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Subcutaneous pedicle Limberg flap for repairing skin defects in the face
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作者 李军辉 邢新 +3 位作者 欧阳天祥 李萍 许洁 郭恩覃 《Journal of Medical Colleges of PLA(China)》 CAS 2005年第2期110-113,共4页
Objective:To investigate the effect of a subcutaneous pedicle Limberg flap for the reconstruction of medium-sized skin defects in the face following skin tumor or scar excision. Methods: From August 2002 to June 2004,... Objective:To investigate the effect of a subcutaneous pedicle Limberg flap for the reconstruction of medium-sized skin defects in the face following skin tumor or scar excision. Methods: From August 2002 to June 2004,the subcutaneous pedicle Limberg flap was designed to repair facial skin defects in 17 patients(19 flaps),and the size of the lesions ranged from 2.0 cm×1.9 cm to 5.0 cm×4.5 cm.The operation was performed under general anesthesia in 2 children,and under local anesthesia in the remaining 15 patients. Results: All flaps survived with primary healing postoperatively.With a follow-up from 1 to 22 months,neither short-term nor long-term postoperative complications such as flap necrosis,hematoma,infection,visible dog-ear and trap door deformity were found,and functionally and cosmetically satisfactory outcomes were achieved. Conclusion: This subcutaneous pedicle Limberg flap provides a competitive repair alternative for the treatment of medium-sized skin defects in the face. 展开更多
关键词 subcutaneous pedicle Limberg flap skin defect FACE
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Application of free vein skin flap on the anterior aspect of wrist in the case of finger injury with vessel and skin defect
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作者 张惠茹 《外科研究与新技术》 2003年第2期89-89,共1页
Objective To introduce an effective reconstruction method for the finger injured with vessel and skin defect. Methods Free skin flap with skin vein was transplanted on the site of tissue defect, connecting by anastomo... Objective To introduce an effective reconstruction method for the finger injured with vessel and skin defect. Methods Free skin flap with skin vein was transplanted on the site of tissue defect, connecting by anastomosis the vein with artery or vein of the finger. Results Seven cases were treated with this method,among which 5 cases have sikin defect on the palm aspect of fingers, the rest have skin defect on the dorsal aspect skin of finger. All fingers survived with good shape and function. Conclusion This is a simple and effective method of finger reconstruction for the patients with defect of vessels and skin. 6 refs. 展开更多
关键词 of Application of free vein skin flap on the anterior aspect of wrist in the case of finger injury with vessel and skin defect
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Repair of facial skin defect with a skin flap of SMAS pedicle
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作者 王晓军 《外科研究与新技术》 2005年第3期214-214,共1页
To report a method of repair facial skin defects with a skin flap of SMAS pedicle.Methods According to the size of defect of skin,design a skin flap with SMAS pedicle for repair of defect.Results The method has been s... To report a method of repair facial skin defects with a skin flap of SMAS pedicle.Methods According to the size of defect of skin,design a skin flap with SMAS pedicle for repair of defect.Results The method has been successfully applied for skin defects of eyelid and lip in 14 cases with satisfied results.The area of the largest flap was 5 cm×3 cm.Conclusion Repairing facial defects such as eyelid skin defect or lip skin defect with skin flap of SMAS pedicle is a very good method.The flap has a good blood supporting and satisfactory color and flexibility.5 refs,6 figs. 展开更多
关键词 Repair of facial skin defect with a skin flap of SMAS pedicle
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Bipedicled Mini V-Y Advancement Flap for Skin Defect of the Face
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作者 Mikiko Ooshima Mariko Kochi +3 位作者 Daichi Morioka Towa Miyamoto Tomoko Tsuda Koichi Kadomatsu 《Modern Plastic Surgery》 2018年第2期15-20,共6页
In young patients, even small circular facial defects after the excision of benign skin tumors present a reconstructive challenge. The usefulness of a V-Y advancement flap for reconstructing such defects is well docum... In young patients, even small circular facial defects after the excision of benign skin tumors present a reconstructive challenge. The usefulness of a V-Y advancement flap for reconstructing such defects is well documented. We refined this technique as a mini V-Y advancement flap consisting of two subcutaneous pedicles that vascularize the skin island via subdermal plexus lateral bridges. This technique was used for 21 middle-aged or younger patients with a small benign skin lesion. None of them experienced any postoperative complications. Aesthetically excellent results were found in all patients. This small advancement flap could be attempted as an alternative to fusiform excision of small skin lesions, particularly in younger patients. 展开更多
关键词 FACIAL skin TUMOR skin defect Advancement FLAP Subdermal PLEXUS
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Regenerative Medicine: A Review of Solutions in the Treatment of Skin Defects
