Cascade adsorptive separation of light hydrocarbons by commercial zeolites

Adsorptive separation of light hydrocarbons by porous solids provides an energy-efficient alternative to state-of-the-art cryogenic distillation.However,an optimal balance between the cost,performance and stability of the sorbent material is yet to be achieved for industrial applications.Here,we report the efficient separation of C2 and C3 hydrocarbons by a faujasite zeolite(Na-X,Si/Al=1.23).A tandem configuration of two fixed-beds packed with Na-X affords complete dynamic separation of the ternary mixture of C_(2)H_(2)/C_(2)H_(4)/C_(2)H_(6)(1/49.5/49.5;v/v/v)under ambient conditions.Pressure-swing desorption on the latter fixed-bed gives ethylene(>99.50%,1.80 mmol g^(-1))and ethane(>99.99%,1.41 mmol g^(-1)).In situ synchrotron X-ray powder diffraction revealed the binding sites for C_(2)H_(2)and C_(2)H_(4)in Na-X.This study highlights the potential application of commercial zeolites for challenging industrial separations.

Effects of Polar Organic Solvent on Separation of Y(edta)^-/Nd(edta)^- Complexes on Polyacrylic Anion Exchangers

The use of polar organic solvents for the separations of rare earth elements (Ⅲ) is effective especially for their extensive separations despite the solubility limitations. The study shows that polyacrylate anion exchangers, particularly the weakly basic, gel anion exchanger Amberlite IRA 68, can be applied to the separation of rare earth complexes with EDTA in H_2O-methanol and H_2O-ethanol systems. In most cases the determined distribution coefficients of Ln^(3+) complexes with EDTA in mixed media like water-methanol on polyacrylate anion exchangers are larger than those in pure water (media.)

Efficient separation of C_(4) olefins using tantalum pentafluor oxide anion-pillared hybrid microporous material

With the increasing demand for synthetic rubber,the purification of 1,3-butadiene(C_(4)H_(6))is of great industrial significance.Herein,the successful removal of n-butene(n-C_(4)H_(8))and iso-butene(iso-C_(4)H_(8))from 1,3-butadiene(C_(4)H_(6))was realized by synthesizing a novel TaOF_(5)^(2-) anion-pillared ultramicroporous material TaOFFIVE-3-Ni(also referred to as ZU-96,TaOFFIVE=TaOF_(5)^(2-),3=pyrazine).Single-component adsorption isotherms show that TaOFFIVE-3-Ni can achieve the exclusion of n-C_(4)H_(8) and iso-C_(4)H_(8) in the low pressure region(0–30 kPa),and uptake C_(4)H_(6) with a high capacity of 92.78 cm^(3)·cm^(-3)(298 K and 100 kPa).The uptake ratio of C_(4)H_(6)/iso-C_(4)H_(8) on TaOFFIVE-3-Ni was 20.83(298 K and 100 kPa),which was the highest among the state-of-the-art adsorbents reported so far.With the rotation of anion and pyrazine ring,the pore size changes continuously,which makes smaller-size C_(4)H_(6) enter the channel while larger-size n-C_(4)H_(8) and iso-C_(4)H_(8) are completely blocked.The excellent breakthrough performance of TaOFFIVE-3-Ni shows great potential in industrial separation of C4 olefins.The specific adsorption binding sites within ZU-96 was further revealed through the modeling calculation.

Y对C611铝合金凝固组织及性能的影响

研究了添加Y元素对C611铝合金凝固组织和力学性能的影响。结果表明,随着Y含量的增加,C611合金中的α-Al组织的二次枝晶间距和共晶Si逐渐细化、变质,割裂基体的针状Al_(4)(Fe,Mn)Si_(2)相尺寸逐步减小。当Y含量为0.10%时,Al_(4)(Fe,Mn)Si_(2)相的平均长度由48.65μm减小到28.20μm,部分Fe以颗粒状Al_(15)(Fe,Mn)4Si_(2)相形式析出弥散分布在共晶硅当中,对基体起到了一定的强化作用;此时铝合金的抗拉强度和伸长率为166 MPa和6.2%,较未添加Y的基体合金分别提升了7.1%和29.2%。

