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Artificial Intelligence Based Meteorological Parameter Forecasting for Optimizing Response of Nuclear Emergency Decision Support System
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作者 BILAL Ahmed Khan HASEEB ur Rehman +5 位作者 QAISAR Nadeem MUHAMMAD Ahmad Naveed Qureshi JAWARIA Ahad MUHAMMAD Naveed Akhtar AMJAD Farooq MASROOR Ahmad 《原子能科学技术》 EI CAS CSCD 北大核心 2024年第10期2068-2076,共9页
This paper presents a novel artificial intelligence (AI) based approach to predict crucial meteorological parameters such as temperature,pressure,and wind speed,typically calculated from computationally intensive weat... This paper presents a novel artificial intelligence (AI) based approach to predict crucial meteorological parameters such as temperature,pressure,and wind speed,typically calculated from computationally intensive weather research and forecasting (WRF) model.Accurate meteorological data is indispensable for simulating the release of radioactive effluents,especially in dispersion modeling for nuclear emergency decision support systems.Simulation of meteorological conditions during nuclear emergencies using the conventional WRF model is very complex and time-consuming.Therefore,a new artificial neural network (ANN) based technique was proposed as a viable alternative for meteorological prediction.A multi-input multi-output neural network was trained using historical site-specific meteorological data to forecast the meteorological parameters.Comprehensive evaluation of this technique was conducted to test its performance in forecasting various parameters including atmospheric pressure,temperature,and wind speed components in both East-West and North-South directions.The performance of developed network was evaluated on an unknown dataset,and acquired results are within the acceptable range for all meteorological parameters.Results show that ANNs possess the capability to forecast meteorological parameters,such as temperature and pressure,at multiple spatial locations within a grid with high accuracy,utilizing input data from a single station.However,accuracy is slightly compromised when predicting wind speed components.Root mean square error (RMSE) was utilized to report the accuracy of predicted results,with values of 1.453℃for temperature,77 Pa for predicted pressure,1.058 m/s for the wind speed of U-component and 0.959 m/s for the wind speed of V-component.In conclusion,this approach offers a precise,efficient,and wellinformed method for administrative decision-making during nuclear emergencies. 展开更多
关键词 prediction of meteorological parameters weather research and forecasting model artificial neural networks nuclear emergency support system
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Evaluation of G3BP1 in the prognosis of acute and acute-on-chronic liver failure after the treatment of artificial liver support system
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作者 Wen-Yuan Li Lu-Wen Wang +1 位作者 Jin Dong Yao Wang 《World Journal of Hepatology》 2024年第2期251-263,共13页
BACKGROUND The increased expression of G3BP1 was positively correlated with the prognosis of liver failure.AIM To investigate the effect of G3BP1 on the prognosis of acute liver failure(ALF)and acute-on-chronic liver ... BACKGROUND The increased expression of G3BP1 was positively correlated with the prognosis of liver failure.AIM To investigate the effect of G3BP1 on the prognosis of acute liver failure(ALF)and acute-on-chronic liver failure(ACLF)after the treatment of artificial liver support system(ALSS).METHODS A total of 244 patients with ALF and ACLF were enrolled in this study.The levels of G3BP1 on admission and at discharge were detected.The validation set of 514 patients was collected to verify the predicted effect of G3BP1 and the viability of prognosis.RESULTS This study was shown that lactate dehydrogenase(LDH),alpha-fetoprotein(AFP)and prothrombin time were closely related to the prognosis of patients.After the ALSS treatment,the patient’amount of decreased G3BP1 index in difference of G3BP1 between the value of discharge and admission(difG3BP1)<0 group had a nearly 10-fold increased risk of progression compared with the amount of increased G3BP1 index.The subgroup analysis showed that the difG3BP1<0 group had a higher risk of progression,regardless of model for end-stage liver disease high-risk or low-risk group.At the same time,compared with the inflam matory marks[tumor necrosis factor-α,interleukin(IL)-1βand IL-18],G3BP1 had higher discrimination and was more stable in the model analysis and validation set.When combined with AFP and LDH,concordance index was respectively 0.84 and 0.8 in training and validation cohorts.CONCLUSION This study indicated that G3BP1 could predict the prognosis of ALF or ACLF patients treated with ALSS.The combination of G3BP1,AFP and LDH could accurately evaluate the disease condition and predict the clinical endpoint of patients. 展开更多
