The concept of Traditional Chinese Medicine(TCM)emphasizes the intrinsic connection between human beings and nature,positing that the human body undergoes distinct physiological changes in response to various natural ...The concept of Traditional Chinese Medicine(TCM)emphasizes the intrinsic connection between human beings and nature,positing that the human body undergoes distinct physiological changes in response to various natural environments.Cold,as a primary external factor in cold areas,necessitates the body's autonomous adaptation to uphold optimal living conditions.The repercussions of cold on the body are both far-reaching and profound,with metabolic equilibrium adjustments playing a pivotal role.This article,rooted in the TCM principle of Yin-Yang balance,delves into the metabolic intricacies and adaptive responses to the human body in cold environments.The effects manifest in heat-producing tissues,systemic substance consumption,the blood substance concentrations,liver function,and metabolic rhythms.The article subsequently presents TCM recommendations for maintaining health in cold climates.It concludes by advocating the exploration of metabolic homeostasis changes as a key avenue for investigating the metabolic traits s of populations in cold regions.We posit that such insights will enhance comprehension of the metabolic shifts in cold region populations and advance the evolution of regional medicine.展开更多
The Institute of Environmental Health and Engineering,consisting of the previousDepartment of Environmental Health and the Department of Sanitary andEnvironmental Engineering of the Institute of Health founded in 1954...The Institute of Environmental Health and Engineering,consisting of the previousDepartment of Environmental Health and the Department of Sanitary andEnvironmental Engineering of the Institute of Health founded in 1954,was establishedin1986.This Institute has around 220 staff in total and 11 departments,namely,theDepartment of Environmental Epidemiology;Department of EnvironmentalChemistry;Department of Environmental Toxicology;Department of EnvironmentalMicrobiology;Department of Soil Hygiene;Department of Water Treatment;展开更多
Traditionally the global management system of an organization is frequently split into a number of individual management systems that are defined and implemented according to specific management systems standards (MSS...Traditionally the global management system of an organization is frequently split into a number of individual management systems that are defined and implemented according to specific management systems standards (MSSs) as well as managed independently. The individual implementation of MSSs is an option that leads to several inefficiencies and sub-optimization of the global management system of an organization. As referred by ISO [1] the interested parties’ requirements increase. A more effective and efficient option for an organization is to integrate, into an integrated management system (IMS), the implementation and management of requirements of multiple MSSs. Certain difficulties are associated to the structuring process, implementation, verification, evaluation, improvement and progressive development of an IMS in the organizations. Several scholars have proposed various theoretical approaches regarding the integration of individual management systems (MSs) leading to the conclusion that there is not a common practice for all organizations as they encompass different characteristics. This paper aims to present and justify a designed methodology to be used by organizations to support the integration of various MSs. Among them are highlighted: the Environmental Management System (EMS) according ISO 14001 [2], the Quality Management System (QMS) according ISO 9001 [3], and the Occupational Health and Safety Management System (OH & SMS) according OHSAS 18001 [4]. The methodology was designed in the context of a Portuguese company, on sequence of an organizational diagnosis and a research that was performed through a questionnaire. The strategy and the research methods took into consideration the case study.展开更多
In this paper, a new modeling approach incorporating both a new environmental multimedia system (EMS) and the Monte Carlo method (MCM) is developed as a tool for the risk assessment of contaminants. An EMS has been de...In this paper, a new modeling approach incorporating both a new environmental multimedia system (EMS) and the Monte Carlo method (MCM) is developed as a tool for the risk assessment of contaminants. An EMS has been developed and validated by the use of field data and investigation to create a 3D simulation of current conditions of the Trail Road Landfill area. In addition, given the high level of uncertainty associated with EMS practices, the MCM approach is embedded into the developed EMS to deal with vague or imprecise model and site conditions related to uncertainties in the system. In this study, two emission rates were examined for risk assessment of Trail Road Landfill site in the years 2016 and 2026;the data are predicted on the basis of the known production trend from 2001 to 2006. The risk quotient (RQ) factors, combined with present and future rates of chemical pollution, provide spatial and temporal assessment of risk from the leachate in Trail Road Landfill site. Results of the risk assessment approach reveal that as the landfill or oil drilling site becomes depleted, adverse effects on the multimedia environment associated with benzene concentration occur, and the potential risk levels have been quantified for the Trail Road Landfill site. The present study indicates that the dispersion of a large volume of pollutants from the landfill or the oil drilling site poses possible risks to the regional multimedia environment. The new EMS will serve as a risk assessment tool to address the fate and transportation of pollutants in complex multimedia environments. This tool will also be useful in the management of the resulting environmental impacts.展开更多
