Association between Serum Ferritin Levels and Metabolic-associated Fatty Liver Disease in Adults:a Cross-sectional Study Based on the NHANES

Objective Ferritin,initially acting as an iron-storage protein,was found to be associated with metabolic diseases.Our study was designed to investigate the association between serum ferritin and metabolic-associated fatty liver disease(MAFLD)using data from the National Health and Nutrition Examination Survey(NHANES)of the United State of America.Methods A cross-sectional study was conducted,enrolling a total of 2145 participants from the NHANES in the 2017–2018 cycles.Hepatic steatosis and liver fibrosis were assessed by ultrasound images and several non-invasive indexes.Multiple regression analysis was conducted to determine the associations between serum ferritin concentration and MAFLD and liver fibrosis.Results The analysis revealed that participants with higher serum ferritin levels(Q3 and Q4 groups)had a higher prevalence of MAFLD than those with the lowest serum ferritin levels[Q3 vs.Q1:OR=2.17(1.33,3.53),P<0.05 in fatty liver index(FLI);Q4 vs.Q1:OR=3.13(1.91,5.13),P<0.05 in FLI].Additionally,participants with the highest serum ferritin levels(Q4 group)displayed a higher prevalence of liver fibrosis[Q4 vs.Q1:OR=2.59(1.19,5.62),P<0.05 in liver stiffness measurement;OR=5.06(1.12,22.94),P<0.05 in fibrosis-4 index],with significantly increased risk observed in participants with concomitant diabetes[OR=7.45(1.55,35.72),P=0.012].Conclusion Our study revealed that elevated serum ferritin levels are associated with a higher prevalence of MAFLD and advanced liver fibrosis in patients.Elevated serum ferritin levels combined with diabetes are important risk factors for liver fibrosis.

Serum tumor markers (carcinoembryonic antigen, carbohydrate antigen 19-9, carbohydrate antigen 72-4, carbohydrate antigen 24-2, ferritin) and gastric cancer prognosis correlation

BACKGROUND Gastric cancer is a kind of malignant tumor which is prevalent all over the world.Although some progress has been made in the treatment of gastric cancer,its prognosis is still not optimistic,so it is of great significance to find reliable prog-nostic indicators to guide the treatment and management of patients with gastric cancer.AIM To explore the relationship between serum levels of five biomarkers[carcinoem-bryonic antigen(CEA),carbohydrate antigen(CA)19-9,CA72-4,CA24-2,and ferritin]and prognosis in patients with gastric cancer.METHODS This study included 200 patients with gastric adenocarcinoma,and conducted an in-depth analysis of their baseline characteristics,relationship between tumor markers and staging,and prognosis.The study found that CA19-9 has a signi-ficant correlation with tumor stage,the average levels of CA24-2,CEA,CA72-4 and ferritin were slightly increased disregarding the stage of tumor.Survival analysis showed that increases in CEA,CA19-9,CA24-2,and ferritin were all associated with shortened overall survival of patients.Further multivariate ana-lysis revealed that elevated serum CA72-4 levels were an inde-pendent adverse prognostic factor.RESULTS This study reveals that there is a significant correlation between the expression levels of serum tumor markers CEA,CA19-9,CA72-4,CA24-2 and ferritin in patients with gastric cancer and prognosis,and can be used as important indicators for prognostic evaluation of gastric cancer.In particular,markers that appear abnormally elevated initially may help identify gastric cancer patients with poor prognosis.CONCLUSION Serum CEA and CA19-9 play an important role in the prognosis assessment of gastric cancer,and are effective tools to guide clinical practice and optimize individualized treatment strategies for gastric cancer patients.