关键词 G3BP1 PROGNOSIS Acute liver failure Acute-on-chronic liver failure Artificial liver support system
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The Support Systems and Coping Strategies of Infertile Women Attending the Out-Patient Consultation Unit of CHRACERH Yaoundé, Cameroon: A Cross-Sectional Study
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作者 Emenguele Pascale Mpono Fidelia Mbi Kobenge +3 位作者 Gabrielle Laure Mengne Etienne Belinga Jean Marie Kasia Thomas Obinchemti Egbe 《Open Journal of Obstetrics and Gynecology》 2024年第6期869-887,共19页
Background: Infertility is a complex disorder with significant psycho-social and economic consequences. It globally affects 10% - 15% of couples. In Cameroon, little is known about what women do to overcome the psycho... Background: Infertility is a complex disorder with significant psycho-social and economic consequences. It globally affects 10% - 15% of couples. In Cameroon, little is known about what women do to overcome the psychosocial aspects of the disease. Objectives: This study aimed to identify the support systems and coping strategies of infertile women attending the outpatient consultation unit of the Gynaecological Endoscopic Surgery and Reproductive Teaching Hospital (CHRACERH), Yaoundé, Cameroon. Methods: A hospital-based cross-sectional study was conducted from the 14th of March to the 6th of April 2023 at CHRACERH Yaoundé. A total of 190 participants were recruited using a convenience sampling method. Data regarding socio-demographic characteristics, support systems and coping strategies were collected using a pretested questionnaire. Descriptive and analytic statistics were conducted using SPSS version 25. Results: The mean age of participants was 39.52 ± 7.64 years. The majority 78.9% of participants were workers (public, private sector, or traders) and were Christians 95.8%. The most common source of psychological support was from family 76.8 and husbands 72.63%. Most of the participants 89.5% resorted to prayer and getting busy 48.4% as a coping strategy. There was no statistically significant relationship between coping strategies and psychological disorders p > 0.05. Conclusion: The main support system of participants was family, husband, and friends. Prayer, getting busy and adoption were the most common coping strategies. There is a need for the Ministry of Public Health and other stakeholders to put in place other support systems and coping strategies (FELICIA) used elsewhere and provide adequate health education and infection control to prevent infertility in Cameroon. 展开更多
关键词 INFERTILITY Coping Strategies support systems Mental Health WOMEN
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Nursing Care of 10 Patients with Vasovagal Reflex Caused by Artificial Liver Support System Treatment
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作者 Yingying Zhang 《Open Journal of Nursing》 2024年第5期177-182,共6页
This study outlines the essential nursing strategies employed in the care of 10 patients experiencing vascular vagal reflex, managed with artificial liver support systems. It highlights a holistic nursing approach tai... This study outlines the essential nursing strategies employed in the care of 10 patients experiencing vascular vagal reflex, managed with artificial liver support systems. It highlights a holistic nursing approach tailored to the distinct clinical manifestations of these patients. Key interventions included early detection of psychological issues prior to initiating treatment, the implementation of comprehensive health education, meticulous monitoring of vital signs throughout the therapy, prompt emergency interventions when needed, adherence to prescribed medication protocols, and careful post-treatment observations including venous catheter management. Following rigorous treatment and dedicated nursing care, 7 patients demonstrated significant improvement and were subsequently discharged. 展开更多
关键词 Vasovagal Reflex Artificial Liver support system Nursing Care
