目的围绕老年射血分数下降的心力衰竭(heart failure with decreased ejection fraction in the elderly,HFrEF)患者,采用沙库巴曲缬沙坦治疗,评定其应用效果及对不良心血管事件发生率所产生的影响。方法基于特定时间(2020年1—12月)及...目的围绕老年射血分数下降的心力衰竭(heart failure with decreased ejection fraction in the elderly,HFrEF)患者,采用沙库巴曲缬沙坦治疗,评定其应用效果及对不良心血管事件发生率所产生的影响。方法基于特定时间(2020年1—12月)及固定范围内(本院),对老年HFrEF患者进行选取(90例),将其按照随机数字表法分成两组,均给予常规抗心力衰竭方案(如β受体阻滞剂、利尿剂等),A组45例基于此,采用贝那普利治疗,B组45例给予沙库巴曲缬沙坦,对比两组治疗前、后的二维超声心动图指标及心功能与心肌纤维化指标、心血管不良事件发生情况。结果B组治疗后左室射血分数(left ventricular ejection fraction,LVEF)较A组高,差异有统计学意义(P<0.05),左心室舒张末期容积(left ventricular end diastolic volume,LVEDV)、左心室收缩末期容积(left ventricular end systolic volume,LVESV)均较A组低,差异有统计学意义(P<0.05)。B组治疗后可溶性生长刺激表达基因2蛋白(soluble growth stimulating expressed gene 2 protein,sST2)、N末端B型钠尿肽前体(N-terminal B-type natriuretic peptide precursor,NT-proBNP)相比A组均偏低,差异有统计学意义(P<0.05),而6 min步行试验(6 min walk test,6 MWT)较A组高,差异有统计学意义(P<0.05)。B组因心力衰竭再入院率(2.22%)较A组(17.78%)低,差异有统计学意义(P<0.05)。结论针对老年HFrEF患者,通过给予沙库巴曲缬沙坦治疗,能改善其左心功能及左心室重构,降低因心力衰竭再入院情况的发生率。展开更多
In this paper, a new lifetime class with decreasing failure rate is introduced by compounding truncated binomial distribution with any proper continuous lifetime distribution. The properties of the proposed class are ...In this paper, a new lifetime class with decreasing failure rate is introduced by compounding truncated binomial distribution with any proper continuous lifetime distribution. The properties of the proposed class are discussed, including a formal proof of its probability density function, distribution function and explicit algebraic formulae for its reliability and failure rate functions. A simple EM-type algorithm for iteratively computing maximum likelihood estimates is presented. The Fisher information matrix is derived in order to obtain the asymptotic covariance matrix. This new class of distributions generalizes several distributions which have been introduced and studied in the literature.展开更多
Risk models with stochastic investment return are widely held in practice, as well as in more challenging research fields. Risk theory is mainly concerned with ruin probability, and a tight bound for ruin ...Risk models with stochastic investment return are widely held in practice, as well as in more challenging research fields. Risk theory is mainly concerned with ruin probability, and a tight bound for ruin probability is the best for practical use. This paper presents a discrete time risk model with stochastic in- vestment return. Conditional expectation properties and martingale inequalities are used to obtain both ex- ponential and non-exponential upper bounds for the ruin probability.展开更多
This paper deals with the simple additive degradation models with single random effect. The authors further study the link between the aging property of the implied lifetime and that of the random variation. It is fou...This paper deals with the simple additive degradation models with single random effect. The authors further study the link between the aging property of the implied lifetime and that of the random variation. It is found that both the aging property of the random variation and the analytical behavior of the mean degradation path influence the aging behavior of the implied lifetime.展开更多
文摘目的围绕老年射血分数下降的心力衰竭(heart failure with decreased ejection fraction in the elderly,HFrEF)患者,采用沙库巴曲缬沙坦治疗,评定其应用效果及对不良心血管事件发生率所产生的影响。方法基于特定时间(2020年1—12月)及固定范围内(本院),对老年HFrEF患者进行选取(90例),将其按照随机数字表法分成两组,均给予常规抗心力衰竭方案(如β受体阻滞剂、利尿剂等),A组45例基于此,采用贝那普利治疗,B组45例给予沙库巴曲缬沙坦,对比两组治疗前、后的二维超声心动图指标及心功能与心肌纤维化指标、心血管不良事件发生情况。结果B组治疗后左室射血分数(left ventricular ejection fraction,LVEF)较A组高,差异有统计学意义(P<0.05),左心室舒张末期容积(left ventricular end diastolic volume,LVEDV)、左心室收缩末期容积(left ventricular end systolic volume,LVESV)均较A组低,差异有统计学意义(P<0.05)。B组治疗后可溶性生长刺激表达基因2蛋白(soluble growth stimulating expressed gene 2 protein,sST2)、N末端B型钠尿肽前体(N-terminal B-type natriuretic peptide precursor,NT-proBNP)相比A组均偏低,差异有统计学意义(P<0.05),而6 min步行试验(6 min walk test,6 MWT)较A组高,差异有统计学意义(P<0.05)。B组因心力衰竭再入院率(2.22%)较A组(17.78%)低,差异有统计学意义(P<0.05)。结论针对老年HFrEF患者,通过给予沙库巴曲缬沙坦治疗,能改善其左心功能及左心室重构,降低因心力衰竭再入院情况的发生率。
文摘In this paper, a new lifetime class with decreasing failure rate is introduced by compounding truncated binomial distribution with any proper continuous lifetime distribution. The properties of the proposed class are discussed, including a formal proof of its probability density function, distribution function and explicit algebraic formulae for its reliability and failure rate functions. A simple EM-type algorithm for iteratively computing maximum likelihood estimates is presented. The Fisher information matrix is derived in order to obtain the asymptotic covariance matrix. This new class of distributions generalizes several distributions which have been introduced and studied in the literature.
基金Supported by the National Natural Science Foundation of China (Nos. 19831020 and 70003002) and the Fundamental Research Foundation of School of Economics and Management,Tsinghua University
文摘Risk models with stochastic investment return are widely held in practice, as well as in more challenging research fields. Risk theory is mainly concerned with ruin probability, and a tight bound for ruin probability is the best for practical use. This paper presents a discrete time risk model with stochastic in- vestment return. Conditional expectation properties and martingale inequalities are used to obtain both ex- ponential and non-exponential upper bounds for the ruin probability.
基金supported by National Natural Science Foundation of China under Grant No.10771090
文摘This paper deals with the simple additive degradation models with single random effect. The authors further study the link between the aging property of the implied lifetime and that of the random variation. It is found that both the aging property of the random variation and the analytical behavior of the mean degradation path influence the aging behavior of the implied lifetime.
