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Calycosin-7-O-β-D-glucopyranoside stimulates osteoblast differentiation through regulating the BMP/WNT signaling pathways 被引量:18
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作者 Jing Jian Lijuan Sun +3 位作者 Xun Cheng Xiaofang Hu Jichao Liang Yong Chen 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2015年第5期454-460,共7页
The iso fl avone calycosin-7-O-β-D-glucopyranoside(CG) is a principal constituent of Astragalus membranaceus(AR) and has been reported to inhibit osteoclast development in vitro and bone loss in vivo. The aim of this... The iso fl avone calycosin-7-O-β-D-glucopyranoside(CG) is a principal constituent of Astragalus membranaceus(AR) and has been reported to inhibit osteoclast development in vitro and bone loss in vivo. The aim of this study was to investigate the osteogenic effects of CG and its underlying mechanism in ST2 cells. The results show that exposure of cells to CG in osteogenic differentiation medium increases ALP activity, osteocalcin(Ocal) m RNA expression and the osteoblastic mineralization process. Mechanistically, CG treatment increased the expression of bone morphogenetic protein 2(BMP-2), p-Smad 1/5/8, β-catenin and Runx2, all of which are regulators of the BMP- or wingless-type MMTV integration site family(WNT)/β-catenin-signaling pathways. Moreover, the osteogenic effects of CG were inhibited by Noggin and DKK-1 which are classical inhibitors of the BMP and WNT/β-catenin-signaling pathways, respectively. Taken together, the results indicate that CG promotes the osteoblastic differentiation of ST2 cells through regulating the BMP/WNT signaling pathways. On this basis, CG may be a useful lead compound for improving the treatment of bone-decreasing diseases and enhancing bone regeneration. 展开更多
关键词 BMP signaling pathway WNT/β-catenin signaling pathway Osteoblastic differentiation Calycosin-7-o-β-d-glucopyranoside ST2 cells
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Lignans from Patrinia scabiosaefolia improve insulin resistance by activating PI-3K/AKT pathway and promoting GLUT4 expression
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作者 Zhenhua Liu Mengke Wang +5 位作者 Lijun Meng Yixiao Chen Qiuyi Wang Yan Zhang Xuefeng Xi Wenyi Kang 《Food Science and Human Wellness》 SCIE CSCD 2023年第6期2014-2021,共8页
Patrinia scabiosaefolia,is used as wild vegetable in China for more than 2000 years,with a variety of pharmacological activities,including anti-inflammatory,anti-tumor and hypoglycemic.Based on our ongoing research on... Patrinia scabiosaefolia,is used as wild vegetable in China for more than 2000 years,with a variety of pharmacological activities,including anti-inflammatory,anti-tumor and hypoglycemic.Based on our ongoing research on chemical constituents and hypoglycemic activity of P.scabiosaefolia,4 lignan compounds,(+)-isolariciresinol(1),7R,7’R,8S,8’S-(+)-neo-olivil-4-O-β-D-glucopyranoside(2),4-O-methylcedrusin(3)and patrinian A(4),were isolated and identifi ed.The hypoglycemic activity showed that compounds 2 and 3 could extremely signifi cantly improve insulin resistance at 100(P<0.001),50(P<0.001)and 25μmol/L(P<0.01)in IR 3T3-L1 cells.While compound 4 only promoted glucose uptake by IR 3T3-L1 cells at 100μmol/L(P<0.01).Western blotting experiments showed that compounds 2 and 4 up-regulated the protein expressions of p-IRS,PI-3K,p-AKT and glucose transporter 4(GLUT4),and promoted the transcription of GLUT4 mRNA.Therefore,the mechanisms of compounds 2 and 4 were presumed to improve IR by activating PI-3K/AKT signaling pathway. 展开更多
关键词 Patrinia scabiosaefolia Insulin resistance Patrinian A 7R 7’R 8S 8’S-(+)-neo-olivil-4-o-β-d-glucopyranoside
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Constituents from Ranunculus sieboldii Miq. 被引量:7
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作者 潘云雪 周长新 +2 位作者 张水利 郑筱祥 赵昱 《Journal of Chinese Pharmaceutical Sciences》 CAS 2004年第2期92-96,共5页