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Applying the Technology Acceptance Model (TAM) in Information Technology System to Evaluate the Adoption of Decision Support System
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作者 Md Azhad Hossain Anamika Tiwari +3 位作者 Sanchita Saha Ashok Ghimire Md Ahsan Ullah Imran Rabeya Khatoon 《Journal of Computer and Communications》 2024年第8期242-256,共15页
With the beginning of the information systems’ spreading, people started thinking about using them for making business decisions. Computer technology solutions, such as the Decision Support System, make the decision-... With the beginning of the information systems’ spreading, people started thinking about using them for making business decisions. Computer technology solutions, such as the Decision Support System, make the decision-making process less complex and simpler for problem-solving. In order to make a high-quality business decision, managers need to have a great deal of appropriate information. Nonetheless, this complicates the process of making appropriate decisions. In a situation like that, the possibility of using DSS is quite logical. The aim of this paper is to find out the intended use of DSS for medium and large business organizations in USA by applying the Technology Acceptance Model (TAM). Different models were developed in order to understand and predict the use of information systems, but the information systems community mostly used TAM to ensure this issue. The purpose of the research model is to determine the elements of analysis that contribute to these results. The sample for the research consisted of the target group that was supposed to have completed an online questionnaire about the manager’s use of DSS in medium and large American companies. The information obtained from the questionnaires was analyzed through the SPSS statistical software. The research has indicated that, this is primarily used due to a significant level of Perceived usefulness and For the Perceived ease of use. 展开更多
关键词 Information Technology Decision support system Business Organization in USA Technology Acceptance Model
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Design and Implementation of the Employment Management Decision Support System based on Machine Learning
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作者 Zhigang Ma 《Journal of Electronic Research and Application》 2024年第5期134-140,共7页
To address the challenges of current college student employment management,this study designed and implemented a machine learning-based decision support system for college student employment management.The system coll... To address the challenges of current college student employment management,this study designed and implemented a machine learning-based decision support system for college student employment management.The system collects and analyzes multidimensional data,uses machine learning algorithms for prediction and matching,provides personalized employment guidance for students,and provides decision support for universities and enterprises.The research results indicate that the system can effectively improve the efficiency and accuracy of employment guidance,promote school-enterprise cooperation,and achieve a win-win situation for all parties. 展开更多
关键词 Machine learning Employment of college students Decision support system Data analysis
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An Intelligent Decision Support System Generator
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作者 Shi Zhenxia and Lu JukangDept. of Computer Science, Shanghai Univ. of Science and Technology, Shanghai 201800, P.R. China 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 1993年第1期45-52,共8页
The focus of this paper is on a new concept framework and an architecture of an intelligent decision support syetem generator (DSSG). The framework results from a synthesis of two existing frameworks: Spragae and Bonc... The focus of this paper is on a new concept framework and an architecture of an intelligent decision support syetem generator (DSSG). The framework results from a synthesis of two existing frameworks: Spragae and Bonczek, while the architecture is a rooted partial order network. From our experience which comes out of the project of DSSG, we consider that they are keys of further research and development of DSS. 展开更多
关键词 Decision support system Decision support system generator Intelligent decision support system AI technology Hypertext technology.
