In 152 primary liver cancer (PLC)cases and 1: 1 matched controls, risk factors for PLC as well as relevent pedigree data were investigated. The results showed that in relatives of cases,PLC accumulative mortality was ...In 152 primary liver cancer (PLC)cases and 1: 1 matched controls, risk factors for PLC as well as relevent pedigree data were investigated. The results showed that in relatives of cases,PLC accumulative mortality was much higher than that in those of controls (0. 46% vs. 0. 07%, P< 0. 001 ). Of the cases, the rate in consanguineous relatives was 0. 55 %, but in non-consanguineous relatives it was 0. 08 % (P< 0. 01 ); and with alienating of consanguinity a regularly downward gradient of the rate could be observed ; in addition, an independent effect of inheritance remained significant when environmental factors were controlled by Logistic regression and stratification skill. And with an inheritance background, the role of some environmental factors as HBV infection, psychic trauma was reinforced significantly. These results provided further evidence for understanding the association between inheritance and PLC.展开更多
文摘In 152 primary liver cancer (PLC)cases and 1: 1 matched controls, risk factors for PLC as well as relevent pedigree data were investigated. The results showed that in relatives of cases,PLC accumulative mortality was much higher than that in those of controls (0. 46% vs. 0. 07%, P< 0. 001 ). Of the cases, the rate in consanguineous relatives was 0. 55 %, but in non-consanguineous relatives it was 0. 08 % (P< 0. 01 ); and with alienating of consanguinity a regularly downward gradient of the rate could be observed ; in addition, an independent effect of inheritance remained significant when environmental factors were controlled by Logistic regression and stratification skill. And with an inheritance background, the role of some environmental factors as HBV infection, psychic trauma was reinforced significantly. These results provided further evidence for understanding the association between inheritance and PLC.