Study on The Method of Quantitative Analysis of Serum Ferritin and Soluble Transferrin Receptor with Protein Microarray Technology

Objective To establish and evaluate a protein serum ferritin （SF） and soluble transferrin receptor microarray method for combined measurement of （sTfR）. Methods Microarrayer was used to print both anti-SF antibodies I and anti-sTfR antibodies I on each protein microarray. Anti-SF antibodies II and anti-sTfR antibodies II were used as detection antibodies and goat antibodies coupled to Cy3 were used as antibodies Ill. The detection conditions of the quantitative analysis method for simultaneous measurement of SF and sTfR with protein microarray were optimized and evaluated. The protein microarray was compared with commercially available traditional tests with 26 serum samples. Results By comparison experiment, mouse monoclonal antibodies were chosen as the probes and contact printing was chosen as the printing method. The concentrations of SF and sTfR probes were 0.5 mg/mL and 0.5 mg/mL respectively, while those of SF and sTfR detection antibodies were 5 μg/mL and 0.36 μg/mL respectively. Intra- and inter-assay variability was between 3.26% and 18.38% for all tests. The regression coefficients comparing protein microarray with traditional test assays were better than 0.81 for SF and sTfR. Conclusion The present study has established a protein microarray method for combined measurement of SF and sTfR.

血清SF、HbA1c水平对妊娠期糖尿病孕妇围产结局的预测价值

目的 探讨血清铁蛋白(SF)、糖化血红蛋白(HbA1c)水平对妊娠期糖尿病(GDM)孕妇发生不良围产结局的预测价值。方法 选取2021年3月至2023年2月于邛崃市妇幼保健院(下称该院)行产前检查并住院分娩的GDM孕妇97例为观察组,另选取同期于该院产检的健康孕妇116例为对照组。比较两组的空腹血糖(FBG)、SF、HbA1c水平,对比分析观察组中不同围产结局孕妇的临床特征以及SF、HbA1c水平,分析GDM孕妇不良围产结局的影响因素以及血清SF、HbA1c水平预测GDM孕妇不良围产结局的价值。结果 观察组的FBG、总胆固醇(TG)、三酰甘油(TC)、低密度脂蛋白胆固醇(LDL-C)、SF、HbA1c水平均高于对照组,差异有统计学意义(P<0.05)。GDM孕妇中围产结局不良组的FBG、TG、TC、SF、HbA1c水平高于良好组,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,FBG、TG、TC、SF、HbA1c是不良围产结局的独立影响因素(P<0.05)。受试者工作特征(ROC)曲线分析结果显示,SF、HbA1c及二者联合预测曲线下面积(AUC)分别为0.741(95%CI:0.638~0.844)、0.685(95%CI:0.570~0.800)、0.874(95%CI:0.797~0.951)。结论 SF、HbA1c在GDM孕妇体内呈高表达,SF联合HbA1c对GDM孕妇围产结局具有一定的预测价值。

生血宝联合琥珀酸亚铁治疗产褥期缺铁性贫血对外周血RBC、Mcv、Sf水平的影响

目的:探讨生血宝联合琥珀酸亚铁治疗产褥期缺铁性贫血对外周血红细胞计数(Red blood cell count,RBC)、平均红细胞体积(Mean corpuscular volume,Mcv)、血清铁蛋白(Serum ferritin,Sf)水平的影响。方法:选择2020年3月~2023年12月本院收治的60例产褥期缺铁性贫血产妇作为研究对象,按随机数字表法分为对照组和观察组,各30例。对照组接受琥珀酸亚铁治疗,观察组接受琥珀酸亚铁联合生血宝治疗。比较治疗前、治疗1m后两组血液指标[RBC、Mcv、平均红细胞血红蛋白含量(Mean corpuscular hemoglobin,MCH)]、铁代谢指标[Sf、转铁蛋白受体(Soluble transferrin receptor,STFR)、转铁蛋白饱和度(Transferin saturation,TSAT)]的变化情况,并比较两组疗效和治疗期间不良反应发生率。结果:观察组治疗有效率明显高于对照组(P<0.05);治疗后,观察组RBC、MCV、MCH、Sf、TSAT水平明显高于对照组(P<0.05),STFR水平明显低于对照组(P<0.05);两组不良反应发生率无明显差异(P>0.05)。结论:生血宝联合琥珀酸亚铁可改善产褥期缺铁性贫血患者血液学指标,提高红细胞的发育程度,改善铁代谢水平。