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作者 Melika Heidarzadeh Kaveh Same +4 位作者 Fatemeh Baghaie Nia Fatemeh Khavari Sina Shahabi Mohammad Hossein Nabian Saied Reza Mehrpour Mohammadabadi 《Open Journal of Regenerative Medicine》 2023年第2期97-113,共17页
The issue of skin defects is a major concern of almost every trauma surgeon after surgery. Despite numerous conventional methods and introduction of the reconstruction ladder, managing skin defects is still a challeng... The issue of skin defects is a major concern of almost every trauma surgeon after surgery. Despite numerous conventional methods and introduction of the reconstruction ladder, managing skin defects is still a challenge for the trauma surgeons. In recent years, parallel to the advances in the more conventional methods of skin repair, regenerative medicine has offered new and novel treatments. This article aims to explore these contemporary regenerative solutions as well as to review the conventional methods of treating skin defects. 展开更多
关键词 Regenerative Medicine skin WOUND defect
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One-step approach for full-thickness skin defect reconstruction in rats using minced split-thickness skin grafts with Pelnac overlay 被引量:11
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作者 Tong Liu Chao Qiu +2 位作者 Chi Ben Haihang Li Shihui Zhu 《Burns & Trauma》 SCIE 2019年第1期167-179,共13页
Background:Split-thickness skin grafting is the current gold standard for the treatment of traumatic skin loss.However,for patients with extensive burns,split-thickness skin grafting is limited by donor skin availabil... Background:Split-thickness skin grafting is the current gold standard for the treatment of traumatic skin loss.However,for patients with extensive burns,split-thickness skin grafting is limited by donor skin availability.Grafting split-thickness skin minced into micrografts increases the expansion ratio but may reduce wound repair quality.Dermal substitutes such as Pelnac can enhance the healing of full-thickness skin wounds,but their application currently requires two surgeries.The present study investigated whether it is possible to repair full-thickness skin defects and improve wound healing quality in a single surgery using Pelnac as an overlay of minced split-thickness skin grafts in a rat model.Methods:A full-thickness skin defect model was established using male Sprague-Dawley rats of 10 weeks old.The animals were randomly divided into control and experimental groups in which Vaseline gauze and Pelnac,respectively,were overlaid on minced split-thickness skin grafts to repair the defects.Wound healing rate and quality were compared between the two groups.For better illustration of the quality of wound healing,some results were compared with those obtained for normal skin of rats.Results:We found that using Pelnac as an overlay for minced split-thickness skin grafts accelerated wound closure and stimulated cell proliferation and tissue angiogenesis.In addition,this approach enhanced collagen synthesis and increased the formation of basement membrane and dermis as well as the expression of growth factors related to wound healing while reducing scar formation.Conclusions:Using minced split-thickness skin grafts overlaid with Pelnac enables the reconstruction of fullthickness skin defects in a single step and can increase the healing rate while improving the quality of wound healing. 展开更多
关键词 skin wound healing Full-thickness skin defect Minced skin graft Pelnac Split-thickness skin grafts RECONSTRUCTION
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Detection of skin defects on loquat using hyperspectral imaging combining both band radio and improved three-phase level set segmentation method 被引量:1
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作者 Zhaoyang Han Bin Li +2 位作者 Qiu Wang Zhaoxiang Sun Yande Liu 《Food Quality and Safety》 SCIE CSCD 2023年第1期100-111,共12页
Background and objectives Skin defects are one of the primary problems that occur in post-harvest grading and processing of loquats.Skin defects lead to the loquat being easily destroyed during transportation and stor... Background and objectives Skin defects are one of the primary problems that occur in post-harvest grading and processing of loquats.Skin defects lead to the loquat being easily destroyed during transportation and storage,which causes the risk of other loquats being infected,affecting the selling price.Materials and Methods In this paper,a method combining band radio image with an improved three-phase level set segmentation algorithm(ITPLSSM)is proposed to achieve high accuracy,rapid,and non-destructive detection of skin defects of loquats.Principal component analysis(PCA)was used to find the characteristic wavelength and PC images to distinguish four types of skin defects.The best band ratio image based on characteristic wavelength was determined.Results The band ratio image(Q782/944)based on PC2 image is the best segmented image.Based on pseudo-color image enhancement,morphological processing,and local clustering criteria,the band ratio image(Q782/944)has better contrast between defective and normal areas in loquat.Finally,the ITPLSSM was used to segment the processing band ratio image(Q782/944),with an accuracy of 95.28%.Conclusions The proposed ITPLSSM method is effective in distinguishing four types of skin defects.Meanwhile,it also effectively segments images with intensity inhomogeneities. 展开更多
关键词 LOQUAT skin defects hyperspectral imaging multispectral images band ratio improved three-phase level set segmentation.
