Overall, the observed results demonstrate the feasibility of a multifunctional implant coating that is simultaneously able to locally deliver clinically relevant doses of antibiotics and an HA coating capable of promoting osteoconduction. This is a potentially promising step toward orthopaedic devices that combine good fixation with the ability to treat and prevent post-surgical infections.
文摘After the first research with this technique done by the first author, ten operations on the foot and ankle were performed on five patients (two boys and three girls) suffering from severe club foot deformity all with bilateral foot affection. Their ages ranged from five to fourteen years. All of them were treated by soft tissue release, skin flap (rotational flap), supplemented with Alkhooly external fixator. The follow up period ranged from two to seven years. The results according to Mittal (1987) [1] were excellent in eight feet (80%) and good in two feet (20%).
文摘Because of both ozone gas and ozone solution are instable which limits the application of ozone, to solve the storage problem, it is necessary to find a kind ofideal ozone carrier which can combine ozone as an "ozonic compound" in which the bond strength between ozone and carrier should not be too high or too low, to appropriately release ozone from the ozonic compound. Combining Criegee’s three-step reaction mechanism of ozone and olefins, the charge, covalent bond levels and energy levels of ozone, ethylene, butadiene and their ozonic compounds were calculated by the first-principles calculation method based on density functional theory methods. The stability of the ozonide, or the bond strength between ozone and ions of carrier were controlled felicitously to release ozone from the ozonide with proper velocity. Ozone antimicrobial was composed on the above principle. It can be used conveniently, especially for common families.
文摘The application of controlled release materials in tandem with chemical oxidants has become an emerging topic within the field of environmental treatment. The controlled release kinetic and mechanistic relationship between these components is important to understand a controlled release system. Potassium permanganate (KMnO<sub>4</sub>) was used as the encapsulated material integrated into polycaprolactone (PCL) producing controlled release biodegradable polymer (CRBP) pellets. In this study, batch experiments were used to examine the release kinetics from the discharge of the pelletized encapsulated oxidant into aqueous systems at various KMnO<sub>4</sub>:PCL ratios of 1:5, 2:5, and 3:5 by mass. Experimental results indicated as the amount of KMnO<sub>4</sub> in the PCL polymer pellets increased, a greater fraction of the oxidant was released as a function of time. The resultant data best fit a linearized diffusion model equation. Additionally, a comparison-controlled release study was conducted that contained the same oxidant at similar mass ratios. Release kinetics determined from this study could lead to effective implementation of CRBP systems and could suggest that CRBP encapsulated with KMnO<sub>4</sub> could serve as a promising controlled release technology in a long-term and controlled manner.
文摘BACKGROUND Adult distal humeral fractures(DHF)comprise 2%-5%of all fractures and 30%of all elbow fractures.Treatment of DHF may be technically demanding due to fracture complexity and proximity of neurovascular structures.Open reduction and internal fixation(ORIF)are often the treatment of choice,but arthroplasty is considered in case of severe comminution or in elderly patients with poor bone quality.Ulnar nerve affection following surgical treatment of distal humerus fractures is a well-recognized complication.AIM To report the risk of ulnar nerve affection after surgery for acute DHFs.METHODS We retrospectively identified 239 consecutive adult patients with acute DHFs who underwent surgery with ORIF,elbow hemiarthroplasty(EHA)or total elbow arthroplasty(TEA)between January 2011 and December 2019.In all cases,the ulnar nerve was released in situ without anterior transposition.We used our institutional database to review patients’medical records for demographics,fracture morphology,type of surgery and ulnar nerve affection immediately;records were reviewed after surgery and at 2 wk and 12 wk of routine clinical outpatient follow-up.Twenty-nine percent patients were excluded due to pre-or postoperative conditions.Final follow-up examination was a telephone interview in which ulnar nerve affection was reported according to the McGowen Classification Score.A total of 210 patients were eligible for interview,but 13 patients declined participation and 17 patients failed to respond.Thus,180 patients were included.RESULTS Mean age at surgery was 64 years(range 18-88 years);121(67.3%)patients were women;59(32.7%)were men.According to the AO/OTA classification system,we recorded 47 patients with type A3,55 patients with type B and 78 patients with type C fractures.According to the McGowen Classification Score,mild ulnar nerve affection was reported in nine patients;severe affection,in two.A total of 69 patients were treated with ORIF of whom three had mild temporary ulnar nerve affection and one had severe ulnar nerve affection.In all,111 patients were treated with arthroplasty(67 EHA,44 TEA)of whom seven had mild ulnar nerve affection and one had severe persistent ulnar nerve affection.No further treatment was provided.CONCLUSION The risk of ulnar nerve affection after surgical treatment for acute DHF is low when the ulnar nerve is released in situ without nerve transposition,independently of the treatment provided.
基金supported by the National Natural Science Foundation of China(grant No.51803114)Shaanxi Province Key R&D Program(grant No.2022NY-195)+4 种基金Xi'an City Innovation Capability Strong Foundation Plan-Agricultural Technology R&D(grant No.21NYYF0025)Shaanxi Province Education Department Service Local Special Program Project(grant No.22jcO15)Shaanxi Province Key R&D Program(grant No.2020SF-411)Industry-University-Research Cooperation Project of Yulin Science and Technology Bureau(grant No.CXY-2020-086)National Key R&D Projects in 2021(grant No.2021YFC1808900).
文摘To improve drug utilization,reduce the drug administration frequency,increase the release time,and reduce the drug side effects in the human body,we prepared(KHA/CMC-Fe^(3+))@CS hydrogel spheres using green and natural potassium humate(KHA),carboxymethyl cellulose(CMC),and chitosan(CS)as raw materials and Fe3+as a crosslinking agent,and loaded them with riboflavin for drug sustainedrelease study using the drop ball method.The tests with FTIR,SEM,TG,and X-ray diffractometer showed that the coordination among KHA,CMC,and Fe^(3+)formed a three-dimensional network structure,where cs was encapsulated on the surface of the hydrogel spheres via noncovalent bonding,resulting in good thermal stability.The stability,drug loading,swelling,and in vitro release of the(KHA/CMC-Fe^(3+))@CS hydrogel spheres were investigated.The results showed that the hydrogel spheres were significantly pH-sensitive,with 11.16 g/g higher swelling in an alkaline environment(pH=7.4)than that in an acidic environment(pH=1.2).The swelling and drug release process of the hydrogel spheres were analyzed using mathematical models,concluding that the hydrogel swelling follows Schott second-order swelling kinetics,and the drug release mechanism was Fickian delivery mode.