SF、HCY和LP-PLA2与急性脑梗死相关性研究

目的 检测急性脑梗死患者血清铁蛋白(SF)、同型半胱氨酸(HCY)和脂蛋白相关凝脂酶A2(LP-PLA2)水平,探讨其与急性脑梗死(ACI)相关性及其临床价值。方法 选取我院2018年1月至2019年10月171例ACI患者作为研究组,根据病情分为大梗死组、中梗死组、小梗死组及腔隙性脑梗死组;同时选取同期的健康体检者50例作为对照组。采用磁微粒化学发光法检测SF、循环酶法检测HCY及电化学发光免疫法检测LP-PLA2水平,并对其进行比较,分析其与脑梗死相关性,对比单项及SF、HCY、LP-PLA2三项联合检测诊断ACI灵敏度及特异度。结果 研究组SF、HCY和LP-PLA2水平均高于对照组(P均<0.05);大梗死组SF、HCY和LP-PLA2水平均高于中梗死、小梗死及腔隙性脑梗死组(P均<0.05),中梗死与小梗死组SF、HCY和LP-PLA2水平均无明显差异(P均>0.05),中梗死、小梗死组SF、HCY和LP-PLA2水平均高于腔隙性脑梗死组(P均<0.05);SF、HCY及LP-PLA2三者联合检测ACI灵敏度是64.7%(110/171),特异度是98%(49/50),三者联合检测灵敏度均高于三者单项检测(P均<0.05)。结论 SF、HCY和LP-PLA2与ACI有明显相关性,且与脑梗死面积密切相关,三者联合检测可提高诊断ACI梗死面积的灵敏度及特异度,对ACI严重程度及临床预后的预判有重要临床价值。

Association of Red Meat Usual Intake with Serum Ferritin and the Risk of Metabolic Syndrome in Chinese Adults: A Longitudinal Study from the China Health and Nutrition Survey

Objective The present study aimed to investigate the association of red meat usual intake with metabolic syndrome(Met S),and explore the contribution of red meat usual intake to serum ferritin.Methods Based on the data from the longitudinal China Health and Nutrition Survey(CHNS),2,797 healthy adults aged 18–75 years without hypertension,diabetes,and Met S were selected in 2009 as subjects and follow-up studies were carried out till 2015.We used the National Cancer Institute(NCI)method to estimate the usual intake of foods.Multivariable logistic regressions were performed to evaluate the association between red meat usual intake and the risk of Met S.Quantile regression analysis was used to study the relationship between red meat consumption and serum ferritin levels.Results After adjusting for potential confounders,red meat,and fresh red meat were positively associated with the risk of Met S(RR=1.41,95%CI:1.05–1.90 and RR=1.37,95%CI:1.02–1.85,respectively).These relationships showed increasing trend(P<0.05).The level of serum ferritin increased significantly with the number of Met S components(P<0.05).The quantile regression analysis showed that red meat and fresh red meat usual intake had a significant positive association with serum ferritin levels across the entire conditional serum ferritin distribution(P<0.05).Processed red meat did not exhibit a similar association.Conclusion Higher red meat usual intake was associated with an increased risk of Met S and elevated serum ferritin levels.

The validity of serum ferritin levels in predicting cardiovascular events of metabolic dysfunction-associated steatotic liver disease patients may need more consideration

We read with great interest the informative study by Armandi et al.,which shed light on the potential role of serum ferritin in predicting the long-term prognosis of patients with metabolic dysfunction-associated steatotic liver disease(1).However,there remain certain facets requiring in-depth investigation and interpretation.First of all,the study found that integrating stepwise increased ferritin thresholds(215.5 and 272µg/L)into predictive models can improve the performance of fibrosis-4(FIB-4)and Non-Alcoholic Fatty Liver Disease Fibrosis Score(NFS)in the longitudinal risk assessment of liver-related events and overall mortality.However,it has been suggested that metabolic hyperferritinaemia(MHF)appears to exhibit a male predominance(2,3).Since the study primarily comprised male participants(65%),it raises the query of whether the ferritin threshold based on the entire population can accurately predict risks within female patients.Therefore,a sex-specific analysis is warranted to ensure a more precise evaluation.