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外源性碱性成纤维细胞生长因子促进大鼠创面愈合的机制 被引量:1
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作者 李振超 杜喜玲 +2 位作者 韩志新 牛大伟 樊昌伟 《中国组织工程研究》 CAS 北大核心 2025年第11期2243-2251,共9页
背景:深入揭示外源性碱性成纤维细胞生长因子促进创面愈合的分子机制。目的:探讨外源性碱性成纤维细胞生长因子对大鼠创面修复中巨噬细胞表型转换和肉芽再生的影响。方法:(1)体外细胞实验:分为正常对照组、低剂量碱性成纤维细胞生长因... 背景:深入揭示外源性碱性成纤维细胞生长因子促进创面愈合的分子机制。目的:探讨外源性碱性成纤维细胞生长因子对大鼠创面修复中巨噬细胞表型转换和肉芽再生的影响。方法:(1)体外细胞实验:分为正常对照组、低剂量碱性成纤维细胞生长因子组、高剂量碱性成纤维细胞生长因子组以及碱性成纤维细胞生长因子+丙戊酸组,其中低、高剂量碱性成纤维细胞生长因子组细胞培养基中分别添加100,200μg/L碱性成纤维细胞生长因子,碱性成纤维细胞生长因子+丙戊酸组细胞培养基中添加200μg/L碱性成纤维细胞生长因子和20 mmol/L Notch1/Jagged1激动剂丙戊酸。通过EdU实验、划痕实验、小管生成实验检测碱性成纤维细胞生长因子对人脐静脉内皮细胞增殖、迁移和血管新生的影响。(2)体内动物实验:SD大鼠按照随机数字表法分为模型组、低剂量碱性成纤维细胞生长因子组、高剂量碱性成纤维细胞生长因子组以及碱性成纤维细胞生长因子+丙戊酸组,构建大鼠全层皮肤缺损开放性创面模型,其中低、高剂量碱性成纤维细胞生长因子组皮下注射100,200μg/L碱性成纤维细胞生长因子,碱性成纤维细胞生长因子+丙戊酸组大鼠皮下注射200μg/L碱性成纤维细胞生长因子的同时腹腔注射10 mg/kg丙戊酸。给药7,14 d检测大鼠创面的愈合率;TUNEL检测创面组织中的细胞凋亡情况;酶联免疫吸附实验检测大鼠血清中丙二醛、超氧化物歧化酶、肿瘤坏死因子α和白细胞介素10水平;免疫荧光检测创面组织中巨噬细胞的表型转换情况;免疫组化检测创面组织中增殖细胞核抗原、CD31和血管内皮生长因子的表达;Western blot法检测创面组织中Notch1、Jagged1的表达。结果与结论:(1)与正常对照组相比,碱性成纤维细胞生长因子能明显促进人脐静脉内皮细胞的增殖、迁移和血管新生,并且具有剂量依赖性;(2)与模型组相比,碱性成纤维细胞生长因子能明显促进创面的愈合,下调创面组织中的细胞凋亡率;降低大鼠血清中丙二醛和肿瘤坏死因子α水平,升高超氧化物歧化酶和白细胞介素10水平;促使创面组织中巨噬细胞向M2型转换,上调创面组织中增殖细胞核抗原、CD31和血管内皮生长因子的表达;抑制创面组织中Notch1、Jagged1的表达,并且均具有剂量依赖性。丙戊酸可部分逆转碱性成纤维细胞生长因子对创面愈合的促进作用。结果表明,碱性成纤维细胞生长因子能明显促进创面愈合与肉芽再生以及诱导巨噬细胞向M2型转换,这可能与调控Notch1/Jagged1信号有关。 展开更多
关键词 碱性成纤维细胞生长因子 全层皮肤缺损 创面 巨噬细胞表型转换 肉芽再生 NOTCH1 JAGGED1
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脱细胞皮肤基质/聚氨酯混纺纤维支架促进大鼠皮肤缺损的修复 被引量:1
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作者 吴辰 江佳慧 +2 位作者 苏豆 刘晨 慈超 《中国组织工程研究》 CAS 北大核心 2025年第4期745-751,共7页
背景:研究证实,将脱细胞基质与聚合物进行混合纺丝不仅可改善纤维的结构性质,还可保存脱细胞基质的生物学活性,但是目前将聚氨酯与脱细胞皮肤基质进行静电纺丝制备皮肤组织工程支架还没有相关报道。目的:观察脱细胞皮肤基质/聚氨酯混纺... 背景:研究证实,将脱细胞基质与聚合物进行混合纺丝不仅可改善纤维的结构性质,还可保存脱细胞基质的生物学活性,但是目前将聚氨酯与脱细胞皮肤基质进行静电纺丝制备皮肤组织工程支架还没有相关报道。目的:观察脱细胞皮肤基质/聚氨酯混纺纤维支架对大鼠皮肤缺损的修复作用。方法:利用静电纺丝技术分别制备聚氨酯静电纺丝纤维支架和脱细胞皮肤基质/聚氨酯混纺纤维支架。扫描电镜下观察纤维结构;将大鼠脂肪间充质干细胞分别接种于两组支架上,扫描电镜下观察支架上的细胞形态。取10只SD大鼠,在每只大鼠背部制作3个1 cm×1 cm的全层皮肤缺损,其中2处缺损分别植入聚氨酯静电纺丝纤维支架(对照组)、脱细胞皮肤基质/聚氨酯混纺纤维支架(实验组),剩余缺损处不植入任何材料(空白对照组)。术后第1,2,3周,观察皮肤创面愈合情况;植入后第3周,进行创面苏木精-伊红染色,计算创面瘢痕面积。结果与结论:①扫描电镜下可见两种静电纺丝纤维均为网状结构,并且大鼠脂肪间充质干细胞在两种支架上沿纤维附着,黏附良好。②随着术后时间的延长,各组皮肤创面逐渐愈合,至术后第3周,实验组、对照组皮肤创面基本愈合,空白对照组创面可见小溃疡形成。皮肤创面苏木精-伊红染色显示,对照组、实验组创面表皮覆盖基本完整,真皮层内可见成纤维细胞长入和炎症细胞浸润,并且实验组创面胶原纤维较为丰富、排列规则有序,与表皮面基本平行;空白对照组创面表皮仍有缺损。实验组创面瘢痕面积小于其他两组(P<0.05,P<0.01)。③结果表明,脱细胞皮肤基质/聚氨酯混纺纤维支架可以有效修复大鼠全层皮肤缺损、改善创面瘢痕形成。 展开更多
关键词 脱细胞皮肤基质 聚氨酯 静电纺丝 皮肤缺损 瘢痕
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Reconstruction of massive skin avulsion of the scrota and penis by combined application of dermal regeneration template(Pelnac) and split-thickness skin graft with vacuum-assisted closure: A case report 被引量:1
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作者 Jia-Jie Fang Peng-Fei Li +3 位作者 Jia-Jun Wu Hai-Ying Zhou Li-Ping Xie Hui Lu 《World Journal of Clinical Cases》 SCIE 2019年第24期4349-4354,共6页
