Refractory chronic cough due to gastroesophageal reflux is a trouble some condition unresponsive to thestandard medical anti-reflux therapy. Its underlying mechanisms may include incomplete acid suppression, non-acid ...Refractory chronic cough due to gastroesophageal reflux is a trouble some condition unresponsive to thestandard medical anti-reflux therapy. Its underlying mechanisms may include incomplete acid suppression, non-acid reflux, transient lower esophageal sphincter relaxations and esophageal hypersensitivity. The diagnosis of this disorder depends on both the findings of multi-channel intraluminal impedance-pH monitoring and the subsequent intensified anti-reflux therapy. The strategies of pharmacological treatment for refractory chronic cough due to reflux include the optimization of proton pump inhibitors and add-on therapies with histamine H2 receptor antagonists, baclofen and gabapentin. However, the further study is needed to satisfy its management.展开更多
目的 观察针药并用治疗肺部手术后慢性咳嗽的临床疗效。方法 将60例肺部手术后慢性咳嗽患者随机分为治疗组和对照组,每组30例。对照组口服复方甲氧那明胶囊治疗,治疗组在对照组基础上采用针刺肺经腧穴治疗。比较两组治疗前后中文版莱斯...目的 观察针药并用治疗肺部手术后慢性咳嗽的临床疗效。方法 将60例肺部手术后慢性咳嗽患者随机分为治疗组和对照组,每组30例。对照组口服复方甲氧那明胶囊治疗,治疗组在对照组基础上采用针刺肺经腧穴治疗。比较两组治疗前后中文版莱斯特咳嗽问卷(Mandarin Chinese version of the Leicester cough questionnaire, LCQ-MC)评分、中医证候积分及各项炎性指标[血清白细胞介素-8(interleukin-8, IL-8)、肿瘤坏死因子-α(tumor necrosis factor, TNF-α)]的变化情况,并比较两组的临床疗效。结果 两组治疗后LCQ-MC评分较治疗前显著增加(P<0.01),中医证候积分较治疗前显著降低(P<0.01),且治疗组优于对照组(P<0.01)。两组治疗后血清IL-8和TNF-α水平均较治疗前显著降低(P<0.01),且治疗组低于对照组(P<0.01,P<0.05)。治疗组和对照组总有效率分别为86.7%和63.3%,两组比较差异有统计学意义(P<0.05)。结论 针药并用可有效改善肺部手术后慢性咳嗽的临床症状,提高临床疗效。展开更多
基金Supported by The National Natural Science Foundation of China,Nos.81170079 and 81470276Shanghai Shenkang Hospital Development Center,No.SHDC12012211
文摘Refractory chronic cough due to gastroesophageal reflux is a trouble some condition unresponsive to thestandard medical anti-reflux therapy. Its underlying mechanisms may include incomplete acid suppression, non-acid reflux, transient lower esophageal sphincter relaxations and esophageal hypersensitivity. The diagnosis of this disorder depends on both the findings of multi-channel intraluminal impedance-pH monitoring and the subsequent intensified anti-reflux therapy. The strategies of pharmacological treatment for refractory chronic cough due to reflux include the optimization of proton pump inhibitors and add-on therapies with histamine H2 receptor antagonists, baclofen and gabapentin. However, the further study is needed to satisfy its management.
文摘目的 观察针药并用治疗肺部手术后慢性咳嗽的临床疗效。方法 将60例肺部手术后慢性咳嗽患者随机分为治疗组和对照组,每组30例。对照组口服复方甲氧那明胶囊治疗,治疗组在对照组基础上采用针刺肺经腧穴治疗。比较两组治疗前后中文版莱斯特咳嗽问卷(Mandarin Chinese version of the Leicester cough questionnaire, LCQ-MC)评分、中医证候积分及各项炎性指标[血清白细胞介素-8(interleukin-8, IL-8)、肿瘤坏死因子-α(tumor necrosis factor, TNF-α)]的变化情况,并比较两组的临床疗效。结果 两组治疗后LCQ-MC评分较治疗前显著增加(P<0.01),中医证候积分较治疗前显著降低(P<0.01),且治疗组优于对照组(P<0.01)。两组治疗后血清IL-8和TNF-α水平均较治疗前显著降低(P<0.01),且治疗组低于对照组(P<0.01,P<0.05)。治疗组和对照组总有效率分别为86.7%和63.3%,两组比较差异有统计学意义(P<0.05)。结论 针药并用可有效改善肺部手术后慢性咳嗽的临床症状,提高临床疗效。