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Study and Implementation on the Grey Comprehensive Evaluation Support System of Ecocity 被引量:2
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作者 黄鹍 陈森发 +1 位作者 孙燕 亓霞 《Journal of Southeast University(English Edition)》 EI CAS 2002年第4期356-360,共5页
According to basic connotation and design principles of ecocity, a comparatively integrated index system is constructed in the paper. And at the same time using hierarchy grey comprehensive evaluation method, a hierar... According to basic connotation and design principles of ecocity, a comparatively integrated index system is constructed in the paper. And at the same time using hierarchy grey comprehensive evaluation method, a hierarchy grey comprehensive evaluation model of ecocity is established, then on the basis of the model, a comprehensive evaluation support system is developed, and the theoretical guidance supplied for construction of ecocity is provided. 展开更多
关键词 ecocity index system evaluating level hierarchy grey comprehensive evaluation evaluation support system
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Method of Establishing Object-Oriented System Structure for Decision Support System 被引量:2
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作者 曹元大 胡军 管春 《Journal of Beijing Institute of Technology》 EI CAS 2002年第3期311-315,共5页
In order to solve existing problems about the method of establishing traditional system structure of decision support system(DSS), O S chart is applied to describe object oriented system structure of general DSS, an... In order to solve existing problems about the method of establishing traditional system structure of decision support system(DSS), O S chart is applied to describe object oriented system structure of general DSS, and a new method of eight specific steps is proposed to establish object oriented system structure of DSS by using the method of O S chart, which is applied successfully to the development of the DSS for the energy system ecology engineering research of the Wangheqiu country. Supplying many scientific effective computing models, decision support ways and a lot of accurate reliable decision data, the DSS plays a critical part in helping engineering researchers to make correct decisions. Because the period for developing the DSS is relatively shorter, the new way improves the efficiency of establishing DSS greatly. It also makes the DSS of system structure more flexible and easy to expand. 展开更多
关键词 decision support system object oriented technology system structure
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Method for designing organization decision support system framework 被引量:1
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作者 Fan Jiancong Liang Yongquan Zeng Qingtian 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2006年第4期764-768,共5页
The concept of organization decision support system (ODSS) is defined according to practical applications and novel understanding. And a framework for ODSS is designed. The framework has three components: infrastru... The concept of organization decision support system (ODSS) is defined according to practical applications and novel understanding. And a framework for ODSS is designed. The framework has three components: infrastructure, decision-making process and decision execution process. Infrastructure is responsible to transfer data and information. Decision-making process is the ODSS's soul to support decision-making. Decision execution process is to evaluate and execute decision results derived from decision-making process. The framework presents a kind of logic architecture. An example is given to verify and analyze the framework. The analysis shows that the framework has practical values, and has also reference values for understanding ODSS and for theoretical studies. 展开更多
关键词 terms-decision support system organization decision organization decision support system.
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Review of the creativity support system
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作者 冯勤超 范伟伟 孙锦 《Journal of Southeast University(English Edition)》 EI CAS 2007年第S1期173-178,共6页
Based on the achievements of domestic and foreign scholars,the concept of the creativity support system(CSS)is introduced and two basic characteristics of the CSS are concluded:one is based on information technology,t... Based on the achievements of domestic and foreign scholars,the concept of the creativity support system(CSS)is introduced and two basic characteristics of the CSS are concluded:one is based on information technology,the other is assisting users in creatively solving problems.Then,the rationale as well as the correlative knowledge of the creativity support system is analyzed.Finally,according to the software that has been developed,the creativity support system's characteristics of the function is discussed. 展开更多
关键词 artificial intelligence CREATIVITY COGNITION creativity support system
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Research and Application of Maize Precision Intelligence Spatial Decision Support System
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作者 王国伟 陈桂芬 +1 位作者 姚玉霞 闫丽 《Agricultural Science & Technology》 CAS 2010年第6期147-151,188,共6页