Serum Ferritin and the Risk of Metabolic Syndrome:A Systematic Review and Dose-Response Meta-Analysis of Cross-sectional Studies

Objective This study aims to assess the dose-response relationship between serum ferritin(SF)and metabolic syndrome(MetS)in the two sexes.Methods We searched for articles on PubMed,the Cochrane Library,EMBASE,and the Web of Science databases that were published from 1950 to 2020.The summary odds ratio(OR)and 95%confidence interval(CI)of the association between SF and MetS were estimated using a random-effects model through a meta-analysis.Based on the methods described by Greenland and Longnecker,we explored the dose-response relationship between the two sexes.Results This study included 14 studies and 74,710 samples.The results of the classical meta-analysis showed that SF was positively associated with MetS(OR=1.77,95%CI:1.59–1.98).Regarding the components of MetS(8 studies included),the results showed that SF was positively associated with abdominal obesity(OR=1.42,95%CI:1.24–1.62),elevated fasting plasma glucose(OR=1.84,95%CI:1.50–2.25),elevated blood pressure(OR=1.17,95%CI:1.08–1.26),elevated triglycerides(OR=2.09,95%CI:1.72–2.54),and reduced high-density lipoprotein cholesterol(OR=1.33,95%CI:1.19–1.49).In the linear dose-response meta-analysis,the ORs of males,females,and postmenopausal females were 1.14(95%CI:1.13–1.16),1.32(95%CI:1.26–1.39),and 1.34(95%CI:1.22–1.47),respectively.Conclusions Our study shows that SF is significantly and positively associated with MetS,and the risk in the male population is higher than that in the female population.This finding also supports the recommendation of using SF as an early warning marker of MetS.

Study on the Correlation between the Expression of Serum Ferritin and Gestational Diabetes Mellitus

Objective: To explore the relationship between serum ferritin (SF) and gestational diabetes mellitus (GDM), for providing new ideas to the prevention and treatment of GDM. Methods: All the pregnant women were selected in Yinan Maternal and Child Health-Care Hospital from December, 2015 to March, 2018 when they were having routine prenatal examination, According to the diagnostic criteria of GDM, 72 patients with GDM were selected as the case group and 72 normal pregnant women were randomly selected as the control group. Fasting venous blood was drawn from all subjects during the first trimester of pregnancy (11-13 weeks) and the second trimester of pregnancy (24-28 weeks). Fasting plasma glucose was measured by glucose oxidase assay and the expression level of SF was determined by electrochemical method. The application value of SF in GDM diagnosis was evaluated by ROC curve. Results: The levels of SF in the case group at early and middle stages are 49.6 ± 18.8 (μg/ml) and 39.8 ± 21.5 (μg/ml), which re 39.4 ± 15.2 (μg/ml) and 32.2 ± 17.6 (μg/ml) in the control group. The levels of SF in the case group were higher than those in the control group (p < 0.05) at early and middle stages. The curve (AUC) of SF level in the diagnosis of GDM was 0.895, p < 0.001; the Youden index was 0.651 and the optimum threshold was 38.6 ng/ml, with a sensitivity of 97.8% and a specificity of 67.3%. Conclusion: The expression level of SF in early pregnancy is correlated with the occurrence of GDM, which may be an important indicator for the prevention and monitoring of GDM.