Background:Based on the principle of“joint consultation,co-building,and sharing”,with the aim of creating an energetic new model of economic growth,the Belt and Road Initiative achieves connectivity and mutual benef...Background:Based on the principle of“joint consultation,co-building,and sharing”,with the aim of creating an energetic new model of economic growth,the Belt and Road Initiative achieves connectivity and mutual benefit.However,the degree of coordinated development of innovation subjects directly affects the improvement and optimization of the Belt and Road Initiative’s strategy implementation environment,and technology efficiency needs improvement.Methods:In this study,a data envelopment analysis model based on the environmental noise elimination algorithm(traditional Chinese medicine-Belt and Road Initiative)was used to identify the technical efficiency of the traditional Chinese medicine industry of Belt and Road Initiative by eliminating the impact of environmental factors.Results:Pure technical ineffectiveness,regional impact,and environmental factors represented by policy responses have a non-linear impact on technical efficiency.The overall technical efficiency of the traditional Chinese medicine industry in the countries along the route shows a trend of annual increases,technical efficiency and scale efficiency are relatively high,and operational efficiency is influenced by the degree of response of the countries along the route and its supporting policies.Conclusion:Pure technical inefficiency is the main factor affecting total technical loss.Geographical advantage is the key factor in operational efficiency.External environmental factors have a significant influence on the operational efficiency of the traditional Chinese medicine industry.展开更多
In order to ameliorate saline-alkaline soil, EM Bokashi has been applied to rice production in conjunction with subdrainage in Ningxia Autonomous Region and Zhejiang Province. The preliminary results can be summarized...In order to ameliorate saline-alkaline soil, EM Bokashi has been applied to rice production in conjunction with subdrainage in Ningxia Autonomous Region and Zhejiang Province. The preliminary results can be summarized as follows： EM Bokashi can increase soil organic matter content, improve soil porosity and permeability, and raise the soil＇s levels of available nutrients; and EM Bokashi combined with subdrainage treatment is more effective in controlling secondary soil salinization and raising the grain yield and quality than other treatments. The results suggest that EM Bokashi can reduce the necessary amount of chemical fertilizer application, thereby improving the agricultural environment, and that the introduction of EM Bokashi into systems of secondary soil salinization control systems has resulted in significant benefits.展开更多
Background:Considering the great heterogeneity of Hepatocellular carcinoma(HCC),more accurate prognostic models are urgently needed.This paper combined the advantages of genomics and pathomics to construct a prognosti...Background:Considering the great heterogeneity of Hepatocellular carcinoma(HCC),more accurate prognostic models are urgently needed.This paper combined the advantages of genomics and pathomics to construct a prognostic model.Methods:First,we collected data from hepatocellular carcinoma patients with complete mRNA expression profiles and clinical annotations from the TCGA database.Then,based on immune-related genes,we used random forest plots to screen prognosis-related genes and build prognostic models.Bioinformatics was used to identify biological pathways,evaluate the tumor microenvironment,and perform drug susceptibility testing.Finally,we divided the patients into different subgroups according to the gene model algorithm.Pathological models were constructed by obtaining HE-stained sections from TCGA in corresponding subgroups of patients.Results:In this study,we constructed a stable prognostic model that could predict overall survival in HCC patients.The signature consisted of six immune-related genes(BX537318.1,TMEM147,CSPG4P12,AC015908.3,CEBPZOS,and SRD5A3).We found increased levels of infiltration of immune cells in the tumor microenvironment in patients with low risk scores,indicating significant antitumor immunity and corresponding to better clinical outcomes.We then screened nine drugs that were more sensitive in the low-risk group than in the high-risk group.Finally,we addressed the complex cellular changes and phenotypic heterogeneity in the HCC microenvironment by combining genomics and pathomics analysis methods.Conclusion:Our study showed that the prognostic evaluation model of HCC based on the immune signaling pathway is feasible and provided a reference value for potential immunotherapy for HCC.展开更多
Acclimatization is a process of biological adaptation when exposed to environmental factors such as hypoxia,cold and heat for prolonged periods of time,where non-genetical variations play a role in allowing subjects t...Acclimatization is a process of biological adaptation when exposed to environmental factors such as hypoxia,cold and heat for prolonged periods of time,where non-genetical variations play a role in allowing subjects to tolerate hypoxic,cold or hot environments.This review focuses on the characteristics and mechanisms of acclimatization found through major research advances by our institute.First,the mechanisms underlying the acclimatization to extreme environments are complex.In our investigations,the physiological changes of multiple systems including the nervous,circulatory,respiratory,and hemopoietic system were demonstrated when the acclimatization to hypoxia was developed,and the underlying significance of hypoxia-inducible factor-1(HIF-1) was investigated.Second,it is suggested that the development of acclimatization to extreme environments is complicated.Hypoxia and cold coexist at high altitude.Our investigations revealed the characteristics of negative cross-relationship in the acclimatization to hypoxia and cold.And third,it is interesting for us to understand that acclimatization to extreme environments is transferable among individuals,and the characteristics of heat acclimatizationinducing factor(HAIF) were presented.The above findings will provide a theoretical guidance for protective operations and help to establish a solid foundation for future research related to acclimatization.展开更多
基金This work was funded by the National Centre for the Development of TCM Education(TC2023002).
