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Assessment of Changes in the Cesarean Scar and Uterus Between One and Two Years after Cesarean Section Using 3D T2w SPACE MRI 被引量:4
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作者 Yafei Qi Yonglan He +5 位作者 Ning Ding Liangkun Ma Tianyi Qian Yuan Li Huadan Xue Zhengyu Jin 《Chinese Medical Sciences Journal》 CAS CSCD 2022年第2期151-158,共8页
Objective Io evaluate changes in morphology of the cesarean scar and uterus between one and two years after cesarean section using high-resolution,three dimensional T2-weighted sampling perfection with application opt... Objective Io evaluate changes in morphology of the cesarean scar and uterus between one and two years after cesarean section using high-resolution,three dimensional T2-weighted sampling perfection with application optimized contrast using diflerent flip angle evolutions Magnetic Resonance Imaging(3DT2w SPACE MRI).Methods This prospective study was performed to investigate morphological changes in the cesarean scars and uterus from one to two years after cesarean section using high-resolution,3D T2w SPACE MRI.The healthy volunteers having no childbearing history were recruited as the controls.All data were measured by two experienced radiologists.All data with normal distribution between the one-year and two-year groups were compared using a paired-sample t test or independent t test.Results Finally,46 women took a pelvic MR examination one year after cesarean section,and a subset of 15 completed the same examination again after two years of cesarean section.Both the uterine length and the anterior wall thickness after two years of cesarean section(5.75±0.46 and 1.45±0.35 cm)were significantly greater than those measured at one year(5.33±0.59 and 1.25±0.27 cm)(t=-2.363 and-2.175,P=0.033 and 0.048).No significant difference was shown in myometrial thickness two years after cesarean section(1.45±0.35 cm)with respect to the control group(1.58±0.21 cm,P=0.170).Nine women who underwent MRI twice were considered to have scar diverticula one year after cesarean section,and still had diverticula two years after cesarean section.The thickness,height,and width of the uterine scar showed no significant change from one to two years(all P>0.05).Conclusions 3D T2w SPACE MRI provides overall morphologic details and shows dynamic changes in the scar and the uterus between one and two years after cesarean section.Scar morphology after cesarean section reached relatively stable one year after cesarean section,and uterine morphology was closer to normal two years after cesarean section. 展开更多
关键词 uterine cesarean SCAR uterine morphology 3d T2w space MRI
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2D TSE与3D SPACE序列对直肠癌术前T分期的诊断价值比较 被引量:2
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作者 马文帅 高远翔 +2 位作者 高耸 郝小磊 冯卫华 《中国医学影像学杂志》 CSCD 北大核心 2022年第9期903-908,共6页