Aim To investigate the chemical composition of Ranunculus sieboldii Miq..Methods Repeated column chromatography over silica gel, polyamide and RP-18 followed by gelfiltration on sephadex LH-20 were used to isolate che... Aim To investigate the chemical composition of Ranunculus sieboldii Miq..Methods Repeated column chromatography over silica gel, polyamide and RP-18 followed by gelfiltration on sephadex LH-20 were used to isolate chemical constituents, and their structures wereelucidated by extensive spectroscopic methods (UV, IR, MS, ~1H NMR, ^(13)C NMR) including 2D NMR(COSY, HMQC, HMBC, NOESY) techniques and by direct comparing spectral data with those reported inliterature. Results Five flavonoid glycosides named apigenin-4'-O-α-L-rhamnopyranoside (1),apigenin-7-O-β-D-glucopyranosyl-4'-O-α-L-rhamnopyranoside (2), apigenin-8-C-α-L-arabinopyranoside(3), apigenin-8-C-β-D-ga-lactopyranoside (4) , tricin-7-O-β-D-glucopyranoside (5), together withtricin (6), luteolin (7), scopoletin (8), esculetin (9), scoparone (10), ferulic acid (11),protocatechuic acid (12) , and tematolide (13) were isolated from the 95% etha-nolic extract of itswhole plant, and their cytotoxic activities were preliminarily tested. Conclusion Compounds 1-12were obtained from this genus and compound 13 from this species for the first time. Furthermore,compound 1 was for the first time isolated from nature while the ^(13)C NMR data of compounds 2 and3 are reported for the first time. The bioassay revealed that compound 1 was active against BEL-7407and A549 cell lines (IC_(45) 43, 77 μg·mL^(-1)), 8 and 10 showed inhibitory activities on KB celllines (IC_(50) 78, 44 μg·mL^(-1)) and HL-60 cell lines (Ic_(50) 85, 85 μg·mL^(-1)), while 7exerted moderate cytotoxic activities on KB, BFL-7407, A549 and HL-60 cell lines with their IC_(50)being 51, 55, 44 and 10 μg·mL^(-1) , respectively. 展开更多
关键词 ranunculus sieboldii miq. flavonoid glycosides apigemn-4'-o-α-L-rhamnopyranoside apigenin-8-C-α-L-arabinopyranoside apigenin-7-o-β-D-glucopvranosyl-4'-o-α-L-rhamnopyranoside cytotoxicity
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青蕨植物化学成分的研究(英文) 被引量:4
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作者 胡浩斌 郑旭东 《西北植物学报》 CAS CSCD 北大核心 2005年第4期781-785,共5页
从青蕨根部的乙酸乙酯提取物中分离得到4个化合物.通过化学及波谱分析鉴定其结构为:saucerneolD1,dehydrogoniothalamin2,1-acetoxyl-2-piperonyl-6-[6-methoxyl-piperonyl]-3,7-dioxabicyclo-[3,3,0]-octane3and5,5′-dihydroxy-3-meth... 从青蕨根部的乙酸乙酯提取物中分离得到4个化合物.通过化学及波谱分析鉴定其结构为:saucerneolD1,dehydrogoniothalamin2,1-acetoxyl-2-piperonyl-6-[6-methoxyl-piperonyl]-3,7-dioxabicyclo-[3,3,0]-octane3and5,5′-dihydroxy-3-methoxy-6,8,3″,3″-tetramethylpyran-3′,4′flavone-7-O-[β-D-apiofuranosyl-1→6]-β-D-glucopyranoside4.其中化合物4为新化合物,化合物1为首次从该属植物中分离得到. 展开更多
关键词 青蕨 saucerneol D 5 5′-dihydroxy-3-methoxy-6 8 3″ 3″-tetramethylpyran-(3′ 4′)flavone-7-o-[β-D-apiofuranosyl-(1→6)]-β-d-glucopyranoside
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Two New Flavonoid Glycosides from Chrysanthemum morifolium 被引量:10
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作者 Jian ZHANG An Wei DING +3 位作者 You Bin LI Da Wei QIAN Jin Ao DUAN Zhi Qi YIN 《Chinese Chemical Letters》 SCIE CAS CSCD 2006年第8期1051-1053,共3页
Two new flavonoid glycosides were isolated from the flowering heads of Chrysanthemum morifolium. Their structures were determined to be luteolin 4'-methoxy-7- O-(6"-O-acetyl)-β-D-glucopyranoside (1) and acaceti... Two new flavonoid glycosides were isolated from the flowering heads of Chrysanthemum morifolium. Their structures were determined to be luteolin 4'-methoxy-7- O-(6"-O-acetyl)-β-D-glucopyranoside (1) and acacetin 7-O-(3"-O-acetyl)-β-D-glucopyranoside (2) by means of 1H and 13C NMR spectroscopic analysis, including 2D NMR technique. 展开更多
关键词 Chrysanthemum morifolium flavonoid glycosides luteolin 4'-methoxy-7-o-(6"-o-acetyl)-β-d-glucopyranoside acacetin 7-o-(3"-o-acetyl)-β-d-glucopyranoside.