Radio Access Network Slicing Based on C/U Plane Separation

Network slicing achieves many interests from industry and academics due to its flexibility and scalability.In this paper,we present a novel slicing scheme for radio access networks(RANs) based on control/user(C/U) plane separation.Firstly,we divide e NBs into two sub-e NBs called Ce NB and Ue NB,for transmitting control data and user data respectively,thereby facilitating C/U plane separation.Secondly,upon Ce NBs and Ue NBs being virtualized,we develop two RAN slices for control and user plane respectively.Experimental results show the feasibility of the proposed scheme.

Y染色体AZFc区缺失患者使用睾丸取精精子与射出精子行ICSI的结局比较

目的 比较Y染色体长臂无精子症因子(AZF)c区缺失患者使用新鲜射出精子与睾丸取精精子行卵胞浆内单精子注射(ICSI)后的受精情况和妊娠结局。方法 采用回顾性队列研究,分析2017年1月至2022年12月因AZFc区缺失于西北妇女儿童医院行自精ICSI助孕患者的临床资料。根据女方取卵日男方不同取精方式分为两组:男方行睾丸手术取精的患者纳入睾丸取精组(n=68),男方新鲜射出精子的患者纳入对照组(n=242),比较两组的一般资料和ICSI结局。结果 睾丸取精组的男方LH水平显著高于对照组(P<0.05)。两组间的卵裂数、双原核(2PN)数、可用胚胎数、优质胚胎数比较均无显著性差异(P>0.05);睾丸取精组的囊胚形成数显著低于对照组(P<0.05)。睾丸取精组、对照组的首个新鲜移植周期数分别为30个周期和125个周期,睾丸取精组的受精率、正常受精率、卵裂率、可用胚胎率、囊胚形成率均显著低于对照组(P<0.05),两组间的种植率、临床妊娠率、流产率及活产率比较均无显著性差异(P>0.05)。单因素Logistic分析结果显示,取精方式与受精率、正常受精率、可用胚胎率、优质胚胎率、囊胚形成率、种植率、临床妊娠率、流产率及活产率不具有显著关联性(P>0.05),但会显著影响卵裂率[OR=2.62,95%CI(0.87,4.36),P=0.003];多因素Logistic回归分析显示,在校正囊胚形成数及男方LH水平这两个混杂因素后,对照组的卵裂率仍显著高于睾丸取精组[OR=-3.002,95%CI(-5.182,-0.821),P=0.007]。结论 对于AZFc区缺失患者,相较于新鲜射出精子,采用睾丸取精精子行ICSI时的卵裂率明显降低,虽然二者的妊娠结局没有明显差异,但考虑到手术取精的风险及经济成本,仍建议优先选择射精精子来进行ICSI。

VSe_(2)/V_(2)C heterocatalyst with built-in electric field for efficient lithium-sulfur batteries:Remedies polysulfide shuttle and conversion kinetics

Lithium sulfur(Li-S)battery is a kind of burgeoning energy storage system with high energy density.However,the electrolyte-soluble intermediate lithium polysulfides(Li PSs)undergo notorious shuttle effect,which seriously hinders the commercialization of Li-S batteries.Herein,a unique VSe_(2)/V_(2)C heterostructure with local built-in electric field was rationally engineered from V_(2)C parent via a facile thermal selenization process.It exquisitely synergizes the strong affinity of V_(2)C with the effective electrocatalytic activity of VSe_(2).More importantly,the local built-in electric field at the heterointerface can sufficiently promote the electron/ion transport ability and eventually boost the conversion kinetics of sulfur species.The Li-S battery equipped with VSe_(2)/V_(2)C-CNTs-PP separator achieved an outstanding initial specific capacity of 1439.1 m A h g^(-1)with a high capacity retention of 73%after 100 cycles at0.1 C.More impressively,a wonderful capacity of 571.6 mA h g^(-1)was effectively maintained after 600cycles at 2 C with a capacity decay rate of 0.07%.Even under a sulfur loading of 4.8 mg cm^(-2),areal capacity still can be up to 5.6 m A h cm^(-2).In-situ Raman tests explicitly illustrate the effectiveness of VSe_(2)/V_(2)C-CNTs modifier in restricting Li PSs shuttle.Combined with density functional theory calculations,the underlying mechanism of VSe_(2)/V_(2)C heterostructure for remedying Li PSs shuttling and conversion kinetics was deciphered.The strategy of constructing VSe_(2)/V_(2)C heterocatalyst in this work proposes a universal protocol to design metal selenide-based separator modifier for Li-S battery.Besides,it opens an efficient avenue for the separator engineering of Li-S batteries.