目的比较三维可变翻转角各向同性快速自旋回波(3D SPACE)序列与传统二维快速自旋回波(2D TSE)序列对直肠癌术前T分期的诊断价值。资料与方法选取2018年1月—2019年12月青岛大学附属医院收治的直肠癌患者75例,术前进行2D TSE及3D SPACE... 目的比较三维可变翻转角各向同性快速自旋回波(3D SPACE)序列与传统二维快速自旋回波(2D TSE)序列对直肠癌术前T分期的诊断价值。资料与方法选取2018年1月—2019年12月青岛大学附属医院收治的直肠癌患者75例,术前进行2D TSE及3D SPACE序列扫描,计算2D TSE及3D SPACE序列图像的信噪比(SNR)、对比噪声及图像评分评估图像质量。以术后病理结果为“金标准”,比较2D TSE及3D SPACE序列诊断直肠癌术前T分期的准确度。结果2D TSE和3D SPACE序列的图像质量在显示直肠浆膜层或外膜[3.00(2.00,3.00)比3.00(3.00,3.00);Z=−0.16,P=0.990]、肠周脂肪[3.00(3.00,3.00)比3.00(3.00,3.00);Z=−0.259,P=0.800]、直肠系膜筋膜[3.00(3.00,3.00)比3.00(3.00,3.00);Z=−1.27,P=0.210]、瘤体[3.00(3.00,3.00)比3.00(3.00,3.00);Z=−0.03,P=0.990]比较,差异无统计学意义。3D SPACE序列在显示直肠黏膜层[3.00(2.00,3.00)比3.00(3.00,3.00);Z=−2.47,P=0.013]、直肠肌层[3.00(2.00,3.00)比3.00(3.00,3.00);Z=−3.21,P=0.001]方面图像质量更高。对于瘤体,3D SPACE序列的SNR优于2D TSE序列(119.95±39.83比83.94±40.34;t=−2.54,P=0.016);对于脂肪(213.56±95.26比191.22±59.47;t=0.80,P=0.430)及肌肉(41.86±19.34比40.40±15.58;t=0.24,P=0.820),2D TSE及3D SPACE序列的SNR差异无统计学意义;两序列对比噪声比差异无统计学意义(19.36±10.11比27.54±18.72;t=−1.54,P=0.140)。与术后病理结果对比,2D TSE序列的诊断一致性(Kappa=0.49,P=0.00)比3D SPACE序列低(Kappa=0.95,P=0.000),两序列对T分期的诊断准确度分别为76.00%和98.67%。结论2D TSE和3D SPACE序列显示直肠浆膜层或外膜、肠周脂肪、直肠系膜筋膜及瘤体一样可靠。3D SPACE序列对于显示直肠黏膜层及直肠肌层较2D TSE序列更优越。对于直肠癌的术前T分期,3D SPACE序列较传统高分辨2D TSE序列的诊断准确度更高,可更好地为临床制订治疗方案提供影像学依据。 展开更多
关键词 直肠癌 术前分期 磁共振成像 2d TSE序列 3d space序列 图像质量
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“3W2D”教学法在创新教学中的应用——以环境学课程为例 被引量:2
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作者 刘强 范春楠 郑金萍 《河南教育学院学报(自然科学版)》 2022年第1期57-60,共4页
环境学是环保人才培养的重要理论基础课程,通过该课程的学习学生能够对国内外存在的主要环境问题以及防治措施有系统的了解,树立较强的环保意识。“3W2D”教学法是将“是什么(What)”“为什么(Why)”“怎么做(How)”以及“大小讨论(Disc... 环境学是环保人才培养的重要理论基础课程,通过该课程的学习学生能够对国内外存在的主要环境问题以及防治措施有系统的了解,树立较强的环保意识。“3W2D”教学法是将“是什么(What)”“为什么(Why)”“怎么做(How)”以及“大小讨论(Discussion)”贯穿教学过程的一种教学方法,对提高学生学习兴趣、激发学生学习主观能动性、提升环保思维等方面具有重要作用,论文对如何在环境学课程中应用该教学法进行了讨论与探析。 展开更多
关键词 环境学 3w2d 教学法 考核 教学改革
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W3D通过调控TLR4/MD2-NF-κB p65信号通路改善LPS诱导的小鼠急性肺损伤 被引量:6
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作者 史新阳 高晓慧 +2 位作者 赵蓓 唐莉 李青山 《中国药理学通报》 CAS CSCD 北大核心 2021年第5期657-661,共5页
目的研究4-(5′-二甲氨基)-萘磺酰氧基苯并噁唑酮(W3D)这一新型结构化合物对脂多糖(lipopolysaccharide,LPS)诱导的小鼠急性肺损伤(acute lung injury,ALI)的保护作用及其作用机制。方法ICR小鼠随机分为对照组、模型组、氯唑沙宗组(12.5... 目的研究4-(5′-二甲氨基)-萘磺酰氧基苯并噁唑酮(W3D)这一新型结构化合物对脂多糖(lipopolysaccharide,LPS)诱导的小鼠急性肺损伤(acute lung injury,ALI)的保护作用及其作用机制。方法ICR小鼠随机分为对照组、模型组、氯唑沙宗组(12.5 mg·kg^(-1))、W3D组(12.5、6.25和3.125 mg·kg^(-1)),气道滴入LPS造模。于造模4 h后给药,12 h后处死小鼠并取肺脏,计算肺湿干比(wwt/dw),HE染色观察肺组织病理变化,试剂盒检测MPO活性、iNOS和炎症因子IL-1β、IL-6、TNF-α的水平,Western blot检测肺组织TLR4、MD2、p-IRAK4、p65蛋白的表达。结果W3D可显著改善小鼠肺水肿状态,降低肺组织湿干比;减少炎性细胞浸润,减轻血管损伤及局部出血等现象;可剂量依赖性抑制MPO活性,降低iNOS、IL-1β、IL-6、TNF-α的表达水平,抑制TLR4、MD2、p-IRAK4、p65蛋白的表达。结论化合物W3D可通过调控TLR4/MD2-NF-κB p65信号通路改善LPS诱导的小鼠急性肺损伤。 展开更多
关键词 4-(5′-二甲氨基)-萘磺酰氧基苯并噁唑酮(w3d) 急性肺损伤 湿干比 MPO 炎症因子 TLR4 Md2
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负幂次势V(r)=W/r^4+D/r^3+C/r^2+B/r径向schrdinger方程的解析解 被引量:1
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作者 周国中 何宝钢 徐昌智 《德州学院学报》 2010年第2期33-37,共5页