BACKGROUND Although skin avulsions to male external genitalia are rare, they can be both physically and psychologically traumatic. Thus, the necessity for judicious management poses significant challenges to surgeons ... BACKGROUND Although skin avulsions to male external genitalia are rare, they can be both physically and psychologically traumatic. Thus, the necessity for judicious management poses significant challenges to surgeons in order to avoid potential permanent disabilities. We report a case of massive penoscrotal skin avulsion and a composite graft was creatively applied to cover the defect which achieved good results. We believe that this case is of great reference value for fellow surgeons.CASE SUMMARY A 52-year-old male presented with massive traumatic avulsion of the penile and scrotal skin following mishandling of an electric drill. The avulsed skin was missing. The patient was diagnosed with massive skin avulsion of external genitalia. Following initial complete debridement of devitalized or infected tissues, Pelnac dermal substitute was secured to the defect with the assistance of negative-pressure wound closure. In the final step, the silicone layer of Pelnac was removed and a split-thickness skin graft was applied. The defect had healed at the two-month follow-up. The patient now has normal erections and satisfactory sexual function.CONCLUSION Our experience with this wound repair demonstrated that the combination of a dermal regeneration template and a split-thickness skin graft with vacuumassisted closure is a safe, well-tolerated and efficient solution for the reconstruction of massive penoscrotal skin defects. 展开更多
关键词 Artificial dermis Dermal regeneration template Massive skin defect Penoscrotal defect Split-thickness skin graft Case report
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3-D bioprinted human-derived skin organoids accelerate full-thickness skin defects repair
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作者 Tao Zhang Shihao Sheng +18 位作者 Weihuang Cai Huijian Yang Jiameng Li Luyu Niu Wanzhuo Chen Xiuyuan Zhang Qirong Zhou Chuang Gao Zuhao Li Yuanwei Zhang Guangchao Wang Hao Shen Hao Zhang Yan Hu Zhifeng Yin Xiao Chen Yuanyuan Liu Jin Cui Jiacan Su 《Bioactive Materials》 SCIE 2024年第12期257-269,共13页
The healing of large skin defects remains a significant challenge in clinical settings.The lack of epidermal sources,such as autologous skin grafting,limits full-thickness skin defect repair and leads to excessive sca... The healing of large skin defects remains a significant challenge in clinical settings.The lack of epidermal sources,such as autologous skin grafting,limits full-thickness skin defect repair and leads to excessive scar formation.Skin organoids have the potential to generate a complete skin layer,supporting in-situ skin regeneration in the defect area.In this study,skin organoid spheres,created with human keratinocytes,fibroblasts,and endothelial cells,showed a specific structure with a stromal core surrounded by surface keratinocytes.We selected an appropriate bioink and innovatively combined an extrusion-based bioprinting technique with dual-photo source cross-linking technology to ensure the overall mechanical properties of the 3D bioprinted skin organoid.Moreover,the 3D bioprinted skin organoid was customized to match the size and shape of the wound site,facilitating convenient implantation.When applied to full-thickness skin defects in immunodeficient mice,the 3D bioprinted human-derived skin organoid significantly accelerated wound healing through in-situ regeneration,epithelialization,vascularization,and inhibition of excessive inflammation.The combination of skin organoid and 3D bioprinting technology can overcome the limitations of current skin substitutes,offering a novel treatment strategy to address large-area skin defects. 展开更多