Anticancer therapeutic strategies for targeting mutant p53-Y220C

The tumor suppressor p53 is a transcription factor with a powerful antitumor activity that is controlled by its negative regulator murine double minute 2(MDM2,also termed HDM2 in humans)through a feedback mechanism.At the same time,TP53 is the most frequently mutated gene in human cancers.Mutant p53 proteins lose wild-type p53 tumor suppression functions but acquire new oncogenic properties,among which are deregulating cell proliferation,increasing chemoresistance,disrupting tissue architecture,and promoting migration,invasion and metastasis as well as several other pro-oncogenic activities.The oncogenic p53 mutation Y220C creates an extended surface crevice in the DNA-binding domain destabilizing p53 and causing its denaturation and aggregation.This cavity accommodates stabilizing small molecules that have therapeutic values.The development of suitable small-molecule stabilizers is one of the therapeutic strategies for reactivating the Y220C mutant protein.In this review,we summarize approaches that target p53-Y220C,including reactivating this mutation with small molecules that bind Y220C to the hydrophobic pocket and developing immunotherapies as the goal for the near future,which target tumor cells that express the p53-Y220C neoantigen.

Optimal activated carbon for separation of CO_2 from(H_2 + CO_2) gas mixture

Seven types of activated carbon were used to investigate the effect of their structure on separation of CO2 from（H2 ＋ CO2） gas mixture by the adsorption method at ambient temperature and higher pressures. The results showed that the limiting factors for separation of CO2 from 53.6 mol% H2 ＋ 46.4 mol% CO2 mixture and from 85.1 mol% H2 ＋ 14.9 mol% CO2 mixture were different at 20 °C and about 2 MPa. The best separation result could be achieved when the pore diameter of the activated carbon ranged from 0.77 to 1.20 nm, and the median particle size was about2.07 lm for 53.6 mol% H2 ＋ 46.4 mol% CO2 mixture and 1.41 lm for 85.1 mol% H2 ＋ 14.9 mol% CO2 mixture. The effect of specific area and pore diameter of activated carbon on separation CO2 from 53.6 mol% H2 ＋ 46.4 mol% CO2 mixture was more significant than that from 85.1 mol% H2 ＋ 14.9 mol% CO2 mixture. CO2 in the gas phase can be decreased from 46.4 mol% to 2.3 mol%–4.3 mol% with a two-stage separation process.

ZIF-9衍生的Co_(x)O_(y)-C@CNT作高性能锂-硫电池的硫宿主

以苯并咪唑为有机配体,并通过简单的方法制备出了ZIF-9@CNT的复合材料,衍生得到了Co_(x)O_(y)-C@CNT复合材料作为锂-硫电池的宿主材料。分布在碳骨架表面的Co_(x)O_(y)不仅可以催化多硫化物快速转化,而且加快了氧化还原反应动力学。碳纳米管组成的导电网络保证了正极材料的导电性。在Co_(x)O_(y)-C和CNT的共同作用下,正极材料表现出优异的电化学性能。在2C下,初始放电比容量可以达到791 mAh·g^(-1),且经过500圈循环后,每圈的容量衰减率仅为0.06%,表现出了良好的循环稳定性。