Serum ferritin levels in children with attention deficit hyperactivity disorder and tic disorder

BACKGROUND Iron plays an important role in neurodevelopmental functions in the brain.Serum ferritin levels are different in children with attention deficit hyperactivity disorder and tic disorder than in healthy children.AIM To explore the current status of iron deficiency in children with neurodevelopmental disorders and its sex and age effects.METHODS A total of 1565 children with attention deficit hyperactivity disorder(ADHD),1694 children with tic disorder(TD),93 children with ASD and 1997 healthy control children were included between January 1,2020,and December 31,2021 at Beijing Children's Hospital.We describe the differences in age levels and ferritin levels between different disease groups and their sex differences.The differences between the sexes in each disease were analyzed using the t test.The incidence rate of low serum ferritin was used to describe the differences between different diseases and different age groups.A chi-square test was used to analyze the difference in the incidence of low serum ferritin between the disease group and the control group.Analysis of variance was used for comparisons between subgroups,and regression analysis was used for confounding factor control.RESULTS A total of 1565 ADHD patients aged 5-12 years were included in this study,and the average serum ferritin levels of male and female children were 36.82±20.64μg/L and 35.64±18.56μg/L,respectively.A total of 1694 TD patients aged 5-12 years were included in this study,and the average serum ferritin levels of male and female children were 35.72±20.15μg/L and 34.54±22.12μg/L,respectively.As age increased,the incidence of low serum ferritin in ADHD and TD first decreased and then increased,and 10 years old was the turning point of rising levels.The incidence of ADHD with low serum ferritin was 8.37%,the incidence of TD with low serum ferritin was 11.04%,and the incidence of the healthy control group with low serum ferritin was 8.61%,among which male children with TD accounted for 9.25%and female children with TD accounted for 11.62%.There was a significant difference among the three groups(P<0.05).In addition,there were 93 children with ASD with an average serum ferritin level of 30.99±18.11μg/L and a serum ferritin incidence of 15.05%.CONCLUSION In conclusion,low serum ferritin is not a risk factor for ADHD or TD.The incidence of low serum ferritin levels in children with ADHD and TD between 5 and 12 years old decreases first and then increases with age.

Effect of minimally invasive intracranial hematoma drainage on inflammatory factors, serum ferritin and serum P substance in patients with hypertensive cerebral hemorrhage

Objective:To study the effect of minimally invasive intracranial hematoma drainage on inflammatory factors, serum ferritin and serum P substance in patients with hypertensive cerebral hemorrhage.Methods:92 cases of hypertensive cerebral hemorrhage patients in our hospital were selected and randomly divided into 2 groups: minimally invasive group (51 cases) and routine group (41 cases). Minimally invasive intracranial hematoma drainage was performed on the minimally invasive group. Bone flap decompression or small bone window craniotomy were used in the routine group. Tumor necrosis factorα (TNF-α), interleukin-6 (IL-6), high sensitive C reactive protein (hs-CRP) and serum protein (SF), serum substance P (SP) in the 2 groups were detected before treatment and 2 weeks after treatment.Results: The comparison of TNF-α, IL-6, hs-CRP, SP, and SF in the two groups before treatment was not statistically significant (P>0.05). TNF-α, IL-6, hs-CRP and SF in both groups after treatment significantly decreased, compared with that before treatment (P<0.01,P<0.05). TNF-α, IL-6, and SF in minimally invasive group decreased more significantly than that in routine group (P<0.01);The comparison of SP in the two groups after treatment significantly increased compared with that before treatment (P<0.01,P<0.05). SP in minimally invasive group increased more significantly than that in routine group (P<0.05).Conclusions:Compared with bone flap decompression or small bone window craniotomy, minimally invasive intracranial hematoma drainage can inhibit inflammatory reaction, reduce the degree of nerve damage and alleviate clinical symptoms more effectively.