关键词 skin organoid skin defect 3D bioprinting Wound healing
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甲基丙烯酰化改性真皮细胞外基质水凝胶促进腹壁缺损修复
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作者 刘忠钰 李文娅 +5 位作者 范永鸿 吕双 裴娟 陈娅琴 刘倍余 孙红玉 《中国组织工程研究》 CAS 北大核心 2025年第10期2074-2082,共9页
背景:目前用于填充腹壁缺损部位的合成高分子材料(如聚丙烯或聚酯)不仅缺乏可降解性和生物活性,还难以适应复杂形状伤口需求,因此,找到免疫原性低、组织相容性好的生物活性材料成为腹壁缺损修复研究的热点。目的:制备甲基丙烯酰化改性... 背景:目前用于填充腹壁缺损部位的合成高分子材料(如聚丙烯或聚酯)不仅缺乏可降解性和生物活性,还难以适应复杂形状伤口需求,因此,找到免疫原性低、组织相容性好的生物活性材料成为腹壁缺损修复研究的热点。目的:制备甲基丙烯酰化改性真皮细胞外基质水凝胶,探讨其在腹壁缺损中的潜在应用价值。方法:(1)依次用0.25%胰蛋白酶、1%Triton X-100对猪真皮进行脱细胞处理,获得真皮细胞外基质;胃蛋白酶消化真皮细胞外基质,经甲基丙烯酸酐改性后光交联形成甲基丙烯酰化改性真皮细胞外基质水凝胶,扫描电镜观察水凝胶的微观形貌,测试其流变学性能、溶胀性等理化性质;(2)将L929成纤维细胞接种到甲基丙烯酰化改性的真皮细胞外基质水凝胶中,检测细胞相容性;(3)将12只SD大鼠随机分为2组(n=6),创建保留腹膜的腹壁缺损模型,聚丙烯组缺损部位填充聚丙烯材料,水凝胶组缺损部位填充甲基丙烯酰化改性真皮细胞外基质水凝胶,两组创面皮肤均用聚丙烯材料覆盖,观察创面愈合情况并进行组织学分析。结果与结论:(1)采用酶解法对猪真皮进行脱细胞后具有良好的脱细胞效果,并且原有的糖胺聚糖及胶原蛋白保留较好。扫描电镜下可见甲基丙烯酰化改性真皮细胞外基质水凝胶为疏松多孔结构,孔径在70-120μm之间,该水凝胶的溶胀比为(16.88±3.24)%,吸水率为(94.24±1.11)%,流变学性能测试表明该水凝胶状态稳定且具有剪切变稀特点,具备可注射性;(2)CCK-8检测与Live/Dead染色结果显示,甲基丙烯酰化改性真皮细胞外基质水凝胶具有良好的细胞相容性;(3)动物实验结果显示,实验组术后7,10,14 d的皮肤创面愈合率高于对照组(P <0.05);皮肤与肌层组织苏木精-伊红、Masson染色显示,与聚丙烯组比较,水凝胶组术后14 d的皮肤创面上皮化情况、毛囊生成、胶原纤维排列及新生血管情况更好,术后28 d的皮肤创面新生组织结构与正常组织相近,并且瘢痕增生较少,术后28 d时可见少量肌肉组织再生;(4)结果表明,甲基丙烯酰化改性真皮细胞外基质水凝胶可促进腹壁缺损大鼠的皮肤创面愈合和肌肉组织再生。 展开更多
关键词 猪真皮 真皮细胞外基质 甲基丙烯酰化改性 水凝胶 光固化 腹壁缺损 皮肤愈合 肌肉组织再生
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Role of adipose-derived stromal cells in pedicle skin flap survival in experimental animal models 被引量:4
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作者 Pericles Foroglou Vasileios Karathanasis +2 位作者 Efterpi Demiri George Koliakos Marios Papadakis 《World Journal of Stem Cells》 SCIE CAS 2016年第3期101-105,共5页
The use of skin flaps in reconstructive surgery is the first-line surgical treatment for the reconstruction of skin defects and is essentially considered the starting point of plastic surgery. Despite their excellent ... The use of skin flaps in reconstructive surgery is the first-line surgical treatment for the reconstruction of skin defects and is essentially considered the starting point of plastic surgery. Despite their excellent usability, their application includes general surgical risks or possible complications, the primary and most common is necrosis of the flap. To improve flap survival, researchers have used different methods, including the use of adiposederived stem cells, with significant positive results. In our research we will report the use of adipose-derived stem cells in pedicle skin flap survival based on current literature on various experimental models in animals. 展开更多
关键词 PEDICLE skin FLAP Adipose STROMAL cells FLAP SURVIVAL Stem cell skin defect RECONSTRUCTIVE surgery
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Prediction of shear-related defect locations in semi-solid casting using numerical flow models 被引量:1
