Changes of somatostatin content in some brain areas of rats during oxygen－induced convulsion

The content of somatostatin(SS) in hippocampus,striatum and frontal cortex tissues of rats exposed to 600 kpa hyperbaric oxygen was determined by means of radioimmunoassay. Initial time of convulsion, severity of convulsion and survival time of rats with convulsion exposed to 700 kPa hyperbaric oxygen after intraperitoneal injection of cysteamine (CSH) or intracerebroventricular injection of anti-somatostatin serum(ASS) were also observed. The results showed that the content of SS in hippocampus and striatum tissues increased remarkably when rats were at near-convulsion ; by the time the rats developed convulsion,it had a significant increase in all brain areas observed. Intraperitoneal injection of CSH or intracerebroventricular injection of ASS could delay initial time of convulsion (ITC),prolong survival time (ST) and reduce severity of convulsion (SOC). These results suggest that SS might play a role in oxygen-induced convulsion and be one of the endogenous agents which caused oxygeninduced convulsion.

生长抑素通过中缝大核发挥镇痛和增强电针镇痛的作用

本工作以钾离子透入引起大鼠甩尾为痛指标，观察了中缝大核微量注射生长抑素、生长抑素的耗竭剂半胱胺和抗生长抑素血清对大鼠痛阈和电针镇痛效应的影响。中缝大核微量注射生长抑素可提高大鼠的痛阈，并使电针镇痛的效应加强。用半胱胺耗竭或用抗生长抑素血清中和中缝大核中的生长抑素，均可使大鼠的痛阈降低，并减弱电针镇痛的效应。这表明生长抑素可能通过中缝大核发挥镇痛和增强电针镇痛的作用。

侧脑室注射生长抑素对大鼠痛阈和电针镇痛作用的影响

目的：观察脑内生长抑素（ＳＳ）对痛阈和针刺镇痛的影响。方法：以钾离子透入引起大鼠甩尾为测痛方法，侧脑室注射生长抑素（ＳＳ）、生长抑素的耗竭剂半胱胺（ＣＳＨ）和抗生长抑素血清（ＡＳＳＳ），电针刺激大鼠足三里。结果：侧脑室注射ＳＳ使大鼠痛阈升高并使电针镇痛的效应增强；侧脑室分别注射ＣＳＨ和ＡＳＳＳ使大鼠痛阈降低并使电针镇痛的效应减弱。结论：无论外源性还是内源性ＳＳ都参与痛觉的调制并在电针镇痛过程中发挥重要的作用。