Effect of urokinase in combined with minimally invasive intracranial hematoma evacuation on serum ferritin, serum P substance, inflammatory factors and vascular endothelial function in patients with hypertensive intracerebral hemorrhage

Objective: To investigate the effects of minimally invasive evacuation of intracranial hematoma on serum SP, SF, vascular endothelial function and inflammatory factors of patients with hypertensive intracerebral hemorrhage. Methods: According to random data table method, a total of 120 patients with hypertensive cerebral hemorrhage from September 2016 to May 2017 were divided into observation group and the control group, 60 cases in each group. The control group was treated with conventional treatment;on the basis of conventional treatment, the observation group underwent minimally invasive evacuation of intracranial hematoma. The levels of serum SF, SP, vascular endothelial function and inflammatory factors changes were compared between the two groups before and after the treatment. Results: Before treatment, the levels of serum SP, SF, NO, ET-1, hs-CRP, IL-6, TNF-α in the two groups were not statistically significant. The levels of hs-CRP, IL-6, TNF-α, SF, ET-1 after treatment in two groups were significantly lower than those in the same group before treatment, and the observation group levels were significantly lower than those in the control group;the levels of SP, NO in the two groups after treatment were significantly higher than before treatment, and the observation group was higher than that the control group with significant difference. Conclusion: The minimally invasive intracranial hematoma evacuation for patients with HICH can effectively improve the levels of SP, SF, inflammatory factors and vascular endothelial function, which is helpful to relieve cerebral edema and lower intracranial pressure, and improve the quality of treatment.

宫颈鳞癌患者血清SCC、SF、CA72-4、CA15-3水平分析

目的:探讨鳞状细胞癌抗原(SCC)、血清铁蛋白(SF)、糖类抗原72-4(CA72-4)和糖类抗原15-3(CA15-3)与宫颈鳞癌关系。方法:选取2019年1月-2021年8月入本院治疗的宫颈鳞癌患者60例纳入宫颈鳞癌组,同期体检健康女性60例为对照组。采用全自动电化学发光免疫分析仪检测血清SCC、SF、CA72-4、CA15-3水平,并对比两组及宫颈鳞癌组不同分化/分期/预后者水平差异;结果:宫颈鳞癌组SCC(4.21±1.05 ng/L)、SF(272.63±29.58 ng/ml)、CA72-4(19.88±3.71 U/ml)、CA15-3(215.46±36.89 U/ml)水平均高于对照组(0.50±0.12 ng/L、59.15±7.11 ng/ml、1.49±0.85 U/ml、8.37±0.51 U/ml),且宫颈鳞癌组中低分化患者高于高分化患者、临床分期增加水平升高;随访1年,肿瘤进展组SCC、SF、CA72-4、CA15-3水平均高于肿瘤无进展组(均P<0.05)。结论:宫颈鳞癌患者血清SCC、SF、CA72-4、CA15-3表达异常升高,且与分化/分期和预后有关,临床可将其作为宫颈鳞癌随访和预后辅助检测指标。

RADIOIMMUNOASSAY OF SERUM FERRITIN LEVEL IN PATIENTS WITH RECURRENT APHTHOUS ULCERATION

The purpose of this study was to assess the correlation between iron deficiency and recurrent aphthous ulceration (RAU). Radioimmunoassay was used to examine the serum ferritin level (SFL) in 52 patients with RAU and in 54 controls. Both were divided into 2 groups in accordance with sex. The 36 female patients were subdivided into 3 age-groups as follows: 8 aged 22-24, 10 aged 25-34, and 18 aged 35-50 while the male patients were gathered as one single group aged 26-57. The subdivision was adapted similarly for the normal age-grouts. Although no significant difference in SFL was found between the male control and the male patient groups, differences between the female control and female patient groups showed highly significant which levels, with the ascendance of age, were P【0.001, P【0.005 and P【0.001, respectively. Also the difference between male and female control groups were significant (P【0.05). However, no significant differences in SFL were discovered among the 3 patient groups. 10 female patients with SFL【12ng/ml were tested with ferrous sulfate for one month, then their SFL was reexamined one week after the treatment. A highly significant difference in SFL was noted between the pre-ad post-treatment (P【0.001). 9 of them showed that the interval of recurrences were prolonged, the number of ulcers reduced, the pain less intensive and its duration shorter than those before the treatment. This study demonstrated that a singificant decrease in iron-storage occurred in female RAU patients. The authors concluded that the decrease SFL was possibly related to menstruation and child bearing.