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作者 F.PINEAU G.D'AMOURS 《中国有色金属学会会刊:英文版》 CSCD 2010年第S3期878-882,共5页
Contaminated surfaces of the feedstock materials in aluminum alloy casting processes often produce various types of defects which can affect the tensile properties of the final products as well as their fatigue reliab... Contaminated surfaces of the feedstock materials in aluminum alloy casting processes often produce various types of defects which can affect the tensile properties of the final products as well as their fatigue reliabilities.Semi-solid processing takes advantage of a much higher apparent viscosity of the die cast materials by limiting the risk of oxides formed at the free surfaces to become incorporated into the casting when the material is injected into the die.Most of existing semi-solid processes that use billets as feedstock material are however tied up with a different type of contaminated surface.During the injection phase,the external-skin on the periphery of the billet,which has been in contact with air and lubricant during the transfer in the shot sleeve,can be incorporated into the casting.When subjected to a heat treatment,the lubricant is decomposed and produces lens shape porosities.This might be a cause of reject for most structural parts.To avoid this kind of defects,the paths along which the billet skin evolves must be controlled during filling.In order to investigate the possibility of skin inclusion into cast parts during injection of the billet,a two-phase finite element mixture model is employed to model the metal flow.The formation of a skin on the periphery of the billet is modeled by setting an initial solid phase concentration profile in the radial direction.Microscopic observations of the real castings show that the approach is able to model the shear layers and to predict the paths along which the"lens porosity"defects could be formed.An Arbitrary Eulerian-Lagangian(ALE) method is also investigated and appears to be very promising to follow the skin movement in the casting. 展开更多
关键词 oxide skin defects TWO-PHASE flow finite element modeling ARBITRARY Eulerian-Lagangian(ALE) method
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Facial Reconstruction with Combined Facial,Neck and Occipital Skin Flap Transplantation
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作者 陶学金 郭三兰 +1 位作者 陈为民 马净植 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2002年第1期80-81,86,共3页
To treat large facial defect (more than 6 cm×4 cm in diameter ) or a wound with bone exposure to atmosphere by less traumatic, easier healing reconstruction method, a pedicle flap including facial, neck, poster... To treat large facial defect (more than 6 cm×4 cm in diameter ) or a wound with bone exposure to atmosphere by less traumatic, easier healing reconstruction method, a pedicle flap including facial, neck, posterior auricle and occipital skin flap was designed and transferred, one by one, to repair facial defect as well as other flap donor sites, but occipital skin flap was only used to cover posterior auricle area. After 2-3 years follow up, well healed skin flaps with good color, elasticity and sensation were observed in all 16 patients. It is concluded that this method is effective and practical. 展开更多