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A new flavone glycoside from Selaginella moellendorffii Hieron. 被引量:14
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作者 Tian Mi Zhu Ke Li Chen Wen Bing Zhou 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第12期1456-1458,共3页
From the ethanol extract of Selaginella moellendorffii Hieron., a new flavone O-glycoside and three known flavone C-glycosides have been isolated and identified as 5-carboxymethyl-4′-hydroxyflavone-7-O-β-D-glucopyra... From the ethanol extract of Selaginella moellendorffii Hieron., a new flavone O-glycoside and three known flavone C-glycosides have been isolated and identified as 5-carboxymethyl-4′-hydroxyflavone-7-O-β-D-glucopyranoside 1, 6,8-di-C-β-D-glueopyranosylapigenin 2, 6-C-[3-D-glucopyranosyl-8-C-β-D-xylopyranosyl apigenin 3, 6-C-B-D-xylopyranosyl-8-C-β-glucopyranosylapigenin 4, respectively. Their structures were elucidated by spectroscopic methods. 展开更多
关键词 SelagineUa moellendorf-fii 5-Carboxymethyl-4-hydroxyflavone-7-o-β-d-glucopyranoside New flavone glycoside
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Two new coumarin glucosides biosynthesized by transgenic hairy roots of Polygonum multiflorum 被引量:5
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作者 Rong Min Yu Liang Bin Zhou +2 位作者 Chun Yan Yan Guo Yan Duan Yu Zhao 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第1期76-78,共3页
The glycosylation of hydroxylcoumarin was investigated by using suspension cultures of hairy roots of Polygonum multiflorum. Two new coumarin glucosides (3 and 4) were biosysthesized by regioselectively glycosylatio... The glycosylation of hydroxylcoumarin was investigated by using suspension cultures of hairy roots of Polygonum multiflorum. Two new coumarin glucosides (3 and 4) were biosysthesized by regioselectively glycosylation of corresponding substrates (1 and 2) in the system. The structures of two products were identified as 7-hydroxy-4-methylcoumarin 5-O-β-D-glucopyranoside and 7- hydroxy-3,4-dimethylcoumarin 5-O-β-D-glucopyranoside on the ground of chemical and spectroscopic methods, respectively. 2007 Rong Min Yu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. 展开更多
关键词 Polygonum multiflorum Hairy roots Glycosylation 7-Hydroxy-4-methylcoumarin 5-o-13-o-glucopyranoside 7-Hydroxy-3 4-dimethylcoumarin 5-o-β-d-glucopyranoside
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A new polyacetylene glycoside from the rhizomes of Atractylodes lancea 被引量:3
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作者 Ying Ji Xu Feng Chao Cheng Xiao Yun Fa Dong Qi Zhi Wang Ming Wang You Yi Zhao 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第7期850-852,共3页
A new polyacetylene glycoside,(1,3Z,11E)-tridecatriene-7,9-diyne-5-hydroxyl-6-O-β-D-glucopyranoside,was isolated from the rhizomes of Atractylodes lancea(Thunb.) DC.Its structure was elucidated on the basis of sp... A new polyacetylene glycoside,(1,3Z,11E)-tridecatriene-7,9-diyne-5-hydroxyl-6-O-β-D-glucopyranoside,was isolated from the rhizomes of Atractylodes lancea(Thunb.) DC.Its structure was elucidated on the basis of spectral analysis. 展开更多
关键词 Atractylodes lancea POLYACETYLENE (1 3Z 11E)-Tridecatriene-7 9-diyne-5-hydroxyl-6-o-β-d-glucopyranoside
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A New Flavan-3-ol Glucoside from Daphniphyllum oldhami 被引量:3
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作者 Zhi Yu SHAO, Da Yuan ZHU, Yue Wei GUOState Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031 《Chinese Chemical Letters》 SCIE CAS CSCD 2003年第9期926-929,共4页
A new flavan-3-ol glucoside, (-)-afzelechin-7-O-β-D-glucopyranoside (1), has been isolated from the stem of Daphniphyllum oldhami. The structure of the new compound was elucidated on the basis of detailed spectroscop... A new flavan-3-ol glucoside, (-)-afzelechin-7-O-β-D-glucopyranoside (1), has been isolated from the stem of Daphniphyllum oldhami. The structure of the new compound was elucidated on the basis of detailed spectroscopie analysis and comparison with related compounds. 展开更多
关键词 Daphniphyllum oldhami flavan-3-ol (-)-afzelechin-7-o-β-d-glucopyranoside.