文摘The concept of Traditional Chinese Medicine(TCM)emphasizes the intrinsic connection between human beings and nature,positing that the human body undergoes distinct physiological changes in response to various natural environments.Cold,as a primary external factor in cold areas,necessitates the body's autonomous adaptation to uphold optimal living conditions.The repercussions of cold on the body are both far-reaching and profound,with metabolic equilibrium adjustments playing a pivotal role.This article,rooted in the TCM principle of Yin-Yang balance,delves into the metabolic intricacies and adaptive responses to the human body in cold environments.The effects manifest in heat-producing tissues,systemic substance consumption,the blood substance concentrations,liver function,and metabolic rhythms.The article subsequently presents TCM recommendations for maintaining health in cold climates.It concludes by advocating the exploration of metabolic homeostasis changes as a key avenue for investigating the metabolic traits s of populations in cold regions.We posit that such insights will enhance comprehension of the metabolic shifts in cold region populations and advance the evolution of regional medicine.
文摘The Institute of Environmental Health and Engineering,consisting of the previousDepartment of Environmental Health and the Department of Sanitary andEnvironmental Engineering of the Institute of Health founded in 1954,was establishedin1986.This Institute has around 220 staff in total and 11 departments,namely,theDepartment of Environmental Epidemiology;Department of EnvironmentalChemistry;Department of Environmental Toxicology;Department of EnvironmentalMicrobiology;Department of Soil Hygiene;Department of Water Treatment;
文摘Traditionally the global management system of an organization is frequently split into a number of individual management systems that are defined and implemented according to specific management systems standards (MSSs) as well as managed independently. The individual implementation of MSSs is an option that leads to several inefficiencies and sub-optimization of the global management system of an organization. As referred by ISO [1] the interested parties’ requirements increase. A more effective and efficient option for an organization is to integrate, into an integrated management system (IMS), the implementation and management of requirements of multiple MSSs. Certain difficulties are associated to the structuring process, implementation, verification, evaluation, improvement and progressive development of an IMS in the organizations. Several scholars have proposed various theoretical approaches regarding the integration of individual management systems (MSs) leading to the conclusion that there is not a common practice for all organizations as they encompass different characteristics. This paper aims to present and justify a designed methodology to be used by organizations to support the integration of various MSs. Among them are highlighted: the Environmental Management System (EMS) according ISO 14001 [2], the Quality Management System (QMS) according ISO 9001 [3], and the Occupational Health and Safety Management System (OH & SMS) according OHSAS 18001 [4]. The methodology was designed in the context of a Portuguese company, on sequence of an organizational diagnosis and a research that was performed through a questionnaire. The strategy and the research methods took into consideration the case study.
文摘In this paper, a new modeling approach incorporating both a new environmental multimedia system (EMS) and the Monte Carlo method (MCM) is developed as a tool for the risk assessment of contaminants. An EMS has been developed and validated by the use of field data and investigation to create a 3D simulation of current conditions of the Trail Road Landfill area. In addition, given the high level of uncertainty associated with EMS practices, the MCM approach is embedded into the developed EMS to deal with vague or imprecise model and site conditions related to uncertainties in the system. In this study, two emission rates were examined for risk assessment of Trail Road Landfill site in the years 2016 and 2026;the data are predicted on the basis of the known production trend from 2001 to 2006. The risk quotient (RQ) factors, combined with present and future rates of chemical pollution, provide spatial and temporal assessment of risk from the leachate in Trail Road Landfill site. Results of the risk assessment approach reveal that as the landfill or oil drilling site becomes depleted, adverse effects on the multimedia environment associated with benzene concentration occur, and the potential risk levels have been quantified for the Trail Road Landfill site. The present study indicates that the dispersion of a large volume of pollutants from the landfill or the oil drilling site poses possible risks to the regional multimedia environment. The new EMS will serve as a risk assessment tool to address the fate and transportation of pollutants in complex multimedia environments. This tool will also be useful in the management of the resulting environmental impacts.