Y染色体AZFc区部分缺失对无精子症和严重少精子症患者ICSI结局的影响

目的 探讨Y染色体无精子因子(AZF)c区部分缺失对无精子症和严重少精子症患者的助孕妊娠结局的影响。方法 回顾性分析2012年1月至2023年10月期间联勤保障部队第九○○医院生殖医学中心收治的80例无精子症和严重少精子症患者的助孕临床资料,根据AZFc区是否存在缺失分为缺失组(存在AZFc区部分缺失,n=34)和对照组(未见缺失,n=46),再根据缺失类型,将缺失组分为gr/gr缺失亚组(n=22)和b2/b3缺失亚组(n=12),比较分析各组的胚胎发育情况及临床妊娠结局。结果 整体缺失组的正常受精率显著低于对照组(60.61%vs.74.44%,P<0.01),而2PN卵裂率、优质胚胎率、HCG阳性率和临床妊娠率在两组间均无显著性差异(均P>0.05)。缺失组中的亚组与对照组相比,gr/gr缺失亚组和b2/b3缺失亚组的正常受精率均显著下降(63.75%、54.47%vs.74.44%,P<0.05),而2PN卵裂率和优质胚胎率的差异无统计学意义(P>0.05);两个缺失亚组间的受精和胚胎发育情况的差异均无统计学意义(P>0.05)。结论 AZFc区的gr/gr缺失与b2/b3缺失虽影响无精子症和严重少精子症患者ICSI过程中的正常受精率,但对ICSI的临床妊娠结局无明显影响。

Y^(3+)掺杂对多孔Na_(3)V_(2)(PO_(4))_(3)/C复合材料储钠性能的影响

采用改进的溶胶凝胶燃烧法成功合成了Y^(3+)掺杂的多孔Na_(3)V_(2)(PO_(4))_(3)/C(记为NVP/C)复合材料,运用XRD、BET、SEM、HRTEM和电化学测试等手段对其进行结构表征和储钠性能测试。结果表明,半径较大的Y^(3+)取代NVP晶体结构中的部分V^(3+)导致晶格膨胀,扩大了Na^(+)的传输通道,加快了Na^(+)的迁移。在制备改性样品过程中,Y^(3+)与PO_(4)^(3-)发生反应,生成新的导电相YPO_(4),提高了复合材料的电子电导率。此外,Y^(3+)掺杂使得不规则多边形NVP颗粒球化并且尺寸略有减小。得益于适当的Y^(3+)掺杂量以及均匀的无定形碳包覆层和多孔结构,NVP/C-Y0.10样品具有优异的储钠性能,其在5 C高倍率下的首次放电比容量高达96.3 m A·h/g,经1000次循环后仍能保持82.2 m A·h/g的可逆容量。

HET-Y(C)型沥青混凝土在提升隧道路面质量中的关键工艺研究

HET-Y(C)型半开级配沥青混凝土具有较大的孔隙及良好的抗滑能力,能够较好地吸收噪声,解决隧道水泥混凝土路面行车噪声大、抗滑性能衰减快、行车舒适性差等问题。文章依托实体工程进行研究,得到拌和时间、摊铺速度、碾压工艺等影响HET-Y(C)型沥青混凝土路面质量的关键施工参数。通车1年后,路面国际平整度指数约为1.0m/km,横向力系数大于62,等级均为优;100km/h行车速度下路面噪声小于73dB,极大提高了隧道路面的行车安全性及舒适性。

VALENCE STATE OF C AtOMS AND σ_t-η_n SEPARABILITY OF MOLECULAR ORBITALS IN THE (BUCKMINSTER)FULLERENE C_(50)

The valence state of C atoms and the structure of molecular orbitals of the (Buckminster)Fullerene C_(60)have been demonstrated. It has been shown that when a motion-coordinate system is adopted, in which the coordinate origin is at every C atom, the z axis is in the direction of the normal and the (x,y) axes are in the direction of tangents of C_(60)'s spherical surface, 240 valence atomic orbitals of C_(60) can be divided into two groups. All (P_x, P_y)atomic orbitals named as Pt ones and all the other P_z atomic orbitals named as p. ones, That is to say that if we name the molecular orbital linearly combined of P_t atomic orbitals as σ_t and the molecular orbital linearly combined of P_n atomic orbitals as π_n, the 240 valence molecular orbitals are of the property of σ_t-π_n separability. It has also been shown that the frontier and nearby frontier molecular orbitals are π_n ones, and therefore the essential physical and chemical properties of C_(60) are determined by its π_n molecular orbitals.