根据波函数的有限性和负幂次势V(r)=W/r4+D/r3+C/r2+B/r的渐近性质,通过待定势波函数的设定,得到势函数表示为V(r)=W/r4+D/r3+C/r2+B/r的schrdinger方程的精确的能量本征值和本征波函数.通过对势参数制约关系、能量本征值和本征波函... 根据波函数的有限性和负幂次势V(r)=W/r4+D/r3+C/r2+B/r的渐近性质,通过待定势波函数的设定,得到势函数表示为V(r)=W/r4+D/r3+C/r2+B/r的schrdinger方程的精确的能量本征值和本征波函数.通过对势参数制约关系、能量本征值和本征波函数的分析,得到势参数制约关系、能量本征值和本征波函数的通式. 展开更多
关键词 负幂次势V(r)=w/r4+d/r3+C/r2+B/r 径向schrdinger方程 解析解
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W22(D)空间中二元第一类算子方程的Hermite数值解
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作者 刘振杰 《哈尔滨商业大学学报(自然科学版)》 CAS 2002年第2期233-235,238,共4页
在W22 (D)空间中讨论了二元第一类算子方程的近似求解问题 。
关键词 算子方程 w22(d)空间 再生核
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Identification of Trichosporon spp. Strains by Sequencing D1/D2 Region and Sub-typing by Sequencing Ribosomal Intergenic Spacer Region of Ribosomal DNA
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作者 曾敬思 Cristina Mariade Souza Motta +4 位作者 福岛和贵 龙泽香代子 Oliane Maria Correia Magalhes Rejane Pereira Neves 西村和子 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2009年第5期655-658,共4页
To re-identify and further group 25 isolates of Trichosporon spp. identified morphologically previously, sequences of D1/D2 region of large subunit (LSU) of ribosomal DNA (rDNA) of 25 tested strains for identifica... To re-identify and further group 25 isolates of Trichosporon spp. identified morphologically previously, sequences of D1/D2 region of large subunit (LSU) of ribosomal DNA (rDNA) of 25 tested strains for identification and those of ribosomal intergenic space 1 (IGS1) region of 11 strains for subgrouping were detected. The identifications of tested strains were changed except 6 strains. According to the alignment of the IGS1 region, 6 T. asahii isolates tested fell into 4 groups and 5 T. faecale isolates into 3 groups. Polymorphism of 2 T. japonicum isolates was found in 10 positions. With the alignments obtained in this research compared with the relative GenBank entries, it was found that T. asahii, T. faecale and T. japonicum species were divided into 7, 3 and 2 subtypes respectively. Morphological and biophysical methods are not sufficient for Trichosporon spp. identification. Sequencing becomes necessary for Trichosporon diagnosis. There is obvious diversity within a species. 展开更多
关键词 Trichonsporon large subunit d1/d2 intergenic space 1
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2-D RAKE RECEIVER BASED ON SPACE-TIME CHANNEL PARAMETER ESTIMATION
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作者 Jiang Bofeng Zhang Jianguo Yin Qinye (Inst. of Info. Eng., School of Electron, and Info. Eng., Xi’an Jiaotong Univ., Xi’an 710049) 《Journal of Electronics(China)》 2001年第2期127-134,共8页
