Urolithiasis is a common condition that affects 5%-10%of the population globally[1].Once afflicted,urolithiasis tends to be recurrent,with up to 50%in most cases in 5 years since the first stone event[2].Despite the s...Urolithiasis is a common condition that affects 5%-10%of the population globally[1].Once afflicted,urolithiasis tends to be recurrent,with up to 50%in most cases in 5 years since the first stone event[2].Despite the significant progress in understanding the pathogenesis and management of urolithiasis,the condition remains a significant public health concern.The aim of this special issue of the Asian Journal of Urology was to provide an update on the current state of knowledge regarding the pathogenesis,diagnosis,and management of urolithiasis.展开更多
To the Editor:Hereditary hemochromatosis(HH)is a lateonset autonomic disease characterized by enhanced intestinal absorption of iron and iron overload,which may lead to liver cirrhosis,cardiomyopathy,diabetes,arthriti...To the Editor:Hereditary hemochromatosis(HH)is a lateonset autonomic disease characterized by enhanced intestinal absorption of iron and iron overload,which may lead to liver cirrhosis,cardiomyopathy,diabetes,arthritis,and skin pigmentation.In 1996,Feder et al[1]cloned the gene responsible for HH(HFE)and reported that 85%of HH patients were homozygous for the C282Y mutation in the HFE gene.This was subsequently termed type 1 HH.Other inherited forms of HH exist that are non HFE-related,an example of which is juvenile hemochromatosis(JH);two genotypes that induce JH have been reported thus far.One JH genotype involves the hemojuvelin gene(HJV),which was cloned from a Greek family with JH by Papanikolaou et al[2]and is known as type 2A HH.The other involves the human antimicrobial peptide(HAMP)gene,which encodes hepcidin and is termed type 2B HH.展开更多
文摘Urolithiasis is a common condition that affects 5%-10%of the population globally[1].Once afflicted,urolithiasis tends to be recurrent,with up to 50%in most cases in 5 years since the first stone event[2].Despite the significant progress in understanding the pathogenesis and management of urolithiasis,the condition remains a significant public health concern.The aim of this special issue of the Asian Journal of Urology was to provide an update on the current state of knowledge regarding the pathogenesis,diagnosis,and management of urolithiasis.
基金This study was supported by a grant from the Beijing Hospitals Authority Youth Programme(No.QML20181805).
文摘To the Editor:Hereditary hemochromatosis(HH)is a lateonset autonomic disease characterized by enhanced intestinal absorption of iron and iron overload,which may lead to liver cirrhosis,cardiomyopathy,diabetes,arthritis,and skin pigmentation.In 1996,Feder et al[1]cloned the gene responsible for HH(HFE)and reported that 85%of HH patients were homozygous for the C282Y mutation in the HFE gene.This was subsequently termed type 1 HH.Other inherited forms of HH exist that are non HFE-related,an example of which is juvenile hemochromatosis(JH);two genotypes that induce JH have been reported thus far.One JH genotype involves the hemojuvelin gene(HJV),which was cloned from a Greek family with JH by Papanikolaou et al[2]and is known as type 2A HH.The other involves the human antimicrobial peptide(HAMP)gene,which encodes hepcidin and is termed type 2B HH.