文摘Background:Based on the principle of“joint consultation,co-building,and sharing”,with the aim of creating an energetic new model of economic growth,the Belt and Road Initiative achieves connectivity and mutual benefit.However,the degree of coordinated development of innovation subjects directly affects the improvement and optimization of the Belt and Road Initiative’s strategy implementation environment,and technology efficiency needs improvement.Methods:In this study,a data envelopment analysis model based on the environmental noise elimination algorithm(traditional Chinese medicine-Belt and Road Initiative)was used to identify the technical efficiency of the traditional Chinese medicine industry of Belt and Road Initiative by eliminating the impact of environmental factors.Results:Pure technical ineffectiveness,regional impact,and environmental factors represented by policy responses have a non-linear impact on technical efficiency.The overall technical efficiency of the traditional Chinese medicine industry in the countries along the route shows a trend of annual increases,technical efficiency and scale efficiency are relatively high,and operational efficiency is influenced by the degree of response of the countries along the route and its supporting policies.Conclusion:Pure technical inefficiency is the main factor affecting total technical loss.Geographical advantage is the key factor in operational efficiency.External environmental factors have a significant influence on the operational efficiency of the traditional Chinese medicine industry.
基金supported by the College Sci-Tech Achievements Industrialization Project of Jiangsu Education Department(Grant No.JH07-010)
文摘In order to ameliorate saline-alkaline soil, EM Bokashi has been applied to rice production in conjunction with subdrainage in Ningxia Autonomous Region and Zhejiang Province. The preliminary results can be summarized as follows： EM Bokashi can increase soil organic matter content, improve soil porosity and permeability, and raise the soil＇s levels of available nutrients; and EM Bokashi combined with subdrainage treatment is more effective in controlling secondary soil salinization and raising the grain yield and quality than other treatments. The results suggest that EM Bokashi can reduce the necessary amount of chemical fertilizer application, thereby improving the agricultural environment, and that the introduction of EM Bokashi into systems of secondary soil salinization control systems has resulted in significant benefits.
文摘Background:Considering the great heterogeneity of Hepatocellular carcinoma(HCC),more accurate prognostic models are urgently needed.This paper combined the advantages of genomics and pathomics to construct a prognostic model.Methods:First,we collected data from hepatocellular carcinoma patients with complete mRNA expression profiles and clinical annotations from the TCGA database.Then,based on immune-related genes,we used random forest plots to screen prognosis-related genes and build prognostic models.Bioinformatics was used to identify biological pathways,evaluate the tumor microenvironment,and perform drug susceptibility testing.Finally,we divided the patients into different subgroups according to the gene model algorithm.Pathological models were constructed by obtaining HE-stained sections from TCGA in corresponding subgroups of patients.Results:In this study,we constructed a stable prognostic model that could predict overall survival in HCC patients.The signature consisted of six immune-related genes(BX537318.1,TMEM147,CSPG4P12,AC015908.3,CEBPZOS,and SRD5A3).We found increased levels of infiltration of immune cells in the tumor microenvironment in patients with low risk scores,indicating significant antitumor immunity and corresponding to better clinical outcomes.We then screened nine drugs that were more sensitive in the low-risk group than in the high-risk group.Finally,we addressed the complex cellular changes and phenotypic heterogeneity in the HCC microenvironment by combining genomics and pathomics analysis methods.Conclusion:Our study showed that the prognostic evaluation model of HCC based on the immune signaling pathway is feasible and provided a reference value for potential immunotherapy for HCC.
文摘Acclimatization is a process of biological adaptation when exposed to environmental factors such as hypoxia,cold and heat for prolonged periods of time,where non-genetical variations play a role in allowing subjects to tolerate hypoxic,cold or hot environments.This review focuses on the characteristics and mechanisms of acclimatization found through major research advances by our institute.First,the mechanisms underlying the acclimatization to extreme environments are complex.In our investigations,the physiological changes of multiple systems including the nervous,circulatory,respiratory,and hemopoietic system were demonstrated when the acclimatization to hypoxia was developed,and the underlying significance of hypoxia-inducible factor-1(HIF-1) was investigated.Second,it is suggested that the development of acclimatization to extreme environments is complicated.Hypoxia and cold coexist at high altitude.Our investigations revealed the characteristics of negative cross-relationship in the acclimatization to hypoxia and cold.And third,it is interesting for us to understand that acclimatization to extreme environments is transferable among individuals,and the characteristics of heat acclimatizationinducing factor(HAIF) were presented.The above findings will provide a theoretical guidance for protective operations and help to establish a solid foundation for future research related to acclimatization.