2-D RAKE receiver is an efficient way to realize the space-time processing for CDMA systems with aperiodic spreading codes. The Direction Of Arrival (DOA) and the relative time delay of every user's multipath must... 2-D RAKE receiver is an efficient way to realize the space-time processing for CDMA systems with aperiodic spreading codes. The Direction Of Arrival (DOA) and the relative time delay of every user's multipath must be known to realize the 2-D RAKE receiver. In the third generation CDMA mobile communication system, auxiliary pilot channel is used in the uplink channels The different user's Vector Channel Impulse Response (VCIR) can be estimated from the pilotichannel easily. The VCIR contains spatial and temporal information. In this paper,by utilizing the known pulse shape function, a parameter matrix method used to estimate the Spatial Signature Vector (SSV) and the relative time delay is proposed in frequency domain.The DOA can be estimated from the SSV. By reconstructing the SSV and utilizing approximate Capon space filter, the performance of the 2-D RAKE receiver with uniform circular array can be improved with a little additional computation work. 展开更多
关键词 2-d RAKE space-TIME CHANNEL SPATIAL SIGNATURE VECTOR
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D2和W1工具钢的动态再结晶
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作者 郭永铭 《五钢科技》 2002年第2期49-49,共1页
在900~1150℃温度范围(对D2)和900~1200℃温度范围(对W1)内以0.1、1和4S^-1的应变率对高碳、高Cr冷作模具钢(D2)和一种水硬碳素工具钢(W1)进行了连续热扭曲试验。应力一应变(σ-ε)曲线上升到峰值应力σp,然后倾斜下降到一稳定状态值... 在900~1150℃温度范围(对D2)和900~1200℃温度范围(对W1)内以0.1、1和4S^-1的应变率对高碳、高Cr冷作模具钢(D2)和一种水硬碳素工具钢(W1)进行了连续热扭曲试验。应力一应变(σ-ε)曲线上升到峰值应力σp,然后倾斜下降到一稳定状态值σss。 展开更多
关键词 d2 w1 工具钢 动态再结晶
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基于改进的2D Otsu方法和YCgCr空间的肤色分割 被引量:1
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作者 赵明华 王理 李鹏 《激光技术》 CAS CSCD 北大核心 2011年第3期428-432,共5页
为了弥补基于固定阈值的肤色分割方法存在的缺陷,在对多种彩色空间和肤色模型进行分析的基础上,提出采用改进的2-D Otsu方法和YC_gC_r彩色空间进行肤色分割。首先将光照补偿之后的肤色样本图像从RGB彩色空间转换到YC_gC_r彩色空间,并利... 为了弥补基于固定阈值的肤色分割方法存在的缺陷,在对多种彩色空间和肤色模型进行分析的基础上,提出采用改进的2-D Otsu方法和YC_gC_r彩色空间进行肤色分割。首先将光照补偿之后的肤色样本图像从RGB彩色空间转换到YC_gC_r彩色空间,并利用样本图像上的179221个肤色点建立2维高斯模型;进而将待分割的图像进行光照补偿并转换到YC_gC_r彩色空间,利用已经建立的高斯模型计算图像的肤色相似度,得到肤色相似度图像;最后,结合像素的空间邻域信息,使用改进的2-D Otsu方法对肤色相似度图像进行2值化处理。对这种方法进行了理论分析和实验验证。结果表明,该肤色分割算法有效地克服了使用固定阈值法进行图像分割时缺乏针对性和抗噪性的缺陷,该算法是可行的。 展开更多
关键词 图像处理 肤色分割 2-d OTSU方法 彩色空间 肤色模型
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广义2-D系统Roesser模型的可接受输入序列研究
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作者 赵胜民 陆昌根 刘则毅 《南京航空航天大学学报》 EI CAS CSCD 北大核心 2000年第6期672-676,共5页
通过将有限矩形上的广义 2 - D Roesser模型转化为等价的代数方程 ,给出了有限矩形上所有输入均为该系统的可接受输入的充要条件 ;利用 2 - D Z-变换以及多项式矩阵的性质 ,给出了无限矩形上所有输入均可接受的充要条件。证明了当系统... 通过将有限矩形上的广义 2 - D Roesser模型转化为等价的代数方程 ,给出了有限矩形上所有输入均为该系统的可接受输入的充要条件 ;利用 2 - D Z-变换以及多项式矩阵的性质 ,给出了无限矩形上所有输入均可接受的充要条件。证明了当系统的输入矩阵行满秩时 ,只要系统在某个有限矩形上的所有输入均为可接受输入 ,则在无限矩形上的所有输入也均为可接受输入。基于矩阵的初等行变换 ,提出了确定广义 2 - D系统 Roesser模型可接受输入序列集合的方法。 展开更多
关键词 状态空间 离散系统 控制问题 2-dRoesser模型 2-dZ-变换
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L_a^2(D)上Toeplitz算子
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作者 杨立敏 《绵阳师范学院学报》 1997年第S2期15-17,共3页
用一种较为直接的方法证明了:T-①,ф=Z^m((α-z/αz))~n为加权位移时,α=0.