关键词 facial defect skin flap RECONSTRUCTION
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A simple alternative technique for harvesting split thickness skin grafts
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作者 Leonidas Pavlidis Manousos-Georgios Pramateftakis +2 位作者 Nikolaos Costogloudis Georgia-Alexandra Spyropoulou Efterpi Demiri 《World Journal of Surgical Procedures》 2013年第2期4-7,共4页
AIM: To assess the use of a simple split skin graft harvesting technique, requiring only a scalpel and a swab.METHODS: During the last 8 mo, we operated on a consecutive series of 52 patients(30 males, 22 females) wit... AIM: To assess the use of a simple split skin graft harvesting technique, requiring only a scalpel and a swab.METHODS: During the last 8 mo, we operated on a consecutive series of 52 patients(30 males, 22 females) with a mean age of 60 years(33-80). We used the technique we present in order to cover small skin defects. All procedures were performed under local anesthesia. Thirty-seven patients underwent bedside surgery, 8 patients were operated on in the outpatient department and the remaining 7 had their graft harvested in the operating room. After antiseptic preparation of the donor site, the margins of the graft were drawn by the use of a surgical marker. A No 15 scalpel was used for the graft elevation, under constant traction with a moist swab.RESULTS: All procedures were completed successfully without immediate complications. The patients tolerated the procedure well. The mean operative time was 15 min. Twenty-four donor sites were left to heal by secondary intention, whereas 28 were sutured with interrupted 3/0 silk sutures in order to heal by primary intention. All 24 sites that were left to heal by secondary intention healed completely in approximately 14 d. For the sites that were sutured, the sutures were removed on the 10 th postoperative day. Out of the 52 operated cases, 6 patients(11%) developed complications. In 4 patients, the split thickness skin grafts were partially lost, whereas in 2 patients the grafts were completely lost. Wound dehiscence was observed in 2 patients, which were treated with local antiseptic and antibiotic therapy.CONCLUSION: The skin graft technique described is simple, costless and effective and can be performed even on an outpatient basis, without the need for special equipment. 展开更多
关键词 skin GRAFT skin defect SPLIT thickness skin reconstruction DERMATOME Tissue HARVESTING
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胸背动脉穿支皮瓣在肩胸背部创面修复中的临床应用 被引量:2
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作者 李承龙 仲海燕 +3 位作者 陈勇 王倩 邹鸣立 袁斯明 《组织工程与重建外科》 CAS 2024年第1期64-68,共5页
目的探讨胸背动脉穿支皮瓣在肩胸背部皮肤软组织缺损修复中的应用。方法自2019年1月至2022年12月,应用胸背动脉穿支皮瓣修复肩胸背部皮肤软组织缺损8例,致伤原因均为肿瘤切除术后。术前应用CTA和手持多普勒超声确认胸背动脉的存在、走... 目的探讨胸背动脉穿支皮瓣在肩胸背部皮肤软组织缺损修复中的应用。方法自2019年1月至2022年12月,应用胸背动脉穿支皮瓣修复肩胸背部皮肤软组织缺损8例,致伤原因均为肿瘤切除术后。术前应用CTA和手持多普勒超声确认胸背动脉的存在、走行、分支及穿支位置。根据创面位置、面积设计胸背动脉穿支皮瓣。皮瓣仅携带穿支发出位置的极少量肌肉,将胸背动脉降支近端从肌肉内剥离,保留胸背动脉横支和胸背神经。如血管蒂长度不足,可切断横支。皮瓣带蒂转移修复创面。供瓣区拉拢缝合。结果8例皮瓣均存活,供瓣区切口愈合好。随访6个月到2年,所有患者受区外观满意,供瓣区无明显畸形,肩关节功能无明显影响。结论胸背动脉穿支皮瓣血供可靠,血管蒂长,且基本完整地保留了背阔肌功能,是修复肩胸背部邻近创面的良好选择。 展开更多
关键词 胸背动脉穿支皮瓣 皮肤软组织缺损 肩胸背部 背阔肌