In order to solve the problem of the maze precision fertilizer,soil fertility evaluation,soil fertility classify and yield projections,the geographic information system with spatial information processing functions,sp... In order to solve the problem of the maze precision fertilizer,soil fertility evaluation,soil fertility classify and yield projections,the geographic information system with spatial information processing functions,spatial data mining techniques with spatial information analysis capabilities,expert system technology in the field of artificial intelligence,traditional information management systems and decision support system were effectively integrated in this study,and the statistical analysis method of GIS and data visualization were combined to design and implement the maize precise intelligent space decision-making system.This system had greatly improved the decision-making ability in agricultural production carried out by agricultural management. 展开更多
关键词 Maize precision operation Space data mining Decision support system Geographic information system VISUALIZATION
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Study on the Decision Support System for Northing of Winter Wheat Cultivation in Hebei Province
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作者 邹立坤 蓝岚 李小娟 《Agricultural Science & Technology》 CAS 2012年第3期630-633,637,共5页
[Objective] This study was to provide methods to improve the scientificity and informatization level of agricultural decision-making system based on the study of Decision Support System for "Northing of Winter Wheat... [Objective] This study was to provide methods to improve the scientificity and informatization level of agricultural decision-making system based on the study of Decision Support System for "Northing of Winter Wheat" in Hebei Province (DSS- NWWH). [Method] The functions, development process, operation guidance as well as input and output modes of DSSNWWH were introduced, and the simulated results of the system were verified by comparing with the actual situations. [Result] The decision support system established in this study could predict whether a wheat variety could live through the winter in a certain area of northern Hebei Province, as well as the growth conditions based on the previous meteorological data or local weather forecast, and provided corresponding cultivation and management measures, making it possible for the user to determine whether the variety could be planted in the region based on the predictions. [Conclusion] The established DSSNWWH in this study can effectively help decision makers make decisions, providing scientific instructions for the northing of winter wheat. 展开更多
关键词 Winter wheat Growing in northern region Decision support system
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SUPPORT SYSTEM FOR FREE SURFACE GRINDING BASED ON PATCH DIVISION
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作者 吴晓君 喜田羲宏 孙树栋 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2005年第4期291-297,共7页
To obtain accurate forms and surfaces in free surface grinding, it is important to provide grinding conditions suitable for a curved surface. A grinding support system for the free surface (GSX-F) is proposed to hel... To obtain accurate forms and surfaces in free surface grinding, it is important to provide grinding conditions suitable for a curved surface. A grinding support system for the free surface (GSX-F) is proposed to help the operator grind a free surface with the high accuracy and the high productivity. To succeed in free surface grinding, the property of a ball type wheel must be known. Therefore, a basic study of free surface grinding with a ball type wheel is carried out based on the grinding center (GC). Some working points for achieving sufficient accuracy in free surface grinding are discussed. GSX-F is constructed using the patch division method and is used to test grinding. Reasonable results are obtained. 展开更多
关键词 grinding center ball type wheel support system free surface grinding patch division
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DEVELOPING EXPERT DECISION SUPPORT SYSTEM WTH VP-EXPERT AND LOTUS 1-2-3 IN RE-BLENDING BY USE
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作者 舒航 杨鹏 《Journal of China University of Mining and Technology》 1994年第2期104-111,共8页
An expert decision support system (EDSS) for multi-bins balance and contro1 of orequality in production ore bins of some large-scale open pit iron mine in China has been developed byexpert svitem tool software VP-EXPE... An expert decision support system (EDSS) for multi-bins balance and contro1 of orequality in production ore bins of some large-scale open pit iron mine in China has been developed byexpert svitem tool software VP-EXPERT and integration software LOTUS 1-2-3 in this paper. Itis known by practicing that a medium-scale EDSS constructed on microcomputer is completcly, feaasible by means of VP-EXEPERT to construct knowledge base system (KBS), LOTUS 1-2-3 tomake decision support system (DSS) and link them with BAT. 展开更多
关键词 VP-EXPERT LOTUS 1-2-3 ore-blending expert system decision support system expert decision support system
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Mechanism of wet shotcrete interacting with rock in support systems 被引量:16
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作者 李莉 吴爱祥 +3 位作者 王贻明 韩斌 王洪江 王春来 《Journal of Central South University》 SCIE EI CAS 2013年第3期821-829,共9页