关键词 L_a^2(d)空间 TOEPLITZ算子 加权位移
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New Pooling Design Constructed with Pseudo-symplectic Space 被引量:1
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作者 赵向会 徐宁 张更生 《Chinese Quarterly Journal of Mathematics》 CSCD 2012年第4期526-534,共9页
Pooling design is a mathematical tool in many application areas. In this paper, we give a new construction of pooling design with subspaces of the pseudo-symplectic space and discuss its properties. We define the desi... Pooling design is a mathematical tool in many application areas. In this paper, we give a new construction of pooling design with subspaces of the pseudo-symplectic space and discuss its properties. We define the design parameters of a d^2-disjunct matrix. Then we discuss the change law of the design parameters in our construction along with their variables. 展开更多
关键词 pooling design dZ-disjunct matrix design parameter pseudo-symplectic space
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Robust Non-Fragile Control of 2-D Discrete Uncertain Systems: An LMI Approach
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作者 Paramanand Sharma Amit Dhawan 《Journal of Signal and Information Processing》 2012年第3期377-381,共5页
This paper considers the problem of robust non-fragile control for a class of two-dimensional (2-D) discrete uncertain systems described by the Fornasini-Marchesini second local state-space (FMSLSS) model under contro... This paper considers the problem of robust non-fragile control for a class of two-dimensional (2-D) discrete uncertain systems described by the Fornasini-Marchesini second local state-space (FMSLSS) model under controller gain variations. The parameter uncertainty is assumed to be norm-bounded. The problem to be addressed is the design of non-fragile robust controllers via state feedback such that the resulting closed-loop system is asymptotically stable for all admissible parameter uncertainties and controller gain variations. A sufficient condition for the existence of such controllers is derived based on the linear matrix inequality (LMI) approach combined with the Lyapunov method. Finally, a numerical example is illustrated to show the contribution of the main result. 展开更多
关键词 2-d dISCRETE Systems Fornasini-Marchesini Second Local STATE-space Model NON-FRAGILE Control Linear Matrix INEQUALITY Lyapunov Methods
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LMI Approach to Suboptimal Guaranteed Cost Control for 2-D Discrete Uncertain Systems
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作者 Amit Dhawan Haranath Kar 《Journal of Signal and Information Processing》 2011年第4期292-300,共9页
This paper studies the problem of the guaranteed cost control via static-state feedback controllers for a class of two-dimensional (2-D) discrete systems described by the Fornasini-Marchesini second local state-space ... This paper studies the problem of the guaranteed cost control via static-state feedback controllers for a class of two-dimensional (2-D) discrete systems described by the Fornasini-Marchesini second local state-space (FMSLSS) model with norm bounded uncertainties. A convex optimization problem with linear matrix inequality (LMI) constraints is formulated to design the suboptimal guaranteed cost controller which ensures the quadratic stability of the closed-loop system and minimizes the associated closed-loop cost function. Application of the proposed controller design method is illustrated with the help of one example. 展开更多
关键词 Linear Matrix INEQUALITY Lyapunov Methods Robust Stability 2-d dISCRETE SYSTEMS Uncertain SYSTEMS Fornasini-Marchesini Second Local STATE-space Model
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纳米CeO_2对激光熔覆Fe/Cr_3C_2复合涂层组织与磨损性能的影响 被引量:5
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作者 肖轶 顾剑锋 +1 位作者 张俊喜 杨有利 《材料导报》 EI CAS CSCD 北大核心 2017年第22期65-69,84,共6页
采用扫描电镜(SEM)、能谱分析仪(EDS)、X射线衍射仪(XRD)、显微硬度仪及滑动磨损试验,研究了1%纳米CeO_2(质量分数)对低碳钢表面激光熔覆Fe/Cr_3C_2复合涂层的组织结构和耐磨性能的影响。结果表明,Fe+Cr_3C_2+1%CeO_2复合涂层的主要组... 采用扫描电镜(SEM)、能谱分析仪(EDS)、X射线衍射仪(XRD)、显微硬度仪及滑动磨损试验,研究了1%纳米CeO_2(质量分数)对低碳钢表面激光熔覆Fe/Cr_3C_2复合涂层的组织结构和耐磨性能的影响。结果表明,Fe+Cr_3C_2+1%CeO_2复合涂层的主要组成相是α-Fe、γ-Fe、Cr_3C_2、Cr_(23)C_6及Cr_7C_3等化合物相;加入1%纳米CeO_2后,复合涂层组织明显细化,未熔Cr_3C_2数量显著减少,初生碳化物由粗大杆状向块状转变,数量增加,分布均匀,有效抑制和消除了裂纹的形成;复合涂层硬度和耐磨性能显著提高,Fe+30%Cr_3C_2+1%CeO_2涂层截面显微硬度提高105HV,增幅达到15.4%,且涂层沿深度方向硬度分布均匀性得到明显改善。 展开更多
关键词 纳米CEO2 激光熔覆 FE基合金 CR3C2 复合涂层 组织 耐磨性
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具有π/2性质的空间及它的一些性质 被引量:1
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作者 刘佳 计东海 《哈尔滨理工大学学报》 CAS 2007年第6期58-59,共2页
本文把对称的Minkowski平面中常数D(X)的结果推广到了具有π/2性质的空间去.