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Primary Observations on the Influence of ^(60)Co Local Irradiation on Free Skin Flaps
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作者 杨建荣 张园 《Journal of Nanjing Medical University》 2002年第4期172-174,共3页
Objective To study the effect of postoperative radiation on free skin flaps. Methods Twenty-nine patients with free skin flaps applied to the plerosis of the postoperative defect were followed up. Twenty-eight out of ... Objective To study the effect of postoperative radiation on free skin flaps. Methods Twenty-nine patients with free skin flaps applied to the plerosis of the postoperative defect were followed up. Twenty-eight out of 29 patients received forearm free flaps while 1 had anterolater-al femoris skin flaps in a size ranging from 14cm×6cm to 8cm×4cm. These flaps were exposed to 60Co radiation ranging 40-69 Gy. Results Observation during irradiation, no visible changes of skin flaps and oral mucous membrane were detected, when irradiation dose was within 40 Gy; some changes may be detected over 40 Gy. Observation 1 - 4 months after irradiation: pigmentations were found in areas of erosion epidermis; skin flaps got dark but without evidence of necrosis. Observation 2 years after irradiation, rib necrosis happened in 29 skin flaps. Hairs were found on 15 of 29 flaps. Sensation occurred within the margin of 1 cm. Conclusion Free skin flap can endure irradiation at the dose of 60 Gy. 展开更多
关键词 free skin flap 60Co irradiation postoperative defect
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双层人工真皮联合诱导膜技术修复足踝部皮肤缺损伴感染的疗效
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作者 张清林 荣存敏 +3 位作者 王美灵 陈磊 栗威 张磊 《临床骨科杂志》 2024年第5期675-679,共5页
目的 探讨双层人工真皮联合诱导膜技术修复足踝部皮肤缺损伴感染的疗效。方法 按创面缺损修复方式不同将64例足踝部皮肤缺损伴感染患者分为对照组(采用双层人工真皮修复后全厚皮片移植治疗,32例)和观察组(采用双层人工真皮联合诱导膜技... 目的 探讨双层人工真皮联合诱导膜技术修复足踝部皮肤缺损伴感染的疗效。方法 按创面缺损修复方式不同将64例足踝部皮肤缺损伴感染患者分为对照组(采用双层人工真皮修复后全厚皮片移植治疗,32例)和观察组(采用双层人工真皮联合诱导膜技术修复后全厚皮片移植治疗,32例)。记录两组人工真皮血管化时间、创面感染情况、移植皮片成活情况。采用温哥华瘢痕量表(VSS)评分评价植皮区瘢痕情况,采用AOFAS踝-后足评分评估踝关节功能恢复情况。结果 患者均获得12个月随访。人工真皮血管化时间观察组短于对照组(P<0.05)。移植皮片成活率观察组高于对照组(P<0.05)。创面感染率观察组低于对照组(P<0.05)。术后12个月VSS评分、AOFAS踝-后足评分两组比较差异均无统计学意义(P>0.05)。结论 双层人工真皮联合诱导膜技术修复足踝部皮肤缺损伴感染,手术操作相对简单易行,对供区损伤小,且可以明显缩短双层人工真皮血管化时间,提高创面修复成功率,降低创面感染率。 展开更多
关键词 人工真皮 诱导膜技术 皮肤缺损 骨外露 肌腱外露 足踝部损伤
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股前外侧穿支皮瓣游离移植修复四肢皮肤缺损的临床疗效
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作者 李康 岳文强 张宏峰 《中国美容医学》 CAS 2024年第12期35-38,共4页
目的:探究股前外侧穿支皮瓣游离移植修复四肢皮肤缺损的临床疗效。方法:选取2018年6月-2023年9月笔者医院收治的98例四肢皮肤缺损患者进行研究,患者皮肤软组织缺损面积为6.12 cm×9.34 cm~15.23 cm×32.74 cm,均行股前外侧穿支... 目的:探究股前外侧穿支皮瓣游离移植修复四肢皮肤缺损的临床疗效。方法:选取2018年6月-2023年9月笔者医院收治的98例四肢皮肤缺损患者进行研究,患者皮肤软组织缺损面积为6.12 cm×9.34 cm~15.23 cm×32.74 cm,均行股前外侧穿支皮瓣游离移植修复,皮瓣切取面积为7.35 cm×10.34 cm~17.63 cm×34.49 cm。观察手术疗效、术后损伤部位功能、感觉恢复情况及术后并发症发生情况。结果:术后随访6个月,皮瓣全部成活,通过皮瓣供血优良度判断,术后优86例,良12例;DASH评分为18~24分,平均(21.46±1.27)分,下肢功能LEFS量表评分为36~52分,平均(43.97±5.57)分。79例患者感觉功能恢复至S3,其余恢复保护性感觉,两点辨别觉为5.3~8.2 mm。供区皮肤饱满红润,无感觉功能障碍。出现并发症共4例(4.08%),其中,感染3例,经抗感染治疗后得到控制;皮瓣边缘坏死1例,经换药或皮瓣移植后愈合,未发生血管危象、感觉障碍等情况。结论:股前外侧穿支皮瓣游离移植修复四肢皮肤缺损疗效显著,能够改善缺损部位的外观和功能,恢复损伤肢体感觉,并发症少,是一种较为理想的选择。 展开更多
关键词 股前外侧穿支皮瓣 游离移植 四肢 皮肤缺损 修复效果
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