In order to have a good understanding of the behavior of wet shotcrete as a support element interacting with the rock mass,mechanism of wet shotcrete interacting with rock in support systems was analyzed through theor... In order to have a good understanding of the behavior of wet shotcrete as a support element interacting with the rock mass,mechanism of wet shotcrete interacting with rock in support systems was analyzed through theoretical,numerical study and analytical analysis.A new model of distribution of rock stress state after wet shotcrete was applied,which includes shotcrete layer,composite layer,strengthening layer,plastic layer and elastic layer,and a full illustration of the rock mass stress state was given after shotcrete interacting with rock mass.At the same time,numerical analysis with FLAC gives a stress distribution along the monitor line,respectively,at the sidewall and roof of the tunnel.The displacement obviously decreases with the depth of rock,the tangential stress for tunnel supported by shotcrete is lower than that without shotcrete,and radial stress for tunnel supported by shotcrete is higher than that without shotcrete.It has been demonstrated by AIRY'S stress function,which gives a reasonable solution.Finally,the application of wet shotcrete in Jinfeng Gold Mine shows that the displacement of tunnel decreases obviously in sidewall and roof. 展开更多
关键词 wet shotcrete support systems MECHANISM SIMULATION distribution of stress
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Detection of PERV by polymerase chain reaction and its safety in bioartificial liver support system 被引量:19
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作者 Hai-Hui Wang Ying-Jie Wang +4 位作者 Hong-Ling Liu Jun Liu Yan-Ping Huang Hai-Tao Guo Yu-Ming Wang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第8期1287-1291,共5页
AIM: To establish a method detecting porcine endogenous retrovirus (PERV) in China experimental minipigs and to evaluate the safety of PERV in three individuals treated with bioartificial liver support systems base... AIM: To establish a method detecting porcine endogenous retrovirus (PERV) in China experimental minipigs and to evaluate the safety of PERV in three individuals treated with bioartificial liver support systems based on porcine hepatocytes. METHODS: Porcine hepatocytes were isolated with two-stage perfusion method, then cultured in the bioreactor, which is separated by a semipermeable membrane (0.2μm) from the lumen through which the patients' blood plasma was circulated. After posthemoperfusion, patients' blood was obtained for screening. Additionally, samples of medium collected from both intraluminal and extraluminal compartments of the laboratory bioreactor and culture supernate in vitro was analyzed. The presence of viral sequences was estimated by polymerase chain reaction (PCR) and reverse transcriptase-polymerase chain reaction (RTPCR). Finally, the infection of virus in the supernate of common culture was ascertained by exposure to the fetal liver cells. RESULTS: PERV-specific gag sequences were found in the porcine hepatocytes using RT-PCR. and were detected in all samples from the intraluminal, extraluminal samples and culture supernate. However, culture supernatant from primary porcine hepatocytes (cleared of cellular debris) failed to infect human fetal liver cells. Finally, RT-PCR detected no PERV infection was found in the blood samples obtained from three patients at various times post-hemoperfusion. CONCLUSION: The assays used are specific and sensitive, identified by second PCR. PERVs could be released from hepatocytes cultured in bioreactor without the stimulation of mitogen and could not be prevented by the hollow fiber semipermeable membrane, indicating the existence of PERV safety in extracorporeal bioartificial liver support system (EBLSS). 展开更多
关键词 PERV Bioartificial liver support systems Polymerase chain reaction
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Multi-agent decision support system for missile defense based on improved PSO algorithm 被引量:5
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作者 Zilong Cheng Li Fan Yulin Zhang 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2017年第3期514-525,共12页
Ballistic missile defense system (BMDS) is important for its special role in ensuring national security and maintaining strategic balance. Research on modeling and simulation of the BMDS beforehand is essential as dev... Ballistic missile defense system (BMDS) is important for its special role in ensuring national security and maintaining strategic balance. Research on modeling and simulation of the BMDS beforehand is essential as developing a real one requires lots of manpower and resources. BMDS is a typical complex system for its nonlinear, adaptive and uncertainty characteristics. The agent-based modeling method is well suited for the complex system whose overall behaviors are determined by interactions among individual elements. A multi-agent decision support system (DSS), which includes missile agent, radar agent and command center agent, is established based on the studies of structure and function of BMDS. Considering the constraints brought by radar, intercept missile, offensive missile and commander, the objective function of DSS is established. In order to dynamically generate the optimal interception plan, the variable neighborhood negative selection particle swarm optimization (VNNSPSO) algorithm is proposed to support the decision making of DSS. The proposed algorithm is compared with the standard PSO, constriction factor PSO (CFPSO), inertia weight linear decrease PSO (LDPSO), variable neighborhood PSO (VNPSO) algorithm from the aspects of convergence rate, iteration number, average fitness value and standard deviation. The simulation results verify the efficiency of the proposed algorithm. The multi-agent DSS is developed through the Repast simulation platform and the constructed DSS can generate intercept plans automatically and support three-dimensional dynamic display of missile defense process. 展开更多