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Two new isoflavonoids from the rhizomes of Belamcanda chinensis 被引量:2
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作者 Zhi Jun Song Fan Luo +3 位作者 Yan Zhou Bin Ru Bai Shu Lin Peng Li Sheng Ding 《Chinese Chemical Letters》 SCIE CAS CSCD 2007年第6期694-696,共3页
Two new isoflavonoids, 6-methoxy-5,7,8,4′-tetrahydryoxyisoflavone (1) and 4′-methoxy -5,6-dihydroxyisoflavone-7-O-β-d-glucopyranoside (2), were isolated from the rhizomes of Belamcanda chinensis (L.) DC. Their stru... Two new isoflavonoids, 6-methoxy-5,7,8,4′-tetrahydryoxyisoflavone (1) and 4′-methoxy -5,6-dihydroxyisoflavone-7-O-β-d-glucopyranoside (2), were isolated from the rhizomes of Belamcanda chinensis (L.) DC. Their structures were elucidated by extensive spectroscopic evidence including 1D NMR, 2D NMR, MS and IR spectra. 展开更多
关键词 Belamcanda chinensis Isoflavanoid 6-Methoxy-5 7 8 4′-tetrahydryoxyisoflavone 4′-Methoxy-5 6-dihydroxyisoflavone-7-o-β-d-glucopyranoside
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New flavan and unusual chalcone glycosides from Drypetes parvifolia 被引量:1
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作者 Viviane Nadège Nenkep Jovita Chi Shirri +5 位作者 Hanh Trinh Van-Dufat Falindor Sipepnou Philippe Vérité Elisabeth Seguin Francois Tillequin Jean Wandji 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第8期943-946,共4页
Two new compounds 7-hydroxy-5-O-(β-D-glucopyranoside) flavan (1) and (Z)-4',6'-dihydroxy-2'-O-(β-D-glucopyranoside) chalcone (2), along with eight known compounds, were isolated from the stem bark of Dr... Two new compounds 7-hydroxy-5-O-(β-D-glucopyranoside) flavan (1) and (Z)-4',6'-dihydroxy-2'-O-(β-D-glucopyranoside) chalcone (2), along with eight known compounds, were isolated from the stem bark of Drypetes parvifolia (Euphorbiaceae). Their structures were established on the basis of spectroscopic analysis and chemical evidence. 展开更多
关键词 Drypetes parvifolia Flavonoid glycosides 7-Hydroxy-5-o-β-d-glucopyranoside flavan (Z)-4' 6'-Dihydroxy-2'-o-(β-D-glucopyr-anoside) chalcone
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A New Flavone Glycoside from Isodon enanderianus
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作者 Zhi NA Shuang Xi MEI +2 位作者 Chao Ming LI Zhong Wen LIN Han Dong SUN 《Chinese Chemical Letters》 SCIE CAS CSCD 2001年第3期233-234,共2页
A new flavone glycoside, 5,8-dihydroxy-4',6,7-trimethoxyflavone 8-O-(-D-glucopyranoside 1, together with three known flavonoids, pedalitin 2, cirsimartin 3 and genkwanin 4, were isolated from the aerial parts of I... A new flavone glycoside, 5,8-dihydroxy-4',6,7-trimethoxyflavone 8-O-(-D-glucopyranoside 1, together with three known flavonoids, pedalitin 2, cirsimartin 3 and genkwanin 4, were isolated from the aerial parts of Isodon enanderianus. Their structures were determined on the basis of spectral data. 展开更多
关键词 Isodon enanderianus flavonoid flavone glycoside 5 8-dihydroxy-4’ 6 7-trimethoxyflavone 8-o-(-d-glucopyranoside.