SEPARATION OF OVERLAPPING INCISIONS OF A.C.OSCILLOPOLAROGRAM USING KALMAN'S FILTER TECHNIQUE

Kalman's Filter Technique for the separation of overlapping incisions of an a.c.oscillopolarogram is presented,the experimental verifications were carried out in various systems with the ions of Pb^(2+),Tl^+,In^(3+)and Cd^(2+).The results showed that the concentration of the depolarizer can be determined directly and easily with this technique in the presence of interference elements.

羟苯磺酸钙治疗脑梗死的疗效及其对C反应蛋白、神经肽Y和皮质醇水平变化的影响

目的观察羟苯磺酸钙治疗脑梗死的疗效及其对血清C反应蛋白(CRP)、神经肽Y(NPY)和皮质醇动态变化的影响。方法选择2011年6月—2012年6月我科住院的脑梗死患者60例,按随机数字表法分为普通治疗组和羟苯磺酸钙治疗组,每组30例,普通治疗组行基础治疗,羟苯磺酸钙治疗组在基础治疗的基础上加用羟苯磺酸钙0.5 g/次,口服,3次/d。两组均连续治疗14 d。观察两组患者治疗前后CRP、NPY、皮质醇及美国国立卫生院脑卒中量表(NIHSS)评分的变化。结果两组患者的血清CRP、NPY水平在治疗后第7天时均高于治疗前和治疗后第14天(P<0.05),且治疗前水平高于治疗后第14天(P<0.05);皮质醇水平在治疗后第7天低于治疗前(P<0.05),治疗后第14天低于治疗后第7天(P<0.05)。组间比较显示,两组治疗后第7、14天时CRP和NPY水平间差异均有统计学意义(P<0.05),皮质醇和NIHSS评分间差异均无统计学意义(P>0.05)。脑梗死患者治疗前和治疗第7天时NIHSS评分与CRP、NPY和皮质醇水平呈正相关(P<0.05),治疗后第14天时NIHSS评分与CRP和NPY水平呈正相关(P<0.05)。结论脑梗死患者血清CRP、NPY和皮质醇水平明显增高,炎症反应、缺血和应激是病情发展的重要机制,羟苯磺酸钙治疗可以降低患者血清CRP、NPY和皮质醇的水平。

急性脑梗死患者血清C反应蛋白、神经肽Y和皮质醇水平动态变化

目的分析急性脑梗死(ACI)患者血清C反应蛋白(CRP)、神经肽Y(NPY)和皮质醇的动态变化水平及临床意义。方法因ACI发病入院的患者共50例,同时选取同期体检健康者50例作为对照组。ACI组在住院第1、7、14、28天,对照组在入组第1天分别测定其血清CRP、NPY和皮质醇水平。同时测定其美国国立卫生研究院脑卒中量表(NIHSS)评分、简易精神状态(MMSE)评分和日常生活活动能力(ADL)评分。分析在发病后不同时间点NIHSS、MMSE和ADL评分与血清CRP、NPY和皮质醇水平之间的相关性。结果 ACI组住院第1、7、14、28天的CRP、NPY、皮质醇和NIHSS评分显著高于对照组,MMSE评分和ADL评分显著低于对照组(P<0.05)。ACI组入院后第7天的CRP、NPY和NIHSS评分最高,MMSE评分和ADL评分最低(P<0.05);ACI组入院后第1天皮质醇水平最高,之后逐渐降低(P<0.05)。ACI组住院第1天的NIHSS评分和血清CRP、NPY、皮质醇呈正相关(P<0.05);MMSE评分、ADL评分与血清CRP、NPY、皮质醇呈负相关(P<0.05)。ACI组住院第7、14、28天的NIHSS评分和血清CRP、NPY呈正相关(P<0.05);MMSE评分、ADL评分与血清CRP、NPY呈负相关(P<0.05),和皮质醇无明显相关性(P>0.05)。结论 ACI患者的血清CRP、NPY和皮质醇水平较正常人群升高,同时伴随着疾病的发展有一定程度的动态变化,和患者预后存在一定的相关性。