关键词 agent-based modeling missile defense system decision support system (DSS) variable neighborhood negative selection particle swarm optimization (PSO)
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Development of a GIS-based Decision Support System for Assessing Land Use Status 被引量:6
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作者 Ryosuke Shibasaki Kanichiro Matsumura 《Geo-Spatial Information Science》 2004年第1期72-78,共7页
The objectives of this study are to assess land s ui tability and to predict the spatial and temporal changes in land use types (LUTs ) by using GIS-based land use management decision support system. A GIS databas e w... The objectives of this study are to assess land s ui tability and to predict the spatial and temporal changes in land use types (LUTs ) by using GIS-based land use management decision support system. A GIS databas e with data on climate, topography, soil characteristic, irrigation condition, f ertilizer application, and special socioeconomic activities has been developed a nd used for the evaluation of land productivity for different crops by integrati ng with a crop growth model-the erosion productivity impact calculator (EPIC). International food policy simulation model (IFPSIM) is also embedded into GIS fo r the predictions of how crop demands and crop market prices will change under a lternative policy scenarios. An inference engine (IE) including land use choice model is developed to illustrate land use choice behavior based on logit models , which allows to analyze how diversified factors ranging from climate changes, crop price changes to land management changes can affect the distribution of agr icultural land use. A test for integrated simulation is taken in each 0.1° by 0.1° grid cell to predict the change of agricultural land use types at globa l level. Global land use changes are simulated from 1992 to 2050. 展开更多
关键词 EPIC land use decision support system international trade model logitmodel
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Hybrid artificial liver support system for treatment of severe liver failure 被引量:8
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作者 Jian-HeGan Xia-QiuZhou +4 位作者 Ai-LanQin Er-PingLuo Wei-FengZhao HongYu JieXu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第6期890-894,共5页
AIM: To construct a novel hybrid artificial liver support system (HALSS) and to evaluate its efficacy in patients with severe liver failure.METHODS: Hepatocytes were isolated from suckling pig by the modified Seglen&#... AIM: To construct a novel hybrid artificial liver support system (HALSS) and to evaluate its efficacy in patients with severe liver failure.METHODS: Hepatocytes were isolated from suckling pig by the modified Seglen's method. Isolated hepatocytes were cultured in a spinner flask for 24 h to form spheroids before use and the functions of spheroids were detected. HALSS consisted of a plasma separator, a hemo-adsorba and a bioreactor with hepatocytes spheroids in its extra-fiber space.HALSS was applied to 10 patients with severe liver failure.The general condition and the biochemical indexes of the patients were studied just before and after the treatment.RESULTS: The number of cells per liver was about 2-4× 1010 (mean, 3.1 ± 1.5 × 1010). The cell viabilities were more than 95%. After 24 h of spheroid culture, most hepatocytes formed spheroids. The levels of albumin and urea in the medium of spheroid culture were higher than those in supernatant of petri dish culture (P = 0.0015 and 0.0001, respectively). The capacity of albumin production and urea synthesis remained stable for more than one wk and declined rapidly after two weeks in vitro. In HALSS group, the duration of HALSS treatment was 6-10 h each time. All patients tolerated the treatment well without any fatal adverse reaction. After HALSS treatment, the general condition, psychic state, encephalopathy and hepatic function of the patients were improved. The survival rate of the HALSS group, Plasmapheresis group and control group was 30% (3/10), 20% (2/10) and 0% (0/10), respectively (P = 0.024). Two weeks after treatment, Tbil and ALT decreased and the PTA level elevated in HALSS group and pasmapheresis group (Pvalue: 0.015 vs 0.020, 0.009vs 0.012 and 0.032 vs 0.041, respectively). But there was no significant change of blood albumin concentration before and after treatment in HAlSS group and Plasmapheresis group.CONCLUSION: The HALSS established by us is effective in supporting liver function of patients with severe liver failure. 展开更多
关键词 Liver failure Hybrid artificial liver support system HEPATOCYTES
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