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A New Diterpene Glycoside from Isodon forrestii
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作者 Shuang Xi MEI Yun Xin DENG +2 位作者 Quan Bin HAN Zhong Wen LIN Han Dong SUN 《Chinese Chemical Letters》 SCIE CAS CSCD 2001年第2期145-146,共2页
A new diterpene glycoside named 9(10-->20)-abeo-7 beta ,10 beta ,11,15-tetrahydroxy-8,11,13-abietatrien-12-O-beta -D-glucopyranoside was isolated from aerial parts of Isodon forrestii. Its structure was determined ... A new diterpene glycoside named 9(10-->20)-abeo-7 beta ,10 beta ,11,15-tetrahydroxy-8,11,13-abietatrien-12-O-beta -D-glucopyranoside was isolated from aerial parts of Isodon forrestii. Its structure was determined by means of spectroscopic studies. 展开更多
关键词 Isodon forrestii diterpene glycoside abietanoid 9(10→20)-abeo-7β 10β 11 15-tetra-hydroxy-8 11 13-abietatrien-12-o-β-d-glucopyranoside
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何首乌化学成分的研究 被引量:22
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作者 袁炜 高增平 +1 位作者 杨建波 王爱国 《中草药》 CAS CSCD 北大核心 2017年第4期631-634,共4页
目的研究何首乌Polygonum multiflorum的化学成分。方法采用大孔吸附树脂(DM-8型)、Sephadex LH-20、反相硅胶柱色谱和液相制备等多种色谱技术进行分离纯化,采用核磁共振等波谱技术进行结构鉴定。结果从何首乌提取物55%乙醇洗脱部位中... 目的研究何首乌Polygonum multiflorum的化学成分。方法采用大孔吸附树脂(DM-8型)、Sephadex LH-20、反相硅胶柱色谱和液相制备等多种色谱技术进行分离纯化,采用核磁共振等波谱技术进行结构鉴定。结果从何首乌提取物55%乙醇洗脱部位中分离得到10个化合物,分别鉴定为thunberginol C 6-O-β-D-glucopyranoside(1)、对羟基苯甲醛(2)、反式-N-咖啡酰酪胺(3)、(Z)-2,3,5,4′-四羟基二苯乙烯-2-O-β-D-葡萄糖苷(4)、(E)-2,3,5,4′-四羟基二苯乙烯-2-O-β-D-葡萄糖苷(5)、白藜芦醇-3-O-β-D-(2″-O-没食子酰)-葡萄糖苷(6)、(E)-2,3,5,4′-四羟基二苯乙烯-2-O-β-D-(3″-没食子酰)-葡萄糖苷(7)、苜蓿素-7-O-β-D-葡萄糖苷(8)、torachrysone-8-O-β-D-glucoside(9)、大黄素-8-O-β-D-葡萄糖苷(10)。结论化合物1为新化合物,命名为何首乌丁素。化合物3和8为首次从何首乌中分离得到。 展开更多
关键词 蓼科 何首乌 thunberginol C 6-o-β-d-glucopyranoside 何首乌丁素 反式-N-咖啡酰酪胺 苜蓿素-7-o-β-D-葡萄糖苷
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续断的化学成分研究 被引量:13
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作者 孙欣光 黄文华 郭宝林 《现代药物与临床》 CAS 2014年第5期459-464,共6页
目的研究续断的化学成分。方法运用大孔树脂、反相硅胶及制备高效液相等色谱技术进行分离纯化,并根据理化性质和波谱数据鉴定化合物的结构。结果分离得到13个化合物,其中7个环烯醚萜苷和6个木脂素类化合物,分别鉴定为马钱苷(1)、獐牙菜... 目的研究续断的化学成分。方法运用大孔树脂、反相硅胶及制备高效液相等色谱技术进行分离纯化,并根据理化性质和波谱数据鉴定化合物的结构。结果分离得到13个化合物,其中7个环烯醚萜苷和6个木脂素类化合物,分别鉴定为马钱苷(1)、獐牙菜苷(2)、6'-O-β-D-apiofuranosyl-sweroside(3)、续断苷H(4)、续断苷F(5)、续断苷E(6)、triplostoside A(7)、(7R,8S,7'R,8'S)-5-methoxyprinsepiol-4-O-β-D-glucopyranoside(8)、(7R,8S,7'R,8'S)-prinsepiol-4-O-β-D-glucopyranoside(9)、acanthoside D(10)、(7R,8S,7'R,8'S)-fraxiresinol-4'-O-β-D-glucopyranoside(11)、(7R,8S,7'R,8'S)-8-hydroxypinoresinol-4'-O-β-D-glucopyranoside(12)、(7R,8S,7'R,8'S)-8-hydroxypinoresinol-4-O-β-D-glucopyranoside(13)。结论其中化合物8、9、11、12、13为首次从川续断属植物中分离得到。 展开更多
关键词 续断 环烯醚萜苷 木脂素 (7R 8S 7′R 8′S)-5-methoxyprinsepiol-4-o-β-d-glucopyranoside (7R 8S 7'R 8'S)-prinsepiol-4-o-β-d-glucopyranoside