河南省健康儿童A、C、Y和W135群流行性脑脊髓膜炎抗体水平回顾性调查

目的观察从未接种脑膜炎奈瑟菌疫苗的健康儿童人群抗体水平。方法采用血清体外杀菌试验检测来自2013年河南省3月龄~6岁儿童的1 944份血样中抗A、C、Y和W135群流行性脑脊髓膜炎(简称流脑)抗体水平,计算抗体几何平均滴度(GMT)和易感人群比例,并进行统计分析。结果研究结果显示,受试者A、C、Y和W135群流脑血清抗体GMT为1∶0.66~1∶1.74,易感人群比例为91.82%~97.63%;不同性别人群血清抗体GMT和易感人群比例差异均无统计学意义(P>0.05)。进一步分析发现,不同年龄组受试者A、C和W135群流脑杀菌抗体GMT和抗体滴度≥1∶8人群比例均无统计学意义(P>0.05)。在6~23月龄受试者中Y群流脑杀菌抗体GMT(1∶3.42)和抗体滴度≥1∶8人群比例(17.51%)显著高于3~5月龄和2~6岁两个年龄组,差异有统计学意义(P<0.05)。结论 3月龄~6岁儿童A、C、Y和W135群流脑抗体水平均较低,为减轻儿童免疫负担,建议对这类易感人群接种多价流脑结合疫苗。

Y_2O_3对WC-B_4C激光合金化层裂纹与耐磨性能的影响

目前,有关稀土氧化物粉末粒度大小及含量对激光陶瓷合金化层裂纹及耐磨性能影响的研究较少。以近纳米级Y2O3-WC-B4C粉末对60CrMnMo钢表面进行激光陶瓷合金化,以提高其耐磨性能。采用金相显微镜、扫描电镜、X射线衍射仪、显微硬度计、轮式磨耗试验机分析、考察了Y2O3含量对合金化层的组织、物相、硬度及耐磨性能的影响。结果表明:Y2O3使合金化层表面更加平整、光滑,表面裂纹减少、变细;合金化层硬度随着Y2O3含量增加而降低;合金化层物相主要有Fe-Cr,Cr23C6,B2W,B13C2等;随Y2O3含量增加,树枝晶减少,合金化层组织更均匀致密,磨损量先减小后增大;Y2O3含量为4%时,合金化层组织最细、耐磨性最好。

平行双钢板与Y型钢板治疗肱骨远端C型骨折的临床疗效观察

目的:探讨平行双钢板与Y型钢板经尺骨鹰嘴截骨入路切开复位内固定治疗肱骨远端C型骨折的临床疗效。方法:选择符合标准的患者60例,随机分为观察组和对照组各30例,观察组采用平行双钢板内固定治疗,对照组采用Y型钢板内固定治疗,比较二者治疗效果。结果:两组患者手术时间、术中出血量及术后住院时间相似,差异无统计学意义(P>0.05)。两组患者术后随访时间相似,差异无统计学意义(P>0.05);观察组患者骨折愈合时间及肘关节功能优于对照组,差异有统计学意义(P<0.05)。观察组患者并发症发生率13.33%,低于对照组的症发生率26.67%,差异有统计学意义(P<0.05)。结论:平行双钢板经尺骨鹰嘴截骨入路切开复位内固定治疗肱骨远端C型骨折术后并发症少,可以早期进行功能锻炼,缩短骨折愈合时间,肘关节功能恢复好。