A novel palladium/copper-catalyzed aerobic synthesis of bisaryl ketones from 1,2-diarylalkenes via C-C double bonds cleavage has been described.This reaction constitutes a new transformation from 1,2-diarylalkenes int...A novel palladium/copper-catalyzed aerobic synthesis of bisaryl ketones from 1,2-diarylalkenes via C-C double bonds cleavage has been described.This reaction constitutes a new transformation from 1,2-diarylalkenes into bisaryl ketones,providing a unifying,simple and environmentally friendly complement to the available methods.展开更多
Genome mining for the search and discovery of two new globin-like enzymes,TriB from Fusarium poae and TutaA from Schizophyllum commne,are involved in the synthesis of two linear terpenes tricinonoic acid(1)and 2-buten...Genome mining for the search and discovery of two new globin-like enzymes,TriB from Fusarium poae and TutaA from Schizophyllum commne,are involved in the synthesis of two linear terpenes tricinonoic acid(1)and 2-butenedioic acid(3).Both in vivo heterologous biosynthesis and in vitro biochemical assays showed that these two enzymes catalyzed the C-C double bond cleavage of a cyclic sesquiterpene precursor(-)-germacrene D(7)and a linear diterpene backbone schizostain(2),respectively.Our work presents an unusual formation mechanism of linear terpenes from fungi and expands the functional skills of globin-like enzymes in the synthesis of terpene compounds.展开更多
基金We are grateful for the financial support from the State Ethnic Affairs Commission(No.12YNZ05)Opening Fund of Key Laboratory of Ethnic Medicine Resource Chemistry(No.MZY 1117).
文摘A novel palladium/copper-catalyzed aerobic synthesis of bisaryl ketones from 1,2-diarylalkenes via C-C double bonds cleavage has been described.This reaction constitutes a new transformation from 1,2-diarylalkenes into bisaryl ketones,providing a unifying,simple and environmentally friendly complement to the available methods.
基金supported by the National Natural Science Foundation of China(No.31870022)Chongqing Science Funds for Distinguished Young Scientists(No.cstc2020jcyjjqX0005)。
文摘Genome mining for the search and discovery of two new globin-like enzymes,TriB from Fusarium poae and TutaA from Schizophyllum commne,are involved in the synthesis of two linear terpenes tricinonoic acid(1)and 2-butenedioic acid(3).Both in vivo heterologous biosynthesis and in vitro biochemical assays showed that these two enzymes catalyzed the C-C double bond cleavage of a cyclic sesquiterpene precursor(-)-germacrene D(7)and a linear diterpene backbone schizostain(2),respectively.Our work presents an unusual formation mechanism of linear terpenes from fungi and expands the functional skills of globin-like enzymes in the synthesis of terpene compounds.