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忍冬叶中的一个新双黄酮苷 被引量:5
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作者 马俊利 李宁 李铣 《中国药物化学杂志》 CAS CSCD 2009年第1期63-64,共2页
通过硅胶柱色谱和Sephadex LH-20柱色谱等分离手段,从忍冬(Lonicera japonica Thunb.)叶中分离得到一个新化合物,利用理化性质和波谱分析,鉴定其结构为ochnaflavone7″-O-β-D-glucopyranoside。
关键词 忍冬 ochnaflavone7-o-β-d-glucopyranoside 结构鉴定
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Chemical Constituents from Dried Aerial Parts of Eclipta prostrata 被引量:8
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作者 HAN Li-feng ZHAO Jing +3 位作者 ZHANG Yi KOJO Agyemang LIU Er-wei WANG Tao 《Chinese Herbal Medicines》 CAS 2013年第4期313-316,共4页
Abstract: Objective To study the constituents in the dried aerial parts of Eclipta prostrata. Methods The constituents wereisolated and purified by column chromatography and their structures were elucidated by spectro... Abstract: Objective To study the constituents in the dried aerial parts of Eclipta prostrata. Methods The constituents wereisolated and purified by column chromatography and their structures were elucidated by spectroscopic methods (1D,2D NMR, UV, IR, and HRESI-TOF-MS) and chemical analyses. Results Eight compounds were isolated andidentified as 7-O-methylorobol-4′-O-β-D-glucopyranoside (1), 3′-hydroxybiochanin A (2), echinocystic acid28-O-β-D-glucopyranoside (3), ecliptasaponin A (4), eclalbasaponin I (5), eclalbasaponin IV (6), echinocystic acid(7), and 3-oxo-16α-hydroxy-olean-12-en-28-oic acid (8). Conclusion Compound 1 is a new compound andcompound 3 is obtained from this genus for the first time. 展开更多
关键词 COMPOSITAE Eclipta prostrata GLYCOSIDE isoflavonoid saponins 7-o-methylorobol-4′-o-β-d-glucopyranoside
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Lignan glucoside from Sinopodophyllum emodi and its cytotoxic activity 被引量:6
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作者 Chang Qi Zhao Yan Yan Zhu +1 位作者 Shu Ying Chen Yukio Ogihara 《Chinese Chemical Letters》 SCIE CAS CSCD 2011年第2期181-184,共4页
A new lignan glycoside was isolated from the n-butanol extract of the roots and rhizomes of Sinopodophyllum emodi.On the basis of spectral evidences,its structure was established and named as 4,5-didemethylpodophyllot... A new lignan glycoside was isolated from the n-butanol extract of the roots and rhizomes of Sinopodophyllum emodi.On the basis of spectral evidences,its structure was established and named as 4,5-didemethylpodophyllotoxin 7'-O-β-D-glucopyranoside. This compound showed cytotoxicity against four human cancer cell lines(Hela,K562,SH-SY5Y and CNE) in vitro. 展开更多
关键词 Sinopodophyllum emodi BERBERIDACEAE 4 5-Didemethylpodophyllotoxin 7-o-β-d-glucopyranoside CYTOTOXICITY
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