关键词 具有π/2性质的空间 d(X)
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Accuracy Assessment of Alos W3d30, Aster Gdem and Srtm30 Dem: A Case Study of Nigeria, West Africa 被引量:6
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作者 O. I. Apeh V. N. Uzodinma +2 位作者 E. S. Ebinne E. C. Moka E. U. Onah 《Journal of Geographic Information System》 2019年第2期111-123,共13页
Digital Elevation Models (DEMs) depict the configuration of the earth surface and are being applied in many areas in earth and environmental sciences. In this study, the accuracy of the Advanced Land Observing Satelli... Digital Elevation Models (DEMs) depict the configuration of the earth surface and are being applied in many areas in earth and environmental sciences. In this study, the accuracy of the Advanced Land Observing Satellite World 3D Digital Surface Model version 2.1 (ALOS W3D30), the Shuttle Radar Topography Mission Digital Elevation Model version 3.0 (SRTM30) and the Advanced Space borne Thermal Emission and Reflection Radiometer Global DEM version 2.0 (ASTER GDEM2) was statistically assessed using high accuracy GPS survey data. Root-Mean-Square errors of ~5.40 m, ~7.47 m and ~20.03 m were obtained for ALOS W3D30, SRTM30 and ASTER GDEM2 respectively. In further analyses, we discovered that ALOS W3D30 and SRTM30 were much more accurate in regions where the height intervals were within 201 m - 400 m and >801 m. ALOS W3D30 proved to be the most accurate DEM that best represents the topography of the earth’s surface and could be used for some earth and environmental applications in Nigeria. We recommend that this study should serve as a guide in the use of any of these DEMs for earth and environmental applications in Nigeria. 展开更多
关键词 ALOS w3d30 ASTER GdEM2 SRTM30 NIGERIA dEMS Accuracy Assessment Root-Mean-Square Error
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GENERALIZATIONS OF THE SUZUKI AND KANNAN FIXED POINT THEOREMS IN G-CONE METRIC SPACES 被引量:1
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作者 Mohammad Sadegh Asgari Zohreh Abbasbigi 《Analysis in Theory and Applications》 2012年第3期248-262,共15页
In this paper we develop the Banach contraction principle and Kannan fixed point theorem on generalized cone metric spaces. We prove a version of Suzuki and Kannan type generalizations of fixed point theorems in gener... In this paper we develop the Banach contraction principle and Kannan fixed point theorem on generalized cone metric spaces. We prove a version of Suzuki and Kannan type generalizations of fixed point theorems in generalized cone metric spaces. 展开更多
关键词 fixed point d-metric space 2-metric space generalized cone metric space Kannan mapping generalized Kannan mapping contractive mapping
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Flip Chip Die-to-Wafer Bonding Review:Gaps to High Volume Manufacturing
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作者 Mario Di Cino Feng Li 《Semiconductor Science and Information Devices》 2022年第1期8-13,共6页
Flip chip die-to-wafer bonding faces challenges for industry adoption due to a variety of technical gaps or process integration factors that are not fully developed to high volume manufacturing(HVM)maturity.In this pa... Flip chip die-to-wafer bonding faces challenges for industry adoption due to a variety of technical gaps or process integration factors that are not fully developed to high volume manufacturing(HVM)maturity.In this paper,flip-chip and wire bonding are compared,then flip-chip bonding techniques are compared to examine advantages for scaling and speed.Specific recent 3-year trends in flip-chip die-to-wafer bonding are reviewed to address the key gaps and challenges to HVM adoption.Finally,some thoughts on the care needed by the packaging technology for successful HVM introduction are reviewed. 展开更多
关键词 Flip chip die-to-wafer(d2w) Chip-to-wafer(C2w) Chip-scale packaging(CSP) High volume manufacturing(HVM) Known good die(KGd) Through silicon via(TSV) Reliability
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