Association between Intestinal Helminthiasis and Serum Ferritin Levels Among School Children

Background: Significant iron deficiency anaemia is a major concern in children with helminthiasis, because it may eventually contribute to the growing health challenges of severe anaemia This descriptive cross sectional study was carried out to determine the association between serum ferritin levels and intestinal helminthiasis among school children. Methods: A structured questionnaire was used to collect the study population data. Stool specimens were obtained and examined on the same day using the sedimentation method for identification of the parasite. Blood samples were also obtained for full blood count and serum ferritin measurement. Results: A total of 246 school children were studied with a response rate of 82%. The prevalence of intestinal helminthiasis was 29.7%. The different helminthes identified included Ascaris lumbricoides, Necator americanus, Trichuris trichiura, Strongyloides stercoralis. Of the population studied, 36.2% were anaemic, 15.9% had microcytosis, and 47.6% had hypochromia. The prevalence of ex-hausted iron stores was 3.7%. Serum ferritin levels were significantly lower in children with intestinal helminthiasis compared with controls. Conclusions: The findings in this study demonstrate an inverse re-lationship between intestinal helminthiasis and serum ferritin levels and this is more marked in pupils with hookworm infections. The control of intestinal hel-minthiasis and prevention of iron deficiency anaemia should be given high priority in the implementation of the school health programme.

血清SF、VEGF联合CEA检测在乳腺癌诊断、复发转移预测中的价值

目的分析血清铁蛋白(SF)、血管内皮细胞生长因子(VEGF)联合血清癌胚抗原(CEA)检测在乳腺癌诊断、复发转移预测中的价值。方法选取2020年2月至2022年1月东营市人民医院收治的104例乳腺疾病患者,病理学检查结果显示54例为乳腺癌患者,将其纳入观察组,50例良性乳腺疾病患者,纳入对照组。对比两组血清SF、VEGF及CEA水平,分析SF、VEGF及CEA单独检测与联合检测在乳腺癌诊断中的敏感性及特异性。随访12个月,根据肿瘤复发转移情况将观察组分为未复发转移组与复发转移组,比较两组血清SF、VEGF及CEA水平,并分析三者联合检测对乳腺癌复发转移的预测价值。结果观察组患者血清SF、VEGF及CEA水平均高于对照组,差异具有统计学意义(P<0.05)。在乳腺癌的诊断中,SF、VEGF及CEA联合检测的敏感性和特异性均高于单项检测(P<0.05)。在54例乳腺癌患者中,发生复发转移的患者有11例,未复发转移的患者有43例。复发转移组患者血清SF、VEGF及CEA水平均高于未复发转移组,差异具有统计学意义(P<0.05)。依据ROC曲线可知,SF、VEGF及CEA联合检测乳腺癌复发转移的敏感度和特异度分别为0.819和0.802,AUC=0.843(95%CI:0.761~0.926),明显高于单项检测(P<0.05)。结论乳腺癌患者血清SF、VEGF及CEA表达水平均升高,三者联合检测在乳腺癌的诊断及术后复发转移的预测中具有重要的指导意义。

Prognostic role of pretreatment serum ferritin concentration in lung cancer patients:A meta-analysis

BACKGROUND The association between pretreatment serum ferritin concentration(SFC)and long-term survival in lung cancer remains unclear now.AIM To identify the prognostic value of pretreatment SFC in lung cancer patients based on current evidence.METHODS The PubMed,EMBASE and Web of Science databases were searched from inception to May 29,2022 for relevant studies.The primary endpoint was overall survival(OS)and the hazard ratios(HRs)with corresponding 95%confidence intervals(CIs)were combined to assess the predictive role of pretreatment SFC for long-term survival of lung cancer patients.The data were then extracted and assessed on the basis of the Reference Citation Analysis(https://www.reference citationanalysis.com/).RESULTS Twelve retrospective studies involving 1654 patients were analyzed.The results manifested that increased pretreatment SFC was associated with worse OS(HR=1.09,95%CI:1.03-1.15,P=0.004).Subgroup analysis stratified by the country(China vs non-China)showed similar results.However,subgroup analysis stratified by tumor type revealed inconsistent results(lung cancer:HR=1.39,P=0.008;small cell lung cancer:HR=1.99,P=0.175;non-small cell lung cancer:HR=1.03,P=0.281).CONCLUSION Pretreatment SFC might serve as a promising prognostic indicator in lung cancer patients and elevated pretreatment SFC predicts worse prognosis.However,more high-quality studies with big sample sizes are still needed to further verify its prognostic value in lung cancer.

Analysis of Serum Ferritin Level and Its Clinical Value in Advanced Gastric Cancer

Objective: To investigate the concentration and clinical significance of serum ferritin (SF) in patients diagnosed with advanced gastric cancer before and after treatment. Methods: Forty patients with advanced gastric cancer diagnosed by cytology or pathology in our hospital were selected, including 25 males and 15 females, aged from 48 to 85 years, and the median age was 61.0 years. 40 healthy volunteers matched with age and education were selected as the control group. In order to study the changes of SF level in the treatment of advanced gastric cancer, we divided the patients into effective group (efficacy evaluation as partial remission or complete remission), ineffective group (efficacy evaluation as no remission) and recurrence group according to the efficacy after treatment. Then the difference of SF level between different groups and the relationship between SF level and curative effect were analyzed. There was no significant difference in gender and age among all groups. Results: The SF levels in the newly diagnosed group, stage III patient group and stage IV patient group were significantly higher than those in the control group. The level of SF in stage IV patients was significantly higher than that in stage III patients. There were significant differences in SF level between the effective treatment group, the newly diagnosed group and the ineffective treatment group, but there was no significant difference in SF level between the newly diagnosed group and the ineffective treatment group. Conclusion: SF level has a certain value in the auxiliary diagnosis of gastric cancer, and it also has a certain guiding significance for the evaluation of curative effect and prognosis after treatment.

妊娠期缺铁性贫血患者SF、TRF指标与围生期结局的相关性分析及临床意义

目的分析妊娠期缺铁性贫血患者血清铁蛋白(SF)、血清转铁蛋白(TRF)指标与围生期结局的相关性及临床意义。方法将2020年8月至2022年8月到医院诊治的43例妊娠期缺铁性贫血患者纳入研究组,另选择同时间段内就诊的43例妊娠期正常女性纳入对照组,两组均接受血清SF、TRF检测。对比两组的SF、TRF水平,观察两组的围生期结局,分析血清SF、TRF与围生期结局的相关性及临床意义。结果研究组的血清SF水平低于对照组,TRF水平高于对照组(P<0.05)。在不良围生期结局发生率方面,研究组高于对照组(P<0.05)。胎儿生长受限、胎儿窘迫、早产及产后出血患者的血清SF水平显著低于非胎儿生长受限、胎儿窘迫、早产及产后出血患者,TRF水平高于非胎儿生长受限、胎儿窘迫、早产及产后出血患者,对比差异有统计学意义(P<0.05)。围生期结局良好组的血清SF水平高于围生期结局不良组,TRF水平低于围生期结局不良组(P<0.05)。妊娠期缺铁性贫血患者ST水平与不良围生期结局呈正相关关系,TRF水平与不良围生期结局呈负相关关系(P<0.05)。结论血清SF、TRF水平与妊娠期缺铁性贫血患者的围生期结局具有相关性,可将其作为诊断妊娠期缺铁性贫血的辅助指标。